Modeling Autism by SHANK Gene Mutations in Mice

Cited by (496)

Items 401–496 of 496

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  2. Acute stress induces changes in epigenome-wide DNA methylation
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  3. Drug discovery strategy for TAK-418, a specific inhibitor of LSD1 enzyme activity, as a novel therapy for autism
    Satoru Matsuda, Yasushi Hattori, Haruhide Kimura · 2024 · Advances in pharmacology
  4. Impairment of Group I Metabotropic Glutamate Receptors in the Dorsal Striatum of the R451C ‐Neuroligin 3 Mouse Model of Autism Spectrum Disorder
    Maria Meringolo, Martina Montanari, Simona D’Antoni, Giuseppina Martella, Ilham El Atiallah, Giulia Ponterio, Annalisa Tassone, Ingrid Reverte, Daniele Caprioli, Georgios Strimpakos et al. · 2025 · Journal of Neurochemistry
  5. A Bidirectional Switch in the Shank3 Phosphorylation State Biases Synapses toward Up or Down Scaling
    Chi-Hong Wu, Vedakumar Tatavarty, Pierre MJ Beltran et al. · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  6. Autism and Fragile X Syndrome
    Heather O’Leary, Tim A. Benke · 2017 · Elsevier eBooks
  7. Transcriptional Determinism and Stochasticity Contribute to the Complexity of Autism Associated SHANK Family Genes
    Xiaona Lu, Pengyu Ni, Paola Suárez-Meade · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  8. Long Term High‐Salt Diet Induces Cognitive Impairments via Down‐Regulating SHANK1
    Cuiping Guo, Yuanyuan Li, Wensheng Li, Tongrui Wu, Yi Liu, Yacoubou Abdoul Razak Mahaman, Jian‐Zhi Wang, Rong Liu, Wei Liu, Hui Shen et al. · 2025 · Advanced Science
  9. Early postnatal dysfunction of ACC PV interneurons in Shank3B−/− mice
    Yi-Chun Shih, Lars Nelson, Michael Janeček, Michael Matarazzo, Andrew D’Agostino, Rui T. Peixoto · 2025 · Molecular Psychiatry
  10. Activity deprivation modulates the Shank3/Homer1/mGluR5 signaling pathway to enable synaptic upscaling
    Andrea A. Guerrero, Gina G. Turrigiano · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  11. Deficiency of Shank3 in the nucleus accumbens reveals a loss of social-specific motivation
    Oakleigh M. Folkes, Meaghan Donahue, Sung Eun Wang, Paola N. Negrón-Moreno, Nicole Xinyen Oo, Sheng-Nan Qiao, Xiaoming Wang, Yong‐hui Jiang · 2025 · Communications Biology
  12. Effect of dietary zinc supplementation on the gastrointestinal microbiome and host gene expression in the Shank3B−/− mouse model of autism spectrum disorder
    Giselle C. Wong, Yewon Jung, Kevin Lee, Chantelle Fourie, Kim M. Handley, Johanna M. Montgomery, Michael W. Taylor · 2025 · Frontiers in Microbiology
  13. Neuropathological insights from SHANK3 mutant animal models
    Jiawei Zhang, Dajian He, Xiao‐Jiang Li · 2023 · Ageing and Neurodegenerative Diseases
  14. Neurometabolic profiles of autism spectrum disorder patients with genetic variants in specific neurotransmission and synaptic genes
    Joana Estela Rezende Vilela, Andreia Carvalho Pereira, Inês R. Violante, Susana Mouga, Célia Rasga, João Xavier Santos, Hugo Martiniano, Ana Rita Marques, Guiomar Oliveira, Miguel S. Castelo-Branco et al. · 2025 · Scientific Reports
  15. Whole Exome Sequencing Revealed Clinical Relevant Variants in A Family Affected with Autism Spectrum Disorder
    Jiaxiu Zhou, Feng Yang, Xiaoge Li, Shaoming Zhou, Fusheng He, Jingwen Liang, Yan Wang, Mingbang Wang, Ruihuan Xu · 2016 · Journal of Psychiatry and Brain Science
  16. Regulation of Innate Immune Response to Fungal Infection inCaenorhabditis elegansby SHN-1/SHANK
    Lingmei Sun, Huirong Li, Li Zhao, Kai Liao · 2020 · Journal of Microbiology and Biotechnology
  17. In Vivo Human Embryonic Spinal Cord Atlas Validates Stem Cell–Derived Human Dorsal Interneurons and Reveals ASD Spinal Signatures
