Down Syndrome Developmental Brain Transcriptome Reveals Defective Oligodendrocyte Differentiation and Myelination

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1. Gene Expression Studies in Down Syndrome: What Do They Tell Us about Disease Phenotypes?
   Laura Chapman, Isabela V. P. Ramnarine, Daniel Zemke, Arshad Majid, Simon Bell · 2024 · International Journal of Molecular Sciences
2. Alzheimer‐related altered white matter microstructural integrity in Down syndrome: A model for sporadic AD?
   Herminia Diana Rosas, Eugene Hsu, Nathaniel David Mercaldo, Florence Lai, Margaret B. Pulsifer, David B. Keator, Adam M. Brickman, Julie C. Price, Michael A. Yassa, Christy L. Hom et al. · 2020 · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring
3. Rescue of deficits by Brwd1 copy number restoration in the Ts65Dn mouse model of Down syndrome
   Sasha L. Fulton, Wendy Wenderski, Ashley E. Lepack, Andrew L. Eagle, Tomas Fanutza, Ryan M. Bastle, Aarthi Ramakrishnan, Emma Catherine Hays, Arianna Neal, Jaroslav M. Bendl et al. · 2022 · Nature Communications
4. Subicular hypotrophy in fetuses with Down syndrome and in the Ts65Dn model of Down syndrome
   Stagni, Fiorenza, Giacomini, Andrea, Emili, Marco, Uguagliati, Beatrice, Bonasoni, Maria Paola, Bartesaghi, Renata, Guidi, Sandra · 2019 · Brain Pathology
5. Glycosphingolipids in neurodegeneration – Molecular mechanisms, cellular roles, and therapeutic perspectives
   Andreas J. Hülsmeier · 2025 · Neurobiology of Disease
6. Endosome Dysregulation in Down Syndrome: A Potential Contributor to Alzheimer Disease Pathology
   Alessia Filippone, Domenico Praticò · 2021 · Annals of Neurology
7. Modeling Down syndrome in cells: From stem cells to organoids
   Gillian Gough, Niamh Louise O’Brien, Ivan Alić, Pollyanna Agnes Goh, Yee Jie Yeap, Jürgen Groet, Dean Nižetić, Aoife Murray · 2019 · Progress in brain research
8. From Organoids to Assembloids: Experimental Approaches to Study Human Neuropsychiatric Disorders
   Rebecca J. Levy, Sergiu P. Pașca · 2025 · Annual Review of Neuroscience
9. linc-mipep and linc-wrb encode micropeptides that regulate chromatin accessibility in vertebrate-specific neural cells
   Valerie A. Tornini, Ho‐Joon Lee, Liyun Miao, Yin Tang, Sarah E Dube, Timothy Gerson, Valeria Schmidt, Katherine Du, Manik Kuchroo, François Kroll et al. · 2023 · eLife
10. Genome-wide miRNA profiling in plasma of pregnant women with down syndrome fetuses
    Iveta Zednikova, Blanka Chylíková, Ond⊘řej Šeda, Marie Korabečná, Eva Pazourková, Miroslav Brestak, M Krkavcová, Pavel Calda, Aleš Hořínek · 2020 · Molecular Biology Reports
11. Cell models for Down syndrome-Alzheimer’s disease research
    Yixing Wu, Nicole R. West, Anita Bhattacharyya, Frances K. Wiseman · 2022 · Neuronal Signaling
12. Disorders of the central nervous system: Insights from Notch and Nrf2 signaling
    Yuwen Chen, Jiao Pang, Ye Lu, Zhentao Zhang, Suijin Lin, Na Lin, Tae Ho Lee, Hekun Liu · 2023 · Biomedicine & Pharmacotherapy
13. The Role of Oxidative Stress in Trisomy 21 Phenotype
    Angelika Buczyńska, Iwona Sidorkiewicz, Adam Jacek Kretowski, Monika Zbucka-Krętowska · 2023 · Cellular and Molecular Neurobiology
14. Trisomy silencing by XIST: translational prospects and challenges
    Khusali Gupta, Jan T. Czerminski, Jeanne Bentley Lawrence · 2024 · Human Genetics
15. Nanotechnology-Based Medical and Biomedical Imaging for Diagnostics
    Kishore Cholkar, Nupoor D. Hirani, Chandramouli Natarajan · 2017 · Elsevier eBooks
16. REST Targets JAK–STAT and HIF-1 Signaling Pathways in Human Down Syndrome Brain and Neural Cells
    Tan Huang, Sharida Fakurazi, Pike-See Cheah, King‐Hwa Ling · 2023 · International Journal of Molecular Sciences
17. Dysregulation of astrocyte-secreted pleiotrophin contributes to neuronal structural and functional deficits in Down syndrome
    Ashley N. Brandebura, Adrien Paumier, Quinn N. Asbell, Tao Tao, Mariel Kristine B Micael, Sherlyn Sanchez, Nicola J. Allen · 2025 · Cell Reports
