Enhancement of dorsal hippocampal activity by knockdown of HCN1 channels leads to anxiolytic- and antidepressant-like behaviors
Open accessAbstract
The hippocampus is an integral brain region for affective disorders. TRIP8b knockout mice lacking functional HCN channels as well as both HCN1 and HCN2 knockout mice have been shown to display antidepressant-like behaviors. The mechanisms or brain regions involved in these alterations in behavior, however, are not clear. We developed a lentiviral shRNA system to examine whether knockdown of HCN1 protein in the dorsal hippocampal CA1 region is sufficient to produce antidepressant-like effects. We found that knockdown of HCN1 channels increased cellular excitability and resulted in physiological changes consistent with a reduction of I(h). Rats infused with lentiviral shRNA-HCN1 in the dorsal hippocampal CA1 region displayed antidepressant- and anxiolytic-like behaviors associated with widespread enhancement of hippocampal activity and upregulation of BDNF-mTOR signaling pathways. Our results suggest that HCN1 protein could be a potential target for treatment of anxiety and depression disorders.
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HCN1 upregulation in lateral habenula drives anxiety during morphine withdrawal, and its inhibition or knockdown reduces this burden.
“HCN1 upregulation in lateral habenula drives anxiety during morphine withdrawal, and its inhibition or knockdown reduces this burden [289].”
From Synaptic Plasticity—Intrinsic Excitability and Antidepressant Discovery (2026) · cites this paper as [289]
The Results section ('Knockdown of HCN1 in dorsal hippocampus exerted anxiolytic-like effects'; page unavailable) reports less anxiety-like behavior after HCN1 knockdown in rats. It studies the dorsal hippocampal CA1 region, not the lateral habenula, and does not report HCN1 upregulation or morphine withdrawal. Those setting and causal details are unsupported. (LLM, conf=0.88)
Experimental — accuracy not yet measuredChronic stress elevates HCN1 and Ih in dorsal CA1, reducing excitability and producing depressive behaviors.
“chronic stress elevates HCN1 and Ih in dorsal Cornu Ammonis area 1 (CA1), reducing excitability and producing depressive behaviors”
From Synaptic Plasticity—Intrinsic Excitability and Antidepressant Discovery (2026) · cites this paper as [289]
The Introduction and Discussion report that knocking down HCN1 in dorsal CA1 reduced Ih-related activity, increased neuronal excitability, and produced antidepressant-like behavior in rats. They do not report that chronic stress elevates HCN1 or Ih in dorsal CA1, or establish that this pathway causes stress-induced depressive behavior. The Results instead mention increased ventral CA1 activity in an animal model of chronic mild stress; page numbers are unavailable in our copy. (LLM, conf=0.85)
Experimental — accuracy not yet measuredLowering HCN surface expression via cAMP signaling or direct HCN1 inhibition rescues stress-related cognitive deficits and post-stroke affective slowing.
“lowering HCN surface expression via cAMP signaling or direct HCN1 inhibition rescues stress-related cognitive deficits and post-stroke affective slowing [289,292,293]”
From Synaptic Plasticity—Intrinsic Excitability and Antidepressant Discovery (2026) · cites this paper as [289]
The Discussion reports that HCN1 knockdown in the dorsal hippocampal CA1 region produced anxiolytic- and antidepressant-like effects in rats. It does not report rescue of stress-related cognitive deficits or post-stroke affective slowing, nor does it show that cAMP signaling lowered HCN surface expression. (LLM, conf=0.85)
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Cites
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
Elbashir, S. M., Harborth, J., Lendeckel, W., Yalcin, A., Weber, K., & Tuschl, T. (2001) · Nature · doi:10.1038/35078107 · Cited by 9,456 · see citing works
Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat
Pellow, S., Chopin, P., File, S. E., & Briley, M. (1985) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(85)90031-7 · Cited by 5,822 · see citing works
Deep Brain Stimulation for Treatment-Resistant Depression
Mayberg, H. S., Lozano, A. M., Voon, V., McNeely, H. E., Seminowicz, D., Hamani, C., Schwalb, J. M., & Kennedy, S. H. (2005) · Neuron · doi:10.1016/j.neuron.2005.02.014 · Cited by 4,059 · see citing works
Antidepressant effects of ketamine in depressed patients
Berman, R. M., Cappiello, A., Anand, A., Oren, D. A., Heninger, G. R., Charney, D. S., & Krystal, J. H. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00230-9 · Cited by 3,856 · see citing works
A Neurotrophic Model for Stress-Related Mood Disorders
Duman, R. S., & Monteggia, L. M. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.02.013 · Cited by 3,375 · see citing works
Behavioral despair in mice: a primary screening test for antidepressants.
Porsolt, R. D., Bertin, A., & Jalfre, M. (1977) · PubMed · Cited by 3,275 · see citing works
The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review.
Prut, L., & Belzung, C. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)01272-x · Cited by 3,190 · see citing works
mTOR-Dependent Synapse Formation Underlies the Rapid Antidepressant Effects of NMDA Antagonists
Li, N., Lee, B., Liu, R.-J., Banasr, M., Dwyer, J. M., Iwata, M., Li, X.-Y., Aghajanian, G., & Duman, R. S. (2010) · Science · doi:10.1126/science.1190287 · Cited by 2,881 · see citing works
NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses
Autry, A. E., Adachi, M., Nosyreva, E., Na, E. S., Los, M. F., Cheng, P.-F., Kavalali, E. T., & Monteggia, L. M. (2011) · Nature · doi:10.1038/nature10130 · Cited by 1,926 · see citing works
Limbic-cortical dysregulation: a proposed model of depression
(1997) · The Journal of Neuropsychiatry and Clinical Neurosciences · doi:10.1176/jnp.9.3.471 · Cited by 1,585 · see citing works
Mayberg, H. S. (2003) · British Medical Bulletin · doi:10.1093/bmb/65.1.193 · Cited by 1,166 · cited 1× · see citing works
“pathologically elevated metabolic activity, implying that alternation in limbic-cortical activity may be involved in this treatment of severe depression (Mayberg, 2003; Mayberg et al., 2005).”
