The DOI matches its Crossref record; 97 of the 97 references it cites were found in a registry or an index.
Inflammation, Cancer and Immunity—Implication of TRPV1 Channel
Open accessAbstract
Process of inflammation and complex interactions between immune and cancer cells within tumor microenvironment are known to drive and shape the outcome of the neoplastic disease. Recent studies increasingly show that ion channels can be used as potential targets to modulate immune response and to treat inflammatory disorders and cancer. The action of both innate and adaptive immune cells is tightly regulated by ionic signals provided by a network of distinct ion channels. TRPV1 channel, known as a capsaicin receptor, was recently documented to be expressed on the cells of the immune system but also aberrantly expressed in the several tumor types. It is activated by heat, protons, proinflammatory cytokines, and associated with pain and inflammation. TRPV1 channel is not only involved in calcium signaling fundamental for many cellular processes but also takes part in cell-environment crosstalk influencing cell behavior. Furthermore, in several studies, activation of TRPV1 by capsaicin was associated with anti-cancer effects. Therefore, TRPV1 provides a potential link between the process of inflammation, cancer and immunity, and offers new treatment possibilities. Nevertheless, in many cases, results regarding TRPV1 are contradictory and need further refinement. In this review we present the summary of the data related to the role of TRPV1 channel in the process of inflammation, cancer and immunity, limitations of the studies, and directions for future research.
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Cites
The capsaicin receptor: a heat-activated ion channel in the pain pathway
Caterina, M. J., Schumacher, M. A., Tominaga, M., Rosen, T. A., Levine, J. D., & Julius, D. (1997) · Nature · doi:10.1038/39807 · Cited by 9,107
Origin and physiological roles of inflammation
Medzhitov, R. (2008) · Nature · doi:10.1038/nature07201 · Cited by 6,618
Understanding the tumor immune microenvironment (TIME) for effective therapy
Binnewies, M., Roberts, E. W., Kersten, K., Chan, V., Fearon, D. F., Merad, M., Coussens, L. M., Gabrilovich, D. I., Ostrand-Rosenberg, S., Hedrick, C. C., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0014-x · Cited by 6,145
TRPA1 mediates formalin-induced pain
McNamara, C. R., Mandel-Brehm, J., Bautista, D. M., Siemens, J., Deranian, K. L., Zhao, M., Hayward, N. J., Chong, J. A., Julius, D., Moran, M. M., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705924104 · Cited by 1,263
Neuroimmune Interactions: From the Brain to the Immune System and Vice Versa
Dantzer, R. (2018) · Physiological Reviews · doi:10.1152/physrev.00039.2016 · Cited by 1,073
Role of neuroinflammation in neurodegenerative diseases (Review)
CHEN, W.-W., ZHANG, X., & HUANG, W.-J. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.4948 · Cited by 932
The transient receptor potential family of ion channels
Nilius, B., & Owsianik, G. (2011) · Genome Biology · doi:10.1186/gb-2011-12-3-218 · Cited by 919
Ion Channels in Innate and Adaptive Immunity
Feske, S., Wulff, H., & Skolnik, E. Y. (2015) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032414-112212 · Cited by 768
Altered urinary bladder function in mice lacking the vanilloid receptor TRPV1
Birder, L. A., Nakamura, Y., Kiss, S., Nealen, M. L., Barrick, S., Kanai, A. J., Wang, E., Ruiz, G., de Groat, W. C., Apodaca, G., et al. (2002) · Nature Neuroscience · doi:10.1038/nn902 · Cited by 703
Ionic immune suppression within the tumour microenvironment limits T cell effector function
Eil, R., Vodnala, S. K., Clever, D., Klebanoff, C. A., Sukumar, M., Pan, J. H., Palmer, D. C., Gros, A., Yamamoto, T. N., Patel, S. J., et al. (2016) · Nature · doi:10.1038/nature19364 · Cited by 678
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A narrative review of molecular mechanism and therapeutic effect of cannabidiol (CBD)
Peng, J., Fan, M., An, C., Ni, F., Huang, W., & Luo, J. (2022) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.13710 · Cited by 282
Therapeutic Potential of Volatile Terpenes and Terpenoids from Forests for Inflammatory Diseases
Kim, T., Song, B., Cho, K. S., & Lee, I.-S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21062187 · Cited by 281
Metadata
- Authors
- Bujak, J. K., Kosmala, D., Szopa, I. M., Majchrzak, K., & Bednarczyk, P.
- Venue
- Frontiers in Oncology
- Publisher
- Frontiers Media SA
- Published
- 2019-10-16
- Volume
- 9
- Pages
- 1087-1087
- ISSN
- 2234-943X (ISSN-L)
- OpenAlex
- W2980961929
- Cited by
- 284
- References
- 97
- FWCI
- 14.64
- Type
- journal article
- Language
- en
- Open access
- gold
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- Bujak, J. K., Kosmala, D., Szopa, I. M., Majchrzak, K., & Bednarczyk, P. (2019). Inflammation, Cancer and Immunity—Implication of TRPV1 Channel. Frontiers in Oncology. https://doi.org/10.3389/fonc.2019.01087
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