Südhof, Thomas C.

Direct conversion of fibroblasts to functional neurons by defined factors

Vierbuchen, T., Ostermeier, A., Pang, Z. P., Kokubu, Y., Südhof, T. C., & Wernig, M. (2010) · Nature

Pluripotent Stem Cells ResearchNeurogenesis and neuroplasticity mechanisms

Cited by 3,017

Mapping genomic loci implicates genes and synaptic biology in schizophrenia

Trubetskoy, V., Pardiñas, A. F., Qi, T., Panagiotaropoulou, G., Awasthi, S., Bigdeli, T. B., Bryois, J., Chen, C.-Y., Dennison, C. A., Hall, L. S., et al. (2022) · Nature

Schizophrenia research and treatmentGenetic Associations and Epidemiology

Cited by 2,964

Neuroligins and neurexins link synaptic function to cognitive disease

Südhof, T. C. (2008) · Nature

Neuroscience and Neuropharmacology ResearchGenetics and Neurodevelopmental Disorders

Cited by 1,849

Rapid single-step induction of functional neurons from human pluripotent stem cells

Zhang, Y., Pak, C., Han, Y., Ahlenius, H., Zhang, Z., Chanda, S., Marro, S., Patzke, C., Acuna, C., Covy, J., et al. (2013) · Neuron

Pluripotent Stem Cells ResearchNeurogenesis and neuroplasticity mechanisms

Cited by 1,644

Synaptotagmin I: A major Ca2+ sensor for transmitter release at a central synapse

Geppert, M., Goda, Y., Hammer, R. E., Li, C., Rosahl, T. W., Stevens, C. F., & Südhof, T. C. (1994) · Cell

Cellular transport and secretionNeuroscience and Neuropharmacology Research

Cited by 1,483

Neurotransmitter Release: The Last Millisecond in the Life of a Synaptic Vesicle

Südhof, T. C. (2013) · Neuron

Cellular transport and secretionNeuroscience and Neuropharmacology Research

Cited by 1,197

Synaptotagmin: a Calcium Sensor on the Synaptic Vesicle Surface

Brose, N., Petrenko, A. G., Südhof, T. C., & Jahn, R. (1992) · Science

Cellular transport and secretionNeuroscience and Neuropharmacology Research

Cited by 979

Synaptotagmin I functions as a calcium regulator of release probability

Fernández-Chacón, R., Königstorfer, A., Gerber, S. H., García, J., Matos, M. F., Stevens, C. F., Brose, N., Rizo, J., Rosenmund, C., & Südhof, T. C. (2001) · Nature

Cellular transport and secretionNeuroscience and Neuropharmacology Research

Cited by 961

SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the Synapse

Koopmans, F., van Nierop, P., Andres-Alonso, M., Byrnes, A., Cijsouw, T., Coba, M. P., Cornelisse, L. N., Farrell, R. J., Goldschmidt, H. L., Howrigan, D. P., et al. (2019) · Neuron

Biomedical Text Mining and OntologiesBioinformatics and Genomic Networks

Cited by 938

Synaptic Neurexin Complexes: A Molecular Code for the Logic of Neural Circuits

Südhof, T. C. (2017) · Cell

Neuroscience and Neuropharmacology ResearchGenetics and Neurodevelopmental Disorders

Cited by 810

Munc13-1 is essential for fusion competence of glutamatergic synaptic vesicles

Augustin, I., Rosenmund, C., Südhof, T. C., & Brose, N. (1999) · Nature

Cellular transport and secretionNeuroscience and Neuropharmacology Research

Cited by 787

Essential functions of synapsins I and II in synaptic vesicle regulation

Rosahl, T. W., Spillane, D., Missler, M., Herz, J., Selig, D. K., Wolff, J. R., Hammer, R. E., Malenka, R. C., & Südhof, T. C. (1995) · Nature