Increased hippocampal bdnf immunoreactivity in subjects treated with antidepressant medication
Chen, B., Dowlatshahi, D., MacQueen, G. M., Wang, J.-F., & Young, L. T. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01083-6 · Cited by 1,164 · see citing works
Lower Hippocampal Volume in Patients Suffering From Depression: A Meta-Analysis
Campbell, S., Marriott, M., Nahmias, C., & MacQueen, G. M. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.4.598 · Cited by 1,156 · see citing works
Queer Current and Pacemaker: The Hyperpolarization-Activated Cation Current in Neurons
Pape, H.-C. (1996) · Annual Review of Physiology · doi:10.1146/annurev.ph.58.030196.001503 · Cited by 1,152 · see citing works
Mayberg, H. S., Brannan, S. K., Tekell, J. L., Silva, J. A., Mahurin, R. K., McGinnis, S., & Jerabek, P. A. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01036-2 · Cited by 1,115 · see citing works
JACOBI, F., WITTCHEN, H.-U., HÖLTING, C., HÖFLER, M., PFISTER, H., MÜLLER, N., & LIEB, R. (2004) · Psychological Medicine · doi:10.1017/s0033291703001399 · Cited by 1,097 · see citing works
Magee, J. C. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-19-07613.1998 · Cited by 981 · see citing works
Lamers, F., van Oppen, P., Comijs, H. C., Smit, J. H., Spinhoven, P., van Balkom, A. J. L. M., Nolen, W. A., Zitman, F. G., Beekman, A. T. F., & Penninx, B. W. J. H. (2011) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.10m06176blu · Cited by 913 · see citing works
The role of the hippocampus in the pathophysiology of major depression
Campbell, S., & MacQUEEN, G. M. (2004) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0441 · Cited by 879 · see citing works
Dwivedi, Y., Rizavi, H. S., Conley, R. R., Roberts, R. C., Tamminga, C. A., & Pandey, G. N. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.8.804 · Cited by 875 · see citing works
Stuart, G. J., Dodt, H., & Sakmann, B. J. (1993) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00374949 · Cited by 804 · see citing works
Lucki, I. (1997) · Behavioural Pharmacology · doi:10.1097/00008877-199711000-00010 · Cited by 803 · see citing works
Kennedy, S. H., Evans, K. R., Krüger, S., Mayberg, H. S., Meyer, J. H., McCann, S., Arifuzzman, A. I., Houle, S., & Vaccarino, F. J. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.6.899 · Cited by 710 · see citing works
Wang, M., Ramos, B. P., Paspalas, C. D., Shu, Y., Simen, A., Duque, A., Vijayraghavan, S., Brennan, A., Dudley, A., Nou, E., et al. (2007) · Cell · doi:10.1016/j.cell.2007.03.015 · Cited by 672 · see citing works
Effects of Chronic Fluoxetine in Animal Models of Anxiety and Depression
Dulawa, S. C., Holick, K. A., Gundersen, B., & Hen, R. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300433 · Cited by 671 · see citing works
Thorne, R. G., & Nicholson, C. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509425103 · Cited by 641 · see citing works
Dendritic Ih normalizes temporal summation in hippocampal CA1 neurons
Magee, J. C. (1999) · Nature Neuroscience · doi:10.1038/9158 · Cited by 617 · see citing works
Selective Erasure of a Fear Memory
Han, J., Kushner, S. A., Yiu, A. P., Hsiang, H., Buch, T., Waisman, A., Bontempi, B., Neve, R. L., Frankland, P. W., & Josselyn, S. A. (2009) · Science · doi:10.1126/science.1164139 · Cited by 570 · see citing works
Hippocampal theta oscillations are travelling waves
Lubenov, E. V., & Siapas, A. G. (2009) · Nature · doi:10.1038/nature08010 · Cited by 543 · see citing works
A Behavioral Role for Dendritic Integration
Nolan, M. F., Malleret, G., Dudman, J. T., Buhl, D. L., Santoro, B., Gibbs, E., Vronskaya, S., Buzsáki, G., Siegelbaum, S. A., Kandel, E. R., et al. (2004) · Cell · doi:10.1016/j.cell.2004.11.020 · Cited by 472 · see citing works
Pharmacological upregulation of h-channels reduces the excitability of pyramidal neuron dendrites
Poolos, N. P., Migliore, M., & Johnston, D. (2002) · Nature Neuroscience · doi:10.1038/nn891 · Cited by 454 · see citing works
Self-citationLeptin: A potential novel antidepressant
Lu, X.-Y., Kim, C. S., Frazer, A., & Zhang, W. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508901103 · Cited by 446 · see citing works
Self-citationPolarized and compartment-dependent distribution of HCN1 in pyramidal cell dendrites
Lőrincz, A., Notomi, T., Tamás, G., Shigemoto, R., & Nusser, Z. (2002) · Nature Neuroscience · doi:10.1038/nn962 · Cited by 442 · see citing works
