Changes in the Synaptic Proteome in Tauopathy and Rescue of Tau-Induced Synapse Loss by C1q Antibodies

Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade

Jack, C. R., Knopman, D. S., Jagust, W. J., Shaw, L. M., Aisen, P. S., Weiner, M. W., Petersen, R. C., & Trojanowski, J. Q. (2010) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70299-6 · Cited by 4,806 · see citing works

Synaptic Pruning by Microglia Is Necessary for Normal Brain Development

Paolicelli, R. C., Bolasco, G., Pagani, F., Maggi, L., Scianni, M., Panzanelli, P., Giustetto, M., Ferreira, T. A., Guiducci, E., Dumas, L., et al. (2011) · Science · doi:10.1126/science.1202529 · Cited by 4,244 · see citing works

Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner

Schafer, D. P., Lehrman, E. K., Kautzman, A. G., Koyama, R., Mardinly, A. R., Yamasaki, R., Ransohoff, R. M., Greenberg, M. E., Barres, B. A., & Stevens, B. (2012) · Neuron · doi:10.1016/j.neuron.2012.03.026 · Cited by 4,089 · see citing works

Complement and microglia mediate early synapse loss in Alzheimer mouse models

Hong, S., Beja-Glasser, V. F., Nfonoyim, B. M., Frouin, A., Li, S., Ramakrishnan, S., Merry, K. M., Shi, Q., Rosenthal, A., Barres, B. A., et al. (2016) · Science · doi:10.1126/science.aad8373 · Cited by 3,343 · see citing works

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

Harold, D., Abraham, R., Hollingworth, P., Sims, R., Gerrish, A., Hamshere, M. L., Pahwa, J. S., Moskvina, V., Dowzell, K., Williams, A., et al. (2009) · Nature Genetics · doi:10.1038/ng.440 · Cited by 3,326 · see citing works

The Classical Complement Cascade Mediates CNS Synapse Elimination

Stevens, B., Allen, N. J., Vazquez, L. E., Howell, G. R., Christopherson, K. S., Nouri, N., Micheva, K. D., Mehalow, A. K., Huberman, A. D., Stafford, B., et al. (2007) · Cell · doi:10.1016/j.cell.2007.10.036 · Cited by 3,313 · see citing works

Synaptic, transcriptional and chromatin genes disrupted in autism

Study, T. D., De Rubeis, S., Autism, H. M. C. F., UK10K Consortium, The Autism Sequencing Consortium, He, X., Goldberg, A. P., Poultney, C. S., Samocha, K., Ercument Cicek, A., et al. (2014) · Nature · doi:10.1038/nature13772 · Cited by 2,746 · see citing works

Schizophrenia risk from complex variation of complement component 4

Sekar, A., Bialas, A. R., de Rivera, H., Davis, A., Hammond, T. R., Kamitaki, N., Tooley, K., Presumey, J., Baum, M., Van Doren, V., et al. (2016) · Nature · doi:10.1038/nature16549 · Cited by 2,394 · see citing works

Tau in physiology and pathology

Wang, Y., & Mandelkow, E. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2015.1 · Cited by 2,251 · see citing works

Synapse Loss and Microglial Activation Precede Tangles in a P301S Tauopathy Mouse Model

Yoshiyama, Y., Higuchi, M., Zhang, B., Huang, S.-M., Iwata, N., Saido, T. C., Maeda, J., Suhara, T., Trojanowski, J. Q., & Lee, V. M.-Y. (2007) · Neuron · doi:10.1016/j.neuron.2007.01.010 · Cited by 2,208 · see citing works

Microglia in Alzheimer’s disease

Hansen, D. V., Hanson, J. E., & Sheng, M. (2018) · Journal of Cell Biology · doi:10.1083/jcb.201709069 · Cited by 1,935 · see citing works

Reducing Endogenous Tau Ameliorates Amyloid ß-Induced Deficits in an Alzheimer's Disease Mouse Model

Roberson, E. D., Scearce-Levie, K., Palop, J. J., Yan, F., Cheng, I. H., Wu, T., Gerstein, H., Yu, G.-Q., & Mucke, L. (2007) · Science · doi:10.1126/science.1141736 · Cited by 1,892 · see citing works

Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models

Ittner, L. M., Ke, Y. D., Delerue, F., Bi, M., Gladbach, A., van Eersel, J., Wölfing, H., Chieng, B. C., Christie, M. J., Napier, I. A., et al. (2010) · Cell · doi:10.1016/j.cell.2010.06.036 · Cited by 1,821 · see citing works

Microglia emerge as central players in brain disease

Salter, M. W., & Stevens, B. (2017) · Nature Medicine · doi:10.1038/nm.4397 · Cited by 1,767 · see citing works

De novo mutations in schizophrenia implicate synaptic networks

Fromer, M., Pocklington, A. J., Kavanagh, D. H., Williams, H. J., Dwyer, S., Gormley, P., Georgieva, L., Rees, E., Palta, P., Ruderfer, D. M., et al. (2014) · Nature · doi:10.1038/nature12929 · Cited by 1,617 · see citing works

Amyloid-β and tau — a toxic pas de deux in Alzheimer's disease

Ittner, L. M., & Götz, J. (2010) · Nature reviews. Neuroscience · doi:10.1038/nrn2967 · Cited by 1,357 · see citing works

The Intersection of Amyloid Beta and Tau at Synapses in Alzheimer’s Disease

Spires-Jones, T. L., & Hyman, B. T. (2014) · Neuron · doi:10.1016/j.neuron.2014.05.004 · Cited by 1,201 · see citing works

A three-dimensional human neural cell culture model of Alzheimer’s disease

Choi, S. H., Kim, Y. H., Hebisch, M., Sliwinski, C., Lee, S., D’Avanzo, C., Chen, H., Hooli, B., Asselin, C., Muffat, J., et al. (2014) · Nature · doi:10.1038/nature13800 · Cited by 1,195 · see citing works

Tau Mislocalization to Dendritic Spines Mediates Synaptic Dysfunction Independently of Neurodegeneration

Hoover, B. R., Reed, M. N., Su, J., Penrod, R. D., Kotilinek, L. A., Grant, M. K., Pitstick, R., Carlson, G. A., Lanier, L. M., Yuan, L.-L., et al. (2010) · Neuron · doi:10.1016/j.neuron.2010.11.030 · Cited by 1,118 · see citing works

The Complement System: An Unexpected Role in Synaptic Pruning During Development and Disease

Stephan, A. H., Barres, B. A., & Stevens, B. (2012) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-061010-113810 · Cited by 1,113 · see citing works

Hippocampal synaptic loss in early Alzheimer's disease and mild cognitive impairment

Scheff, S. W., Price, D. A., Schmitt, F. A., & Mufson, E. J. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.09.012 · Cited by 1,017 · see citing works

Differential Regulation of Dynein and Kinesin Motor Proteins by Tau

Dixit, R., Ross, J. L., Goldman, Y. E., & Holzbaur, E. L. F. (2008) · Science · doi:10.1126/science.1152993 · Cited by 1,012 · see citing works

The Postsynaptic Architecture of Excitatory Synapses: A More Quantitative View

Sheng, M., & Hoogenraad, C. C. (2007) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.76.060805.160029 · Cited by 1,010 · see citing works