18. C21orf91 Regulates Oligodendroglial Precursor Cell Fate—A Switch in the Glial Lineage?
    Laura Reiche, Peter Göttle, Lydie Lane, Paula D Duek, Mina Park, Kasum Azim, Jana Schütte, Anastasia Manousi, Jessica Schira‐Heinen, Patrick Küry · 2021 · Frontiers in Cellular Neuroscience
19. Disruption of neuronal RHEB signaling impairs oligodendrocyte differentiation and myelination through mTORC1-DLK1 axis
    Haijiao Huang, Bo Jing, Feiyan Zhu, Wanxiang Jiang, Ping Tang, Liyang Shi, Huiting Chen, Guoru Ren, Shiyao Xia, Luoling Wang et al. · 2023 · Cell Reports
20. Transcriptional consequences of trisomy 21 on neural induction
    Martinez, José L., Piciw, Jennifer G., Crockett, Madeline, Sorci, Isabella A., Makwana, Nikunj, Sirois, Carissa L., Giffin-Rao, Yathindar, Bhattacharyya, Anita · 2024 · Frontiers in Cellular Neuroscience
21. Large-scale organoid study suggests effects of trisomy 21 on early fetal neurodevelopment are more subtle than variability between isogenic lines and experiments
    Jan T. Czerminski, Oliver D. King, Jeanne Bentley Lawrence · 2023 · Frontiers in Neuroscience
22. Chromosome-wise Protein Interaction Patterns and Their Impact on Functional Implications of Large-Scale Genomic Aberrations
    Isa Kristina Kirk, Nils Weinhold, Kirstine Belling, Niels Erik Skakkebæk, Thomas Skøt Jensen, Henrik Christian Bidstrup Leffers, Anders Juul, Søren Brunak · 2017 · Cell Systems
23. Single cell ATAC-seq identifies broad changes in neuronal abundance and chromatin accessibility in Down Syndrome
    Roman Spektor, Jee Won Yang, Seo Yeon Lee, Paul D. Soloway · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
24. Endosomal Sorting Protein SNX27 and Its Emerging Roles in Human Cancers
    Shreya Deb, Jun Sun · 2022 · Cancers
25. From neurodevelopment to neurodegeneration: utilizing human stem cell models to gain insight into Down syndrome
    Lauren Ashley Watson, Hiruy S. Meharena · 2023 · Frontiers in Genetics
26. Molecular and cellular processes disrupted in the early postnatal Down syndrome prefrontal cortex
    Risgaard, Ryan D., Hanthanan Arachchilage, Kalpana, Knaack, Sara A., Hosseini, Masoumeh, Chen, Rachel J., Kumarage, Pubudu, Schmidt, Danielle K., Huang, Xiang, Sheng, Jie, Wang, Carlos J. et al. · 2026 · Science
27. A single-cell multiomic analysis identifies molecular and gene-regulatory mechanisms dysregulated in developing Down syndrome neocortex
    Celine K. Vuong, Alexis Weber, Patrick Seong, Nana Matoba, Yu-Jen Chen, Jordan Peyer, Shahab Younesi, Angelo Salinda, Daniel Gomez, Gabriella Rivas et al. · 2026 · Science
28. Shaking up the silence: consequences of HMGN1 antagonizing PRC2 in the Down syndrome brain
    Sean J. Farley, Alla Grishok, Ella Zeldich · 2022 · Epigenetics & Chromatin
29. Neocortical neuronal production and maturation defects in the TcMAC21 mouse model of Down syndrome
    Nobuhiro Kurabayashi, Kazuki Fujii, Yuta Otobe, Shingo Hiroki, Masaharu Hiratsuka, Hikari Yoshitane, Yasuhiro Kazuki, Keizo Takao · 2023 · iScience
30. Association Analysis of Variants of DSCAM and BACE2 With Hirschsprung Disease Susceptibility in Han Chinese and Functional Evaluation in Zebrafish
    Yan-Jiao Lu, Wenwen Yu, Mengmeng Cui, Xianxian Yu, Huan-Lei Song, Mei-Rong Bai, Wenjie Wu, Bei-Lin Gu, Jun Wang, Wei Cai et al. · 2021 · Frontiers in Cell and Developmental Biology
