Autism-Associated Neuroligin-3 Mutations Commonly Disrupt Tonic Endocannabinoid Signaling

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Items 201–287 of 287

  1. Quantitative Spatial Analysis of Neuroligin-3 mRNA Expression in the Enteric Nervous System Reveals a Potential Role in Neuronal–Glial Synapses and Reduced Expression in Nlgn3R451C Mice
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    Fernando Calahorro · 2014 · Invertebrate Neuroscience
  3. Perspectives on the Role of Endocannabinoids in Autism Spectrum Disorders
    Mason L. Yeh, Eric S. Levine · 2017 · OBM Neurobiology
  4. Hypomyelination in autism-associated neuroligin-3 mutant mice impairs parvalbumin interneuron excitability, gamma oscillations, and sensory discrimination
    Yongxiang He, Jiong Li, Wei Zheng, Junhong Liu, Zhao-Jun Dong, Yang Lü, Shuting Tang, Yanping Zou, Tianyu Gao, Yuqian Yang et al. · 2025 · Nature Communications
  5. Neuroligin-3 Regulates Excitatory Synaptic Transmission and EPSP-Spike Coupling in the Dentate Gyrus In Vivo
    Julia Muellerleile, Matej Vnencak, Angelo Ippolito, Dilja Krueger‐Burg, Tassilo Jungenitz, Stephan Wolfgang Schwarzacher, Peter Jedlička · 2021 · Molecular Neurobiology
  6. Impact of converging sociocultural and substance-related trends on US autism rates: combined geospatiotemporal and causal inferential analysis
    Albert Stuart Reece, Gary Kenneth Hulse · 2022 · European Archives of Psychiatry and Clinical Neuroscience
  7. A perspective on molecular signalling dysfunction, its clinical relevance and therapeutics in autism spectrum disorder
    Sushmitha S. Purushotham, Neeharika M. N. Reddy, Michelle Ninochka D’Souza, Nilpawan Roy Choudhury, Anusa Ganguly, Niharika Gopalakrishna, Ravi Sondekoppa Muddashetty, James Premdoss Clement · 2022 · Experimental Brain Research
  8. Explorations and perspectives on the neurobiological bases of autism spectrum disorder
    John J. Foxe, Sophie Molholm, Stéphane J. Baudouin, Mark T. Wallace · 2018 · European Journal of Neuroscience
  9. Comparative mapping of selected structural determinants on the extracellular domains of cholinesterase-like cell-adhesion molecules
    Davide Comoletti, Laura Trobiani, Arnaud Chatonnet, Yves Bourne, P. Marchot · 2020 · Neuropharmacology
  10. A Comprehensive, FAIR File Format for Neuroanatomical Structure Modeling
    Aidan Sullivan, Susan J. Tappan, Paul J. Angstman, A. Rodriguez, Gavin Thomas, D. M. Hoppes, Muhammad‐Amri Abdul‐Karim, Maci Heal, Jacob R. Glaser · 2021 · Neuroinformatics
  11. Advancing multiscale structural mapping of the brain through fluorescence imaging and analysis across length scales
    L. J. Hogstrom, Syuan-Ming Guo, K. Murugadoss, Mark Bathe · 2015 · Interface Focus
  12. Chimeric brain models to study human glial-neuronal and macroglial-microglial interactions
    Jin, Mengmeng, Ma, Ziyuan, Zhang, Haiwei, Dang, Rui, Papetti, Ava V., Stillitano, Alessandro C., Zou, Lisa, Goldman, Steven A., Jiang, Peng · 2026 · Cell Reports
  13. Deletion of neuroligins from astrocytes does not detectably alter synapse numbers or astrocyte cytoarchitecture by maturity