Rapid and persistent modulation of actin dynamics regulates postsynaptic reorganization underlying bidirectional plasticity

Okamoto, K.-I., Nagai, T., Miyawaki, A., & Hayashi, Y. (2004) · Nature Neuroscience · doi:10.1038/nn1311 · Cited by 854 · see citing works

Synaptic Dysfunction in Neurodevelopmental Disorders Associated with Autism and Intellectual Disabilities

Zoghbi, H. Y., & Bear, M. F. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a009886 · Cited by 797 · see citing works

Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction

Weinhard, L., di Bartolomei, G., Bolasco, G., Machado, P., Schieber, N. L., Neniskyte, U., Exiga, M., Vadisiute, A., Raggioli, A., Schertel, A., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-03566-5 · Cited by 790 · see citing works

Progranulin Deficiency Promotes Circuit-Specific Synaptic Pruning by Microglia via Complement Activation

Lui, H., Zhang, J., Makinson, S. R., Cahill, M. K., Kelley, K. W., Huang, H.-Y., Shang, Y., Oldham, M. C., Martens, L. H., Gao, F., et al. (2016) · Cell · doi:10.1016/j.cell.2016.04.001 · Cited by 729 · see citing works

Three dimensions of the amyloid hypothesis: time, space and 'wingmen'

Musiek, E. S., & Holtzman, D. M. (2015) · Nature Neuroscience · doi:10.1038/nn.4018 · Cited by 697 · see citing works

Hippocampal LTP Is Accompanied by Enhanced F-Actin Content within the Dendritic Spine that Is Essential for Late LTP Maintenance In Vivo

Fukazawa, Y., Saitoh, Y., Ozawa, F., Ohta, Y., Mizuno, K., & Inokuchi, K. (2003) · Neuron · doi:10.1016/s0896-6273(03)00206-x · Cited by 695 · see citing works

A complement–microglial axis drives synapse loss during virus-induced memory impairment

Vasek, M. J., Garber, C., Dorsey, D., Durrant, D. M., Bollman, B., Soung, A., Yu, J., Perez-Torres, C., Frouin, A., Wilton, D. K., et al. (2016) · Nature · doi:10.1038/nature18283 · Cited by 671 · see citing works

Diverse Brain Myeloid Expression Profiles Reveal Distinct Microglial Activation States and Aspects of Alzheimer’s Disease Not Evident in Mouse Models

Friedman, B. A., Srinivasan, K., Ayalon, G., Meilandt, W. J., Lin, H., Huntley, M. A., Cao, Y., Lee, S.-H., Haddick, P. C. G., Ngu, H., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2017.12.066 · Cited by 662 · see citing works

Automated Three-Dimensional Detection and Shape Classification of Dendritic Spines from Fluorescence Microscopy Images

Rodriguez, A., Ehlenberger, D. B., Dickstein, D. L., Hof, P. R., & Wearne, S. L. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001997 · Cited by 571 · see citing works

New insights on the role of microglia in synaptic pruning in health and disease

Hong, S., Dissing-Olesen, L., & Stevens, B. (2016) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2015.12.004 · Cited by 557 · see citing works

The stress of dieting

Hutchinson, E. (2011) · Nature reviews. Neuroscience · doi:10.1038/nrn2985 · Cited by 534 · see citing works

Characterization of the proteome, diseases and evolution of the human postsynaptic density

Bayés, À., van de Lagemaat, L. N., Collins, M. O., Croning, M. D. R., Whittle, I. R., Choudhary, J. S., & Grant, S. G. N. (2011) · Nature Neuroscience · doi:10.1038/nn.2719 · Cited by 499 · see citing works

Semiquantitative Proteomic Analysis of Rat Forebrain Postsynaptic Density Fractions by Mass Spectrometry

Peng, J., Kim, M. J., Cheng, D., Duong, D. M., Gygi, S. P., & Sheng, M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400103200 · Cited by 473 · see citing works

Tau post-translational modifications in wild-type and human amyloid precursor protein transgenic mice

Morris, M., Knudsen, G. M., Maeda, S., Trinidad, J. C., Ioanoviciu, A., Burlingame, A. L., & Mucke, L. (2015) · Nature Neuroscience · doi:10.1038/nn.4067 · Cited by 472 · see citing works

The Synaptic Accumulation of Hyperphosphorylated Tau Oligomers in Alzheimer Disease Is Associated With Dysfunction of the Ubiquitin-Proteasome System

Tai, H., Serrano‐Pozo, A., Hashimoto, T., Frosch, M. P., Spires‐Jones, T. L., & Hyman, B. T. (2012) · American Journal Of Pathology · doi:10.1016/j.ajpath.2012.06.033 · Cited by 456 · see citing works

Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivo

Fulga, T. A., Elson-Schwab, I., Khurana, V., Steinhilb, M. L., Spires, T. L., Hyman, B. T., & Feany, M. B. (2007) · Nature Cell Biology · doi:10.1038/ncb1528 · Cited by 452 · see citing works

Cryosectioning and immunolabeling

Slot, J. W., & Geuze, H. J. (2007) · Nature Protocols · doi:10.1038/nprot.2007.365 · Cited by 444 · see citing works

Synapses and Alzheimer's Disease

Sheng, M., Sabatini, B. L., & Sudhof, T. C. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005777 · Cited by 436 · see citing works

Kalirin-7 Controls Activity-Dependent Structural and Functional Plasticity of Dendritic Spines

Xie, Z., Srivastava, D. P., Photowala, H., Kai, L., Cahill, M. E., Woolfrey, K. M., Shum, C. Y., Surmeier, D. J., & Penzes, P. (2007) · Neuron · doi:10.1016/j.neuron.2007.10.005 · Cited by 373 · see citing works

2014 Update of the Alzheimer’s Disease Neuroimaging Initiative: A review of papers published since its inception

Weiner, M. W., Veitch, D. P., Aisen, P. S., Beckett, L. A., Cairns, N. J., Cedarbaum, J., Green, R. C., Harvey, D., Jack, C. R., Jagust, W., et al. (2015) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2014.11.001 · Cited by 348 · see citing works

Untangling the brain’s neuroinflammatory and neurodegenerative transcriptional responses

Srinivasan, K., Friedman, B. A., Larson, J. L., Lauffer, B. E., Goldstein, L. D., Appling, L. L., Borneo, J., Poon, C., Ho, T., Cai, F., et al. (2016) · Nature Communications · doi:10.1038/ncomms11295 · Cited by 336 · see citing works

Effector-attenuating Substitutions That Maintain Antibody Stability and Reduce Toxicity in Mice

Lo, M., Kim, H. S., Tong, R. K., Bainbridge, T. W., Vernes, J.-M., Zhang, Y., Lin, Y. L., Chung, S., Dennis, M. S., Zuchero, Y. J. Y., et al. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.767749 · Cited by 312 · see citing works

Errant gardeners: glial-cell-dependent synaptic pruning and neurodevelopmental disorders

Neniškytė, U., & Gross, C. T. (2017) · Nature reviews. Neuroscience · doi:10.1038/nrn.2017.110 · Cited by 309 · see citing works

Genetic Control of Human Brain Transcript Expression in Alzheimer Disease

Webster, J. A., Gibbs, J. R., Clarke, J., Ray, M., Zhang, W., Holmans, P., Rohrer, K., Zhao, A., Marlowe, L., Kaleem, M., et al. (2009) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2009.03.011 · Cited by 304 · see citing works

