Changes in the Synaptic Proteome in Tauopathy and Rescue of Tau-Induced Synapse Loss by C1q Antibodies

Dejanovic, Borislav, Huntley, Melanie A., De Mazière, Ann, Meilandt, William J., Wu, Tiffany, Srinivasan, Karpagam, Jiang, Zhiyu, Gandham, Vineela +9 more·2018·Neuron
DOI 10.1016/j.neuron.2018.10.014

Cited by (503)

Items 401–500 of 503

  1. Preclinical and first-in-human evaluation of VG-3927/SAR448851, an oral small-molecule TREM2 agonist for Alzheimer’s disease
    Borislav Dejanovic, Matthew D. Figley, Elizabeth F. Weisman, Beril Kiragasi, Frederick W. Gergits, Kelley Larson, Abigail J. Renoux, Raj Rajagovindan, Bhaumik A. Pandya, Jonathan B. Houze et al. · 2026 · Science Translational Medicine
  2. Complements lead to insults
    Natasha Bray · 2018 · Nature reviews. Neuroscience
  3. Recent advances in neurodegenerative disease research
    Ekta Singh, Rahul Dilawari · 2024 · Elsevier eBooks
  4. (−)‐Epicatechin Rescues Memory Deficits by Activation of Autophagy in a Mouse Model of Tauopathies
    Yanqing Wu, Ting Li, Xingjun Jiang, Jianmin Ling, Zaihua Zhao, Jiahui Zhu, Chongyang Chen, Qian Liu, Xifei Yang, Xuefeng Shen et al. · 2025 · MedComm
  5. Antemortem Domain-Specific Cognitive Functions Predict Postmortem Neuropathological Traits in the Framingham Heart Study
    Donghe Li, Yueh‐Ting Wang, Ting Fang Alvin Ang, Weiming Xia, Nurgül Aytan, Jesse Mez, Sherral Devine, Rhoda Au, Lindsay A. Farrer, Thor D. Stein et al. · 2022 · Research Square
  6. Early synaptic pathology is associated with small tau aggregates in Alzheimer’s disease
    Emre Fertan, Shekhar Kedia, Georg Meisl, Matthew W. Cotton, Annelies Quaegebeur, Maria Grazia Spillantini, David Klenerman · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  7. Spatially resolved translational dysregulation in Grin2a +/- mouse model of schizophrenia
    Mingrui Wu, Jiahao Huang, Sameer Aryal, Zohreh Farsi, Hongyu Chen, Yiming Zhou, Shuchen Luo, Wendy Xueyi Wang, Kevin Bonanno, Margaret Yin et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  8. Effects of phthalates, environmental endocrine disrupting chemicals, on the neurovascular unit in adult male mouse
    Delnia Ahmadpour · 2021 · theses.fr (ABES)
  9. Transmission of Alzheimer pathology in murine and primate models : from proteinopathies to neuronal and cognitive impairments
    Suzanne Lam · 2021 · theses.fr (ABES)
  10. iAstrocytes model cytokine influences on complement expression and neuronal network synchronization
    Nader Morshed, Matthew Demers, Ana Gonzalez‐Ramos, Henna Jäntti, Jordan L. Doman, Sean D'Souza, Letian Li, Adam J. Granger, Matthew B. Johnson, Beth Stevens · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  11. G179(P) Long Term Follow-Up For Paediatric Oncology Patients at a Paediatric Department of a General Hospital
    S M Murphy, K. Husselbee · 2013 · Archives of Disease in Childhood
  12. Study of pre-synaptic internalisation in human schizophrenia brains
    Makis Tzioras, Anna J. Stevenson, Delphine Boche, Tara L. Spires‐Jones · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  13. A novel equilibrative nucleoside transporter 1 inhibitor alleviates Tau-mediated neurodegeneration
