Down Syndrome Developmental Brain Transcriptome Reveals Defective Oligodendrocyte Differentiation and Myelination

Olmos-Serrano, Jose Luis, Kang, Hyo Jung, Tyler, William A., Silbereis, John C., Cheng, Feng, Zhu, Ying, Pletikos, Mihovil, Jankovic-Rapan, Lucija +9 more·2016·Neuron

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  1. Expresión de genes asociados a discapacidad mental en cerebros de pacientes con síndrome de Down
    Meliza Santiago Ospina, Alejandra Rodríguez, Julio César Montoya · 2016
  2. The Altered Roles of Glia in Neurodevelopmental Disorders
    Rachel L. Doser · 2017 · UA Campus Repository (The University of Arizona)
  3. A New Approach to The Pathogenesis of Down Syndrome: An Integrated Quantitative Neuro-Transcriptome Analysis of Several Brain Areas in Human Trisomy 21.
    Alejandra Rodríguez-Ortiz, Julio César Montoya Villegas, Adalberto Sánchez, José María Satizábal Soto, Yecid Mina-Paz, Felipe García‐Vallejo · 2021 · Research Square
  4. The dark side of the brain, myelinating glia in central and peripheral nervous systems
    Roman Chrast, Gonçalo Castelo‐Branco · 2021 · Seminars in Cell and Developmental Biology
  5. Transcriptômica de autismo e deficiências intelectuais: uma abordagem de biologia de sistemas para identificar especificidades e convergências
    Bruna Garbes Gonçalves Pinto · 2021 · Digital Library of Theses and Dissertations (Universidade de São Paulo)
  6. Identificação de modelos celulares de fácil obtenção com preservação de módulos de co-expressão desregulados em transtorno do espectro autista e deficiência intelectual
    Camily Rodrigues · 2021
  7. Faculty Opinions recommendation of Restoration of brain circulation and cellular functions hours post-mortem.
    Laurent Villard · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  8. Faculty Opinions recommendation of Multimodal Single-Cell Analysis Reveals Physiological Maturation in the Developing Human Neocortex.
    Vı́ctor Borrell · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  9. Gene-dosage imbalance and altered neurogenesis in Down syndrome
    Bani Bandana Ganguly · 2022 · Elsevier eBooks
  10. Development of Cortical Neuron Heterogeneity and Impact of Neurodevelopmental Disorders
    Zhen Li, William A. Tylerand, Tarik F. Haydar · 2023
  11. Developmental and Evolutionary Origins of Cortical Projection Neuron Identity and Connectivity
    Navjot Kaur, Rothem Kovner, Kevin T. Gobeske, Nenad Šestan · 2023 · Wiley eBooks
  12. Pleiotropic effects of trisomy and pharmacologic modulation on structural, functional, molecular, and genetic systems in a Down syndrome mouse model
    Sergi Llambrich, Birger Tielemans, Ellen Saliën, Marta Atzori, Kaat Wouters, Vicky Van Bulck, Mark Platt, Laure Vanherp, Nuria Gallego Fernandez, Laura Grau de la Fuente et al. · 2024 · eLife
  13. Copy number variations of proteins associated with neurodegenerative diseases and rare neurological disorders
    Zhangzhong Yang, Peng Lei · 2024 · Scientia Sinica Vitae
  14. Human Models of Down Syndrome
    Megan Jandy, Hao Hu, Yan Liu, Anita Bhattacharyya · 2025 · Springer eBooks
  15. Down Syndrome: Progress in Defining Pathogenesis and Treatments for Neurodevelopmental Deficits and Alzheimer’s Disease
    Renata Bartesaghi, Xu‐Qiao Chen, Aaron D. Johnstone, Utpal Das, William Cary Mobley · 2025 · Springer eBooks
  16. Genetic and Molecular Insights into the Links Between Heat Stroke, Alzheimer’s Disease, and Down Syndrome: A Mini-Review
    Hisahide Nishio, Hirokuni Negishi, Hiroyuki Awano, Jumpei Oba · 2025 · Genes
  17. Functional development of midbrain and pons during human gestation and electrophysiological markers for DS intervention
    Yongkang Wu, Yingmei Fu, Hao Yang Peng, Yanni Chen, Wang Fanglin, Jian Wang, Jinli Ou, Yigang Dong, Qingmiao Hu, Yan Cui et al. · 2025 · Journal of Advanced Research
  18. The endocannabinoid system in intellectual disability
    Anna Vázquez-Oliver, Lucía de los Reyes‐Ramírez, Lorena Galera-López, Andrés Ozaita · 2025 · Handbook of behavioral neuroscience
  19. Additional file 1 of The transcriptome profile of human trisomy 21 blood cells
    Francesca Antonaros, Rossella Zenatelli, Guerri, Giulia, Bertelli, Matteo, Locatelli, Chiara, Beatrice Vione, Francesca Catapano, Alice Gori, Lorenza Vitale, Maria Chiara Pelleri et al. · 2021 · Figshare
  20. Additional file 12 of The transcriptome profile of human trisomy 21 blood cells
    Francesca Antonaros, Rossella Zenatelli, Guerri, Giulia, Bertelli, Matteo, Locatelli, Chiara, Beatrice Vione, Catapano, Francesca, Alice Gori, Lorenza Vitale, Maria Chiara Pelleri et al. · 2021 · Figshare
