The DOI matches its Crossref record; 127 of the 127 references it cites were found in a registry or an index.
Rapid Reconfiguration of the Functional Connectome after Chemogenetic Locus Coeruleus Activation
Open accessAbstract
Abstract The locus coeruleus (LC) supplies norepinephrine (NE) to the entire forebrain, regulates many fundamental brain functions, and is implicated in several neuropsychiatric diseases. Although selective manipulation of the LC is not possible in humans, studies have suggested that strong LC activation might shift network connectivity to favor salience processing. To test this hypothesis, we use a mouse model to study the impact of LC stimulation on large-scale functional connectivity by combining chemogenetic activation of the LC with resting-state fMRI, an approach we term “chemo-connectomics”. LC activation rapidly interrupts ongoing behavior and strongly increases brain-wide connectivity, with the most profound effects in the salience and amygdala networks. We reveal a direct correlation between functional connectivity changes and transcript levels of alpha-1, alpha-2 , and beta-1 adrenoceptors across the brain, and a positive correlation between NE turnover and functional connectivity within select brain regions. These results represent the first brain-wide functional connectivity mapping in response to LC activation, and demonstrate a causal link between receptor expression, brain states and functionally connected large-scale networks at rest. We propose that these changes in large-scale network connectivity are critical for optimizing neural processing in the context of increased vigilance and threat detection.
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1 retracted
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Questions and controversies in the study of time-varying functional connectivity in resting fMRI
Lurie, D. J., Kessler, D., Bassett, D. S., Betzel, R. F., Breakspear, M., Kheilholz, S., Kucyi, A., Liégeois, R., Lindquist, M. A., McIntosh, A. R., et al. (2020) · Network Neuroscience · doi:10.1162/netn_a_00116 · Cited by 648
The role of the salience network in cognitive and affective deficits
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Noradrenergic circuit control of non-REM sleep substates
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Metadata
- Authors
- Zerbi, V., Floriou-Servou, A., Markicevic, M., Vermeiren, Y., Sturman, O., Privitera, M., von Ziegler, L., Ferrari, K. D., Weber, B., De Deyn, P. P., Wenderoth, N., & Bohacek, J.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2019-08
- Volume
- 103
- Issue
- 4
- Pages
- 702-718.e5
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2952216243
- Cited by
- 317
- References
- 127
- FWCI
- 18.52
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Zerbi, V., Floriou-Servou, A., Markicevic, M., Vermeiren, Y., Sturman, O., Privitera, M., von Ziegler, L., Ferrari, K. D., Weber, B., De Deyn, P. P., Wenderoth, N., & Bohacek, J. (2019). Rapid Reconfiguration of the Functional Connectome after Chemogenetic Locus Coeruleus Activation. Neuron. https://doi.org/10.1016/j.neuron.2019.05.034
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