PSD-95 Is Required to Sustain the Molecular Organization of the Postsynaptic Density

Chen, X., Nelson, C. D., Li, X., Winters, C. A., Azzam, R. N., Sousa, A. A., Leapman, R. D., Gainer, H., Sheng, M., & Reese, T. S. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.5968-10.2011 · Cited by 304 · see citing works

Amyloid-β oligomers induce synaptic damage via Tau-dependent microtubule severing by TTLL6 and spastin

Zempel, H., Luedtke, J., Kumar, Y., Biernat, J., Dawson, H., Mandelkow, E., & Mandelkow, E. (2013) · The EMBO Journal · doi:10.1038/emboj.2013.207 · Cited by 283 · see citing works

Activity-Dependent Tau Protein Translocation to Excitatory Synapse Is Disrupted by Exposure to Amyloid-Beta Oligomers

Frandemiche, M. L., De Seranno, S., Rush, T., Borel, E., Elie, A., Arnal, I., Lanté, F., & Buisson, A. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.4261-13.2014 · Cited by 272 · see citing works

C1q Binds Phosphatidylserine and Likely Acts as a Multiligand-Bridging Molecule in Apoptotic Cell Recognition

Païdassi, H., Tacnet‐Delorme, P., Garlatti, V., Darnault, C., Ghebrehiwet, B., Gaboriaud, C., Arlaud, G. J., & Frachet, P. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.4.2329 · Cited by 270 · see citing works

Local Pruning of Dendrites and Spines by Caspase-3-Dependent and Proteasome-Limited Mechanisms

Ertürk, A., Wang, Y., & Sheng, M. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.3121-13.2014 · Cited by 231 · see citing works

Genes with de novo mutations are shared by four neuropsychiatric disorders discovered from NPdenovo database

Li, J., Cai, T., Jiang, Y. W., Chen, H., He, X., Chen, C., Li, X., Shao, Q., Xia, R., Li, Z., et al. (2015) · Molecular Psychiatry · doi:10.1038/mp.2015.40 · Cited by 208 · see citing works

PS2APP Transgenic Mice, Coexpressing hPS2mut and hAPPswe, Show Age-Related Cognitive Deficits Associated with Discrete Brain Amyloid Deposition and Inflammation

Richards, J., Higgins, G., Ouagazzal, A., Ozmen, L., Kew, J., Bohrmann, B., Malherbe, P., Brockhaus, M., Loetscher, H., Czech, C., et al. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-26-08989.2003 · Cited by 197 · see citing works

Caspase-2 cleavage of tau reversibly impairs memory

Zhao, X., Kotilinek, L. A., Smith, B., Hlynialuk, C., Zahs, K., Ramsden, M., Cleary, J., & Ashe, K. H. (2016) · Nature Medicine · doi:10.1038/nm.4199 · Cited by 187 · see citing works

Pathway-driven discovery of epilepsy genes

Noebels, J. L. (2015) · Nature Neuroscience · doi:10.1038/nn.3933 · Cited by 187 · see citing works

Local apoptotic-like mechanisms underlie complement-mediated synaptic pruning

Györffy, B. A., Kun, J., Török, G., Bulyáki, É., Borhegyi, Z., Gulyássy, P., Kis, V., Szocsics, P., Micsonai, A., Matkó, J., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1722613115 · Cited by 186 · see citing works

Correlative light-electron microscopy (CLEM) combining live-cell imaging and immunolabeling of ultrathin cryosections

van Rijnsoever, C., Oorschot, V. M. J., & Klumperman, J. (2008) · Nature Methods · doi:10.1038/nmeth.1263 · Cited by 185 · see citing works

Actin Out: Regulation of the Synaptic Cytoskeleton

Spence, E. F., & Soderling, S. H. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.r115.655118 · Cited by 171 · see citing works

Kalirin regulates cortical spine morphogenesis and disease-related behavioral phenotypes

Cahill, M. E., Xie, Z., Day, M., Photowala, H., Barbolina, M. V., Miller, C. A., Weiss, C., Radulovic, J., Sweatt, J. D., Disterhoft, J. F., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904636106 · Cited by 170 · see citing works

Mutations in the guanine nucleotide exchange factor gene IQSEC2 cause nonsyndromic intellectual disability

Shoubridge, C., Tarpey, P. S., Abidi, F., Ramsden, S. L., Rujirabanjerd, S., Murphy, J. A., Boyle, J., Shaw, M. A., Gardner, A. E., Proos, A., et al. (2010) · Nature Genetics · doi:10.1038/ng.588 · Cited by 151 · see citing works

Aβ mediates F-actin disassembly in dendritic spines leading to cognitive deficits in Alzheimer's disease

Kommaddi, R. P., Das, D., Karunakaran, S., Nanguneri, S., Bapat, D., Ray, A., Shaw, E., Bennett, D. A., Nair, D., & Ravindranath, V. (2018) · The Journal of Neuroscience · doi:10.1523/jneurosci.2127-17.2017 · Cited by 135 · see citing works

The Impact of Peptide Abundance and Dynamic Range on Stable-Isotope-Based Quantitative Proteomic Analyses

Bakalarski, C. E., Elias, J. E., Villén, J., Haas, W., Gerber, S. A., Everley, P. A., & Gygi, S. P. (2008) · Journal of Proteome Research · doi:10.1021/pr800333e · Cited by 126 · see citing works

The Human Tau Interactome: Binding to the Ribonucleoproteome, and Impaired Binding of the Proline-to-Leucine Mutant at Position 301 (P301L) to Chaperones and the Proteasome

Gunawardana, C. G., Mehrabian, M., Wang, X., Mueller, I., Lubambo, I., Jonkman, J. E. N., Wang, H., & Schmitt‐Ulms, G. (2015) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m115.050724 · Cited by 118 · see citing works

An autism spectrum disorder-related de novo mutation hotspot discovered in the GEF1 domain of Trio

Sadybekov, A., Tian, C., Arnesano, C., Katritch, V., & Herring, B. E. (2017) · Nature Communications · doi:10.1038/s41467-017-00472-0 · Cited by 111 · see citing works

Palmitoylation of Gephyrin Controls Receptor Clustering and Plasticity of GABAergic Synapses

Dejanovic, B., Semtner, M., Ebert, S., Lamkemeyer, T., Neuser, F., Lüscher, B., Meier, J. C., & Schwarz, G. (2014) · PLoS Biology · doi:10.1371/journal.pbio.1001908 · Cited by 109 · see citing works

Kalirin and Trio proteins serve critical roles in excitatory synaptic transmission and LTP

Herring, B. E., & Nicoll, R. A. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1600179113 · Cited by 98 · see citing works

IQGAP1 Regulates NR2A Signaling, Spine Density, and Cognitive Processes

Gao, C., Frausto, S. F., Guedea, A. L., Tronson, N. C., Jovasevic, V., Leaderbrand, K., Corcoran, K. A., Guzmán, Y. F., Swanson, G. T., & Radulović, J. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.1300-11.2011 · Cited by 96 · see citing works

Arf6-GEF BRAG1 Regulates JNK-Mediated Synaptic Removal of GluA1-Containing AMPA Receptors: A New Mechanism for Nonsyndromic X-Linked Mental Disorder

