Clonally related forebrain interneurons disperse broadly across both functional areas and structural boundaries
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The medial ganglionic eminence (MGE) gives rise to the majority of mouse forebrain interneurons. Here, we examine the lineage relationship among MGE-derived interneurons using a replication-defective retroviral library containing a highly diverse set of DNA barcodes. Recovering the barcodes from the mature progeny of infected progenitor cells enabled us to unambiguously determine their respective lineal relationship. We found that clonal dispersion occurs across large areas of the brain and is not restricted by anatomical divisions. As such, sibling interneurons can populate the cortex, hippocampus striatum, and globus pallidus. The majority of interneurons appeared to be generated from asymmetric divisions of MGE progenitor cells, followed by symmetric divisions within the subventricular zone. Altogether, our findings uncover that lineage relationships do not appear to determine interneuron allocation to particular regions. As such, it is likely that clonally related interneurons have considerable flexibility as to the particular forebrain circuits to which they can contribute.
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Lineage analysis shows that one progenitor cell can produce interneurons that populate different regions of the telencephalon.
“Indeed, lineage analysis studies have shown that the same progenitor cell can generate interneurons populating different regions of the telencephalon (Harwell et al., 2015; Mayer et al., 2015).”
From Development and Functional Diversification of Cortical Interneurons (2018) · cites this paper as Mayer et al., 2015
Clonally related interneurons disperse widely across the telencephalon, and spatially restricted clusters of interneurons are comprised of cells unrelated by a common progenitor.
“clonally related interneurons disperse widely across the telencephalon and that spatially restricted clusters of interneurons are in fact comprised of cells unrelated by a common progenitor”
From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [766]
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References 49 · Cited by 113
- Authors
- Mayer, C., Jaglin, X. H., Cobbs, L. V., Bandler, R. C., Streicher, C., Cepko, C. L., Hippenmeyer, S., & Fishell, G.
- Affiliations
- NYU Langone Health (US)
- Institute of Science and Technology Austria (AT)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Fishell, Gord
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2015-09
- Volume
- 87
- Issue
- 5
- Pages
- 989-998
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC4560602
- OpenAlex
- W2121005041
- Cited by
- 113
- References
- 49
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 7 · 2023: 5 · 2022: 6 · 2021: 15 · 2020: 19 · 2019: 12 · 2018: 13 · 2017: 16 · 2016: 9 · 2015: 3
- FWCI
- 5.53
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01MH071679, MH095147, R01MH095147, R37MH071679)
- National Cancer Institute (P30CA016087)
- National Institute of Neurological Disorders and Stroke (NS 081297, P01NS074972, R01NS081297)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- medial ganglionic eminence, DNA barcoding, asymmetric cell division, symmetric cell division, subventricular zone, globus pallidus, hippocampus, striatum, cortical interneurons
- MeSH terms
- Thyroid Nuclear Factor 1, Animals, Carrier Proteins, Cell Differentiation, Cell Movement, Embryo, Mammalian, Geniculate Bodies, Interneurons, Luminescent Proteins, Mice, Transgenic, Microtubule-Associated Proteins, Nuclear Proteins, Stem Cells, Time Factors, Transcription Factors, Gene Library, Prosencephalon, Gene Expression Regulation, Developmental, Microdissection, 1-Alkyl-2-acetylglycerophosphocholine Esterase, Mice, DNA Barcoding, Taxonomic, Nestin
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