A transient translaminar GABAergic interneuron circuit connects thalamocortical recipient layers in neonatal somatosensory cortex
Open accessAbstract
GABAergic activity is thought to influence developing neocortical sensory circuits. Yet the late postnatal maturation of local layer (L)4 circuits suggests alternate sources of GABAergic control in nascent thalamocortical networks. We show that a population of L5b, somatostatin (SST)-positive interneuron receives early thalamic synaptic input and, using laser-scanning photostimulation, identify an early transient circuit between these cells and L4 spiny stellates (SSNs) that disappears by the end of the L4 critical period. Sensory perturbation disrupts the transition to a local GABAergic circuit, suggesting a link between translaminar and local control of SSNs. Conditional silencing of SST+ interneurons or conversely biasing the circuit toward local inhibition by overexpression of neuregulin-1 type 1 results in an absence of early L5b GABAergic input in mutants and delayed thalamic innervation of SSNs. These data identify a role for L5b SST+ interneurons in the control of SSNs in the early postnatal neocortex.
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Layer 5 SST+ interneurons receive dense transient thalamic inputs during the first postnatal week and innervate layer 4 excitatory neurons, layer 5 pyramidal cells and immature PV+ interneurons.
“Interestingly, layer 5 SST+ interneurons receive dense transient thalamic inputs during the first week of postnatal development and innervate both layer 4 excitatory neurons and layer 5 pyramidal cells and immature PV+ interneurons (Marques-Smith et al., 2016; Tuncdemir et al., 2016).”
From Development and Functional Diversification of Cortical Interneurons (2018) · cites this paper as Marques-Smith et al., 2016
Layer 5 SST+ interneurons transiently control early sensory-evoked activity in layer 4 before the canonical PV+ feedforward inhibitory circuit appears.
“This suggests that layer 5 SST+ interneurons transiently control early sensory-evoked activity in layer 4 prior to the emergence of the canonical feedforward inhibitory circuit mediated by PV+ interneurons (Marques-Smith et al., 2016).”
From Development and Functional Diversification of Cortical Interneurons (2018) · cites this paper as Marques-Smith et al., 2016
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References 91 · Cited by 173
- Authors
- Marques-Smith, A., Lyngholm, D., Kaufmann, A.-K., Stacey, J. A., Hoerder-Suabedissen, A., Becker, E. B. E., Wilson, M. C., Molnár, Z., & Butt, S. J. B.
- Affiliations
- University of Oxford (GB)
- University of New Mexico Health Sciences Center (US)
- Corresponding author
- Butt, Simon J.B.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2016-02
- Volume
- 89
- Issue
- 3
- Pages
- 536-549
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC4742537
- OpenAlex
- W2256316452
- Cited by
- 173
- References
- 91
- Citations by year
- 2026: 14 · 2025: 19 · 2024: 22 · 2023: 21 · 2022: 14 · 2021: 22 · 2020: 12 · 2019: 14 · 2018: 16 · 2017: 14 · 2016: 5
- FWCI
- 9.16
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Neuron (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Strathprints: The University of Strathclyde institutional repository (University of Strathclyde) (acceptedVersion)
- Funders
- Wellcome Trust (086362/Z/08/Z, 102386/Z/13/Z)
- Medical Research Council (MR/K004387/1, G00900901)
- Fundação para a Ciência e a Tecnologia
- Studienstiftung des Deutschen Volkes
- Brain and Behavior Research Foundation (19079)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- GABAergic interneurons, somatostatin interneurons, spiny stellate neurons, thalamocortical circuits, neuregulin-1, sensory perturbation, local inhibition
- MeSH terms
- Animals, Electric Stimulation, Female, gamma-Aminobutyric Acid, Interneurons, Male, Membrane Potentials, Mice, Transgenic, Neural Pathways, Photic Stimulation, Somatosensory Cortex, Somatostatin, Thalamus, Neuregulin-1, Mice
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