    Ching‐Pang Chang, Ya‐Gin Chang, Pei‐Yun Chuang, Thi Ngoc Anh Nguyen, Fang-Yi Chou, Sin‐Jhong Cheng, Hui‐Mei Chen, Lee‐Way Jin, Kévin Carvalho, Vincent Huin et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  14. Alzheimer’s disease as a syndrome of overloaded amyloidic synaptic tagging in memory networks
    Niall Murphy · 2021
  15. Neuroinflammation triggers microglial phagocytosis of synapses via induction of synaptic filopodia
    Carla Cangalaya, Susanne Wegmann, Wei‐Lun Sun, Lisa Diez, Anna Gottfried, Karin Richter, Stoyan Stoyanov, Janelle M.P. Pakan, Klaus‐Dieter Fischer, Alexander E. Dityatev · 2022 · Research Square
  16. Therapeutic and immunomodulatory functions of the translocator protein in Alzheimer's disease
    Lauren Hermes Fairley · 2022
  17. Roles of Purinergic Receptors in Alzheimer’s Disease
    Cécile Delarasse, David L Blum · 2023 · Springer eBooks
  18. ENT1 inhibition rescues energy dysfunction and pathology in a model of tauopathy
    Ching‐Pang Chang, Ya‐Gin Chang, Pei‐Yun Chuang, Anh Nguyen, Kuo-Chen Wu, Fang-Yi Chou, Sin‐Jhong Cheng, Hui‐Mei Chen, Lee‐Way Jin, Kévin Carvalho et al. · 2024
  19. Additional file 1 of Association of CSF proteins with tau and amyloid β levels in asymptomatic 70-year-olds
    Julia Remnestål, Sofia Bergström, Jennie Olofsson, Evelina Sjöstedt, Mathias Uhlén, Kaj Blennow, Henrik Zetterberg, Anna Zettergren, Silke Kern, Ingmar Gr. Skoog et al. · 2021 · Figshare
  20. Autoimmune Astrocytopathy
    Jorge Daniel Correale, Mariano Marrodán · 2024 · Springer eBooks
  21. Soluble TREM2 distinguishes neuromyelitis optica spectrum disorder from MOG antibody disease
    Omar Chuquisana, Marianna Spatola, Alessandro Dinoto, María Sepúlveda, Sara Mariotto, Mar Tintoré, Xavier Montalbán, Manuel Comabella, Jan D. Lünemann · 2024 · Brain
  22. Autoimmune Astrocytopathy
    Jorge Daniel Correale, Mariano Marrodán · 2024 · Springer eBooks
  23. Alzheimer’s Disease
    Dennis Chan, Tara L. Spires‐Jones, Frank A. Provenzano, Elizabeth B. C. Glennon, Karen Duff · 2025 · Oxford University Press eBooks
  24. OTULIN Interactome Reveals Immune Response and Autophagy Associated with Tauopathy in a Mouse Model
    Ling Li, Mingqi Li, Yuyang Zhou, David G. Kakhniashvili, Xusheng Wang, Francesca‐Fang Liao · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  25. Protein kinase CK2α′ as a dual modulator of neuroimmune signaling and synaptic dysfunction in tauopathy
    Angel White, Peter Gavrilyuk, Persephone Gu, Rafael Falcon Moya, Robert Henry Thurston, Amal Fickak, Nicholas B Rozema, Prarthana Keshavaram, Scott Vermilyea, Riley Schlichte et al. · 2026 · Translational Neurodegeneration
  26. Activity-driven proprioceptive synaptic refinement in the developing spinal cord by complement signaling mechanisms
    Chetan Nagaraja, Serena Ortiz, Akash R. Murali, Aiza Sarwar, Theanne N. Griffith · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  27. Additional file 8 of Deletion of Abi3/Gngt2 influences age-progressive amyloid β and tau pathologies in distinctive ways
    Kristen R. Ibanez, Karen N. McFarland, Jennifer Phillips, Mariet Allen, Christian B. Lessard, Lillian Zobel, De La Cruz, Elsa Gonzalez, Shah, Shivani, Quan Vo, Wang, Xue et al. · 2022 · Figshare