Hu, H., Vervaeke, K., & Storm, J. F. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2002.029249 · Cited by 410 · see citing works
Liu, R.-J., Lee, F. S., Li, X.-Y., Bambico, F., Duman, R. S., & Aghajanian, G. K. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.09.030 · Cited by 403 · see citing works
High-speed imaging reveals neurophysiological links to behavior in an animal model of depression
Airan, R. D., Meltzer, L. A., Roy, M., Gong, Y., Chen, H., & Deisseroth, K. (2007) · Science · doi:10.1126/science.1144400 · Cited by 396 · see citing works
Nolan, M. F., Malleret, G., Lee, K. H., Gibbs, E., Dudman, J. T., Santoro, B., Yin, D., Thompson, R. F., Siegelbaum, S. A., Kandel, E. R., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00884-5 · Cited by 320 · see citing works
Seizure-Induced Plasticity of h Channels in Entorhinal Cortical Layer III Pyramidal Neurons
Shah, M. M., Anderson, A. E., Leung, V. C. M., Lin, X., & Johnston, D. (2004) · Neuron · doi:10.1016/j.neuron.2004.10.011 · Cited by 288 · see citing works
Self-citationProjection-Specific Neuromodulation of Medial Prefrontal Cortex Neurons
Dembrow, N. C., Chitwood, R. A., & Johnston, D. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.3644-10.2010 · Cited by 281 · see citing works
Self-citationHCN1 Channel Subunits Are a Molecular Substrate for Hypnotic Actions of Ketamine
Chen, X., Shu, S., & Bayliss, D. A. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.3481-08.2009 · Cited by 279 · see citing works
Nolan, M. F., Malleret, G., Dudman, J. T., Buhl, D. L., Santoro, B., GIBBS, E., Vronskaya, S., Buzsáki, G., Siegelbaum, S. A., & Kandel, E. R. (2004) · Cell · doi:10.1016/s0092-8674(04)01055-4 · Cited by 274 · see citing works
Molecular and Cellular Approaches to Memory Allocation in Neural Circuits
Silva, A. J., Zhou, Y., Rogerson, T., Shobe, J. L., & Balaji, J. (2009) · Science · doi:10.1126/science.1174519 · Cited by 266 · see citing works
Narayanan, R., & Johnston, D. (2007) · Neuron · doi:10.1016/j.neuron.2007.10.033 · Cited by 257 · see citing works
Self-citationMonteggia, L. M., Eisch, A. J., Tang, M. D., Kaczmarek, L. K., & Nestler, E. J. (2000) · Molecular Brain Research · doi:10.1016/s0169-328x(00)00155-8 · Cited by 232 · see citing works
Brager, D. H., & Johnston, D. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3520-07.2007 · Cited by 207 · see citing works
Self-citationFunctional Differentiation Along the Anterior-Posterior Axis of the Hippocampus in Monkeys
Colombo, M., Fernandez, T., Nakamura, K., & Gross, C. G. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.80.2.1002 · Cited by 167 · see citing works
Acute administration of leptin produces anxiolytic-like effects: a comparison with fluoxetine
Liu, J., Garza, J. C., Bronner, J., Kim, C. S., Zhang, W., & Lu, X. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1684-3 · Cited by 163 · see citing works
Self-citationTominaga, T., Tominaga, Y., Yamada, H., Matsumoto, G., & Ichikawa, M. (2000) · Journal of Neuroscience Methods · doi:10.1016/s0165-0270(00)00270-3 · Cited by 140 · see citing works
Performance on a Virtual Reality Spatial Memory Navigation Task in Depressed Patients
Gould, N. F., Holmes, M. K., Fantie, B. D., Luckenbaugh, D. A., Pine, D. S., Gould, T. D., Burgess, N., Manji, H. K., & Zarate, C. A. (2007) · American Journal of Psychiatry · doi:10.1176/ajp.2007.164.3.516 · Cited by 140 · see citing works
Plasticity of dendritic excitability
Frick, A., & Johnston, D. (2005) · Journal of Neurobiology · doi:10.1002/neu.20148 · Cited by 138 · see citing works
Self-citationSeizure risk associated with psychotropic drugs: clinical and pharmacokinetic considerations.
Alldredge, B. K. (1999) · PubMed · Cited by 134 · see citing works
Lewis, A. S., Vaidya, S. P., Blaiss, C. A., Liu, Z., Stoub, T. R., Brager, D. H., Chen, X., Bender, R. A., Estep, C. M., Popov, A. B., et al. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0936-11.2011 · Cited by 123 · see citing works
Self-citationBrewster, A. L., Chen, Y., Bender, R. A., Yeh, A., Shigemoto, R., & Baram, T. Z. (2006) · Cerebral Cortex · doi:10.1093/cercor/bhk021 · Cited by 96 · see citing works
Borelli, K. G., Nobre, M. J., Brandão, M. L., & Coimbra, N. C. (2004) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2003.12.009 · Cited by 94 · see citing works
Incidence of seizures during treatment with tricyclic antidepressant drugs and bupropion.