    Samantha Rose Golf, Justin H. Trotter, Jinzhao Wang, George Nakahara, Xiao Han, Marius Wernig, Thomas Christian Südhof · 2023 · eLife
  14. Daily oscillation of the excitation/inhibition ratio is disrupted in two mouse models of autism
    Michelle Bridi, Nancy Luo, Grace Kim, Benjamin J Menarchek, Rachel A. Lee, Bryan A. Rodríguez, Daniel Severín, Cristian Moreno, Altagracia Contreras, Christian Wesselborg et al. · 2024 · iScience
  15. Synaptic Targets and Cellular Sources of CB1 Cannabinoid Receptor and Vesicular Glutamate Transporter‐3 Expressing Nerve Terminals in Relation to GABAergic Neurons in the Human Cerebral Cortex
    Péter Somogyi, Sawa Horie, Istvan Paul Lukacs, Emily Hunter, Barbara Sárkány, Tim J. Viney, James Livermore, Puneet Plaha, Richard J. Stacey, Olaf Ansorge et al. · 2025 · European Journal of Neuroscience
  16. Impaired cecal motility and secretion alongside expansion of gut-associated lymphoid tissue in the Nlgn3R451C mouse model of autism
    Chalystha Yie Qin Lee, Gayathri K. Balasuriya, Madushani Herath, Ashley Edwin Franks, Elisa L. Hill‐Yardin · 2023 · Scientific Reports
  17. Génétique des schizophrénies : mise en perspective des schizophrénies à début précoce et autres pathologies du développement
    Claudine Laurent‐Levinson, Marianna Giannitelli, David Cohen, Douglas F. Levinson · 2013 · Neuropsychiatrie de l Enfance et de l Adolescence
  18. The Genetic and Epigenetic Basis Involved in the Pathophysiology of ASD: Therapeutic Implications
    Maria Carmen Carrascosa-Romero, Carlos de Cabo · 2017 · InTech eBooks
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    Daryl Efron · 2021 · Australian Journal of General Practice
  20. Astrocytic Neuroligins Are Not Required for Synapse Formation or a Normal Astrocyte Cytoarchitecture
    Samantha Rose Golf, Justin H. Trotter, George Nakahara, Thomas Christian Südhof · 2023
  21. Human-Mouse Chimeric Brain Models to Study Human Glial-Neuronal and Macroglial-Microglial Interactions
    Mengmeng Jin, Ziyuan Ma, Haiwei Zhang, Ava V. Papetti, Rui Dang, Alessandro C. Stillitano, Lisa Zou, Steven A. Goldman, Peng Jiang · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  22. Faster Gastrointestinal Transit, Reduced Small Intestinal Smooth Muscle Tone and Dysmotility in the Nlgn3R451C Mouse Model of Autism
    Suzanne Hosie, Tanya Abo-Shaban, Kevin Mou, Gayathri K. Balasuriya, Mitra Mohsenipour, Mohammed Uthman A. Alamoudi, Rhiannon T. Filippone, Gabrielle Therese Belz, Ashley Edwin Franks, Joel C. Bornstein et al. · 2024 · International Journal of Molecular Sciences
  23. Endocannabinoids and disrupted synchronous oscillations in autism spectrum disorders
    Stephen I. Deutsch, Jessica A. Burket, Maria R. Urbano · 2016 · Future Neurology
  24. Electrophysiology of Endocannabinoid Signaling
    Alessandra Musella, Diego Centonze · 2022 · Methods in molecular biology
  25. State-dependent coupling of hippocampal oscillations
    Brijesh Modi, Matteo Guardamagna, Federico Stella, Marilena Griguoli, Enrico Cherubini, Francesco Paolo Battaglia · 2023 · eLife
  26. Increased Network Inhibition in the Dentate Gyrus of Adult Neuroligin-4 Knock-Out Mice