  28. Additional file 11 of Deletion of Abi3/Gngt2 influences age-progressive amyloid β and tau pathologies in distinctive ways
    Kristen R. Ibanez, Karen N. McFarland, Jennifer Phillips, Mariet Allen, Christian B. Lessard, Lillian Zobel, De La Cruz, Elsa Gonzalez, Shah, Shivani, Quan Vo, Wang, Xue et al. · 2022 · Figshare
  29. Additional file 2 of Neuroligin-1 in brain and CSF of neurodegenerative disorders: investigation for synaptic biomarkers
    Elena Camporesi, Tammaryn Lashley, Gobom, Johan, Juan Lantero‐Rodriguez, Oskar Hansson, Henrik Zetterberg, Kaj Blennow, Bruno Becker · 2021 · Figshare
  30. Additional file 9 of Association of CSF proteins with tau and amyloid β levels in asymptomatic 70-year-olds
    Julia Remnestål, Sofia Bergström, Jennie Olofsson, Evelina Sjöstedt, Mathias Uhlén, Kaj Blennow, Henrik Zetterberg, Anna Zettergren, Silke Kern, Ingmar Gr. Skoog et al. · 2021 · Figshare
  31. Additional file 6 of Association of CSF proteins with tau and amyloid β levels in asymptomatic 70-year-olds
    Julia Remnestål, Sofia Bergström, Jennie Olofsson, Evelina Sjöstedt, Mathias Uhlén, Kaj Blennow, Henrik Zetterberg, Anna Zettergren, Silke Kern, Ingmar Gr. Skoog et al. · 2021 · Figshare
  32. Additional file 3 of Association of CSF proteins with tau and amyloid β levels in asymptomatic 70-year-olds
    Julia Remnestål, Sofia Bergström, Jennie Olofsson, Evelina Sjöstedt, Mathias Uhlén, Kaj Blennow, Henrik Zetterberg, Anna Zettergren, Silke Kern, Ingmar Gr. Skoog et al. · 2021 · Figshare
  33. Additional file 2 of Loss of presenilin function enhances tau phosphorylation and aggregation in mice
    Carlos M. Soto-Faguás, Paula Sanchez-Molina, Carlos A. Saura · 2021 · Figshare
  34. Additional file 1 of Alzheimer risk gene product Pyk2 suppresses tau phosphorylation and phenotypic effects of tauopathy
    A. Harrison Brody, Sarah Helena Nies, Guan, Fulin, Levi M. Smith, Bandhan Mukherjee, Santiago A. Salazar, Lee, Suho, Lam, Tu Kiet T., Stephen M. Strittmatter · 2022 · Figshare
  35. Additional file 1 of Mouse serum albumin induces neuronal apoptosis and tauopathies
    Hou, Sheng-jie, Huang, Ya-ru, Jie Zhu, Jia, Ying-bo, Niu, Xiao-yun, Yang, Jin-ju, Yu, Xiao-lin, Du, Xiao-yu, Liang, Shi-yu, Cui, Fang et al. · 2024 · Figshare
  36. Additional file 6 of Deletion of Abi3/Gngt2 influences age-progressive amyloid β and tau pathologies in distinctive ways
    Kristen R. Ibanez, Karen N. McFarland, Jennifer Phillips, Mariet Allen, Christian B. Lessard, Lillian Zobel, De La Cruz, Elsa Gonzalez, Shah, Shivani, Quan Vo, Wang, Xue et al. · 2022 · Figshare
  37. Additional file 1 of Rutin prevents tau pathology and neuroinflammation in a mouse model of Alzheimer’s disease
    Sun, Xiao-ying, Li, Ling-jie, Dong, Quan-Xiu, Zhu, Jie, Huang, Ya-ru, Hou, Sheng-jie, Yu, Xiao-lin, Liu, Rui-tian · 2021 · Figshare
  38. Additional file 4 of Deletion of Abi3/Gngt2 influences age-progressive amyloid β and tau pathologies in distinctive ways
    Kristen R. Ibanez, McFarland, Karen N., Jennifer Phillips, Mariet Allen, Christian B. Lessard, Lillian Zobel, De La Cruz, Elsa Gonzalez, Shah, Shivani, Quan Vo, Wang, Xue et al. · 2022 · Figshare
  39. Born to Scratch: Towards Cutaneous Microtrauma in Newborns as a Driver of Immune Imprinting
