Rescuing Over-activated Microglia Restores Cognitive Performance in Juvenile Animals of the Dp(16) Mouse Model of down Syndrome.
Pinto, Bruno, Morelli, Giovanni, Rastogi, Mohit, Savardi, Annalisa, Fumagalli, Amos, Petretto, Andrea, Bartolucci, Martina, Varea, Emilio +4 more·2020·Neuron
Cited by (135)
Items 101–135 of 135
- SARS-CoV-2 Infection Causes Heightened Disease Severity and Mortality in a Mouse Model of Down SyndromeRoger D. Pechous, Priyangi A. Malaviarachchi, Zhuo Xing, Avrium Douglas, Samantha D. Crane, Hayley M. Theriot, Zijing Zhang, Alireza Ghaffarieh, Lu Huang, Y. Eugene Yu et al. · 2024 · Biomedicines
- Long-term decreased cannabinoid type-1 receptor activity restores specific neurological phenotypes in the Ts65Dn mouse model of Down syndromeAnna Vázquez‐Oliver, Silvia Pérez‐García, Nieves Pizarro, Laura Molina‐Porcel, Rafael de la Torre, Rafael J. Maldonado, Andrés Ozaita · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
- Pre-Implantation factor (PIF) restores working memory and promotes microglial ramification in the adult Dp(16)1Yey mouse model of Down syndromeRodolphe Dard, Solenn Day, Kevin Faury, Jessica Ziga, Janany Kandiah, Nadim Kassis, Yoann Rodriguez, François Vialard, Manon Moreau, Nathalie Janel · 2025 · European Journal of Pharmacology
- Targeting dysregulated CB1 receptors in a Down syndrome mouse model improves neurological outcomesAnna Vázquez‐Oliver, Silvia Pérez‐García, Rafael Romero‐Pérez, Nieves Pizarro, Diana Galarraga‐Shinin, Laura Molina‐Porcel, Rafael de la Torre, Rafael J. Maldonado, Andrés Ozaita · 2025 · Alzheimer s & Dementia
- Neuroprotective effects of quercetin in LPS-induced depression: implications for antidepressant therapyLei Sun, Zifan Ding, Jie Chen, Yirong Kong, Ye Qin, Fang Han, Longfei Du, Yuan Liu · 2026 · Progress in Neuro-Psychopharmacology and Biological Psychiatry
- Type I Interferon Signaling Drives Microglial Dysfunction and Senescence in Human iPSC Models of Down Syndrome and Alzheimer’s DiseaseMengmeng Jin, Ranjie Xu, Le Wang, Mahabub Maraj Alam, Ziyuan Ma, Sining Zhu, Alessandra Cadete Martini, Azadeh Jadali, Matteo Bernabucci, Ping Xie et al. · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
- Cathepsin B abundance, activity and microglial localisation in Alzheimer’s disease – Down syndrome and early onset Alzheimer’s disease; the role of elevated cystatin BYixing Wu, Paige Mumford, Suzanna Noy, Karen Cleverley, Alicja Mrzyglod, Dinghao Luo, Floris J. van Dalen, Martijn Verdoes, Elizabeth Fisher, Frances K. Wiseman · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
- Viral mimicry and memory deficits upon microglial deletion of ATRXSarfraz Shafiq, Arsham Ghahramani, K. Mansour, Miguel Ángel Peña-Ortiz, Julia Kathryn Sunstrum, Yan Yi Jiang, Megan E. Rowland, Wataru Inoue, Nathalie G. Bérubé · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- التفاعل بین نمط إستجابة المحادثة الآلیة الذکیة ومستواها ببیئة التعلم النقال وأثره على تنمیة التحصیل المعرفى ومهارات قوة السیطرة المعرفیة والتقبل التکنولوجى لدى طلاب معلم الحاسب الآلىآیة طلعت أحمد إسماعیل · 2021 · تکنولوجيا التعليم سلسلة دراسات وبحوث
- Co-Exposure of Alumina Nanoparticles and Chronic Stress Aggravates Hippocampal Microglia Pyroptosis by Activating Cathepsin B/Nlrp3 Signaling PathwayHaiyang Zhang, Jibin Wang, Chuqian Ruan, Zhicheng Gao, Qiuxiang Zhu, Shoujun Li · 2022 · SSRN Electronic Journal
