The DOI matches its Crossref record; 64 of the 64 references it cites were found in a registry or an index.
Reducing Astrocyte Calcium Signaling In Vivo Alters Striatal Microcircuits and Causes Repetitive Behavior
Open accessAbstract
Summary Astrocytes tile the central nervous system, but their functions in neural microcircuits in vivo and their roles in mammalian behavior remain incompletely defined. We used 2-photon laser scanning microscopy, electrophysiology, MINIscopes, RNA-seq and a genetic approach to explore the effects of reduced striatal astrocyte Ca2+ signaling in vivo. In wild type mice, reducing striatal astrocyte Ca2+-dependent signaling increased repetitive self-grooming behaviors by altering medium spiny neuron (MSN) activity. The mechanism involved astrocyte-mediated neuromodulation mediated by ambient GABA and was corrected by blocking astrocyte GABA transporter 3 (GAT-3). Furthermore, in a mouse model of Huntington’s disease, dysregulation of GABA and astrocyte Ca2+ signaling accompanied excessive self-grooming, which was relieved by blocking GAT-3. Assessments with RNA-seq revealed astrocyte genes and pathways regulated by Ca2+ signaling in a cell autonomous and non-cell autonomous manner, including Rab11a, a regulator of GAT-3 functional expression. Thus, striatal astrocytes contribute to neuromodulation controlling mouse obsessive-compulsive-like behavior.
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Metadata
- Authors
- Yu, X., Taylor, A. M. W., Nagai, J., Golshani, P., Evans, C. J., Coppola, G., & Khakh, B. S.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2018-09
- Volume
- 99
- Issue
- 6
- Pages
- 1170-1187.e9
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2889033116
- Cited by
- 398
- References
- 64
- FWCI
- 12.69
- Type
- journal article
- Language
- en
- Open access
- bronze
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