Myers, K. R., Wang, G., Sheng, Y., Conger, K. K., Casanova, J. E., & Zhu, J. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.1942-12.2012 · Cited by 70 · see citing works

GluN2B Antagonism Affects Interneurons and Leads to Immediate and Persistent Changes in Synaptic Plasticity, Oscillations, and Behavior

Hanson, J. E., Weber, M., Meilandt, W. J., Wu, T. Z., Luu, T., Deng, L., Shamloo, M., Sheng, M., Scearce-Levie, K. A., & Zhou, Q. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.19 · Cited by 55 · see citing works

Phosphoproteomic characterization of DNA damage response in melanoma cells following MEK/PI3K dual inhibition

Kirkpatrick, D. S., Bustos, D. J., Dogan, T., Chan, J., Phu, L., Young, A. E., Friedman, L. S., Belvin, M. P., Song, Q., Bakalarski, C. E., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1309473110 · Cited by 54 · see citing works

EGFR Inhibitor Erlotinib Delays Disease Progression but Does Not Extend Survival in the SOD1 Mouse Model of ALS

Pichon, C. E. L., Domínguez, S. L., Solanoy, H. O., Ngu, H., Lewin‐Koh, N., Chen, M., Eastham‐Anderson, J., Watts, R. J., & Scearce-Levie, K. A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062342 · Cited by 50 · see citing works

Erratum: Genes with de novo mutations are shared by four neuropsychiatric disorders discovered from NPdenovo database

Li, J., Cai, T., Jiang, Y., Chen, H., He, X., Chen, C., Li, X., Shao, Q., Ran, X., Li, Z., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2015.58 · Cited by 47 · see citing works

A sequence variant in human KALRN impairs protein function and coincides with reduced cortical thickness

Russell, T. A., Blizinsky, K. D., Cobia, D. J., Cahill, M. E., Xie, Z., Sweet, R. A., Duan, J., Gejman, P. V., Wang, L., Csernansky, J. G., et al. (2014) · Nature Communications · doi:10.1038/ncomms5858 · Cited by 39 · see citing works

Subunit-selective N-Methyl-d-aspartate (NMDA) Receptor Signaling through Brefeldin A-resistant Arf Guanine Nucleotide Exchange Factors BRAG1 and BRAG2 during Synapse Maturation

Elagabani, M. N., Briševac, D., Kintscher, M., Pohle, J., Köhr, G., Schmitz, D., & Kornau, H. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.691717 · Cited by 32 · see citing works

Chronic GluN2B Antagonism Disrupts Behavior in Wild-Type Mice Without Protecting Against Synapse Loss or Memory Impairment in Alzheimer's Disease Mouse Models

Hanson, J. E., Meilandt, W. J., Gogineni, A., Reynen, P. H., Herrington, J. B., Weimer, R. M., Scearce-Levie, K. A., & Zhou, Q. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.5106-13.2014 · Cited by 25 · see citing works

A Functional MiR-124 Binding-Site Polymorphism in IQGAP1 Affects Human Cognitive Performance

Yang, L., Zhang, R., Li, M., Wu, X., Wang, J., Huang, L., Shi, X., Li, Q., & Su, B. (2014) · PLoS ONE · doi:10.1371/journal.pone.0107065 · Cited by 19 · see citing works

Intact neurobehavioral development and dramatic impairments of procedural-like memory following neonatal ventral hippocampal lesion in rats

Lecourtier, L., Antal, M., Cosquer, B., Schumacher, A., Samama, B., Angst, M.-J., Ferrandon, A., Koning, E., Cassel, J., & Nehlig, A. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.01.040 · Cited by 15 · see citing works

Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets

Gao, C., Jiang, J., Tan, Y., & Chen, S. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01588-0 · Cited by 1,616 · see citing works

Synergy between amyloid-β and tau in Alzheimer’s disease

Busche, M. A., & Hyman, B. T. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-0687-6 · Cited by 1,242 · see citing works

Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases

Loh, J. S., Mak, W. Q., Tan, L. K. S., Ng, C. X., Chan, H. H., Yeow, S. H., Foo, J. B., Ong, Y. S., How, C. W., & Khaw, K. Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01743-1 · Cited by 1,193 · see citing works

Alzheimer's disease

López, J. A., González, H. M., & Léger, G. C. (2019) · Handbook of clinical neurology · doi:10.1016/b978-0-12-804766-8.00013-3 · Cited by 834 · see citing works

Neuroinflammation in Alzheimer disease

Heneka, M. T., van der Flier, W. M., Jessen, F., Hoozemanns, J., Thal, D. R., Boche, D., Brosseron, F., Teunissen, C., Zetterberg, H., Jacobs, A. H., et al. (2025) · Nature Reviews Immunology · doi:10.1038/s41577-024-01104-7 · Cited by 638 · see citing works

Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer’s Disease Progression

Bai, B., Wang, X., Li, Y., Chen, P.-C., Yu, K., Dey, K. K., Yarbro, J. M., Han, X., Lutz, B. M., Rao, S., et al. (2020) · Neuron · doi:10.1016/j.neuron.2019.12.015 · Cited by 632 · see citing works

Synaptic degeneration in Alzheimer disease

Tzioras, M., McGeachan, R. I., Durrant, C. S., & Spires-Jones, T. L. (2023) · Nature Reviews Neurology · doi:10.1038/s41582-022-00749-z · Cited by 504 · see citing works

New insights into the immune functions of complement

Reis, E. S., Mastellos, D. C., Hajishengallis, G., & Lambris, J. D. (2019) · Nature reviews. Immunology · doi:10.1038/s41577-019-0168-x · Cited by 474 · see citing works

Gamma Entrainment Binds Higher-Order Brain Regions and Offers Neuroprotection

Adaikkan, C., Middleton, S. J., Marco, A., Pao, P., Mathys, H., Kim, D. N.-W., Gao, F., Young, J. Z., Suk, H., Boyden, E. S., et al. (2019) · Neuron · doi:10.1016/j.neuron.2019.04.011 · Cited by 469 · see citing works

Complement C3 Is Activated in Human AD Brain and Is Required for Neurodegeneration in Mouse Models of Amyloidosis and Tauopathy

Wu, T., Dejanovic, B., Gandham, V. D., Gogineni, A., Edmonds, R., Schauer, S., Srinivasan, K., Huntley, M. A., Wang, Y., Wang, T.-M., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.07.060 · Cited by 466 · see citing works

Local externalization of phosphatidylserine mediates developmental synaptic pruning by microglia

Scott‐Hewitt, N., Perrucci, F., Morini, R., Erreni, M., Mahoney, M., Witkowska, A., Carey, A. E., Faggiani, E., Schuetz, L. T., Mason, S., et al. (2020) · The EMBO Journal · doi:10.15252/embj.2020105380 · Cited by 425 · see citing works

Microglia modulate neurodegeneration in Alzheimer’s and Parkinson’s diseases

Bartels, T., De Schepper, S., & Hong, S. (2020) · Science · doi:10.1126/science.abb8587 · Cited by 412 · see citing works

TLR4 Cross-Talk With NLRP3 Inflammasome and Complement Signaling Pathways in Alzheimer's Disease