Peck, A. W., Stern, W. C., & Watkinson, C. (1983) · PubMed · Cited by 88 · see citing works
Antidepressant-like effects of NMDA-receptor antagonist injected into the dorsal hippocampus of rats
Padovan, C. M., & Guimarães, F. S. (2003) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2003.09.015 · Cited by 78 · see citing works
McLaughlin, R. J., Hill, M. N., Morrish, A. C., & Gorzalka, B. B. (2007) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e3282ee7b44 · Cited by 77 · see citing works
Selective Serotonin Reuptake Inhibitor Treatment for Generalized Anxiety Disorder
Ball, S. G., Kuhn, A., Wall, D., Shekhar, A., & Goddard, A. W. (2005) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v66n0113 · Cited by 66 · see citing works
Safety and Efficacy of Prolonged Outpatient Ketamine Infusions for Neuropathic Pain
Webster, L. R., & Walker, M. J. (2006) · American Journal of Therapeutics · doi:10.1097/00045391-200607000-00004 · Cited by 45 · see citing works
Louboutin, J. P., Reyes, B. A. S., Agrawal, L., Bockstaele, E. V., & Strayer, D. S. (2007) · Gene Therapy · doi:10.1038/sj.gt.3302939 · Cited by 38 · see citing works
Dendritic voltage-gated ion channels
Magee, J. C. (2007) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780198566564.003.0009 · Cited by 26 · see citing works
Epilepsy, depression and antidepressant drugs
Salzberg, M. R., & Vajda, F. J. E. (2001) · Journal of Clinical Neuroscience · doi:10.1054/jocn.2000.0896 · Cited by 25 · see citing works
Distinguishing anxiolysis and hyperactivity in an open space behavioral test
Ennaceur, A., Michalíková, S., van Rensburg, R., & Chazot, P. L. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.09.042 · Cited by 24 · see citing works
Fluoxetine treatment of depressed patients with comorbid anxiety disorders
Sonawalla, S. B., Farabaugh, A. H., Johnson, M. W., Morray, M., Delgado, M. L., Pingol, M. G., Rosenbaum, J. F., & D, M. F. M. (2002) · Journal of Psychopharmacology · doi:10.1177/026988110201600304 · Cited by 22 · see citing works
Chang, P. Y., Taylor, P. E., & Jackson, M. B. (2007) · Journal of Neurophysiology · doi:10.1152/jn.00532.2007 · Cited by 15 · see citing works
Self-citationPrévenir les hallucinations aiguës associées à la perfusion intraveineuse continue de kétamine
Remérand, F., Couvret, C., Pourrat, X., Tendre, C. L., Baud, A., & Fusciardi, J. (2007) · Therapies · doi:10.2515/therapie:200802 · Cited by 13 · see citing works
Zhao, Y., Keating, K., Dolman, C., & Thorpe, R. (2008) · Human Gene Therapy · doi:10.1089/hum.2007.119 · Cited by 11 · see citing works
Flagged first, then by citations
1 of the 68 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Zheng, P., Zeng, B., Zhou, C., Liu, M., Fang, Z., Xu, X., Zeng, L., Chen, J., Fan, S., Du, X., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.44 · Cited by 2,023 · see citing works
Ketamine and Ketamine Metabolite Pharmacology: Insights into Therapeutic Mechanisms
Zanos, P., Moaddel, R., Morris, P. J., Riggs, L. M., Highland, J. N., Georgiou, P., Pereira, E. F. R., Albuquerque, E. X., Thomas, C. J., Zarate, C. A., et al. (2018) · Pharmacological Reviews · doi:10.1124/pr.117.015198 · Cited by 1,260 · see citing works
Koga, K., Descalzi, G., Chen, T., Ko, H., Lu, J., Li, S., Son, J., Kim, T., Kwak, C., Huganir, R. L., et al. (2014) · Neuron · doi:10.1016/j.neuron.2014.12.021 · Cited by 360 · see citing works
mTOR in Brain Physiology and Pathologies
Bockaert, J., & Marin, P. (2015) · Physiological Reviews · doi:10.1152/physrev.00038.2014 · Cited by 360 · see citing works
Selective information routing by ventral hippocampal CA1 projection neurons
Ciocchi, S., Passecker, J., Malagon‐Vina, H., Mikuš, N., & Klausberger, T. (2015) · Science · doi:10.1126/science.aaa3245 · Cited by 344 · see citing works
Loss of Dickkopf-1 Restores Neurogenesis in Old Age and Counteracts Cognitive Decline
Seib, D. R., Corsini, N. S., Ellwanger, K., Plaas, C., Mateos, Á., Pitzer, C., Niehrs, C., Celikel, T., & Martín-Villalba, A. (2013) · Cell stem cell · doi:10.1016/j.stem.2012.11.010 · Cited by 294 · see citing works
Huo, R., Zeng, B., Zeng, L., Cheng, K., Li, B., Luo, Y., Wang, H., Zhou, C., Fang, L., Li, W., et al. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00489 · Cited by 221 · see citing works
Parrott, J. M., Redus, L., Santana-Coelho, D., Morales, J., Gao, X., & O'Connor, J. C. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.200 · Cited by 174 · see citing works
Gassen, N. C., Hartmann, J., Zschocke, J., Stepan, J., Hafner, K., Zellner, A., Kirmeier, T., Kollmannsberger, L. K., Wagner, K. V., Dedic, N., et al. (2014) · PLoS Medicine · doi:10.1371/journal.pmed.1001755 · Cited by 177 · see citing works
Hippocampus: Molecular, Cellular, and Circuit Features in Anxiety
Shi, H., Wang, S., Wang, X., Zhang, R.-X., & Zhu, L. (2023) · Neuroscience Bulletin · doi:10.1007/s12264-023-01020-1 · Cited by 151 · see citing works
Sartiani, L., Mannaioni, G., Masi, A., Novella Romanelli, M., & Cerbai, E. (2017) · Pharmacological Reviews · doi:10.1124/pr.117.014035 · Cited by 143 · see citing works
Santoro, B., & Shah, M. M. (2020) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010919-023356 · Cited by 108 · see citing works
Stimulation of entorhinal cortex-dentate gyrus circuitry is antidepressive
Yun, S., Reynolds, R. P., Petrof, I., White, A., Rivera, P. D., Segev, A., Gibson, A. D., Suarez, M., DeSalle, M. J., Ito, N., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0002-1 · Cited by 120 · see citing works
Proteomics analysis of the gut–brain axis in a gut microbiota-dysbiosis model of depression
Liu, Y., Wang, H., Gui, S., Zeng, B., Pu, J., Zheng, P., Zeng, L., Luo, Y., Wu, Y., Zhou, C., et al. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01689-w · Cited by 104 · see citing works
HCN2 channels in the ventral tegmental area regulate behavioral responses to chronic stress
Zhong, P., Vickstrom, C. R., Liu, X., Hu, Y., Yu, L., Yu, H.-G., & Liu, Q.-S. (2018) · eLife · doi:10.7554/elife.32420 · Cited by 99 · see citing works
“Interestingly, depolarizing current injections elicited significantly more action potentials following HCN1 knockdown, knockout, and Ih blockade in hippocampal neurons (Kim et al., 2012; Lewis et al., 2011).”