    Arturo Tozzi · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  40. Additional file 5 of Association of CSF proteins with tau and amyloid β levels in asymptomatic 70-year-olds
    Julia Remnestål, Sofia Bergström, Jennie Olofsson, Evelina Sjöstedt, Mathias Uhlén, Kaj Blennow, Henrik Zetterberg, Anna Zettergren, Silke Kern, Ingmar Gr. Skoog et al. · 2021 · Figshare
  41. Additional file 10 of Association of CSF proteins with tau and amyloid β levels in asymptomatic 70-year-olds
    Julia Remnestål, Sofia Bergström, Jennie Olofsson, Evelina Sjöstedt, Mathias Uhlén, Kaj Blennow, Henrik Zetterberg, Anna Zettergren, Silke Kern, Ingmar Gr. Skoog et al. · 2021 · Figshare
  42. Additional file 1 of Deletion of Abi3/Gngt2 influences age-progressive amyloid β and tau pathologies in distinctive ways
    Kristen R. Ibanez, McFarland, Karen N., Jennifer Phillips, Mariet Allen, Christian B. Lessard, Lillian Zobel, De La Cruz, Elsa Gonzalez, Shah, Shivani, Quan Vo, Wang, Xue et al. · 2022 · Figshare
  43. Additional file 4 of Association of CSF proteins with tau and amyloid β levels in asymptomatic 70-year-olds
    Julia Remnestål, Sofia Bergström, Jennie Olofsson, Evelina Sjöstedt, Mathias Uhlén, Kaj Blennow, Henrik Zetterberg, Anna Zettergren, Silke Kern, Ingmar Gr. Skoog et al. · 2021 · Figshare
  44. Additional file 1 of Impacts of autofluorescence on fluorescence based techniques to study microglia
    Zhang, Haozhe, Tan, Chen, Xiaoyue Shi, Xu, Ji · 2022 · Figshare
  45. Additional file 2 of Deletion of Abi3/Gngt2 influences age-progressive amyloid β and tau pathologies in distinctive ways
    Kristen R. Ibanez, Karen N. McFarland, Jennifer Phillips, Mariet Allen, Christian B. Lessard, Lillian Zobel, De La Cruz, Elsa Gonzalez, Shah, Shivani, Quan Vo, Xue Wang et al. · 2022 · Figshare
  46. Additional file 2 of Association of CSF proteins with tau and amyloid β levels in asymptomatic 70-year-olds
    Julia Remnestål, Sofia Bergström, Jennie Olofsson, Evelina Sjöstedt, Mathias Uhlén, Kaj Blennow, Henrik Zetterberg, Anna Zettergren, Silke Kern, Ingmar Gr. Skoog et al. · 2021 · Figshare
  47. Additional file 1 of Pathological changes induced by Alzheimer’s brain inoculation in amyloid-beta plaque-bearing mice
    Suzanne Lam, Anne‐Sophie Hérard, Susana Boluda, Fanny Petit, Sabiha Eddarkaoui, Karine Cambon, Jean‐Luc Picq, Luc Buée, Charles J. Duyckaerts, Stéphane Haı̈k et al. · 2022 · Figshare
  48. Additional file 2 of Mouse serum albumin induces neuronal apoptosis and tauopathies
    Hou, Sheng-jie, Huang, Ya-ru, Jie Zhu, Jia, Ying-bo, Niu, Xiao-yun, Yang, Jin-ju, Yu, Xiao-lin, Du, Xiao-yu, Liang, Shi-yu, Cui, Fang et al. · 2024 · Figshare
  49. Additional file 9 of Deletion of Abi3/Gngt2 influences age-progressive amyloid β and tau pathologies in distinctive ways
    Kristen R. Ibanez, Karen N. McFarland, Jennifer Phillips, Mariet Allen, Christian B. Lessard, Lillian Zobel, De La Cruz, Elsa Gonzalez, Shah, Shivani, Quan Vo, Wang, Xue et al. · 2022 · Figshare
  50. Additional file 2 of Complement C1q-mediated microglial synaptic elimination by enhancing desialylation underlies sevoflurane-induced developmental neurotoxicity
    Gang Wang, Huayue Liu, Meng, Xiao-wen, Ying Chen, Weiming Zhao, Li, Wen-ting, Xu, Han-bing, Peng, Ke, Ji, Fu-hai · 2024 · Figshare
