The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.
The Drosophila IR20a Clade of Ionotropic Receptors Are Candidate Taste and Pheromone Receptors
Open accessAbstract
Insects use taste to evaluate food, hosts, and mates. Drosophila has many “orphan” taste neurons that express no known taste receptors. The Ionotropic Receptor (IR) superfamily is best known for its role in olfaction, but virtually nothing is known about a clade of ~35 members, the IR20a clade. Here, a comprehensive analysis of this clade reveals expression in all taste organs of the fly. Some members are expressed in orphan taste neurons, whereas others are coexpressed with bitter- or sugar-sensing Gustatory receptor (Gr) genes. Analysis of the closely related IR52c and IR52d genes reveals signatures of adaptive evolution, roles in male mating behavior, and sexually dimorphic expression in neurons of the male foreleg, which contacts females during courtship. These neurons are activated by conspecific females and contact a neural circuit for sexual behavior. Together, these results greatly expand the repertoire of candidate taste and pheromone receptors in the fly.
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Cites
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Self-citationFunctional Architecture of Olfactory Ionotropic Glutamate Receptors
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Cited by
Multimodal Chemosensory Circuits Controlling Male Courtship in Drosophila
Clowney, E. J., Iguchi, S., Bussell, J. J., Scheer, E., & Ruta, V. (2015) · Neuron · doi:10.1016/j.neuron.2015.07.025 · Cited by 255
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Gustatory Processing in Drosophila melanogaster
Scott, K. (2018) · Annual Review of Entomology · doi:10.1146/annurev-ento-020117-043331 · Cited by 215
A complex peripheral code for salt taste in Drosophila
Jaeger, A. H., Stanley, M., Weiss, Z. F., Musso, P.-Y., Chan, R. C., Zhang, H., Feldman-Kiss, D., & Gordon, M. D. (2018) · eLife · doi:10.7554/elife.37167 · Cited by 157
Chemoreceptor co-expression in Drosophila melanogaster olfactory neurons
Task, D., Lin, C.-C., Vulpe, A., Afify, A., Ballou, S., Brbic, M., Schlegel, P., Raji, J., Jefferis, G. S., Li, H., et al. (2022) · eLife · doi:10.7554/elife.72599 · Cited by 141
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Metadata
- Authors
- Koh, T.-W., He, Z., Gorur-Shandilya, S., Menuz, K., Larter, N. K., Stewart, S., & Carlson, J. R.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2014-08
- Volume
- 83
- Issue
- 4
- Pages
- 850-865
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2057582929
- Cited by
- 300
- References
- 59
- FWCI
- 9.80
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Koh, T.-W., He, Z., Gorur-Shandilya, S., Menuz, K., Larter, N. K., Stewart, S., & Carlson, J. R. (2014). The Drosophila IR20a Clade of Ionotropic Receptors Are Candidate Taste and Pheromone Receptors. Neuron. https://doi.org/10.1016/j.neuron.2014.07.012
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