The DOI matches its Crossref record; 203 of the 203 references it cites were found in a registry or an index.
The Aging Navigational System
Open accessAbstract
The discovery of neuronal systems dedicated to computing spatial information, composed of functionally distinct cell types such as place and grid cells, combined with an extensive body of human-based behavioral and neuroimaging research has provided us with a detailed understanding of the brain's navigation circuit. In this review, we discuss emerging evidence from rodents, non-human primates, and humans that demonstrates how cognitive aging affects the navigational computations supported by these systems. Critically, we show 1) that navigational deficits cannot solely be explained by general deficits in learning and memory, 2) that there is no uniform decline across different navigational computations, and 3) that navigational deficits might be sensitive markers for impending pathological decline. Following an introduction to the mechanisms underlying spatial navigation and how they relate to general processes of learning and memory, the review discusses how aging affects the perception and integration of spatial information, the creation and storage of memory traces for spatial information, and the use of spatial information during navigational behavior. The closing section highlights the clinical potential of behavioral and neural markers of spatial navigation, with a particular emphasis on neurodegenerative disorders.
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Cites
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Cited by
Spatial navigation deficits — overlooked cognitive marker for preclinical Alzheimer disease?
Coughlan, G., Laczó, J., Hort, J., Minihane, A.-M., & Hornberger, M. (2018) · Nature Reviews Neurology · doi:10.1038/s41582-018-0031-x · Cited by 500
Global Determinants of Navigation Ability
Coutrot, A., Silva, R., Manley, E., de Cothi, W., Sami, S., Bohbot, V. D., Wiener, J. M., Hölscher, C., Dalton, R. C., Hornberger, M., et al. (2018) · Current Biology · doi:10.1016/j.cub.2018.06.009 · Cited by 293
Self-citationEntropy of city street networks linked to future spatial navigation ability
Coutrot, A., Manley, E., Goodroe, S., Gahnstrom, C., Filomena, G., Yesiltepe, D., Dalton, R. C., Wiener, J. M., Hölscher, C., Hornberger, M., et al. (2022) · Nature · doi:10.1038/s41586-022-04486-7 · Cited by 243
Self-citationLarge-scale assessment of human navigation ability across the lifespan
van der Ham, I. J. M., Claessen, M. H. G., Evers, A. W. M., & van der Kuil, M. N. A. (2020) · Scientific Reports · doi:10.1038/s41598-020-60302-0 · Cited by 76
AMPA Receptors in Synaptic Plasticity, Memory Function, and Brain Diseases
de León-López, C. A. M., Carretero-Rey, M., & Khan, Z. U. (2025) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-024-01529-7 · Cited by 73
Metadata
- Authors
- Lester, A. W., Moffat, S. D., Wiener, J. M., Barnes, C. A., & Wolbers, T.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2017-08
- Volume
- 95
- Issue
- 5
- Pages
- 1019-1035
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2751705769
- Cited by
- 391
- References
- 203
- FWCI
- 14.89
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Lester, A. W., Moffat, S. D., Wiener, J. M., Barnes, C. A., & Wolbers, T. (2017). The Aging Navigational System. Neuron. https://doi.org/10.1016/j.neuron.2017.06.037
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