Neuroscience and Neuropharmacology ResearchCellular transport and secretion

Cited by 719

α-Neurexins couple Ca2+ channels to synaptic vesicle exocytosis

Missler, M., Zhang, W., Rohlmann, A., Kattenstroth, G., Hammer, R. E., Gottmann, K., & Südhof, T. C. (2003) · Nature

Neuroscience and Neuropharmacology ResearchCellular transport and secretion

Cited by 699

Towards an Understanding of Synapse Formation

Südhof, T. C. (2018) · Neuron

Neuroscience and Neuropharmacology ResearchGenetics and Neurodevelopmental Disorders

Cited by 698

Neuroligin 1 is a postsynaptic cell-adhesion molecule of excitatory synapses

Song, J.-Y., Ichtchenko, K., Südhof, T. C., & Brose, N. (1999) · Proceedings of the National Academy of Sciences

Neuroscience and Neuropharmacology ResearchGenetics and Neurodevelopmental Disorders

Cited by 696

Rim is a putative Rab3 effector in regulating synaptic-vesicle fusion

Wang, Y., Okamoto, M., Schmitz, F., Hofmann, K., & Südhof, T. C. (1997) · Nature

Cellular transport and secretionNeuroscience and Neuropharmacology Research

Cited by 684

A Neural Circuit for Memory Specificity and Generalization

Xu, W., & Südhof, T. C. (2013) · Science

Memory and Neural MechanismsMemory Processes and Influences

Cited by 634

Hierarchical Mechanisms for Direct Reprogramming of Fibroblasts to Neurons

Wapinski, O. L., Vierbuchen, T., Qu, K., Lee, Q. Y., Chanda, S., Fuentes, D. R., Giresi, P. G., Ng, Y. H., Marro, S., Neff, N. F., et al. (2013) · Cell

Pluripotent Stem Cells ResearchNeurogenesis and neuroplasticity mechanisms

Cited by 627

Common circuit defect of excitatory-inhibitory balance in mouse models of autism

Gogolla, N., LeBlanc, J. J., Quast, K. B., Südhof, T. C., Fagiolini, M., & Hensch, T. K. (2009) · Journal of Neurodevelopmental Disorders

Autism Spectrum Disorder ResearchGenetics and Neurodevelopmental Disorders

Cited by 610

RIM proteins tether Ca2+ channels to presynaptic active zones via a direct PDZ-domain interaction

Kaeser, P. S., Deng, L., Wang, Y., Dulubova, I., Liu, X., Rizo, J., & Südhof, T. C. (2011) · Cell

Neuroscience and Neuropharmacology ResearchIon channel regulation and function

Cited by 607

Ca2+-dependent and -independent activities of neural and non-neural synaptotagmins

Li, C., Ullrich, B., Zhang, J. Z., Anderson, R. G. W., Brose, N., & Südhof, T. C. (1995) · Nature

Cellular transport and secretionNeuroscience and Neuropharmacology Research

Cited by 599

Activity-Dependent Validation of Excitatory versus Inhibitory Synapses by Neuroligin-1 versus Neuroligin-2

Chubykin, A. A., Atasoy, D., Etherton, M. R., Brose, N., Kavalali, E. T., Gibson, J. R., & Südhof, T. C. (2007) · Neuron

Neuroscience and Neuropharmacology ResearchGenetics and Neurodevelopmental Disorders

Cited by 594

RIBEYE, a Component of Synaptic Ribbons

Schmitz, F., Königstorfer, A., & Südhof, T. C. (2000) · Neuron

Neuroscience and Neuropharmacology ResearchCellular transport and secretion

Cited by 581

RIM1α forms a protein scaffold for regulating neurotransmitter release at the active zone

Schoch, S., Castillo, P. E., Jo, T., Mukherjee, K., Geppert, M., Wang, Y., Schmitz, F., Malenka, R. C., & Südhof, T. C. (2002) · Nature

Neuroscience and Neuropharmacology ResearchCellular transport and secretion

Cited by 579