    Julia Muellerleile, Matej Vnencak, Mohammad Valeed Ahmed Sethi, Tassilo Jungenitz, Stephan Wolfgang Schwarzacher, Peter Jedlička · 2023 · eNeuro
  27. Perturbation of 3D nuclear architecture, epigenomic aging and dysregulation, and cannabinoid synaptopathy reconfigures conceptualization of cannabinoid pathophysiology: part 2—Metabolome, immunome, synaptome
    Albert Stuart Reece, Gary Kenneth Hulse · 2023 · Frontiers in Psychiatry
  28. Autism Spectrum Disorder
    Kylie O’Brien, Philip Blair · 2021 · Springer eBooks
  29. Slc6a20a Heterozygous and Homozygous Mutant Mice Display Differential Behavioral and Transcriptomic Changes
    Junhyung Kim, Junyeop Daniel Roh, Seongbin Kim, Hyojin Kang, Mihyun H. Bae, Eunjoon Kim · 2022 · Frontiers in Molecular Neuroscience
  30. Genetic dissection of the endocannabinoid system and how it changed our knowledge of cannabinoid pharmacology and mammalian physiology
    Beat Lutz · 2014 · Wiley eBooks
  31. The Endocannabinoid System in the Control of Behavior
    Edgar Soria Gómez, Mathilde Metna‐Laurent, Luigi Bellocchio, Arnau Busquets-García, Giovanni Marsicano · 2017 · Wiley eBooks
  32. Synaptic protein mutations in autism
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  33. Analyses of Human Genetic Data to Identify Clinically Relevant Domains of Neuroligins
    Alexander W. Lehr, Kathryn F McDaniel, Katherine W. Roche · 2024 · Genes
  34. Deletion of Neuroligins from Astrocytes Does Not Detectably Alter Synapse Numbers or Astrocyte Cytoarchitecture by Maturity
    Samantha Rose Golf, Justin H. Trotter, Jinzhao Wang, George Nakahara, Xiao Han, Marius Wernig, Thomas Christian Südhof · 2025 · eLife
  35. Extracellular neuroligin-ICAM5 coupling drives dendritic growth via actin remodeling
    Cydric Geyskens, Brigitt Raux, Nuno Apóstolo, Ellis Boonen, Jeroen Vandensteen, Beatriz Marques, João Machado, llkem Kumru, Julie Nys, Eline Creemers et al. · 2026 · iScience
  36. Unraveling the Role of Neuroligin3 in Autism Spectrum Disorders: Pathophysiological Insights and Targeted Therapies
    Fatima Azzahrae El Yacoubi, Mohamed Oukabli, Azeddine Ibrahimi, Hassan Kisra, Mounia Bensaid · 2023 · CNS & Neurological Disorders - Drug Targets
  37. Cannabis Compounds: Potential Therapy for Neurological Disease
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  38. Multivalent cannabinoid epigenotoxicities and multigenerational aging
    Albert Stuart Reece, Gary Kenneth Hulse · 2025 · Elsevier eBooks
  39. Geospatiotemporal and causal inferential analysis of United States congenital anomalies as a function of multiple cannabinoid- and substance-exposures: Phenocopying thalidomide and hundred megabase-scale genotoxicity
    Albert Stuart Reece, Gary Kenneth Hulse · 2025 · Elsevier eBooks
  40. Linked rise of cannabis use and autism incidence demonstrated by close three-level geospatiotemporal relationships, USA, 1990–2011
    Albert Stuart Reece, Gary Kenneth Hulse · 2025 · Elsevier eBooks
  41. Enhanced CB1 receptor function in GABAergic neurons mediates hyperexcitability and impaired sensory-driven synchrony of cortical circuits in Fragile X Syndrome model mice