    Sandeep Gupta, Eric Heinrichs, Cristian Rodriguez, Emily Friedman, Salena Gallardo, T. Demirjie, Teny Panosian, Keith D. Phan, Anooshik Tahmasian, Yahir Verdin et al. · 2025 · SSRN Electronic Journal
  18. A Neurodevelopmental Perspective for Autism-Associated Gene Function
    Jessie Poquérusse, Bryan W. Luikart · 2017 · OBM Neurobiology
  19. Disruption of autism-associated Pcdh9 gene leads to transcriptional alterations, synapses overgrowth and aberrant excitatory transmission in the CA1
    Federico Miozzo, Luca Murru, Greta Maiellano et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  20. Late onset and regional heterogeneity of synaptic deficits in cortical PV interneurons of Shank3B −/− mice
    Yi-Chun Shih, Lars Nelson, Michael Janeček, Rui T. Peixoto · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  21. Gut microbiota diversity is altered in a sex-dependent manner in Shank3B heterozygote mice
    Finley Turner, Mykle Williams, Sophie Gregoretti, Delano Bielamowicz, Kylie Roach, Lil Gehner, Anjali Kunnatha, Shekinah Phillips, Rosie Hagel, Rebecca Harshman et al. · 2025 · Frontiers in Microbiomes
  22. SHANK3 downregulation in the VTA accelerates the extinction of contextual associations induced by non-familiar conspecific interaction
    Sebastiano Bariselli, Alessandro Contestabile, Stamatina Tzanoulinou · 2018 · bioRxiv (Cold Spring Harbor Laboratory)
  23. Somatosensory processing deficits and altered cortico-hippocampal connectivity in Shank3b −/− mice
    Luigi Balasco, Marco Pagani, Luca Pangrazzi · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  24. JIP2 haploinsufficiency contributes to neurodevelopmental abnormalities in human pluripotent stem cell-derived neural progenitors and cortical neurons
    Reinhard Roessler, Johanna E. Goldmann, Chikdu Shivalila · 2017 · bioRxiv (Cold Spring Harbor Laboratory)
  25. Neuron-specific protein expression at striatal excitatory synapses
    Yizhi Wang, Tamara Perez‐Rosello, Dalton James Surmeier, Jeffrey N. Savas · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  26. Serum MAP1A as a Potential Biomarker for Autism Spectrum Disorder
    Jiwon Jeong, Seung Hyeun Lee, Dongsun Park · 2026 · Brain Sciences
  27. Genetic Screen to Characterize Shank Interactors at the Drosophila Neuromuscular Junction
    Ashley Hogg · 2018 · TSpace (University of Toronto)
  28. Imbalances of Inhibitory and Excitatory Systems in Autism Spectrum Disorders
    Reed C. Carroll · 2023 · Springer eBooks
  29. Deficiency of Shank3 in the Nucleus Accumbens Reveals a Loss of Social-Specific Motivation
    Oakleigh M. Folkes, Meaghan Donahue, Sung Eun Wang · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  30. Synaptic protein mutations in autism
    Ann Katrin Sauer, John A. Walsh, Darragh Curran, Nazanin Zohourian, Janelle E. Stanton, Ioannis Zabetakis, James A. L. Brown, Andreas Martin Grabrucker · 2026 · Neurobiology of Disease
  31. Human iPSC Models: A Platform for Investigating Neurodevelopmental Diseases
    Cindy E. McKinney · 2014 · Journal of Molecular and Genetic Medicine
  32. Myosin Va Brain-Specific Mutation Alters Mouse Behavior and Disrupts Hippocampal Synapses
    Swarna Pandian, Jian-Ping Zhao, Yasunobu Murata · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  33. Pre-existing DNA methylation signatures in the prefrontal cortex of alcohol-naïve nonhuman primates define neural vulnerability for future risky ethanol consumption
    Rita P. Cervera‐Juanes, Kip D. Zimmerman, Larry Wilhelm, Clara Christine Lowe, Steven W. Gonzales, Tim Carlson, ROBERT J. HITZEMANN, Betsy M. Ferguson, Kathleen A. Grant · 2025 · Neurobiology of Disease
  34. Animal models of autism spectrum disorder: Bridging biology to behaviour
    Pilar Martinez Olondo, Alban de Kerchove d’Exaerde · 2026 · Developmental Medicine & Child Neurology