BackgroundGreenwood, T. A., Lazzeroni, L. C., Maihofer, A. X., Swerdlow, N. R., Calkins, M. E., Freedman, R., Green, M. F., Light, G. A., Nievergelt, C. M., Nuechterlein, K. H., et al. (2019) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2019.2850 · Cited by 100 · see citing works
Kim, C. S., & Johnston, D. (2015) · Journal of Neurophysiology · doi:10.1152/jn.00951.2014 · Cited by 95 · see citing works
Self-citationStepan, J., Dine, J., & Eder, M. (2015) · Frontiers in Neuroscience · doi:10.3389/fnins.2015.00160 · Cited by 86 · see citing works
Melatonin Alleviates Neuroinflammation and Metabolic Disorder in DSS-Induced Depression Rats
Lv, W., Liu, C., Yu, L., Zhou, J., Li, Y., Xiong, Y., Guo, A., Chao, L., Qu, Q., Guang-wei, W., et al. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/1241894 · Cited by 85 · see citing works
HCN Channels Modulators: The Need for Selectivity
Novella Romanelli, M., Sartiani, L., Masi, A., Mannaioni, G., Manetti, D., Mugelli, A., & Cerbai, E. (2016) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026616999160315130832 · Cited by 73 · see citing works
Changes in Hippocampal Plasticity in Depression and Therapeutic Approaches Influencing These Changes
Xu, W., Yao, X., Zhao, F., Zhao, H., Cheng, Z., Yang, W., Cui, R., Xu, S., & Li, B. (2020) · Neural Plasticity · doi:10.1155/2020/8861903 · Cited by 73 · see citing works
Synaptic Regulation of a Thalamocortical Circuit Controls Depression-Related Behavior
Miller, O. H., Bruns, A., Ammar, I. B., Mueggler, T., & Hall, B. J. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.08.002 · Cited by 69 · see citing works
Electrical properties of kisspeptin neurons and their regulation of GnRH neurons
Piet, R., de Croft, S., Liu, X., & Herbison, A. E. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.05.006 · Cited by 65 · see citing works
Ketamine as a therapeutic agent for depression and pain: mechanisms and evidence
Subramanian, S., Haroutounian, S., Palanca, B. J. A., & Lenze, E. J. (2022) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2022.120152 · Cited by 68 · see citing works
GluN2A mediates ketamine-induced rapid antidepressant-like responses
Su, T., Lu, Y., Fu, C., Geng, Y., & Chen, Y. (2023) · Nature Neuroscience · doi:10.1038/s41593-023-01436-y · Cited by 63 · see citing works
Ligand-induced structural changes in the cyclic nucleotide-modulated potassium channel MloK1
Kowal, J., Chami, M., Baumgartner, P., Arheit, M., Chiu, P., Rangl, M., Simon Scheuring, A., Schroeder, G. F., Nimigean, C. M., & Stahlberg, H. (2014) · Nature Communications · doi:10.1038/ncomms4106 · Cited by 63 · see citing works
Chang, X., Wang, J., Jiang, H. F., Shi, L., & Xie, J. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00141 · Cited by 63 · see citing works
Lv, W.-J., Wu, X.-L., Chen, W.-Q., Li, Y.-F., Zhang, G.-F., Chao, L.-M., Zhou, J.-H., Guo, A., Liu, C., & Guo, S.-N. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/7902874 · Cited by 61 · see citing works
Tamási, V., Petschner, P., Ádori, C., Kirilly, E., Andó, R. D., Tóthfalusi, L., Juhász, G., & Bagdy, G. (2014) · PLoS ONE · doi:10.1371/journal.pone.0113662 · Cited by 61 · see citing works
Fan, J., Li, D., Chen, H., Huang, J., Xu, J., Zhu, W., Chen, J., & Wang, F. (2018) · British Journal of Pharmacology · doi:10.1111/bph.14519 · Cited by 61 · see citing works
Tao, C., Zhang, G., Huang, J., Li, Z., Tao, H. W., & Zhang, L. I. (2023) · Nature Neuroscience · doi:10.1038/s41593-023-01397-2 · Cited by 60 · see citing works
An entorhinal-visual cortical circuit regulates depression-like behaviors
Lu, J., Zhang, Z., Yin, X., Tang, Y., Ji, R., Chen, H., Guang, Y., Gong, X., He, Y., Zhou, W., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01540-8 · Cited by 58 · see citing works
Kim, C. S., Brager, D. H., & Johnston, D. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.28 · Cited by 55 · see citing works
Self-citationHCN Channel Targets for Novel Antidepressant Treatment
Ku, S. M., & Han, M.-H. (2017) · Neurotherapeutics · doi:10.1007/s13311-017-0538-7 · Cited by 54 · see citing works
Huang, C., Yang, X., Zeng, B., Zeng, L., Gong, X., Zhou, C., Xia, J., Lian, B., Qin, Y., Yang, L., et al. (2019) · Journal of Proteomics · doi:10.1016/j.jprot.2018.11.023 · Cited by 54 · see citing works
Han, Y. S., Heuermann, R. J., Lyman, K. A., Fisher, D. W., Ismail, Q.-A., & Chetkovich, D. M. (2016) · Molecular Psychiatry · doi:10.1038/mp.2016.99 · Cited by 53 · see citing works
Applying ketamine to alleviate the PTSD-like effects by regulating the HCN1-related BDNF
Hou, L., Qi, Y., Sun, H., Wang, G., Li, Q., Wang, Y., Zhang, Z., Du, Z., & Sun, L. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.03.019 · Cited by 51 · see citing works
Chen, W., Xie, B., Zhang, C., Xu, K.-L., Niu, Y., Tang, X., Zhang, P., Zou, W., Hu, B., & Tian, Y. (2013) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e3283654258 · Cited by 50 · see citing works