31. Fatty Acids: A Safe Tool for Improving Neurodevelopmental Alterations in Down Syndrome?
    C. Martínez-Cué, R. Bartesaghi · 2022 · Nutrients
32. Impaired macroglial development and axonal conductivity contributes to the neuropathology of DYRK1A-related intellectual disability syndrome
    Isabel Pijuan, Elisa Balducci, Cristina Soto‐Sánchez, Eduardo Fernández, Marı́a José Barallobre, Maria Lourdes Arbonés · 2022 · Scientific Reports
33. Increased propensity for infantile spasms and altered neocortical excitation-inhibition balance in a mouse model of down syndrome carrying human chromosome 21
    Li‐Rong Shao, Feng Gao, Viveka Chinnasamy, Yasuhiro Kazuki, Mistuo Oshimura, Roger H. Reeves, Carl E. Stafstrom · 2023 · Neurobiology of Disease
34. GnRH and Cognition
    Loïc Kacimi, Vincent Prévot · 2025 · Endocrinology
35. The Evolving Landscape of Functional Models of Autism Spectrum Disorder
    Jai Ranjan, Aniket Bhattacharya · 2025 · Cells
36. Maternal Glucose Supplementation in a Murine Model of Chorioamnionitis Alleviates Dysregulation of Autophagy in Fetal Brain
    Jun Lei, Wenyu Zhong, Ahmad Almalki, Hongxi Zhao, Hattan Arif, Rayyan Rozzah, Ghada Al Yousif, Nader Alhejaily, Dan Wu, Michael McLane et al. · 2017 · Reproductive Sciences
37. The influence of sleep on language production modalities in preschool children with Down syndrome
    Natalia Arias‐Trejo, Armando Quetzalcóatl Angulo‐Chavira, Bianca I. Demara, Carlos Figueroa, Jamie Ogline Edgin · 2020 · Journal of Sleep Research
38. Proteomic analysis of six- and twelve-month hippocampus and cerebellum in a murine Down syndrome model
    Guido N. Vacano, David S. Gibson, Abdullah Arif Turjoman, Jeremy W. Gawryluk, Jonathan D. Geiger, Mark William Duncan, David Patterson · 2017 · Neurobiology of Aging
39. Single-Nucleus Profiling Identifies Accelerated Oligodendrocyte Precursor Cell Senescence in a Mouse Model of Down Syndrome
    Bianca Rusu, Bharti Kukreja, Taiyi Wu, Sophie J. Dan, Min Yi Feng, Brian Thomas Kalish · 2023 · eNeuro
40. Risk of Alzheimer's disease in Down syndrome: Insights gained by multi‐omics
    Hui‐Qi Qu, Yichuan Liu, John J. Connolly, Frank D. Mentch, Charlly Kao, Hakon H. Hakonarson · 2025 · Alzheimer s & Dementia
41. Single‐cell landscape analysis reveals systematic senescence in mammalian Down syndrome
    Yao Chen, Yanyu Xiao, Yanye Zhang, Renying Wang, Feixia Wang, Huajing Gao, Yifeng Liu, Runju Zhang, Huiyu Sun, Ziming Zhou et al. · 2023 · Clinical and Translational Medicine
42. Single-nucleus RNA sequencing reveals cell type-specific transcriptome alterations of Down syndrome hippocampus using the Dp16 mouse model
    Zuolin Zhou, Chunchun Zhi, Die Chen, Zhaowei Cai, Xiaoling Jiang · 2023 · Genes & Genomics