Yang, J., Wise, L., & Fukuchi, K.-I. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00724 · Cited by 387 · see citing works

The complexity of tau in Alzheimer’s disease

Naseri, N. N., Wang, H., Guo, J. D., Sharma, M., & Luo, W. (2019) · Neuroscience Letters · doi:10.1016/j.neulet.2019.04.022 · Cited by 374 · see citing works

Transcriptional signature in microglia associated with Aβ plaque phagocytosis

Grubman, A., Choo, X. Y., Chew, G., Ouyang, J. F., Sun, G., Croft, N. P., Rossello, F. J., Simmons, R., Buckberry, S., Landin, D. V., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-23111-1 · Cited by 357 · see citing works

Neuromyelitis optica spectrum disorders: from pathophysiology to therapeutic strategies

Contentti, E. C., & Correale, J. D. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02249-1 · Cited by 347 · see citing works

Clinical promise of next-generation complement therapeutics

Mastellos, D. C., Ricklin, D., & Lambris, J. D. (2019) · Nature Reviews Drug Discovery · doi:10.1038/s41573-019-0031-6 · Cited by 346 · see citing works

Complement C1q-dependent excitatory and inhibitory synapse elimination by astrocytes and microglia in Alzheimer’s disease mouse models

Dejanovic, B., Wu, T., Tsai, M.-C., Graykowski, D., Gandham, V. D., Rose, C. M., Bakalarski, C. E., Ngu, H., Wang, Y., Pandey, S., et al. (2022) · Nature Aging · doi:10.1038/s43587-022-00281-1 · Cited by 341 · see citing works

Immune Signaling in Neurodegeneration

Hammond, T. R., Marsh, S. E., & Stevens, B. (2019) · Immunity · doi:10.1016/j.immuni.2019.03.016 · Cited by 336 · see citing works

Selective removal of astrocytic APOE4 strongly protects against tau-mediated neurodegeneration and decreases synaptic phagocytosis by microglia

Wang, C., Xiong, M., Gratuze, M., Bao, X., Shi, Y., Andhey, P. S., Manis, M., Schroeder, C., Yin, Z., Madore, C., et al. (2021) · Neuron · doi:10.1016/j.neuron.2021.03.024 · Cited by 334 · see citing works

Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy

Wang, C., Fan, L., Khawaja, R. R., Liu, B., Zhan, L., Kodama, L., Chin, M., Li, Y., Le, D., Zhou, Y., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-29552-6 · Cited by 333 · see citing works

Neuron-glia signaling in synapse elimination

Wilton, D. K., Dissing-Olesen, L., & Stevens, B. (2019) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-070918-050306 · Cited by 332 · see citing works

The clinical promise of biomarkers of synapse damage or loss in Alzheimer’s disease

the Synaptic Health Endpoints Working Group, Colom-Cadena, M., Spires-Jones, T., Zetterberg, H., Blennow, K., Caggiano, A., DeKosky, S. T., Fillit, H., Harrison, J. E., Schneider, L. S., et al. (2020) · Alzheimer's Research & Therapy · doi:10.1186/s13195-020-00588-4 · Cited by 328 · see citing works

Perivascular cells induce microglial phagocytic states and synaptic engulfment via SPP1 in mouse models of Alzheimer’s disease

De Schepper, S., Ge, J. Z., Sierksma, A., Crowley, G., Ferreira, L. S. S., Garceau, D., Toomey, C. E., Sokolova, D., Rueda-Carrasco, J., Shin, S.-H., et al. (2023) · Nature Neuroscience · doi:10.1038/s41593-023-01257-z · Cited by 295 · see citing works

Microglial phagocytosis of neurons in neurodegeneration, and its regulation

Butler, C. A., Popescu, A. S., Kitchener, E. J. A., Allendorf, D. H., Puigdellívol, M., & Brown, G. C. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15327 · Cited by 293 · see citing works

Rutin prevents tau pathology and neuroinflammation in a mouse model of Alzheimer’s disease

Sun, X., Li, L., Dong, Q.-X., Zhu, J., Huang, Y., Hou, S., Yu, X., & Liu, R. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02182-3 · Cited by 285 · see citing works

The good, the bad, and the opportunities of the complement system in neurodegenerative disease

Schartz, N. D., & Tenner, A. J. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-02024-8 · Cited by 283 · see citing works

Impact of TREM2R47H variant on tau pathology–induced gliosis and neurodegeneration

Gratuze, M., Leyns, C. E. G., Sauerbeck, A. D., St-Pierre, M.-K., Xiong, M., Kim, N., Serrano, J. R., Tremblay, M.-È., Kummer, T. T., Colonna, M., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci138179 · Cited by 252 · see citing works

Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model

Clayton, K., Delpech, J. C., Herron, S., Iwahara, N., Ericsson, M., Saito, T., Saido, T. C., Ikezu, S., & Ikezu, T. (2021) · Molecular Neurodegeneration · doi:10.1186/s13024-021-00440-9 · Cited by 245 · see citing works

Cellular and pathological functions of tau

Bravo, C. P., Naguib, S. A., & Gan, L. (2024) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-024-00753-9 · Cited by 245 · see citing works

The role of pathological tau in synaptic dysfunction in Alzheimer’s diseases

Wu, M., Zhang, M., Yin, X., Chen, K., Hu, Z., Zhou, Q., Cao, X., Chen, Z., & Liu, D. (2021) · Translational Neurodegeneration · doi:10.1186/s40035-021-00270-1 · Cited by 241 · see citing works

Neuronal excitation/inhibition imbalance: core element of a translational perspective on Alzheimer pathophysiology

Maestú, F., de Haan, W., Busche, M. A., & DeFelipe, J. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101372 · Cited by 235 · see citing works

Microglia-neuron crosstalk: Signaling mechanism and control of synaptic transmission

Marinelli, S., Basilico, B., Marrone, M. C., & Ragozzino, D. (2019) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2019.05.017 · Cited by 233 · see citing works

GABAergic dysfunction in excitatory and inhibitory (E/I) imbalance drives the pathogenesis of Alzheimer's disease

Bi, D., Wen, L., Wu, Z., & Shen, Y. (2020) · Alzheimer's & Dementia · doi:10.1002/alz.12088 · Cited by 232 · see citing works

Microglia and Astrocytes in Disease: Dynamic Duo or Partners in Crime?

