Rescuing Over-activated Microglia Restores Cognitive Performance in Juvenile Animals of the Dp(16) Mouse Model of down Syndrome.

Pinto, Bruno, Morelli, Giovanni, Rastogi, Mohit, Savardi, Annalisa, Fumagalli, Amos, Petretto, Andrea, Bartolucci, Martina, Varea, Emilio +4 more·2020·Neuron

Cited by (135)

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  2. Long-term decreased cannabinoid type-1 receptor activity restores specific neurological phenotypes in the Ts65Dn mouse model of Down syndrome
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  3. Pre-Implantation factor (PIF) restores working memory and promotes microglial ramification in the adult Dp(16)1Yey mouse model of Down syndrome
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  4. Targeting dysregulated CB1 receptors in a Down syndrome mouse model improves neurological outcomes
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  6. Type I Interferon Signaling Drives Microglial Dysfunction and Senescence in Human iPSC Models of Down Syndrome and Alzheimer’s Disease
    Mengmeng Jin, Ranjie Xu, Le Wang, Mahabub Maraj Alam, Ziyuan Ma, Sining Zhu, Alessandra Cadete Martini, Azadeh Jadali, Matteo Bernabucci, Ping Xie et al. · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  7. Cathepsin B abundance, activity and microglial localisation in Alzheimer’s disease – Down syndrome and early onset Alzheimer’s disease; the role of elevated cystatin B
    Yixing Wu, Paige Mumford, Suzanna Noy, Karen Cleverley, Alicja Mrzyglod, Dinghao Luo, Floris J. van Dalen, Martijn Verdoes, Elizabeth Fisher, Frances K. Wiseman · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  8. Viral mimicry and memory deficits upon microglial deletion of ATRX
    Sarfraz Shafiq, Arsham Ghahramani, K. Mansour, Miguel Ángel Peña-Ortiz, Julia Kathryn Sunstrum, Yan Yi Jiang, Megan E. Rowland, Wataru Inoue, Nathalie G. Bérubé · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  9. التفاعل بین نمط إستجابة المحادثة الآلیة الذکیة ومستواها ببیئة التعلم النقال وأثره على تنمیة التحصیل المعرفى ومهارات قوة السیطرة المعرفیة والتقبل التکنولوجى لدى طلاب معلم الحاسب الآلى
    آیة طلعت أحمد إسماعیل · 2021 · تکنولوجيا التعليم سلسلة دراسات وبحوث
  10. Co-Exposure of Alumina Nanoparticles and Chronic Stress Aggravates Hippocampal Microglia Pyroptosis by Activating Cathepsin B/Nlrp3 Signaling Pathway
    Haiyang Zhang, Jibin Wang, Chuqian Ruan, Zhicheng Gao, Qiuxiang Zhu, Shoujun Li · 2022 · SSRN Electronic Journal
  11. Modulation by SIRT1-mTORC1 Pathway Microglia Pruning Retinal Ganglion Cell Dendrites
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  12. Binding of RAGE (AAs 362-367) and RIPK1 induces cognitive deficit in chronic hyperglycemia-derived neuroinflammation
    Xiaoyan Zhou, Yandong Zhu, Lin Gao, Yan Li, Hui Li, Yan Liu, Ankang Hu, Changjiang Ying, Yuanjian Song · 2022 · Research Square
  13. The Struggle of Neural Progenitors in Down Syndrome Brain: The Need for Neuromodulation Beyond Symptomatic Mitigations
    King‐Hwa Ling, Pike-See Cheah · 2022 · Malaysian Journal of Medicine and Health Sciences
  14. بیئة تعلم منتشر قائمة على التفاعل بین نمط الإبحار ومستوى السعة العقلیة لتنمیة مهارات قوة السیطرة المعرفیة لدى تلامیذ المرحلة الإعدادیة
    دالیا محمود محمد بقلاوة, هبه محمد حسن عبد الحق · 2023 · المجلة العلمية المحکمة للجمعية المصرية للکمبيوتر التعليمي
  15. Investigating Brain Alterations in the Dp1Tyb Mouse Model of Down Syndrome
    Maria Elisa Serrano Navacerrada, Eugene Kim, Bernard M. Siow, Da Ma, Loreto Rojo Gonzalez, Camilla Simmons, Darryl Hayward, Dorota Gibbins, Nisha Singh, André Strydom et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  16. Human induced pluripotent stem cell-derived microglia contribute to the pathophysiology of Fragile X syndrome via increased RAC1 signaling
    Poulomi Banerjee, Shreya Das Sharma, Karen Burr, Kimberley J. Morris, Tuula E. Ritakari, Paul S. Baxter, James D. Cooper, Alessandra Cardinalli, Srividya Subash, Evdokia Paza et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  17. P2Y12 receptor ligands enable design of fluorescent imaging probes for microglia
    Hiroshi Nonaka, Mengchu Wang, Itaru Hamachi · 2024 · Chemistry Letters
  18. Hampered AMPK-ULK1 cascade in Alzheimer’s disease (AD) instigates mitochondria dysfunctions and AD-related alterations that are alleviated by metformin
    Arnaud Mary, Samantha Barale, Fanny Eysert, Audrey Valverde, Sandra Lacas‐Gervais, Charlotte Bauer, Sabiha Eddarkaoui, Luc Buée, Valérie Buée‐Scherrer, Frédéric Checler et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  19. Impact of Cre/LoxP-Mediated Chromosome Engineering Technology on Down Syndrome Research