  35. Altered synaptic ultrastructure in the prefrontal cortex of Shank3-deficient rats
    Sarah Jacot-Descombes, Neha U. Keshav, Dara L. Dickstein et al. · 2020 · Research Square
  36. Postsynaptic Density/Architecture at Excitatory Synapses ☆
    Hans‐Christian Kornau · 2017 · Elsevier eBooks
  37. Shank3B deficiency disrupts GABAergic synaptic transmission in pyramidal neurons of the medial prefrontal cortex region in autism spectrum disorder
    Hang Yin, Ke Sun, Chenyang Wang, Songqiao Fan, Jiaqi Wang, Shitai He, Hui meng Lei, Shuo Pang, Jie Chen, G G Zhang · 2026 · Molecular Brain
  38. ASPECTOS GENÉTICOS DO TRANSTORNO DO ESPECTRO AUTISTA (TEA)
    Maria Denise Fernandes Carvalho de Andrade, Ellaine Dóris Fernandes Carvalho, Krishnamurti de Moraes Carvalho · 2022 · Amplla Editora eBooks
  39. Description of a patient with developmental delay and dysmorphic features caused by a novel SHANK2 deletion
    David Molina Herranz, Amelia Moreno Sánchez, Gema Carmen Marcén, Belén Salinas Salvador, Raquel Pérez Delgado, Silvia Izquierdo Álvarez · 2023 · Egyptian Journal of Medical Human Genetics
  40. Genetic Engineering of Nonhuman Primate Models for Studying Neurodevelopmental Disorders
    Rahul Suresh, Platon Megagiannis, Hong Chen, Rogier Landman, Jitendra Sharma, Yang Zhou · 2022 · Neuromethods
  41. Genes and their Involvement in the Pathogenesis of Autism Spectrum Disorder: Insights from Earlier Genetic Studies
    Rishabh Chaudhary, Emma Steinson · 2023 · Springer eBooks
  42. Impaired metabotropic glutamate type 5 receptor signaling in the dorsal striatum of the R451C-neuroligin 3 mouse model of Autism Spectrum Disorder
    Maria Meringolo, Martina Montanari, Simona D’Antoni, Giuseppina Martella, Ilham El Atiallah, Giulia Ponterio, Annalisa Tassone, Ingrid Reverte, Daniele Caprioli, Georgios Strimpakos et al. · 2024 · Research Square
  43. Evaluating the cannabinoid CB1 receptor as a therapeutic target in a Shank3 mouse model of autism and Phelan-McDermid syndrome
    Flavio Tomasi · 2023 · theses.fr (ABES)
  44. Graph Theory Identifies Autistic Patterns in the Prefrontal Circuit of a Mouse Model of Autism
    Yun Li, Rongsong Liu, Yan Zhang, Mallory Lai, Viyaleta Davydzenka, Casey M. Moffitt, Nathaniel England, Giovanni Barbera, Rong Chen, Da‐Ting Lin · 2026 · Research Square
  45. Déterminants moteurs des troubles du spectre autistiques (TSA)
    Tareq Al Sagheer · 2017 · theses.fr (ABES)
  46. Effect of dietary zinc supplementation on the gastrointestinal microbiota and host gene expression in the Shank3B −/− mouse model of autism spectrum disorder
    Giselle C. Wong, Yewon Jung, Kevin C. Lee, Chantelle Fourie, Kim M. Handley, Johanna M. Montgomery, Michael W. Taylor · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  47. Brain-Wide Subnetworks within and between Naturally Socializing Typical and Autism Model Mice
    Odeya Marmor, Renana Terner, Vivian Khuory, Shelly Ginzburg, Haitham Amal, Ariel Gilad · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  48. Phase separation-mediated actin bundling by the postsynaptic density condensates
    Xudong Chen, Bowen Jia, Shihan Zhu · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  49. Local regulation and function of importin-β1 in hippocampal neurons during transcription-dependent plasticity
    Yan Jun Lee · 2021 · DR-NTU (Nanyang Technological University)
  50. TRANSTORNO DO ESPECTRO AUTISTA E DIAGNÓSTICO POR IMAGEM
    Yuri Borges Morais, Levy da Costa Felix, Sayd Douglas Rolim Carneiro Oliveira · 2022 · Amplla Editora eBooks
  51. Genome-wide methylomics identifies pre-existing DNA methylation signatures in the prefrontal cortex of alcohol-naïve rhesus monkeys defining neural vulnerability for future risky ethanol consumption.