Liddelow, S. A., Marsh, S. E., & Stevens, B. (2020) · Trends in Immunology · doi:10.1016/j.it.2020.07.006 · Cited by 226 · see citing works

Microglia and monocytes in inflammatory CNS disease: integrating phenotype and function

Spiteri, A. G., Wishart, C. L., Pamphlett, R., Locatelli, G., & King, N. J. C. (2022) · Acta Neuropathologica · doi:10.1007/s00401-021-02384-2 · Cited by 216 · see citing works

Therapeutic Targeting of the Complement System: From Rare Diseases to Pandemics

Garred, P., Tenner, A. J., & Mollnes, T. E. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000072 · Cited by 215 · see citing works

Microglia in Brain Development, Homeostasis, and Neurodegeneration

Bohlen, C. J., Friedman, B. A., Dejanovic, B., & Sheng, M. (2019) · Annual Review of Genetics · doi:10.1146/annurev-genet-112618-043515 · Cited by 212 · see citing works

Therapeutic Inhibition of the Complement System in Diseases of the Central Nervous System

Carpanini, S. M., Torvell, M., & Morgan, B. P. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00362 · Cited by 207 · see citing works

Spermidine and spermine delay brain aging by inducing autophagy in SAMP8 mice

Xu, T., Li, H., Dai, Z., Lau, G. K., Li, B., Zhu, W., Liu, X.-Q., Liu, H.-F., Cai, W.-W., Huang, S., et al. (2020) · Aging · doi:10.18632/aging.103035 · Cited by 204 · see citing works

The Inflamed Brain in Schizophrenia: The Convergence of Genetic and Environmental Risk Factors That Lead to Uncontrolled Neuroinflammation

Comer, A. L., Carrier, M., Tremblay, M., & Cruz‐Martín, A. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00274 · Cited by 204 · see citing works

Synapse pathology in Alzheimer’s disease

Griffiths, J., & Grant, S. G. N. (2022) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2022.05.028 · Cited by 203 · see citing works

Intersection of pathological tau and microglia at the synapse

Vogels, T., Murgoci, A.-N., & Hromádka, T. (2019) · Acta Neuropathologica Communications · doi:10.1186/s40478-019-0754-y · Cited by 197 · see citing works

Pathophysiological subtypes of Alzheimer’s disease based on cerebrospinal fluid proteomics

Tijms, B. M., Gobom, J., Reus, L. M., Jansen, I. E., Hong, S., Dobričić, V., Kilpert, F., ten Kate, M., Barkhof, F., Tsolaki, M., et al. (2020) · Brain · doi:10.1093/brain/awaa325 · Cited by 192 · see citing works

Exploiting microglial and peripheral immune cell crosstalk to treat Alzheimer’s disease

Dionisio-Santos, D. A., Olschowka, J. A., & O’Banion, M. K. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1453-0 · Cited by 184 · see citing works

Microglia and complement mediate early corticostriatal synapse loss and cognitive dysfunction in Huntington’s disease

Wilton, D. K., Mastro, K. J., Heller, M. D., Gergits, F. W., Willing, C. R., Fahey, J. B., Frouin, A., Daggett, A., Gu, X., Kim, Y. A., et al. (2023) · Nature Medicine · doi:10.1038/s41591-023-02566-3 · Cited by 179 · see citing works

Amyloid Beta and Tau Cooperate to Cause Reversible Behavioral and Transcriptional Deficits in a Model of Alzheimer’s Disease

Pickett, E. K., Herrmann, A. G., McQueen, J., Abt, K., Dando, O., Tulloch, J., Jain, P., Dunnett, S., Sohrabi, S., Fjeldstad, M. P., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.11.044 · Cited by 179 · see citing works

TREM2 receptor protects against complement-mediated synaptic loss by binding to complement C1q during neurodegeneration

Zhong, L., Sheng, X., Wang, W., Li, Y., Zhuo, R., Wang, K., Zhang, L., Hu, D.-D., Hong, Y., Chen, L., et al. (2023) · Immunity · doi:10.1016/j.immuni.2023.06.016 · Cited by 168 · see citing works

Targeting synapse function and loss for treatment of neurodegenerative diseases

Dejanovic, B., Sheng, M., & Hanson, J. E. (2023) · Nature Reviews Drug Discovery · doi:10.1038/s41573-023-00823-1 · Cited by 168 · see citing works

Fluid Biomarkers for Synaptic Dysfunction and Loss

Camporesi, E., Nilsson, J., Brinkmalm, A., Becker, B., Ashton, N. J., Blennow, K., & Zetterberg, H. (2020) · Biomarker Insights · doi:10.1177/1177271920950319 · Cited by 165 · see citing works

Ubiquitin Ligase COP1 Suppresses Neuroinflammation by Degrading c/EBPβ in Microglia

Ndoja, A., Reja, R., Lee, S.-H., Webster, J. D., Ngu, H., Rose, C. M., Kirkpatrick, D. S., Modrusan, Z. D., Chen, Y.-J. J., Dugger, D. L., et al. (2020) · Cell · doi:10.1016/j.cell.2020.07.011 · Cited by 160 · see citing works

Microglial TYROBP/DAP12 in Alzheimer's Disease: Transduction of Physiological and Pathological Signals Across TREM2

Haure-Mirande, J.-V., Audrain, M., Ehrlich, M. E., & Gandy, S. (2022) · Molecular Neurodegeneration · doi:10.1186/s13024-022-00552-w · Cited by 159 · see citing works

Increased expression of schizophrenia-associated gene C4 leads to hypoconnectivity of prefrontal cortex and reduced social interaction

Comer, A. L., Jinadasa, T., Sriram, B., Phadke, R. A., Kretsge, L. N., Nguyen, T. P. H., Antognetti, G., Gilbert, J. P., Lee, J., Newmark, E., et al. (2020) · PLoS Biology · doi:10.1371/journal.pbio.3000604 · Cited by 159 · see citing works

The synapse as a treatment avenue for Alzheimer’s Disease

Peng, L., Bestard‐Lorigados, I., & Song, W. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01565-z · Cited by 158 · see citing works

Microglia mediate neurocognitive deficits by eliminating C1q-tagged synapses in sepsis-associated encephalopathy

Chung, H.-Y., Wickel, J., Hahn, N., Mein, N., Schwarzbrunn, M., Koch, P., Ceanga, M., Haselmann, H., Baade-Büttner, C., von Stackelberg, N., et al. (2023) · Science Advances · doi:10.1126/sciadv.abq7806 · Cited by 156 · see citing works

Microglial activation states and their implications for Alzheimer's Disease

Valiukas, Z., Tangalakis, K., Apostolopoulos, V., & Feehan, J. (2025) · The Journal of Prevention of Alzheimer s Disease · doi:10.1016/j.tjpad.2024.100013 · Cited by 155 · see citing works

The neuronal pentraxin Nptx2 regulates complement activity and restrains microglia-mediated synapse loss in neurodegeneration

Zhou, J., Wade, S. D., Graykowski, D., Xiao, M.-F., Zhao, B., Giannini, L. A. A., Hanson, J. E., van Swieten, J. C., Sheng, M., Worley, P. F., et al. (2023) · Science Translational Medicine · doi:10.1126/scitranslmed.adf0141 · Cited by 152 · see citing works

Microglial priming of antigen presentation and adaptive stimulation in Alzheimer’s disease

Das, R., & Chinnathambi, S. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03132-2 · Cited by 147 · see citing works

Astrocyte-microglia interaction drives evolving neuromyelitis optica lesion

Chen, T., Lennon, V. A., Liu, Y., Bosco, D. B., Li, Y., Yi, M., Zhu, J., Wei, S., & Wu, L. (2020) · Journal of Clinical Investigation · doi:10.1172/jci134816 · Cited by 147 · see citing works

Retinal changes in Alzheimer's disease— integrated prospects of imaging, functional and molecular advances

Gupta, V. B., Chitranshi, N., den Haan, J., Mirzaei, M., You, Y., Lim, J. K. H., Basavarajappa, D. K., Godinez, A., Angelantonio, S. D., Sachdev, P. S., et al. (2020) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2020.100899 · Cited by 143 · see citing works

Cognitive enhancement and neuroprotective effects of OABL, a sesquiterpene lactone in 5xFAD Alzheimer's disease mice model