    Zhuo Xing, Avrium Douglas, Annie Pao, Tiffany J. Glass, Nadine P. Connor, Y. Eugene Yu · 2025 · Springer eBooks
  20. A microRNA-based Therapy against Human Medulloblastoma Validated in a Xenotransplant Model using Wild-Type Mouse Embryos
    Carlotta Spattini, Letizia La Rosa, Rui Cruz Pereira, Lidia Giantomasi, Roberta Pelizzoli, Kiril Tuntevski, Giuseppe Battaglia, Andrea Di Fonzo, Andrea Armirotti, Davide De Pietri Tonelli · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  21. El síndrome de Down
    José María Borrel Martínez, María del Carmen Ortega Bernardo, Francisco Tomás Aguirre, Fernando Moldenhauer Díaz, Rafael Fernández-Delgado Cerdá · 2025 · FMC - Formación Médica Continuada en Atención Primaria
  22. Preventing Differentiation Towards Primitive Macrophages in Stem Cells With Down Syndrome
    Koki Harada, Keiichi Ishihara, Sayaka Wakayama, Teruhiko Wakayama, Sae Yamamoto, Haruhiko Sago, Shun Shimohama, Satoshi Akiba, Florent Ginhoux, Kazuyuki Takata · 2025 · Immunology
  23. Additional file 1 of Cathepsin B abundance, activity and microglial localisation in Alzheimer’s disease-Down syndrome and early onset Alzheimer’s disease; the role of elevated cystatin B
    Yixing Wu, Paige Mumford, Suzanna Noy, Karen Cleverley, Alicja Mrzyglod, Luo, Dinghao, van Dalen, Floris, Martijn Verdoes, Elizabeth Fisher, Frances K. Wiseman · 2023 · Figshare
  24. Additional file 1 of Inhibition of microglia overactivation restores neuronal survival in a mouse model of CDKL5 deficiency disorder
    Giuseppe Galvani, Nicola Mottolese, Laura Gennaccaro, Manuela Loi, Giorgio Medici, Marianna Tassinari, Fuchs, Claudia, Elisabetta Ciani, Stefania Trazzi · 2021 · Figshare
  25. Additional file 2 of Inhibition of microglia overactivation restores neuronal survival in a mouse model of CDKL5 deficiency disorder
    Giuseppe Galvani, Nicola Mottolese, Laura Gennaccaro, Manuela Loi, Giorgio Medici, Marianna Tassinari, Fuchs, Claudia, Elisabetta Ciani, Stefania Trazzi · 2021 · Figshare
  26. Additional file 2 of Prolonged anesthesia induces neuroinflammation and complement-mediated microglial synaptic elimination involved in neurocognitive dysfunction and anxiety-like behaviors
    Xu, Feng, Han, Linlin, Wang, Yafeng, Daling Deng, Ding, Yuanyuan, Zhao, Shuai, Zhang, Qingtong, Ma, Lulin, Xiangdong Chen · 2023 · Figshare
  27. Additional file 1 of Prolonged anesthesia induces neuroinflammation and complement-mediated microglial synaptic elimination involved in neurocognitive dysfunction and anxiety-like behaviors
    Xu, Feng, Linlin Han, Wang, Yafeng, Daling Deng, Ding, Yuanyuan, Zhao, Shuai, Zhang, Qingtong, Ma, Lulin, Xiangdong Chen · 2023 · Figshare
  28. Down Syndrome
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  29. Identifying priority pollutants NO2, O3, PM2.5 and PM10 for preventive strategies against birth defects in China: A regional analysis
    Falin He, Tiancheng Xie, Xinwen Huang, Chuan Wang, Zhenglu Wang, Tian Tang · 2026 · Journal of Hazardous Materials
  30. Anti-inflammatory and pro-proliferative effects of fasudil in human trisomy 21 neural progenitor cells
    Laura L. Baxter, Sarah E. Lee, Kevin A. Fuentes, Iman A Mosley, Jonathan D. Raymond, Fayçal Guedj, Di Zhou, Donna K. Slonim, Elliot J. Glotfelty, David Tweedie et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  31. Étude du neurodéveloppement et de l'infertilité masculine chez différents modèles murins de Trisomie 21
    Rodolphe Dard · 2024
  32. Rescuing prefrontal cortical excitation-inhibition imbalance with early-life microglial ablation ameliorates ASD-like behaviors in male BTBR mice
    Xinggao Zhang, Meifeng Gong, Zhenyang Chen, Jing Luo, Zijun Zhao, Zhirui Wu, Jinghui Zhao, Yuanyuan Ma, Lina Nie, Xiaotang Fan · 2026 · Brain Behavior and Immunity
  33. Fasudil induces anti-inflammatory transcriptomic changes and increased proliferation in human trisomy 21 neural progenitor cells
    Laura L. Baxter, Sarah E. Lee, Kevin A. Fuentes, Iman A Mosley, Jonathan D. Raymond, Fayçal Guedj, Di Zhou, Donna K. Slonim, Elliot J. Glotfelty, David Tweedie et al. · 2026 · Biology Open
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  35. Glial Dysfunction and Memory Impairments in a Model of Pediatric Obstructive Sleep Apnea
    Michael R. Williamson, Jorge Botas, Mahyar J. Hedayatpour, Thea Zlatkov, Akdes Serin Harmancı, Christopher M. Yates, Kenneth J. Nobleza, Roshan Ailani, Adam C. Adler, Farrah Kheradmand et al. · 2026 · Glia