43. Spatiotemporal development of spinal neuronal and glial populations in the Ts65Dn mouse model of down syndrome.
    Aziz, Nadine M., Klein, Jenny A., Brady, Morgan R., Olmos-Serrano, Jose Luis, Gallo, Vittorio, Haydar, Tarik F. · 2019 · Journal of Neurodevelopmental Disorders
44. Single‐nucleus analysis reveals oxidative stress in Down syndrome basal forebrain neurons at birth
    Nicole R. West, Kalpana Hanthanan Arachchilage, Sara Knaack, Shawn MacGregor, Masoumeh Hosseini, Ryan D. Risgaard, Pubudu Kumarage, Jose L. Martinez, Su‐Chun Zhang, Daifeng Wang et al. · 2025 · Alzheimer s & Dementia
45. Molecular cartography of the human down syndrome and trisomic mouse brain
    Min Yi Feng, Wuxinhao Cao, Nareh Tahmasian, Bharti Kukreja, Gen Lin Li, Bianca Rusu, Ji‐Young Youn, Brian Thomas Kalish · 2025 · Nature Communications
46. Perspectives on pain in Down syndrome
    Ammara Shaikh, Yun‐Qing Li, Jie Lu · 2023 · Medicinal Research Reviews
47. Beyond Quiescent and Active: Intermediate Microglial Transcriptomic States in a Mouse Model of Down Syndrome
    Álvaro Fernández‐Blanco, Cèsar Sierra, Clara Tejido, Mara Dierssen · 2024 · International Journal of Molecular Sciences
48. Sex-dependent monoamine oxidase isoforms expression patterns during human brain ageing
    Cristina Sanfilippo, Paola Castrogiovanni, Rosa Imbesi, Giuseppe Lazzarino, Valentina Di Pietro, Giovanni Li Volti, Daniele Tibullo, Ignazio Alberto Barbagallo, Giacomo Lazzarino, Roberto Avola et al. · 2021 · Mechanisms of Ageing and Development
49. Cell type characterization of spatiotemporal gene co-expression modules in Down syndrome brain
    Sihwan Seol, Joonhong Kwon, Hyo Jung Kang · 2022 · iScience
50. Extracellular Vesicle Treatment Alleviates Neurodevelopmental and Neurodegenerative Pathology in Cortical Spheroid Model of Down Syndrome
    Campbell, Natalie Baker, Patel, Yesha, Moore, Tara L., Medalla, Maria, Zeldich, Ella · 2023 · International Journal of Molecular Sciences
51. Organizational Events
    Hannah C. Kinney, Joseph J. Volpe · 2017 · Elsevier eBooks
52. The Drosophila homolog of APP promotes Dscam expression to drive axon terminal growth, revealing interaction between Down syndrome genes
    Sarah Pizzano, Gabriella R Sterne, Macy W. Veling, L. Amanda Xu, Ty Hergenreder, Bing Ye · 2023 · Disease Models & Mechanisms
53. Reversal of neurodevelopmental impairment and cognitive enhancement by pharmacological intervention with the polyphenol polydatin in a Down syndrome model
    Marco Emili, Fiorenza Stagni, Carla A. Russo, Laura Angelozzi, Sandra Guidi, Renata Bartesaghi · 2024 · Neuropharmacology
54. Sexual and Metabolic Differences in Hippocampal Evolution: Alzheimer’s Disease Implications
    José Manuel Martı́nez-Martos, Vanesa Cantón-Habas, Manuel Rich‐Ruiz, María José Reyes-Medina, Marı́a Jesús Ramı́rez-Expósito, María Pilar Carrera-González · 2024 · Life
55. Specificities of phonation biomechanics in Down Syndrome children
    Irene Hidalgo de la Guía, Elena Garayzábal, Pedro Gómez‐Vilda, Daniel Palacios Alonso · 2020 · Biomedical Signal Processing and Control
56. Advances in Research on Down Syndrome
    Subrata Dey · 2018 · InTech eBooks
57. TempShift Reveals the Sequential Development of Human Neocortex and Skewed Developmental Timing of Down Syndrome Brains
    Zhou, Yuqiu, Tao, Li, Zhu, Ying · 2023 · Brain Sciences
58. Analysis of genotype effects and inter-individual variability in iPSC-derived trisomy 21 neural progenitor cells
    Sarah Emerson Lee, Laura L. Baxter, Monica I Duran, Samuel D Morris, Iman A Mosley, K. Fuentes, Jeroen L. A. Pennings, Fayçal Guedj, Diana W. Bianchi · 2024 · Human Molecular Genetics