Tang, J., Huang, L.-F., Deng, J., Wang, Y., Guo, C., Peng, X.-N., Liu, Z., & Gao, J. (2022) · Redox Biology · doi:10.1016/j.redox.2022.102229 · Cited by 132 · see citing works

Phagocytosis of full-length Tau oligomers by Actin-remodeling of activated microglia

Das, R. R., Balmik, A. A., & Chinnathambi, S. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1694-y · Cited by 129 · see citing works

Complement dysregulation in the central nervous system during development and disease

Lee, J. D., Coulthard, L. G., & Woodruff, T. M. (2019) · Seminars in Immunology · doi:10.1016/j.smim.2019.101340 · Cited by 125 · see citing works

Amyloid-β, tau, and the cholinergic system in Alzheimer’s disease: seeking direction in a tangle of clues

Majdi, A., Sadigh‐Eteghad, S., Aghsan, S. R., Farajdokht, F., Vatandoust, S. M., Abbas-Abad, A. N., & Mahmoudi, J. (2020) · Reviews in the Neurosciences · doi:10.1515/revneuro-2019-0089 · Cited by 124 · see citing works

Cell Death and NeurodegenerationPreprint

Andreone, B. J., Larhammar, M., & Lewcock, J. W. (2019) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a036434 · Cited by 122 · see citing works

Microglia‐synapse engulfment via PtdSer‐TREM2 ameliorates neuronal hyperactivity in Alzheimer's disease models

Rueda‐Carrasco, J., Sokolova, D., Lee, S., Childs, T., Jurčáková, N., Crowley, G., Schepper, S. D., Ge, J. Z., Lachica, J., Toomey, C. E., et al. (2023) · The EMBO Journal · doi:10.15252/embj.2022113246 · Cited by 120 · see citing works

The Classical Complement Pathway Mediates Microglia-Dependent Remodeling of Spinal Motor Circuits during Development and in SMA

Vukojicic, A., Delestrée, N., Fletcher, E. V., Pagiazitis, J. G., Sankaranarayanan, S., Yednock, T. A., Barres, B. A., & Mentis, G. Z. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.11.013 · Cited by 117 · see citing works

TREM2-independent microgliosis promotes tau-mediated neurodegeneration in the presence of ApoE4.

Gratuze, M., Schlachetzki, J. C. M., D’Oliveira Albanus, R., Jain, N., Novotny, B., Brase, L., Rodriguez, L., Mansel, C., Kipnis, M., O’Brien, S., et al. (2023) · Neuron · doi:10.1016/j.neuron.2022.10.022 · Cited by 115 · see citing works

Synaptic Elimination in Neurological Disorders

Cardozo, P. L., de Lima, I. B. Q., Maciel, E. M. A., Silva, N. C., Dobránsky, T., & Ribeiro, F. M. (2019) · Current Neuropharmacology · doi:10.2174/1570159x17666190603170511 · Cited by 113 · see citing works

Do Microglial Sex Differences Contribute to Sex Differences in Neurodegenerative Diseases?

Kodama, L., & Gan, L. (2019) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2019.05.001 · Cited by 113 · see citing works

The contribution of glial cells to Huntington's disease pathogenesis

Wilton, D. K., & Stevens, B. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.104963 · Cited by 112 · see citing works

The complement cascade in the regulation of neuroinflammation, nociceptive sensitization, and pain

Warwick, C. A., Keyes, A. L., Woodruff, T. M., & Usachev, Y. M. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.101085 · Cited by 112 · see citing works

Tau Oligomer–Containing Synapse Elimination by Microglia and Astrocytes in Alzheimer Disease

Taddei, R. N., Perbet, R., Mate de Gerando, A., Wiedmer, A. E., Sanchez-Mico, M., Connors Stewart, T., Gaona, A., Melloni, A., Amaral, A. C., Duff, K., et al. (2023) · JAMA Neurology · doi:10.1001/jamaneurol.2023.3530 · Cited by 110 · see citing works

Human astrocytes and microglia show augmented ingestion of synapses in Alzheimer’s disease via MFG-E8

Tzioras, M., Daniels, M. J. D., Davies, C., Baxter, P. S., King, D., McKay, S., Varga, B. V., Popovic, K., Hernandez, M., Stevenson, A. J., et al. (2023) · Cell Reports Medicine · doi:10.1016/j.xcrm.2023.101175 · Cited by 109 · see citing works

Comparative profiling of the synaptic proteome from Alzheimer’s disease patients with focus on the APOE genotype

Hesse, R., Hurtado, M. L., Jackson, R. J., Eaton, S. L., Herrmann, A. G., Colom‐Cadena, M., Tzioras, M., King, D., Rose, J. L., Tulloch, J., et al. (2019) · Acta Neuropathologica Communications · doi:10.1186/s40478-019-0847-7 · Cited by 103 · see citing works

Microglia and Astrocytes in Alzheimer’s Disease: Significance and Summary of Recent Advances

Deng, Q., Wu, C., Parker, E., Liu, T. C.-Y., Duan, R., & Yang, L. (2023) · Aging and disease · doi:10.14336/ad.2023.0907 · Cited by 102 · see citing works

Reversal of synapse loss in Alzheimer mouse models by targeting mGluR5 to prevent synaptic tagging by C1Q

Spurrier, J. M., Nicholson, L., Fang, X. T., Stoner, A. J., Toyonaga, T., Holden, D., Siegert, T. R., Laird, W., Allnutt, M. A., Chiasseu, M., et al. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abi8593 · Cited by 102 · see citing works

Artificial intelligence-driven multi-omics approaches in Alzheimer's disease: Progress, challenges, and future directions

Ren, F., Wei, J., Chen, Q., Hu, M., Yu, L., Mi, J., Zhou, X., Qin, D., Wu, J., & Wu, A. (2025) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2025.07.030 · Cited by 97 · see citing works

TREM2 is required for microglial instruction of astrocytic synaptic engulfment in neurodevelopment

Jay, T. R., von Saucken, V. E., Muñoz, B., Codocedo, J. F., Atwood, B. K., Lamb, B. T., & Landreth, G. E. (2019) · Glia · doi:10.1002/glia.23664 · Cited by 97 · see citing works

Lesions without symptoms: understanding resilience to Alzheimer disease neuropathological changes

Gómez-Isla, T., & Frosch, M. P. (2022) · Nature Reviews Neurology · doi:10.1038/s41582-022-00642-9 · Cited by 96 · see citing works

Exacerbation of C1q dysregulation, synaptic loss and memory deficits in tau pathology linked to neuronal adenosine A2A receptor

Carvalho, K., Faivre, É., Pietrowski, M. J., Marques, X., Gómez‐Murcia, V., Deleau, A., Huin, V., Hansen, J. N., Kozlov, S. O., Danis, C., et al. (2019) · Brain · doi:10.1093/brain/awz288 · Cited by 92 · see citing works

Porphyromonas gingivalis and the pathogenesis of Alzheimer’s disease

Liu, S., Butler, C. A., Ayton, S., Reynolds, E. C., & Dashper, S. G. (2023) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2022.2163613 · Cited by 92 · see citing works

Apolipoprotein E4 Reduction with Antisense Oligonucleotides Decreases Neurodegeneration in a Tauopathy Model