  21. Additional file 6 of The transcriptome profile of human trisomy 21 blood cells
    Francesca Antonaros, Rossella Zenatelli, Guerri, Giulia, Bertelli, Matteo, Locatelli, Chiara, Beatrice Vione, Francesca Catapano, Alice Gori, Lorenza Vitale, Maria Chiara Pelleri et al. · 2021 · Figshare
  22. Additional file 3 of The transcriptome profile of human trisomy 21 blood cells
    Francesca Antonaros, Rossella Zenatelli, Guerri, Giulia, Bertelli, Matteo, Locatelli, Chiara, Beatrice Vione, Francesca Catapano, Alice Gori, Lorenza Vitale, Maria Chiara Pelleri et al. · 2021 · Figshare
  23. Additional file 4 of The transcriptome profile of human trisomy 21 blood cells
    Francesca Antonaros, Zenatelli, Rossella, Guerri, Giulia, Bertelli, Matteo, Locatelli, Chiara, Beatrice Vione, Francesca Catapano, Alice Gori, Lorenza Vitale, Maria Chiara Pelleri et al. · 2021 · Figshare
  24. Additional file 2 of The transcriptome profile of human trisomy 21 blood cells
    Francesca Antonaros, Zenatelli, Rossella, Guerri, Giulia, Bertelli, Matteo, Locatelli, Chiara, Beatrice Vione, Francesca Catapano, Alice Gori, Lorenza Vitale, Maria Chiara Pelleri et al. · 2021 · Figshare
  25. Additional file 5 of The transcriptome profile of human trisomy 21 blood cells
    Francesca Antonaros, Rossella Zenatelli, Guerri, Giulia, Bertelli, Matteo, Locatelli, Chiara, Beatrice Vione, Catapano, Francesca, Alice Gori, Lorenza Vitale, Maria Chiara Pelleri et al. · 2021 · Figshare
  26. Single-cell atlas of the fetal Down syndrome cortex uncovers chromosome 21 regulators of intellectual disability gene networks
    Michael Lattke, Wee Leng Tan, Salil Kalarikkal Sukumaran, Kagistia Hana Utami, Marcos Sintes, Srinivasan Sakthivel, Jonathan Tan, Auriel Theodora Jacobea Lim, Vibhavari Aysha Bansal, Katerina Rekopoulou et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  27. Genome-wide cell type-specific and sex-specific transcriptional dysregulation in the islet of Langerhans underlies islet dysfunction in Down syndrome-related diabetes
    Cyrus R. Sethna, Maria Del Carmen Mendoza Niemes, Bayley J. Waters, Matthew R. Wagner, Jacob Smith, Sutichot D. Nimkulrat, Julia Lemanski, Nicolas G Pintozzi, Valentina Lo Sardo, Barak Blum · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  28. Trisomy 21 Drives ADARB1 Overexpression and Premature RNA Recoding in the Developing Fetal Brain
    Michael S. Breen, Andy Yang, Xuran Wang, Miguel Rodríguez de los Santos, Ran TAO, Daniel R. Weinberger, Joel E. Kleinman, Kalina Yonkova Mihova, Gergana S. Stancheva, Sylvia Savova et al. · 2026 · Nature Communications
  29. Multi-omics data integration and interactive visual data mining to explore mitochondrial dynamics
    Fabio Marchianò · 2022 · theses.fr (ABES)
  30. Fonctions de PAK1 dans la régulation du cytosquelette d’actine : implication dans la myélinisation du système nerveux central
    Lucas Baudouin · 2021 · theses.fr (ABES)
  31. Étude du neurodéveloppement et de l'infertilité masculine chez différents modèles murins de Trisomie 21
    Rodolphe Dard · 2024
  32. Early dynamics of the genome in Down syndrome
    Tarik F. Haydar, Zhen Li · 2026 · Science
  33. RegRegSEA: a web server for regulatory region set enrichment analysis of epigenomic data
    Tobias William Wolff, Friederike Grandke, MISBAH SAYEEDA, Pascal Hirsch, Matthias Flotho, Andreas Keller · 2026 · Nucleic Acids Research
  34. Multiomics and proteomic insights into Alzheimer’s disease biology in Down syndrome
    Mitchell Martá-Ariza, T R Wisniewski · 2026 · Expert Review of Neurotherapeutics
  35. Oligodendrocyte Enriched Brain Organoids Reveal Impaired Oligodendroglial Maturation and Altered Neural Network Activity in Down Syndrome
    Marta Boira Marti, Sean D. Morrison, Selin Pars, Bahaa Al-mhanawi, Peter G. Noakes, Ernst Jurgen Wolvetang, Mohammed R. Shaker · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  36. Epilepsy Mechanisms in Down Syndrome: Genetic and Pathophysiological Perspectives Across the Lifespan
    Carl E. Stafstrom, Li‐Rong Shao · 2026 · Journal of Clinical Medicine
  37. A pattern to rule them all: tracing a human brain map of molecular aspects shared by Alzheimer’s disease and dementia with Lewy bodies
    Riccardo Rocco Ferrari, Maria Garofalo, Rosalinda Di Gerlando, Elisa Pellegrini, Francesca Dragoni, Bartolo Rizzo, Michele Rossi, Chiara Calatozzolo, Antonio Guaita, Annalisa Davin et al. · 2026 · GeroScience
  38. Human-induced pluripotent stem cell-derived neural cells to model epigenetic regulations in the nervous system and brain disorders in vitro
    YAN HONG, Guo-li Ming, HONGJUN SONG · 2026 · Handbook of clinical neurology