Wide dispersion and diversity of clonally related inhibitory interneurons
Open accessAbstract
The mammalian neocortex is composed of two major neuronal cell types with distinct origins: excitatory pyramidal neurons and inhibitory interneurons, generated in dorsal and ventral progenitor zones of the embryonic telencephalon, respectively. Thus, inhibitory neurons migrate relatively long distances to reach their destination in the developing forebrain. The role of lineage in the organization and circuitry of interneurons is still not well understood. Utilizing a combination of genetics, retroviral fate mapping, and lineage-specific retroviral barcode labeling, we find that clonally related interneurons can be widely dispersed while unrelated interneurons can be closely clustered. These data suggest that migratory mechanisms related to the clustering of interneurons occur largely independent of their clonal origin.
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Individual progenitor cells in the MGE generate both SST+ and PV+ interneurons.
“clonal studies have shown that individual progenitor cells in the MGE generate both SST+ and PV+ interneurons”
From Development and Functional Diversification of Cortical Interneurons (2018) · cites this paper as Harwell et al., 2015
Lineage analysis shows that one progenitor cell can produce interneurons that populate different regions of the telencephalon.
“Indeed, lineage analysis studies have shown that the same progenitor cell can generate interneurons populating different regions of the telencephalon (Harwell et al., 2015; Mayer et al., 2015).”
From Development and Functional Diversification of Cortical Interneurons (2018) · cites this paper as Harwell et al., 2015
Clonally related interneurons disperse widely across the telencephalon, and spatially restricted clusters of interneurons are comprised of cells unrelated by a common progenitor.
“clonally related interneurons disperse widely across the telencephalon and that spatially restricted clusters of interneurons are in fact comprised of cells unrelated by a common progenitor”
From Hippocampal GABAergic Inhibitory Interneurons (2017) · cites this paper as [469]
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References 54 · Cited by 106
- Authors
- Harwell, C. C., Fuentealba, L. C., Gonzalez-Cerrillo, A., Parker, P. R. L., Gertz, C. C., Mazzola, E., Garcia, M. T., Alvarez-Buylla, A., Cepko, C. L., & Kriegstein, A. R.
- Affiliations
- Harvard University (US)
- University of California, San Francisco (US)
- Gladstone Institutes (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Harwell, Corey C.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2015-09
- Volume
- 87
- Issue
- 5
- Pages
- 999-1007
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC4581718
- OpenAlex
- W2114586459
- Cited by
- 106
- References
- 54
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 8 · 2023: 8 · 2022: 4 · 2021: 11 · 2020: 11 · 2019: 9 · 2018: 13 · 2017: 17 · 2016: 11 · 2015: 2
- FWCI
- 5.76
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke (R01NS035710)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R37HD032116, R01HD032116)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- inhibitory interneurons, clonal origin, neocortex, neuronal migration, lineage tracing, telencephalon
- MeSH terms
- Animals, Cell Movement, Cells, Cultured, Cerebral Cortex, Embryo, Mammalian, Interneurons, Nerve Net, Nerve Tissue Proteins, Neural Inhibition, Organ Culture Techniques, Telencephalon, Transduction, Genetic, Cell Lineage, Green Fluorescent Proteins, Mice, Neural Stem Cells, Laser Capture Microdissection, In Vitro Techniques
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