Litvinchuk, A., Huynh, T. V., Shi, Y., Jackson, R. J., Finn, M. B., Manis, M., Francis, C. M., Tran, A. C., Sullivan, P. M., Ulrich, J. D., et al. (2021) · Annals of Neurology · doi:10.1002/ana.26043 · Cited by 91 · see citing works

Glial Control of Synapse Number in Healthy and Diseased Brain

Lee, E., & Chung, W. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00042 · Cited by 90 · see citing works

Neuronal NR4A1 deficiency drives complement-coordinated synaptic stripping by microglia in a mouse model of lupus

Han, X., Xu, T., Ding, C., Wang, D., Yao, G., Chen, H., Fang, Q., Hu, G., & Sun, L. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00867-y · Cited by 89 · see citing works

Tau fibrils induce glial inflammation and neuropathology via TLR2 in Alzheimer’s disease–related mouse models

Dutta, D., Jana, M., Paidi, R. K., Majumder, M., Raha, S., Dasarathy, S., & Pahan, K. (2023) · Journal of Clinical Investigation · doi:10.1172/jci161987 · Cited by 87 · see citing works

Motor cortex transcriptome reveals microglial key events in amyotrophic lateral sclerosis

Dols‐Icardo, O., Montal, V., Sirisi, S., López‐Pernas, G., Cervera‐Carles, L., Querol‐Vilaseca, M., Muñoz, L., Belbin, O., Alcolea, D. A., Molina‐Porcel, L., et al. (2020) · Neurology Neuroimmunology & Neuroinflammation · doi:10.1212/nxi.0000000000000829 · Cited by 87 · see citing works

Dendritic Spines: Mediators of Cognitive Resilience in Aging and Alzheimer’s Disease

Walker, C. K., & Herskowitz, J. H. (2021) · The Neuroscientist · doi:10.1177/1073858420945964 · Cited by 86 · see citing works

Long-term diazepam treatment enhances microglial spine engulfment and impairs cognitive performance via the mitochondrial 18 kDa translocator protein (TSPO)

Shi, Y., Cui, M., Ochs, K., Brendel, M., Strübing, F., Briel, N., Eckenweber, F., Zou, C., Banati, R. B., Liu, G. J., et al. (2022) · Nature Neuroscience · doi:10.1038/s41593-022-01013-9 · Cited by 85 · see citing works

Neurons burdened by DNA double-strand breaks incite microglia activation through antiviral-like signaling in neurodegeneration

Welch, G. M., Boix, C. A., Schmauch, E., Davila-Velderrain, J., Victor, M. B., Dileep, V., Bozzelli, P. L., Su, Q., Cheng, J. D., Lee, A., et al. (2022) · Science Advances · doi:10.1126/sciadv.abo4662 · Cited by 84 · see citing works

The Transcriptional Landscape of Microglial Genes in Aging and Neurodegenerative Disease

Bonham, L. W., Sirkis, D. W., & Yokoyama, J. S. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01170 · Cited by 83 · see citing works

Brain-region-specific changes in neurons and glia and dysregulation of dopamine signaling in Grin2a mutant mice

Farsi, Z., Nicolella, A. A., Simmons, S., Aryal, S., Shepard, N., Brenner, K. S., Lin, S., Herzog, L. E., Moran, S. P., Stalnaker, K. J., et al. (2023) · Neuron · doi:10.1016/j.neuron.2023.08.004 · Cited by 82 · see citing works

The Complement System: A Powerful Modulator and Effector of Astrocyte Function in the Healthy and Diseased Central Nervous System

Pekna, M., & Pekny, M. (2021) · Cells · doi:10.3390/cells10071812 · Cited by 81 · see citing works

Present and future of microglial pharmacology

Šimončičová, E., de Andrade, E. G., Vecchiarelli, H. A., Awogbindin, I. O., Delage, C. I., & Tremblay, M. (2022) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2021.11.006 · Cited by 79 · see citing works

Flavonoids as an Intervention for Alzheimer’s Disease: Progress and Hurdles Towards Defining a Mechanism of Action

Hole, K. L., & Williams, R. J. (2020) · Brain Plasticity · doi:10.3233/bpl-200098 · Cited by 78 · see citing works

Classical complement cascade initiating C1q protein within neurons in the aged rhesus macaque dorsolateral prefrontal cortex

Datta, D., Leslie, S. N., Morozov, Y. M., Duque, A., Rakic, P., van Dyck, C. H., Nairn, A. C., & Arnsten, A. F. T. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1683-1 · Cited by 76 · see citing works

Microglia and Wnt Pathways: Prospects for Inflammation in Alzheimer’s Disease

Yang, Y., & Zhang, Z. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.00110 · Cited by 76 · see citing works

Lowering Synaptogyrin-3 expression rescues Tau-induced memory defects and synaptic loss in the presence of microglial activation

Largo‐Barrientos, P., Apóstolo, N., Creemers, E., Callaerts‐Vegh, Z., Swerts, J., Davies, C., McInnes, J., Wierda, K. D. B., Strooper, B. D., Spires‐Jones, T. L., et al. (2021) · Neuron · doi:10.1016/j.neuron.2020.12.016 · Cited by 76 · see citing works

Complement System in Alzheimer’s Disease

Shah, A., Kishore, U., & Shastri, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222413647 · Cited by 76 · see citing works

The Complement System in the Central Nervous System: From Neurodevelopment to Neurodegeneration

Chen, Y., Chu, J. M. T., Chang, R. C., & Wong, G. T. C. (2022) · Biomolecules · doi:10.3390/biom12020337 · Cited by 76 · see citing works

Dysregulation of complement at the synapse in P301S mice and human tauopathies

Nimmo, J., Daskoulidou, N., Pottelberge, S. V., Muynck, L. D., & Morgan, B. P. (2026) · Acta Neuropathologica Communications · doi:10.1186/s40478-026-02347-2

Complement C1q-dependent excitatory and inhibitory synapse elimination by astrocytes and microglia in Alzheimer’s disease mouse models

Dejanovic, B., Wu, T., Tsai, M.-C., Graykowski, D., Gandham, V. D., Rose, C. M., Bakalarski, C. E., Ngu, H., Wang, Y., Pandey, S., et al. (2022) · Nature Aging · doi:10.1038/s43587-022-00281-1 · Cited by 341 · see citing works

Identification of Protein Tyrosine Phosphatase Receptor Zeta as a Novel Complement C1q Synaptic Interacting Partner

Benskey, M. J. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.089467

Complement and microglia mediate early synapse loss in Alzheimer mouse models

Hong, S., Beja-Glasser, V. F., Nfonoyim, B. M., Frouin, A., Li, S., Ramakrishnan, S., Merry, K. M., Shi, Q., Rosenthal, A., Barres, B. A., et al. (2016) · Science · doi:10.1126/science.aad8373 · Cited by 3,343 · see citing works

Terminal complement pathway activation drives synaptic loss in Alzheimer’s disease models

Carpanini, S. M., Torvell, M., Bevan, R. J., Byrne, R. A. J., Daskoulidou, N., Saito, T., Saido, T. C., Taylor, P. R., Hughes, T. R., Zelek, W. M., et al. (2022) · Acta Neuropathologica Communications · doi:10.1186/s40478-022-01404-w · Cited by 95 · see citing works