Lim, J., Bang, Y., Choi, J.-H., Han, A., Kwon, M., Liu, K., & Choi, H. J. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.4051-15.2017 · Cited by 50 · see citing works
HCN Channels: New Therapeutic Targets for Pain Treatment
Ramírez, D., Zúñiga, R., Concha, G., & Zúñiga, L. (2018) · Molecules · doi:10.3390/molecules23092094 · Cited by 48 · see citing works
Ni, L., Xu, Y., Dong, S., Kong, Y., Wang, H., Lu, G., Wang, Y., Li, Q., Li, C., Du, Z., et al. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-0782-1 · Cited by 48 · see citing works
Villarroel, H. S., Bompolaki, M., Mackay, J. P., Tapia, A. P. M., Michaelson, S. D., Leitermann, R. J., Marr, R. A., Urban, J. H., & Colmers, W. F. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.3528-17.2018 · Cited by 45 · see citing works
Target deconvolution studies of (2R,6R)-hydroxynorketamine: an elusive search
Bonaventura, J., Gomez, J. L., Carlton, M. L., Lam, S., Sánchez‐Soto, M., Morris, P. J., Moaddel, R., Kang, H. J., Zanos, P., Gould, T. D., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01673-w · Cited by 46 · see citing works
Liu, K., Li, J.-Y., Tan, H., Du, C., Xie, W., Zhang, Y., Ma, W.-L., & Zhang, L. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.03.031 · Cited by 43 · see citing works
The enigmatic HCN channels: A cellular neurophysiology perspective
Mishra, P., & Narayanan, R. (2025) · Proteins: Structure, Function, and Bioinformatics · doi:10.1002/prot.26643 · Cited by 40 · see citing works
Honnuraiah, S., & Narayanan, R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0055590 · Cited by 43 · see citing works
Lee, E. H., & Han, P. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.03.014 · Cited by 40 · see citing works
Ion Channel Dysfunction and Neuroinflammation in Migraine and Depression
Eren‐Koçak, E., & Dalkara, T. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.777607 · Cited by 39 · see citing works
Stress, depression, and hippocampus: from biochemistry to electrophysiology
Idunkova, A., Lacinová, Ľ., & Hoppanová, L. (2023) · General Physiology and Biophysics · doi:10.4149/gpb_2023001 · Cited by 36 · see citing works
Zhang, X., Zhao, Y., Du, Y., Sun, H., Zhang, W., Wang, A., Li, Q., Li, C., Wang, Y., Du, Z., et al. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.02.058 · Cited by 34 · see citing works
Kim, J., Lei, Y., Lu, X.-Y., & Kim, C. S. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01682-9 · Cited by 33 · see citing works
“Normal rats demonstrate antidepressant- and anxiolytic-like effects when HCN1 protein is lowered in the dorsal but not ventral CA1 area [42].”
BackgroundMethodInfluentialSelf-citationNoam, Y., Ehrengruber, M. U., Koh, A., Feyen, P., Manders, E. M. M., Abbott, G. W., Wadman, W. J., & Baram, T. Z. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.522060 · Cited by 31 · see citing works
Mishra, P., & Narayanan, R. (2014) · Journal of Neurophysiology · doi:10.1152/jn.00601.2013 · Cited by 30 · see citing works
HCN channel antagonist ZD7288 ameliorates neuropathic pain and associated depression
Yang, L., Liu, X., Yao, K., Sun, Y., Jiang, F., Yan, H., Mao, P., Fan, S., Wei, X., Liu, Y., et al. (2019) · Brain Research · doi:10.1016/j.brainres.2019.03.036 · Cited by 30 · see citing works
Hou, L., Guo, Y., Lian, B., Wang, Y., Li, C., Wang, G., Li, Q., Pang, J.-J., Sun, H., & Sun, L. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00215 · Cited by 30 · see citing works
mGluR5 in hippocampal CA1 pyramidal neurons mediates stress-induced anxiety-like behavior
Li, X., Du, Z., Xu, J.-N., Liang, Z.-M., Lin, S., Chen, H. H., Li, S.-J., Li, X., Yang, J., & Gao, T. (2023) · Neuropsychopharmacology · doi:10.1038/s41386-023-01548-w · Cited by 30 · see citing works
Wu, X., Wang, J., Song, L., Guan, Y., Cao, C., Cui, Y., Zhang, Y., & Liu, C. (2021) · Neuroscience · doi:10.1016/j.neuroscience.2021.07.029 · Cited by 28 · see citing works
Masi, A., Narducci, R., Landucci, E., Moroni, F., & Mannaioni, G. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12104 · Cited by 29 · see citing works
Seo, H., Seol, M.-J., & Lee, K. (2015) · Molecular Brain · doi:10.1186/s13041-015-0103-4 · Cited by 28 · see citing works
Neuropeptide S modulates the amygdaloidal HCN activities (I) in rats: Implication in chronic pain
Zhang, S., You, Z., Wang, S., Yang, J., Yang, L., Sun, Y., Mi, W., Yang, L., McCabe, M. F., Shen, S., et al. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.02.004 · Cited by 28 · see citing works
Physiology and Therapeutic Potential of SK, H, and M Medium AfterHyperPolarization Ion Channels
Dwivedi, D., & Bhalla, U. S. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.658435 · Cited by 26 · see citing works
ΔFosB Decreases Excitability of Dorsal Hippocampal CA1 Neurons
Eagle, A. L., WILLIAMS, E. S., Beatty, J. A., Cox, C. L., & Robison, A. J. (2018) · eNeuro · doi:10.1523/eneuro.0104-18.2018 · Cited by 26 · see citing works
HCN1 Channels: A New Therapeutic Target for Depressive Disorders?