    D. Gonzalez, CR Jonak, Matteo Bernabucci, Gemma Molinaro, K. Collins, SA Assad, Jay R. Gibson, Devin K. Binder, Kimberly M. Huber · 2025 · Molecular Psychiatry
  42. Perinatal LC-ω-3-PUFA supplementation offsets prenatal THC-induced cognitive deficit via sex-specific modulation of hippocampal neuroplasticity
    Gianluca Lavanco, Valentina Castelli, Cesare D'Amico, Salvatore Feo, Martin Kuchař, Petr Palivec, Anna Brancato, Carla Cannizzaro · 2026 · European Journal of Pharmacology
  43. The Ecology of Wild Cannabis sativa
    Ernest Small · 2016 · CRC Press eBooks
  44. The Role of Neuroligins in the Cerebellum Highlights the Diversity of Synapse-Specifying Molecules
    Jessica E. Messier · 2017 · Journal of Neuroscience
  45. Cannabis Chemistry: Cannabinoids in Cannabis, Humans, and Other Species
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  46. The endocannabinoid system in autism spectrum disorder
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  47. Proteinkomplexe an inhibitorischen Synapsen in psychiatrischen Störungen
    Dilja Krueger‐Burg · 2019 · BIOspektrum
  48. Daily oscillation of the excitation/inhibition ratio is disrupted in two mouse models of autism
    Michelle Bridi, Nancy Luo, Grace Kim, Caroline O’Ferrall, Ruchit V. Patel, Sarah J. Bertrand, Sujatha Kannan, Alfredo Kirkwood · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  49. Caecal dysfunction in the NL3 R451C mouse model of autism
    Chalystha Yie Qin Lee, Gayathri K. Balasuriya, Madushani Herath, Ashley Edwin Franks, Elisa L. Hill‐Yardin · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  50. Causal association between mTOR-dependent circulating protein levels and autism spectrum disorder: a Mendelian randomization study
    Jingfen Fu, Meiyuan Dong, Ling‐Ling Chen, Chunhui Du, Ze Yu, Hongqiang Wang · 2024 · Research Square
  51. Deletion of Neuroligins from Astrocytes Does Not Detectably Alter Synapse Numbers or Astrocyte Cytoarchitecture by Maturity
    Samantha Rose Golf, Justin H. Trotter, Jinzhao Wang, George Nakahara, Xiao Han, Marius Wernig, Thomas Christian Südhof · 2025 · eLife
  52. Synaptic networks shape clinical phenotypes in neurodevelopmental disorders: An integrative clinical, genetic and biological perspective
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  53. Molecular Pathways in Autistic Spectrum Disorders
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  54. The Endocannabinoid System in Fragile X Syndrome
    Henry G. S. Martin, Daniela Neuhofer, Olivier J. Manzoni · 2017 · Elsevier eBooks
  55. Autismo ed infi ammazione
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  56. Role of adhesion proteins Neuroligin 2 and IgSF9b in the amygdala anxiety circuitry
    Olga Babaev · 2018 · eDiss (Georg-August-Universität Göttingen)
  57. Is the Use of Cannabis During Pregnancy a Risk Factor for Autism?
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  59. Неканоническая активность эндоканнабиноидов и их рецепторов в центральных и периферических синапсах
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  61. Faculty Opinions recommendation of Role of Striatal Direct Pathway 2-Arachidonoylglycerol Signaling in Sociability and Repetitive Behavior.