59. Coordinated Regulation of Myelination by Growth Factor and Amino-acid Signaling Pathways
    Zhiwen Yang, Zongyan Yu, B. Xiao · 2022 · Neuroscience Bulletin
60. KARS Mutations Impair Brain Myelination by Inducing Oligodendrocyte Deficiency: One Potential Mechanism and Improvement by Melatonin
    Lijia Yu, Zhilin Chen, Xiao-Long Zhou, Fei Teng, Qing‐Ran Bai, Lixi Li, Yunhong Li, Ying Liu, Qiyu Zeng, Yong Wang et al. · 2024 · Journal of Pineal Research
61. Cerebral organoid proteomics reveals signatures of dysregulated cortical development associated with human trisomy 21
    Tristan D. McClure‐Begley, Christopher C. Ebmeier, Kerri A. Ball, Jeremy R. Jacobsen, Igor Kogut, Ganna Bilousova, Michael W. Klymkowsky, William M. Old · 2018 · bioRxiv (Cold Spring Harbor Laboratory)
62. Development of Alzheimer’s disease in Down syndrome
    O Adapta García, Eduardo Domínguez-de-la-Cruz, Itzel Guadalupe Luna-Martínez, José Alfonso Garnett-Carbajal, Jesús Antonio Villegas-Piña · 2025 · Exploration of neuroscience
63. Single-cell atlas of the developing Down syndrome brain cortex
    Michael Lattke, Wee Leng Tan, Salil K. Sukumaran, Kagistia Hana Utami, Marcos Sintes, Srinivasan Sakthivel, Jonathan Tan, Auriel Theodora Jacobea Lim, Vibhavari Aysha Bansal, Katerina Rekopoulou et al. · 2026 · Nature Medicine
64. Association of plasma neurofilament light chain with microstructural white matter changes in Down syndrome
    Herminia Diana Rosas, Nathaniel David Mercaldo, Yasemin G. Hasimoglu, Melissa E. Petersen, Lydia R. Lewis, Florence Lai, David K. Powell, Asim Dhungana, Ali Demir, David Keater et al. · 2024 · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring
65. Infantile Spasms in Pediatric Down Syndrome: Potential Mechanisms Driving Therapeutic Considerations
    Carl E. Stafstrom, Li‐Rong Shao · 2024 · Children
66. Pleiotropic effects of trisomy and pharmacologic modulation on structural, functional, molecular, and genetic systems in a Down syndrome mouse model
    Sergi Llambrich, Birger Tielemans, Ellen Saliën, Marta Atzori, Kaat Wouters, Vicky Van Bulck, Mark Platt, Laure Vanherp, Nuria Gallego Fernandez, Laura Grau de la Fuente et al. · 2024 · eLife
67. Advancing Knowledge of Down Syndrome Brain Development and Function With Human Stem Cells
    Anita Bhattacharyya · 2020 · American Journal on Intellectual and Developmental Disabilities
68. Total cell N-glycosylation is altered during differentiation of induced pluripotent stem cells to neural stem cells and is disturbed by trisomy 21
    Ana Cindrić, Frano Vučković, Aoife Murray, Thomas Klarić, Ivan Alić, Dražen Juraj Petrović, Jasminka Krištić, Dean Nižetić, Gordan Lauc · 2024 · BBA Advances
69. RELA Fusion-Positive Ependymoma in a Child with Down Syndrome: A Case Report
    J. Chan, A. Kashanian, S. Bannykh, F. Majlessipour, J. Breunig, M. Danielpour · 2021 · Pediatric Neurosurgery
70. Complement pathway dysregulation and astrocyte alterations in Down syndrome: evidence from postmortem brain tissue and iPSC-derived astrocytes
    André Luíz Teles e Silva, Pedro Henrique Prado de Oliveira, Bruno Yukio Yokota-Moreno, Jéssica da Silva Fausto, Jonatan Peña Avila, Helder Imoto Nakaya, Andrea Laurato Sertie, Bruna Lancia Zampieri · 2025 · Acta Neuropathologica Communications
71. Synaptic and intrinsic membrane defects disrupt early neural network dynamics in Down syndrome
    Saad B. Hannan, Ivan Alić, Aoife Murray, Joonhong Kwon, Martin Mortensen, Hyo Jung Kang, Ante Plećaš, Pollyanna Agnes Goh, Niamh Louise O’Brien, Richard Naud et al. · 2026 · Nature Communications