Shah, M. M. (2012) · Science Signaling · doi:10.1126/scisignal.2003593 · Cited by 26 · see citing works
Qiao, G., Qian, Z., Sun, H., Xu, W., Yan, Z.-Y., Liu, Y., Zhou, J., Zhang, H., Wang, L.-J., Pan, X., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0071184 · Cited by 26 · see citing works
HCN4 knockdown in dorsal hippocampus promotes anxiety‐like behavior in mice
Günther, A., Luczak, V., Gruteser, N., Abel, T. G., & Baumann, A. (2018) · Genes Brain & Behavior · doi:10.1111/gbb.12550 · Cited by 26 · see citing works
Foote, K. M., Lyman, K. A., Han, Y. S., Michailidis, I. E., Heuermann, R. J., Mandikian, D., Trimmer, J. S., Swanson, G. T., & Chetkovich, D. M. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.010027 · Cited by 25 · see citing works
Quantitative Trait Loci and a Novel Genetic Candidate for Fear Learning
Knoll, A. T., Halladay, L. R., Holmes, A., & Levitt, P. R. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.0177-16.2016 · Cited by 24 · see citing works
Stores, Channels, Glue, and Trees: Active Glial and Active Dendritic Physiology
Ashhad, S., & Narayanan, R. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1223-5 · Cited by 25 · see citing works
Han, Y. S., Lyman, K. A., Foote, K. M., & Chetkovich, D. M. (2020) · Channels · doi:10.1080/19336950.2020.1740501 · Cited by 25 · see citing works
Mishra, P., & Narayanan, R. (2021) · Physiological Reports · doi:10.14814/phy2.14963 · Cited by 25 · see citing works
Lyman, K. A., Han, Y. S., & Chetkovich, D. M. (2017) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2017.1287899 · Cited by 25 · see citing works
Inhibition of HCN channel activity in the thalamus attenuates chronic pain in rats
Ding, W., You, Z., Shen, S., Chen, L. L., Zhu, S., & Mao, J. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.08.021 · Cited by 24 · see citing works
Functional coupling of Tmem74 and HCN1 channels regulates anxiety-like behavior in BLA neurons
Shao, L.-X., Jiang, Q., Liu, X., Gong, D.-M., Yin, Y., Wu, G., Sun, N.-H., Wang, C.-K., Chen, Q., Yu, C., et al. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0402-8 · Cited by 23 · see citing works
Günther, A., Luczak, V., Abel, T. G., & Baumann, A. (2017) · Journal of Experimental Biology · doi:10.1242/jeb.154583 · Cited by 23 · see citing works
Disturbed Processing of Contextual Information in HCN3 Channel Deficient Mice
Stieglitz, M. S., Fenske, S., Hammelmann, V., Bećirović, E., Schöttle, V., Delorme, J. E., Schöll-Weidinger, M., Mader, R. M., Deussing, J. M., Wolfer, D. P., et al. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00436 · Cited by 23 · see citing works
Store depletion-induced h-channel plasticity rescues a channelopathy linked to Alzheimer’s disease
Musial, T. F., Molina-Campos, E., Bean, L. A., Ybarra, N., Borenstein, R., Russo, M. L., Buss, E. W., Justus, D., Neuman, K. M., Ayala, G. D., et al. (2018) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2018.06.004 · Cited by 23 · see citing works
A Possible Link Between HCN Channels and Depression
Kim, C. S., & Johnston, D. (2018) · Chronic Stress · doi:10.1177/2470547018787781 · Cited by 23 · see citing works
Self-citationNi, L., Xu, Y., Dong, S., Kong, Y., Wang, H., Lu, G., Wang, Y., Li, Q., Li, C., Du, Z., et al. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-0795-9 · Cited by 23 · see citing works
Gerstner, N., Fröhlich, A. S., Matosin, N., Gagliardi, M., Cruceanu, C., Ködel, M., Rex‐Haffner, M., Tu, X., Mostafavi, S., Ziller, M. J., et al. (2025) · Science Advances · doi:10.1126/sciadv.adq2290 · Cited by 23 · see citing works
Circuit- and laminar-specific regulation of medial prefrontal neurons by chronic stress
Liu, W.-Z., Wang, C.-Y., Wang, Y., Cai, M.-T., Zhong, W.-X., Liu, T., Wang, Z.-H., Pan, H.-Q., Zhang, W.-H., & Pan, B.-X. (2023) · Cell & Bioscience · doi:10.1186/s13578-023-01050-2 · Cited by 21 · see citing works
Lee, S. Y., Vuong, T. A., So, H.-K., Kim, H., Kim, Y. B., Kang, J., Kwon, I., & Cho, H. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-020-0417-x · Cited by 20 · see citing works
Han, Y. S., Lyman, K. A., Clutter, M., Schiltz, G. E., Ismail, Q.-A., Prados, D. B., Luan, C.-H., & Chetkovich, D. M. (2015) · SLAS DISCOVERY · doi:10.1177/1087057115589590 · Cited by 20 · see citing works
Phillips, A. M., Kim, T., Vargas, E., Petrou, S., & Reid, C. A. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.12.007 · Cited by 20 · see citing works
Jiang, Y.-F., Liu, J., Yang, J., Guo, Y., Hu, W. M., Zhang, J., La, X.-M., Xie, W., Wang, H., & Zhang, L. (2020) · Neuropsychobiology · doi:10.1159/000505212 · Cited by 19 · see citing works
Up-regulation of HCN2 channels in a thalamocortical circuit mediates allodynia in mice
