The DOI matches its Crossref record; 118 of the 118 references it cites were found in a registry or an index.
The role of the salience network in cognitive and affective deficits
Open accessAbstract
Analysis and interpretation of studies on cognitive and affective dysregulation often draw upon the network paradigm, especially the Triple Network Model, which consists of the default mode network (DMN), the frontoparietal network (FPN), and the salience network (SN). DMN activity is primarily dominant during cognitive leisure and self-monitoring processes. The FPN peaks during task involvement and cognitive exertion. Meanwhile, the SN serves as a dynamic “switch” between the DMN and FPN, in line with salience and cognitive demand. In the cognitive and affective domains, dysfunctions involving SN activity are connected to a broad spectrum of deficits and maladaptive behavioral patterns in a variety of clinical disorders, such as depression, insomnia, narcissism, PTSD (in the case of SN hyperactivity), chronic pain, and anxiety, high degrees of neuroticism, schizophrenia, epilepsy, autism, and neurodegenerative illnesses, bipolar disorder (in the case of SN hypoactivity). We discuss behavioral and neurological data from various research domains and present an integrated perspective indicating that these conditions can be associated with a widespread disruption in predictive coding at multiple hierarchical levels. We delineate the fundamental ideas of the brain network paradigm and contrast them with the conventional modular method in the first section of this article. Following this, we outline the interaction model of the key functional brain networks and highlight recent studies coupling SN-related dysfunctions with cognitive and affective impairments.
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Citations
Cites
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Cited by
Onciul, R., Tataru, C.-I., Dumitru, A. V., Crivoi, C., Serban, M., Covache-Busuioc, R.-A., Radoi, M. P., & Toader, C. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14020550 · Cited by 113
Uncovering psychedelics: from neural circuits to therapeutic applications
Melani, A., Bonaso, M., Biso, L., Zucchini, B., Conversano, C., & Scarselli, M. (2025) · Pharmaceuticals · doi:10.3390/ph18010130 · Cited by 17
Marais, A.-L., & Roche-Labarbe, N. (2025) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2025.101519 · Cited by 12
Metadata
- Authors
- Schimmelpfennig, J., Topczewski, J., Zajkowski, W., & Jankowiak-Siuda, K.
- Venue
- Frontiers in Human Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2023-03-20
- Volume
- 17
- Pages
- 1133367-1133367
- ISSN
- 1662-5161 (ISSN-L)
- OpenAlex
- W4327977666
- Cited by
- 325
- References
- 118
- FWCI
- 45.40
- Type
- journal article
- Language
- en
- Open access
- gold
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- Schimmelpfennig, J., Topczewski, J., Zajkowski, W., & Jankowiak-Siuda, K. (2023). The role of the salience network in cognitive and affective deficits. Frontiers in Human Neuroscience. https://doi.org/10.3389/fnhum.2023.1133367
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