  51. Additional file 1 of α-Synuclein propagation leads to synaptic abnormalities in the cortex through microglial synapse phagocytosis
    Dayana Pérez-Acuña, Shin, Soo Jean, Ka Hyun Rhee, Kim, Sang Jeong, Lee, Seung-Jae · 2023 · Figshare
  52. Additional file 1 of A 3D human co-culture to model neuron-astrocyte interactions in tauopathies
    Kevin Llewelyn Batenburg, Claudia Sestito, Paulien Cornelissen‐Steijger, van Weering, Jan R. T., Leo Price, Vivi Majella Heine, Wiep Scheper · 2024 · Figshare
  53. Additional file 2 of A 3D human co-culture to model neuron-astrocyte interactions in tauopathies
    Kevin Llewelyn Batenburg, Claudia Sestito, Paulien Cornelissen‐Steijger, van Weering, Jan R. T., Leo Price, Vivi Majella Heine, Wiep Scheper · 2024 · Figshare
  54. Additional file 3 of Loss of presenilin function enhances tau phosphorylation and aggregation in mice
    Carlos M. Soto-Faguás, Paula Sanchez-Molina, Carlos A. Saura · 2021 · Figshare
  55. Additional file 3 of Deletion of Abi3/Gngt2 influences age-progressive amyloid β and tau pathologies in distinctive ways
    Kristen R. Ibanez, Karen N. McFarland, Jennifer Phillips, Mariet Allen, Christian B. Lessard, Lillian Zobel, De La Cruz, Elsa Gonzalez, Shah, Shivani, Quan Vo, Wang, Xue et al. · 2022 · Figshare
  56. Additional file 10 of Deletion of Abi3/Gngt2 influences age-progressive amyloid β and tau pathologies in distinctive ways
    Kristen R. Ibanez, Karen N. McFarland, Jennifer Phillips, Mariet Allen, Christian B. Lessard, Lillian Zobel, De La Cruz, Elsa Gonzalez, Shah, Shivani, Quan Vo, Wang, Xue et al. · 2022 · Figshare
  57. Additional file 1 of Sirt1 protects against hippocampal atrophy and its induced cognitive impairment in middle-aged mice
    Zuhao Sun, Zhao, Shuang, Xinjun Suo, Dou, Yan · 2022 · Figshare
  58. Additional file 1 of Loss of presenilin function enhances tau phosphorylation and aggregation in mice
    Carlos M. Soto-Faguás, Paula Sanchez-Molina, Carlos A. Saura · 2021 · Figshare
  59. Additional file 7 of Association of CSF proteins with tau and amyloid β levels in asymptomatic 70-year-olds
    Julia Remnestål, Sofia Bergström, Jennie Olofsson, Evelina Sjöstedt, Mathias Uhlén, Kaj Blennow, Henrik Zetterberg, Anna Zettergren, Silke Kern, Ingmar Gr. Skoog et al. · 2021 · Figshare
  60. Additional file 1 of Equilibrative nucleoside transporter 1 inhibition rescues energy dysfunction and pathology in a model of tauopathy
    Chang, Ching-Pang, Chang, Ya-Gin, Chuang, Pei-Yun, Nguyen, Thi Ngoc Anh, Wu, Kuo-Chen, Chou, Fang-Yi, Cheng, Sin-Jhong, Chen, Hui-Mei, Jin, Lee-Way, Carvalho, Kevin et al. · 2021 · Figshare
  61. Additional file 1 of Neuroligin-1 in brain and CSF of neurodegenerative disorders: investigation for synaptic biomarkers
    Elena Camporesi, Tammaryn Lashley, Gobom, Johan, Juan Lantero‐Rodriguez, Oskar Hansson, Henrik Zetterberg, Kaj Blennow, Bruno Becker · 2021 · Figshare
  62. Additional file 1 of Elevated CSF and plasma complement proteins in genetic frontotemporal dementia: results from the GENFI study
    Emma Louise van der Ende, Carolin Heller, Aitana Sogorb‐Esteve, Imogen J. Swift, David J. McFall, Georgia Peakman, Arabella Bouzigues, Jackie M. Poos, Lize Corrine Jiskoot, Jessica L. Panman et al. · 2022 · Figshare