Yu, J., Hu, R. M., Mao, Y., Tai, Y., Qun, S., Zhang, Z., Chen, D., & Jin, Y. (2022) · National Science Review · doi:10.1093/nsr/nwac275 · Cited by 19 · see citing works
Lyman, K. A., Han, Y., Zhou, C., Renteria, I., Besing, G.-L., Kurz, J. E., & Chetkovich, D. M. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abl4580 · Cited by 17 · see citing works
Short- and long-term plasticity in CA1 neurons from mice lacking h-channel auxiliary subunit TRIP8b
Brager, D. H., Lewis, A. S., Chetkovich, D. M., & Johnston, D. (2013) · Journal of Neurophysiology · doi:10.1152/jn.00218.2013 · Cited by 17 · see citing works
Self-citationAntidepressant Effects of (S)-Ketamine through a Reduction of Hyperpolarization-Activated Current Ih
Kim, C. S., & Johnston, D. (2020) · iScience · doi:10.1016/j.isci.2020.101239 · Cited by 16 · see citing works
Self-citationSarkisova, K. Y., Fedosova, E. A., Shatskova, A. B., Rudenok, M. M., Stanishevskaya, V. A., & Slominsky, P. A. (2023) · Diagnostics · doi:10.3390/diagnostics13030398 · Cited by 16 · see citing works
King, M. V., Kurian, N., Qin, S., Παπαδοπούλου, Ν., Westerink, B. H. C., Cremers, T. I. F. H., Epping-Jordan, M. P., Poul, E. L., Ray, D. E., Fone, K. C. F., et al. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.220 · Cited by 16 · see citing works
Harde, E., Hierl, M., Weber, M., Waiz, D., Wyler, R., Wach, J.-Y., Haab, R., Gundlfinger, A., He, W., Schnider, P., et al. (2024) · Cell Chemical Biology · doi:10.1016/j.chembiol.2023.11.004 · Cited by 14 · see citing works
Antidepressant-like activity of a brain penetrant HCN channel inhibitor in mice
Pinares-Garcia, P., Spyrou, J., McKenzie, C. E., Forster, I. C., Soh, M. S., Mohamed Syazwan, E., Atif, M., & Reid, C. A. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1159527 · Cited by 15 · see citing works
HCN channels in the hippocampus regulate active coping behavior
Fisher, D. W., Han, Y. S., Lyman, K. A., Heuermann, R. J., Bean, L. A., Ybarra, N., Foote, K. M., Dong, H., Nicholson, D. A., & Chetkovich, D. M. (2018) · Journal of Neurochemistry · doi:10.1111/jnc.14539 · Cited by 15 · see citing works
Understanding the pharmacogenetics of selective serotonin reuptake inhibitors
Fabbri, C., Minarini, A., Niitsu, T., & Serretti, A. (2014) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1517/17425255.2014.928693 · Cited by 14 · see citing works
Raab‐Graham, K. F., Workman, E. R., Namjoshi, S. V., & Niere, F. (2016) · Brain Research · doi:10.1016/j.brainres.2016.04.020 · Cited by 13 · see citing works
Chen, J., Zhu, W., Zeng, X., Yang, K., Peng, H., & Hu, L. (2022) · Acta Neurobiologiae Experimentalis · doi:10.55782/ane-2022-033 · Cited by 13 · see citing works
Lou, F., Long, H., Luo, S., Liu, Y., Pu, J., Wang, H., Ji, P., & Jin, X. (2022) · Experimental Neurology · doi:10.1016/j.expneurol.2022.114268 · Cited by 13 · see citing works
mTOR referees memory and disease through mRNA repression and competition
Raab‐Graham, K. F., & Niere, F. (2017) · FEBS Letters · doi:10.1002/1873-3468.12675 · Cited by 13 · see citing works
Assessing genomic diversity and selective pressures in Bashan cattle by whole-genome sequencing data
Sun, L., Qu, K., Liu, Y., Ma, X., Chen, N., Zhang, J., Huang, B., & Lei, C. (2021) · Animal Biotechnology · doi:10.1080/10495398.2021.1998094 · Cited by 12 · see citing works
Protein complexes as psychiatric and neurological drug targets
Kato, A., & Witkin, J. M. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.01.018 · Cited by 11 · see citing works
- Authors
- Kim, C. S., Chang, P. Y., & Johnston, D.
- Affiliations
- The University of Texas at Austin (US)
- Corresponding author
- Johnston, Daniel
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2012-08
- Volume
- 75
- Issue
- 3
- Pages
- 503-516
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC3418514
- OpenAlex
- W2012579750
- Cited by
- 158
- References
- 68
- Citations by year
- 2026: 10 · 2025: 10 · 2024: 7 · 2023: 17 · 2022: 13 · 2021: 10 · 2020: 12 · 2019: 8 · 2018: 22 · 2017: 11 · 2016: 9 · 2015: 10 · 2014: 9 · 2013: 8 · 2012: 1
- FWCI
- 6.59
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (MH48432)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- HCN1 channels, dorsal hippocampus, CA1 region, shRNA knockdown, hyperpolarization-activated current, cell excitability, antidepressant-like behavior, anxiolytic-like behavior, brain-derived neurotrophic factor, mTOR signaling, anxiety disorders, depression, TRIP8b
- MeSH terms
- Animals, Anxiety, Behavior, Animal, Depression, Hippocampus, Immunohistochemistry, Male, Blotting, Western, Potassium Channels, Rats, Sprague-Dawley, Patch-Clamp Techniques, RNA, Small Interfering, Rats, Cyclic Nucleotide-Gated Cation Channels, Gene Knockdown Techniques, Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels
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