    Giovanni Marsicano, Arnau Busquets-García · 2018 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  62. Roles of the autism candidate genes neuroligin-3, neuroligin-4, and neurobeachin in synaptic plasticity ande excitation-inhibition balance in the dentate gyrus
    Julia Muellerleile · 2022 · Publication Server of Goethe University Frankfurt am Main (Goethe University Frankfurt)
  63. Avaliação dos efeitos do canabidiol sobre as consequências comportamentais induzidas pelo tratamento com o ácido valproico durante o período embrionário do zebrafish
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  64. Deletion of neuroligins from astrocytes does not detectably alter synapse numbers or astrocyte cytoarchitecture by maturity
    Samantha Rose Golf, Justin H. Trotter, Jinzhao Wang, George Nakahara, Xiao Han, Marius Wernig, Thomas Christian Südhof · 2023 · eLife
  65. Genes and their Involvement in the Pathogenesis of Autism Spectrum Disorder: Insights from Earlier Genetic Studies
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  66. Impaired metabotropic glutamate type 5 receptor signaling in the dorsal striatum of the R451C-neuroligin 3 mouse model of Autism Spectrum Disorder
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  67. Sleepless nights and social plights: medial septum GABAergic hyperactivity in a neuroligin 3–deficient autism model
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  68. Impaired metabotropic glutamate type 5 receptor signaling in the dorsal striatum of the R451C-neuroligin 3 mouse model of Autism Spectrum Disorder
    Maria Meringolo, Martina Montanari, Simona D’Antoni, Giuseppina Martella, Ilham El Atiallah, Giulia Ponterio, Annalisa Tassone, Ingrid Reverte, Daniele Caprioli, Georgios Strimpakos et al. · 2025 · Research Square
  69. Close parallels between cannabis use and deteriorating US Mental Health at four levels supports and extends the epidemiological salience of demonstrated causal mental health relationships: A geospatiotemporal study
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  71. Endocannabinoid regulation of hippocampal circuits
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  72. Additional file 6 of Co-occurrence across time and space of drug- and cannabinoid- exposure and adverse mental health outcomes in the National Survey of Drug Use and Health: combined geotemporospatial and causal inference analysis
    Albert Stuart Reece, Gary Kenneth Hulse · 2020 · Figshare
  73. Additional file 1 of Co-occurrence across time and space of drug- and cannabinoid- exposure and adverse mental health outcomes in the National Survey of Drug Use and Health: combined geotemporospatial and causal inference analysis
    Albert Stuart Reece, Gary Kenneth Hulse · 2020 · Figshare
  74. Additional file 1 of Imbalance of flight–freeze responses and their cellular correlates in the Nlgn3−/y rat model of autism
    Natasha J. Anstey, Vijayakumar Kapgal, Tiwari, Shashank, Thomas C. Watson, Anna Karina Hugger Toft, Owen Dando, Felicity H. Inkpen, Paul S. Baxter, Zrinko Kozić, Adam D. Jackson et al. · 2022 · Figshare
  75. Additional file 4 of Co-occurrence across time and space of drug- and cannabinoid- exposure and adverse mental health outcomes in the National Survey of Drug Use and Health: combined geotemporospatial and causal inference analysis
    Albert Stuart Reece, Gary Kenneth Hulse · 2020 · Figshare
  76. Additional file 2 of Co-occurrence across time and space of drug- and cannabinoid- exposure and adverse mental health outcomes in the National Survey of Drug Use and Health: combined geotemporospatial and causal inference analysis
    Albert Stuart Reece, Gary Kenneth Hulse · 2020 · Figshare
  77. Additional file 8 of Co-occurrence across time and space of drug- and cannabinoid- exposure and adverse mental health outcomes in the National Survey of Drug Use and Health: combined geotemporospatial and causal inference analysis
    Albert Stuart Reece, Gary Kenneth Hulse · 2020 · Figshare
  78. Additional file 5 of Co-occurrence across time and space of drug- and cannabinoid- exposure and adverse mental health outcomes in the National Survey of Drug Use and Health: combined geotemporospatial and causal inference analysis
    Albert Stuart Reece, Gary Kenneth Hulse · 2020 · Figshare
  79. Additional file 3 of Co-occurrence across time and space of drug- and cannabinoid- exposure and adverse mental health outcomes in the National Survey of Drug Use and Health: combined geotemporospatial and causal inference analysis
    Albert Stuart Reece, Gary Kenneth Hulse · 2020 · Figshare
  80. Additional file 2 of Imbalance of flight–freeze responses and their cellular correlates in the Nlgn3−/y rat model of autism
    Natasha J. Anstey, Vijayakumar Kapgal, Tiwari, Shashank, Thomas C. Watson, Anna Karina Hugger Toft, Owen Dando, Felicity H. Inkpen, Paul S. Baxter, Zrinko Kozić, Adam D. Jackson et al. · 2022 · Figshare
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  86. Autismus-Spektrum-Störung
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  87. NLGN3 autism variants have distinct functional impact on synapses and sleep behavior in Drosophila
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