  63. Additional file 5 of Deletion of Abi3/Gngt2 influences age-progressive amyloid β and tau pathologies in distinctive ways
    Kristen R. Ibanez, Karen N. McFarland, Jennifer Phillips, Mariet Allen, Christian B. Lessard, Lillian Zobel, De La Cruz, Elsa Gonzalez, Shah, Shivani, Quan Vo, Wang, Xue et al. · 2022 · Figshare
  64. Additional file 7 of Deletion of Abi3/Gngt2 influences age-progressive amyloid β and tau pathologies in distinctive ways
    Kristen R. Ibanez, Karen N. McFarland, Jennifer Phillips, Mariet Allen, Christian B. Lessard, Lillian Zobel, De La Cruz, Elsa Gonzalez, Shah, Shivani, Quan Vo, Wang, Xue et al. · 2022 · Figshare
  65. Additional file 1 of Complement C1q-mediated microglial synaptic elimination by enhancing desialylation underlies sevoflurane-induced developmental neurotoxicity
    Gang Wang, Huayue Liu, Xiaowen Meng, Ying Chen, Weiming Zhao, Li, Wen-ting, Xu, Han-bing, Peng, Ke, Ji, Fu-hai · 2024 · Figshare
  66. Additional file 8 of Association of CSF proteins with tau and amyloid β levels in asymptomatic 70-year-olds
    Julia Remnestål, Sofia Bergström, Jennie Olofsson, Evelina Sjöstedt, Mathias Uhlén, Kaj Blennow, Henrik Zetterberg, Anna Zettergren, Silke Kern, Ingmar Gr. Skoog et al. · 2021 · Figshare
  67. Additional file 3 of Mouse serum albumin induces neuronal apoptosis and tauopathies
    Hou, Sheng-jie, Huang, Ya-ru, Zhu, Jie, Jia, Ying-bo, Niu, Xiao-yun, Yang, Jin-ju, Yu, Xiao-lin, Du, Xiao-yu, Liang, Shi-yu, Cui, Fang et al. · 2024 · Figshare
  68. Entorhinal Cortex Wolframin-1-expressing neurons propagate tau to CA1 neurons and impair hippocampal memory
    Jean-Christophe Delpech, Srinidhi Venkatesan Kalavai, Dhruba Pathak, Arun Reddy Ravula, Heena Vanmalibhai Lad, Emma Catherine Hays, Nina Touch, Andrea Rau, Charlotte Madore, Maria Medalla et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  69. Cross-Species Translation Enhances the Use of Mouse Models for Translatability and Drug Discovery in Late-Onset Alzheimer’s Disease
    Jee Hyun Park, Jinsheng Yu, Brendan P. Lucey, Douglas K. Brubaker · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  70. Rôle de la protéine C3 du système du complément dans les déficits mnésiques précoces sur un modèle expérimental de sclérose en plaques
    Julien Bourel · 2019 · theses.fr (ABES)
  71. Étude des perturbations astrocytaires sous l’influence de l’apolipoprotéine E4 : implications et applications dans la maladie d’Alzheimer
    Laurie Arnaud · 2021 · theses.fr (ABES)
  72. Étude du rôle de la microglie dans la propagation de la protéine Tau : mise en place de nouveaux modèles
    Charlotte Duwat · 2021 · theses.fr (ABES)
  73. Regulation of Alzheimer pathology by amyloid seeds : from toxic effects to therapeutic opportunities, in mouse model of amyloidosis
    Marina Célestine · 2023 · theses.fr (ABES)
  74. Role of T-cell immunity in the pathophysiology of Alzheimer’s disease and other Tauopathies
    Karen Matta · 2024 · theses.fr (ABES)
  75. Astrocytes dysfunction in tauopathies
    Emma Augustin · 2023 · theses.fr (ABES)
  76. Targeting microglial C1q alleviates blood–brain barrier disruption in the thalamus after cortical infarction