72. The Connection Between Socioeconomic Factors and Dietary Habits of Children with Down Syndrome in Croatia
    Maja Ergović Ravančić, Valentina Obradović, Jadranka Vraneković · 2025 · Foods
73. Spatial and Temporal Expression of High-Mobility-Group Nucleosome-Binding (HMGN) Genes in Brain Areas Associated with Cognition in Individuals with Down Syndrome
    Alejandra Rodríguez-Ortiz, Julio César Montoya-Villegas, Felipe García‐Vallejo, Yecid Mina-Paz · 2021 · Genes
74. Brain volumes, cognitive, and adaptive skills in school-age children with Down syndrome
    Rebecca Grzadzinski, Kattia Mata, Ambika S. Bhatt, Alapika Jatkar, Dea Garic, Mark D. Shen, Jessica B. Girault, Tanya St. John, Juhi Pandey, Lonnie Zwaigenbaum et al. · 2024 · Journal of Neurodevelopmental Disorders
75. Development of Molecular Neuropathology in Down Syndrome across the Lifespan
    Anita Bhattacharyya, Luis de la Torre-Ubieta, Ying Zhu, Elizabeth Head, Vivek Swarup, André M. M. Sousa · 2025 · Journal of Neuroscience
76. Mid-gestational cell-type-specific transcriptomic signatures in the prefrontal and superior temporal cortex in Down syndrome
    Rui-Ze Niu, Lu-Lu Xue, Xiao-He Tian, Li-Ren Huangfu, Li Chen, Chen-Yang Zhai, Shi-Feng Wang, Yang-Yang Zhao, Zong-Jin Gan, Hao-Yue Qin et al. · 2025 · Nature Communications
77. Neuroinflammation as a driver of Down syndrome-associated Alzheimer’s disease
    Hui‐Qi Qu, Ásbjörg Ósk Snorradóttir, Alvaro Gutierrez-Uzquiza, Charlly Kao, Michael March, Hakon H. Hakonarson · 2026 · Brain Behavior and Immunity
78. White matter aging across the lifespan in Down syndrome: developmental origins, Alzheimer's disease progression, and therapeutic implications
    Justine A. Silva, Jr‐Jiun Liou, Simren Parikh, Natalie C. Edwards, Julia Kofler, Milos D. Ikonomovic, Florence Lai, Herminia Diana Rosas, David K. Powell, Frederick A. Schmitt et al. · 2026 · npj Dementia
79. Neurogenesis, Myelination, and Circuitry: The Case for a Distributed Therapeutic Regimen in Down Syndrome
    Tarik F. Haydar · 2020 · American Journal on Intellectual and Developmental Disabilities
80. Cognitive impairments in adult mice with RIP140 overexpression in neural stem cells.
    Xin-Juan Wang, Shimeng Ren, Wei-Dong Yu, Qing Mu, Shuai Ye, C. Cui, Jing-Zhu Guo · 2020 · Behavioural Brain Research
81. Inhibition of miR-128 Enhances Vocal Sequence Organization in Juvenile Songbirds
    Caitlin Aamodt, Stephanie A. White · 2022 · Frontiers in Behavioral Neuroscience
82. Comparative analysis of the down syndrome hippocampal non-coding RNA transcriptomes using a mouse model
    Zhaowei Cai, Zhilan Xiao, Yufang Wang · 2020 · Genes & Genomics
83. Neurobiology of Down Syndrome
    Stella Sakhon, Jamie Ogline Edgin · 2020 · The Wiley Encyclopedia of Health Psychology
84. Modeling Down syndrome neurodevelopment with isogenic cerebral organoids
    Jan T. Czerminski, Oliver D. King, Jeanne Bentley Lawrence · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
85. Complement system alteration in iPSC-derived astrocytes from individuals with Down syndrome
    André Luíz Teles e Silva, Pedro Henrique Prado de Oliveira, Bruno Yukio Yokota-Moreno, Jonathan P. Avila, Helder Imoto Nakaya, Jéssica da Silva Fausto, Andrea Laurato Sertie, Bruna Lancia Zampieri · 2024 · Research Square
86. Is the prolongation latency of visual evoked potentials a pathological sign in children with Down’s syndrome without ocular abnormalities? Case–control study of children with Down’s syndrome