    Rita P. Cervera‐Juanes, Kip D. Zimmerman, Larry Wilhelm, Clara Christine Lowe, Steven W. Gonzales, Tim Carlson, ROBERT J. HITZEMANN, Betsy M. Ferguson, Kathy A. Grant · 2024 · Research Square
  52. Social Novelty Recruits a Dysfunctional Nucleus Accumbens Ensemble That Drives Social Avoidance in a Shank3 −/− Autism Model
    Oakleigh M. Folkes, Meaghan Donahue, Rafael E. Perez, Angelica M. Minier-Toribio, Paola N. Negrón-Moreno, Marina R. Picciotto, Yong-Hui Jiang · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  53. Metilación del gen SHANK3 y tiempos de reacción antes y después de un entrenamiento de tipo aeróbico en una población pediátrica con Trastorno de Espectro Autista en la ciudad de Bogotá
    Hernández Sandoval, Erika Yolanda · 2020
  54. TEA LEVE: ANTIGA SINDROME DE ASPERGER
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  55. Cyclin-dependent kinase-like 5 (CDKL5) binds to talin and is anchored at the postsynaptic density via direct interaction with PDZ domains
    Y Otani, Emily Goodall, Vignesh Srinivasan, Neil J. Ball, Samuel F. H. Barnett, Tobias Zech, Juha Saarikangas, Benjamin Thomas Goult · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  56. Dysregulation of NRSF/REST via EHMT1 is associated with psychiatric disorders
    Mouhamed Alsaqati, Brittany A. Davis, Jamie Wood, Megan Jones, Lora Jones, Aishah Westwood, Olena Petter, Anthony R Isles, David E.J. Linden, Marianne B. M. van den Bree et al. · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  57. METILAÇÃO DO DNA ENVOLVIDA NA EXPRESSÃO DO TRANSTORNO DO ESPECTRO AUTISTA
    Diego Oliveira Maia, Adriana da Silva Alves, Sabrina Costa Mavignier Guimarães, Igor Glauber Braz Rocha, GABRIELLA BARROSO DE ALBUQUERQUE, Gislei Frota Aragão · 2022 · Amplla Editora eBooks
  58. New Challenges In Non-Linear Signal And Image Processing
    Stephen Marshall, Edward R. Dougherty · 2004
  59. Expression deregulation of SHANK3 gene in children with autism spectrum disorder and attention deficit and hyperactivity disorder
    Hanieh Bai, Seyed Yousef Seyedena, Morteza Karimipoor, Mehrdad Hashemi · 2021 · Journal of Human Genetics and Genomics