    Linhui Peng, Meiyan Chen, Xialin Zuo, Xiaomei Wu, Ming Gong, Zifeng Qin, Weiwen Sun, En Xu · 2026 · Journal of Neuroinflammation
  77. C3 and C5 complement cascade activation in brain injury and disease: Molecular mechanisms, pathological roles, and therapeutic implications
    Geoffrey E. Woodard · 2026 · Neurochemistry International
  78. Vertebrate Animal Models of Primary 4-Repeat Tauopathies
    Denglei Ma, Edward A. Burton · 2026 · Contemporary clinical neuroscience
  79. Enhanced engulfment by microglia and oligodendrocyte precursor cells contributes to synapse loss in the primary visual cortex following optic nerve injury
    Qinyuan Hu, Deling Li, Yixiao Fu, Xinyi Zhang, Yiru Huang, Yuning Zhang, Jingjing Wang, Liling Liu, Minbin Yu · 2026 · Brain Research Bulletin
  80. Microglial Pruning of Excitatory Synapses in the Hippocampus Is Complement C3 ‐Independent in Physiological and Neuroinflammatory States
    Eric W. Salter, Ashish Kadia, Lijia Zhang, Jonathan S. Thacker, Sun-Lim Choi, Liam T. Ralph, Gang Lei, Fuzi Jin, John Georgiou, Graham L. Collingridge · 2026 · Glia
  81. Dysregulation of complement at the synapse in P301S mice and human tauopathies
    Jacqui Nimmo, Nikoleta Daskoulidou, Sophie Van Pottelberge, Louis De Muynck, B. Paul Morgan · 2026 · Acta Neuropathologica Communications
  82. SynCAR platform for capturing neuronal synaptic proteopathic seeds
    Rebecca M. Sebastian, Robert Kupp, Dhaval M. Nanavati, Iwan Parfentev, Thomas J. Krzystek, Nandini Romanul, Kiran Yanamandra, Christina N Preiss, Justine D. Manos, Hai-yan Wu et al. · 2026 · iScience
  83. Synaptic dysfunction as a major driver in Alzheimer's disease: Beyond the amyloid paradigm
    Natalia Mierzwa, Michalina Wężyk · 2026 · Neuroscience & Biobehavioral Reviews
  84. The human retina in Alzheimer’s disease: Pathology, mechanisms, and biomarkers
    Luis Pérez de Sevilla Müller, Sriparna Majumdar, Brandy S. Recio · 2026 · Ageing Research Reviews
  85. Alzheimer Hastalığında Aβ ve Tau'nun İkili Doğası: Sinaptik Budama, Aktin Disfonksiyonu ve Homeostatik Restorasyon
    Hilal Karakurt, Merve Yunak, Fahrettin Afşin Sarı, Aybars Kökçe · 2026 · OSMANGAZİ JOURNAL OF MEDICINE
  86. Microglia-mediated neuroinflammation in Alzheimer’s disease: mechanisms and emerging therapeutic targets
    Lianjing Xu, Ying Zhang, Li Jiang, Jin Feng Xing, Jing Hu, Tianye Lan, Guang Ta · 2026 · Frontiers in Cellular Neuroscience
  87. CSF complement proteins are associated with early tau pathology and synaptic damage in an asymptomatic population at risk of Alzheimer’s disease
    Julia Loncke, Mélissa Savard, Cynthia Picard, Henrik Zetterberg, Daniel S. Auld, Mohamed Badawy, Simon Ducharme, the Alzheimer’s Disease Neuroimaging Initiative, Sylvia Villeneuve, John C.S. Breitner et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  88. MECANISMOS MOLECULARES DA NEUROTOXICIDADE: ESTRESSE OXIDATIVO, NEUROINFLAMAÇÃO E DEGENERAÇÃO NEURAL – REVISÃO SISTEMÁTICAMECANISMOS MOLECULARES DA NEUROTOXICIDADE: ESTRESSE OXIDATIVO, NEUROINFLAMAÇÃO E DEGENERAÇÃO NEURAL – REVISÃO SISTEMÁTICA
    Helena do Rocio Lemes Stelmack · 2026 · Revista Científica Ipedss
  89. MAPT regulates autophagic-lysosomal function and phagocytosis in human microglia