    Dobrila Karlica, Hana Karlica, Ana Jerončić, Ivan Borjan, Ivana Mudnić · 2023 · BMJ Open Ophthalmology
87. Using Zebrafish to Study the Mechanisms That Underlie Down Syndrome
    Anna J. Moyer, Summer B. Thyme · 2025 · Springer eBooks
88. Abnormal neuronal and synaptic morphology in Down syndrome brains reproduces in human isogenic cellular models
    Ante Plećaš, Gillian Gough, Danka Grčević, Hanna Jackowiak, Kinga Skieresz‐Szewczyk, Matija Horaček, Iva Šimunić, Željka Krsnik, Dinko Mitrečić, Aoife Murray et al. · 2026 · Cell Death and Disease
89. Functional Neurogenomics: A New Approach to Study Cognitive Disability in Down Syndrome Brain
    Felipe García‐Vallejo, Alejandra Rocío Rodríguez Ortiz, Camila Azcárate Gómez, Meliza Santiago Ospina, Julio César Montoya Villegas, Adalberto Sánchez Gómez, José Soto · 2018 · InTech eBooks
90. Temporal and Spatial Differential Expression of Glutamate Receptor Genes in the Brain of Down Syndrome
    Alejandra Rocio Rodríguez Ortiz, Mailyn Alejandra Bedoya Saldarriaga, Julio César Montoya Villegas, F. García-Vallejo · 2019 · Gene Regulation
91. Integrated Quantitative Neuro-Transcriptome Analysis of Several Brain Areas in Human Trisomy 21
    Alejandra Rodríguez-Ortiz, Julio César Montoya-Villegas, Felipe García‐Vallejo, Yecid Mina-Paz · 2022 · Genes
92. An exploratory study of plasma ceramides in comorbidities in Down syndrome
    Gordon Worley, Seul Kee Byeon, P. Brian Smith, Sarah J. Hart, Sarah P. Young, Akhilesh Pandey, Priya Sunil Kishnani · 2023 · American Journal of Medical Genetics Part A
93. Organizational Events
    Robin Lynn Haynes, Hannah C. Kinney, Joseph J. Volpe · 2024 · Elsevier eBooks
94. Enduring differential patterns of neuronal loss and myelination along 6-month pulsatile gonadotropin-releasing hormone therapy in individuals with Down syndrome
    Michela Adamo, Mihály Gayer, An Jacobs, Q. Raynaud, Raphael Sebbah, Giulia Di Domenicantonio, A. Latypova, N. Vionnet, Ferath Kherif, A. Lutti et al. · 2025 · Brain Communications
95. Deep learning algorithms reveal genomic markers for anxiety disorder in a large cohort of children with down syndrome
    Yichuan Liu, Hui‐Qi Qu, Xiao Chang, Frank D. Mentch, Haijun Qiu, Shahram Torkamandi, Kenny Nguyen, Kayleigh Ostberg, Tian-Cheng Wang, Joseph Glessner et al. · 2025 · Molecular Psychiatry
96. Modeling Down Syndrome Neurodevelopment with Dosage Compensation
    Jan T. Czerminski · 2019 · eScholarship@UMassChan
97. Cerebellar degeneration-related protein 1 expression in fibroblasts of patients affected by down syndrome
    Michele Salemi, Giancarlo Rappazzo, Federico Ridolfo, Maria Grazia Salluzzo, Rossella Cannarella, Roberto Castiglione, Salvatore Caniglia, Cataldo Tirolo, Aldo Eugenio Calogero, Corrado Romano · 2020 · All Life
98. Trisomie 21, GnRH et cognition
    Vincent Prévot, Nelly Pitteloud · 2023 · médecine/sciences
99. Clemastine fumarate enhances myelination and promotes functional recovery in a syndromic ASD mouse model of Pitt-Hopkins Syndrome
    Joseph F. Bohlen, Colin M. Cleary, Debamitra Das, Srinidhi Rao Sripathy, Norah Sadowski, Gina Shim, Rakaia F. Kenney, Ingrid P. Buchler, Daniel Kent Mulkey, Brady J. Maher · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
100. Pleiotropic effects of trisomy and pharmacologic modulation on structural, functional, molecular, and genetic systems in a Down syndrome mouse model
     Sergi Llambrich, Birger Tielemans, Ellen Saliën, Marta Atzori, Kaat Wouters, Vicky Van Bulck, Mark Platt, Laure Vanherp, Nuria Gallego Fernandez, Laura Grau de la Fuente et al. · 2023 · eLife