  60. Activité hippocampique associée aux stimuli sociaux chez la souris Shank3 modèle des Troubles du Spectre Autistique.
    Loïc Bordes · 2019 · theses.fr (ABES)
  61. Shank3 mutation disrupts affective touch encoding in the dorsal medial prefrontal cortex of Beagle dogs
    Yanhe Zhou, Yue He, Minna Dan, Lintao Jia, Kun Guo, Ying Fang, Li Hu, Xiang Yu, Jinfen Wang, Dajun Xing et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  62. 40-Hz Auditory Steady State Response (ASSR) as a Biomarker of Abnormalities in SHANK3 Gene: a Case-Report of 15-years Old Girl with Rare Microduplication in 22q13.33
    Anastasia K. Neklyudova, Galina V. Portnova, Anna B. Rebreikina · 2020 · Preprints.org
  63. Gene expression profiling in trigeminal ganglia from Cntnap2 -/- and Shank3b -/- mouse models of autism spectrum disorder
    Alessandra G. Ciancone-Chama, Yuri Bozzi, Luigi Balasco · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  64. Modeling SHANK2 Related Neuropsychiatric Disorders in Mice
    Andrea L. Pappas · 2015 · DukeSpace (Duke University)
  65. DIETAS ISENTAS DE GLÚTEN E CASEÍNA EM CRIANÇAS E ADOLESCENTES COM TEA
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  66. Association between anesthetics and autism spectrum disorder: from bench to bedside
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  67. LEVANTAMENTO HISTÓRICO DE PUBLICAÇÕES SOBRE O TRANSTORNO DO ESPECTRO AUTISTA INSERIDAS NA PLATAFORMA PUBMED DE 1946 A 2022
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  68. Case Study and Literature Review of Phelan-McDermid Syndrome Caused By a Pathogenic Mutation in The SHANK3 Gene
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  69. Could neutrophil extracellular traps drive the development of autism?
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  70. Shank3 establishes AMPA receptor subunit composition at cerebellar mossy fiber-granule cell synapses and shapes regional microglia activation
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  71. Development of a Locus-specific qPCR-HRM Method for DNA Methylation Analysis of the SHANK3 Gene
    Sema Tiryaki · 2026 · Acibadem Universitesi Saglik Bilimleri Dergisi
  72. Graph theory identifies altered prefrontal microcircuit organization in Shank3 mice, a mouse Model of autism
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  73. SHANK3 Deficiency in AgRP Neurons Inhibits Diet-Induced Obesity by Activating p38α
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  74. Impaired metabotropic glutamate type 5 receptor signaling in the dorsal striatum of the R451C-neuroligin 3 mouse model of Autism Spectrum Disorder
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  75. The autophagy proteome in the brain
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  76. The Scrib1 Interactome and its relevance for synaptic plasticity & neurodevelopmental disorders
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  77. Integrating epilepsy and other comorbidities into autism spectrum disorder research: a call for animal models
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  78. Shank3 establishes AMPA receptor subunit composition at cerebellar mossy fiber-granule cell synapses and is associated with altered regional microglial morphology
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  79. The Role of SHANK3 /PROSAP2 in the Pathophysiology of Autism Spectrum Disorder and Phelan–Mcdermid Syndrome
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  80. Human iPSC Models: A Platform for Investigating Neurodevelopmental
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  81. Altered synaptic ultrastructure in the prefrontal cortex of Shank3-deficient rats
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  82. CONSIDERAÇÕES NEUROPSICOLÓGICAS NO TRATAMENTO DO TRANSTORNO DO ESPECTRO DO AUTISMO E SUA INTERFACE COM A IMITAÇÃO
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  83. Immp2l knockdown increases stimulus-driven instrumental behaviour but does not alter goal-directed learning or neuron density in cortico-striatal circuits in a mouse model of Tourette syndrome and autism spectrum disorder
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  84. Genetic influence on brain volume alterations related to self-reported childhood abuse
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  86. Article Open Access
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  87. Reply to “Concerns regarding the interpretation of Shank3 protein isoforms expressed in Shank3B−/− mice: potential off-target effects by a neomycin resistance cassette”
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  88. DNA methylation signatures in the prefrontal cortex of alcohol-naïve nonhuman primates predict risk for future ethanol drinking.
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  89. Inhibition of lysine-specific demethylase 1 enzyme activity by TAK-418 as a novel therapy for autism
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  90. Early Postnatal Dysfunction of ACC PV Interneurons in Shank3B -/- Mice
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  92. Effets des ions bromures dans les modèles murins d'autisme et sur la signalisation des récepteurs couplés aux protéines G
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  93. Social Encoding in the Medial Prefrontal Cortex
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  96. Drug development targeting synaptic molecules ^|^mdash; autism mouse models as an example
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