    Kylie J. Schache, Rui Zhang, A. Street, Emma Starr, Jacob A. Marsh, David J.E. Kast, Sally Temple, Abhirami Kannan Iyer, Celeste M M. Karch · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  90. Highly stable hydrophobic dietary polyphenols enhance brain delivery and neuroprotection: Tunable crystallization properties in interfacial assembly
    Xiaojuan Chen, Lei Ge, Kaikai Li, Bin Zhou, Haoyang Fu, Fuqiang Liang, Yuhao Geng, Xiaoyang Zou, Jing Li, Bin Li et al. · 2026 · Nano Today
  91. Dendrimer-delivered shRNA against CCL20-CCR6 attenuates complement-mediated synaptic loss and neuroinflammation after repetitive brain injury
    Karthick Mayilsamy, Parthvi Bharatkumar Patel, Ryan J. Green, Sashank Bikkasani, Kristina Tosi, Shreyasi Majumdar, Santosh Kumar Prajapati, Eleni Markoutsa, Tiara Wolf, Jennifer Guergues et al. · 2026 · Molecular Therapy
  92. Astrocytic synapse engulfment is differentially controlled by APOE genotype
    Sowmya Sekizar, Kristján Holt, Sharon Meyers, Makis Tzioras, Declan King, Jane Tulloch, Rosemary J. Jackson, Tara L. Spires‐Jones · 2026 · Neuroscience
  93. Activation of TREM2 via single-domain antibodies improves synaptic and cognitive function in 5×FAD mice
    Xiaoxiao Yu, Qiaoyun Ren, Yanchun Gao, Sha Xie, Rui Dang, Jinguo Meng, Zhipeng Su, Meng Li, Yuanbo Ao, An Liu et al. · 2026 · Cell Reports
  94. Remodeling of the brain immune microenvironment in Alzheimer’s disease: interactions among microglia, astrocytes, complement, and the neurovascular unit
    Tong Wang, Lu Wang, Jianing Cao, Yi Zhao, Zongling He, Fengmei Lu · 2026 · Frontiers in Immunology
  95. CD8+ t cell-mediated regulation of synaptic integrity in Alzheimer’s disease
    Hua Fu, Jing Yang, Miao Zhang · 2026 · Frontiers in Immunology
  96. Sparse neuronal C4 elevation induces network-wide transcriptomic and lipid-droplet remodeling in the cortical microenvironment
    Marta Sánchez-Carbonell, Sonia Bolshakova, Juan E Ávila-Pagán, Yaseer A. Sabir, Clay Griffin-Derr, Dominik Stich, Sofia V Cieslewicz, Sheyla Esther Carmen Sifuentes, Rhushikesh A. Phadke, Alison Brack et al. · 2026 · PLoS Computational Biology
  97. TIA1 is required for microglial activation in tauopathy
    Chelsea Joy Webber, Sophie J.F. van der Spek, Anna Lourdes Cruz, Sambhavi Puri, Yiren Shao, Cheng Zhang, Jacqueline T.M. Aw, Georgia-Zeta Papadimitriou, Rebecca Roberts, Kiki Jiang et al. · 2026 · Cell Reports
  98. Epigenetics in Traumatic Brain Injury
    Mark Doumit, Quingkun Liu, Alexis N. Pulliam, Rasha Hammamieh, Kevin K. W. Wang, Yehia S. Mechref, Fatemeh G. Haghighi, Michelle C. LaPlaca, Firas H. Kobeissy · 2026 · Journal of Neurotrauma
  99. Synaptic transmission and plasticity: molecular mechanisms, biological functions and therapeutic opportunities in neurodegenerative diseases
    Jianxu Sun, Ge Gao, Sitong Wang, Shuai Li, Jinglan Tang, Hongmei Liu, Tie-Shan Tang · 2026 · Signal Transduction and Targeted Therapy
  100. Alzheimer’s disease as a multilevel pathological network: mechanisms, heterogeneity, and therapeutic translation
    Jiangpeng Feng, Xiaoyao Huang, Yang Shi, Ying Gao, Jinzhe Chen, Zhongxing Song, Xinmin Mao, Shuliang Niu, Jie Li, Jianguang Li · 2026 · Frontiers in Aging Neuroscience