The DOI matches its Crossref record.
Tmem100 Is a Regulator of TRPA1-TRPV1 Complex and Contributes to Persistent Pain
Open accessAbstract
SUMMARY TRPA1 and TRPV1 are crucial pain mediators, but how their interaction contributes to persistent pain is unknown. Here, we identify Tmem100 as a potentiating modulator of TRPA1-V1 complexes. Tmem100 is co-expressed and forms a complex with TRPA1 and TRPV1 in DRG neurons. Tmem100-deficient mice show a reduction in inflammatory mechanical hyperalgesia and TRPA1- but not TRPV1-mediated pain. Single-channel recording in a heterologous system reveals that Tmem100 selectively potentiates TRPA1 activity in a TRPV1-dependent manner. Mechanistically, Tmem100 weakens the association of TRPA1 and TRPV1, thereby releasing the inhibition of TRPA1 by TRPV1. A Tmem100 mutant, Tmem100-3Q, exerts the opposite effect, i.e., it enhances the association of TRPA1 and TRPV1 and strongly inhibits TRPA1. Strikingly, a cell-permeable peptide (CPP) containing the C-terminal sequence of Tmem100-3Q mimics its effect and inhibits persistent pain. Our study unveils a context-dependent modulation of the TRPA1-V1 complex, and Tmem100-3Q CPP is a promising pain therapy.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Mammalian Transient Receptor Potential TRPA1 Channels: From Structure to Disease
Talavera, K., Startek, J. B., Alvarez-Collazo, J., Boonen, B., Alpizar, Y. A., Sanchez, A., Naert, R., & Nilius, B. (2020) · Physiological Reviews · doi:10.1152/physrev.00005.2019 · Cited by 403
Inflammation, Cancer and Immunity—Implication of TRPV1 Channel
Bujak, J. K., Kosmala, D., Szopa, I. M., Majchrzak, K., & Bednarczyk, P. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.01087 · Cited by 284
TRPA1 channels: molecular sentinels of cellular stress and tissue damage
Viana, F. (2016) · The Journal of Physiology · doi:10.1113/jp270935 · Cited by 210
Xie, Z., Feng, J., Hibberd, T. J., Chen, B. N., Zhao, Y., Zang, K., Hu, X., Yang, X., Chen, L., Brookes, S. J., et al. (2023) · Neuron · doi:10.1016/j.neuron.2022.11.015 · Cited by 84
Methylglyoxal Requires AC1 and TRPA1 to Produce Pain and Spinal Neuron Activation
Griggs, R. B., Laird, D. E., Donahue, R. R., Fu, W., & Taylor, B. K. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00679 · Cited by 33
Metadata
- Authors
- Weng, H.-J., Patel, K. N., Jeske, N. A., Bierbower, S. M., Zou, W., Tiwari, V., Zheng, Q., Tang, Z., Mo, G. C. H., Wang, Y., Geng, Y., Zhang, J., Guan, Y., Akopian, A. N., & Dong, X.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2015-02
- Volume
- 85
- Issue
- 4
- Pages
- 833-846
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2029608563
- Cited by
- 181
- References
- 0
- FWCI
- 10.85
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Tmem100 Is a Regulator of TRPA1-TRPV1 Complex and Contributes to Persistent Pain. https://app.cochat.ai/papers/10.1016/j.neuron.2014.12.065
- The paper
- Weng, H.-J., Patel, K. N., Jeske, N. A., Bierbower, S. M., Zou, W., Tiwari, V., Zheng, Q., Tang, Z., Mo, G. C. H., Wang, Y., Geng, Y., Zhang, J., Guan, Y., Akopian, A. N., & Dong, X. (2015). Tmem100 Is a Regulator of TRPA1-TRPV1 Complex and Contributes to Persistent Pain. Neuron. https://doi.org/10.1016/j.neuron.2014.12.065
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