- Modulation by SIRT1-mTORC1 Pathway Microglia Pruning Retinal Ganglion Cell DendritesKe Yao, Qianxue Mou, Xiaotong Lou, Meng Ye, Bowen Zhao, Yuanyuan Hu, Jing Luo, Hong Zhang, Xing Li, Yin Zhao · 2022 · SSRN Electronic Journal
- Binding of RAGE (AAs 362-367) and RIPK1 induces cognitive deficit in chronic hyperglycemia-derived neuroinflammationXiaoyan Zhou, Yandong Zhu, Lin Gao, Yan Li, Hui Li, Yan Liu, Ankang Hu, Changjiang Ying, Yuanjian Song · 2022 · Research Square
- The Struggle of Neural Progenitors in Down Syndrome Brain: The Need for Neuromodulation Beyond Symptomatic MitigationsKing‐Hwa Ling, Pike-See Cheah · 2022 · Malaysian Journal of Medicine and Health Sciences
- بیئة تعلم منتشر قائمة على التفاعل بین نمط الإبحار ومستوى السعة العقلیة لتنمیة مهارات قوة السیطرة المعرفیة لدى تلامیذ المرحلة الإعدادیةدالیا محمود محمد بقلاوة, هبه محمد حسن عبد الحق · 2023 · المجلة العلمية المحکمة للجمعية المصرية للکمبيوتر التعليمي
- Investigating Brain Alterations in the Dp1Tyb Mouse Model of Down SyndromeMaria Elisa Serrano Navacerrada, Eugene Kim, Bernard M. Siow, Da Ma, Loreto Rojo Gonzalez, Camilla Simmons, Darryl Hayward, Dorota Gibbins, Nisha Singh, André Strydom et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
- Human induced pluripotent stem cell-derived microglia contribute to the pathophysiology of Fragile X syndrome via increased RAC1 signalingPoulomi Banerjee, Shreya Das Sharma, Karen Burr, Kimberley J. Morris, Tuula E. Ritakari, Paul S. Baxter, James D. Cooper, Alessandra Cardinalli, Srividya Subash, Evdokia Paza et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- P2Y12 receptor ligands enable design of fluorescent imaging probes for microgliaHiroshi Nonaka, Mengchu Wang, Itaru Hamachi · 2024 · Chemistry Letters
- Hampered AMPK-ULK1 cascade in Alzheimer’s disease (AD) instigates mitochondria dysfunctions and AD-related alterations that are alleviated by metforminArnaud Mary, Samantha Barale, Fanny Eysert, Audrey Valverde, Sandra Lacas‐Gervais, Charlotte Bauer, Sabiha Eddarkaoui, Luc Buée, Valérie Buée‐Scherrer, Frédéric Checler et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- Impact of Cre/LoxP-Mediated Chromosome Engineering Technology on Down Syndrome ResearchZhuo Xing, Avrium Douglas, Annie Pao, Tiffany J. Glass, Nadine P. Connor, Y. Eugene Yu · 2025 · Springer eBooks
- A microRNA-based Therapy against Human Medulloblastoma Validated in a Xenotransplant Model using Wild-Type Mouse EmbryosCarlotta Spattini, Letizia La Rosa, Rui Cruz Pereira, Lidia Giantomasi, Roberta Pelizzoli, Kiril Tuntevski, Giuseppe Battaglia, Andrea Di Fonzo, Andrea Armirotti, Davide De Pietri Tonelli · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- El síndrome de DownJosé María Borrel Martínez, María del Carmen Ortega Bernardo, Francisco Tomás Aguirre, Fernando Moldenhauer Díaz, Rafael Fernández-Delgado Cerdá · 2025 · FMC - Formación Médica Continuada en Atención Primaria
- Preventing Differentiation Towards Primitive Macrophages in Stem Cells With Down SyndromeKoki Harada, Keiichi Ishihara, Sayaka Wakayama, Teruhiko Wakayama, Sae Yamamoto, Haruhiko Sago, Shun Shimohama, Satoshi Akiba, Florent Ginhoux, Kazuyuki Takata · 2025 · Immunology
- Additional file 1 of Cathepsin B abundance, activity and microglial localisation in Alzheimer’s disease-Down syndrome and early onset Alzheimer’s disease; the role of elevated cystatin BYixing Wu, Paige Mumford, Suzanna Noy, Karen Cleverley, Alicja Mrzyglod, Luo, Dinghao, van Dalen, Floris, Martijn Verdoes, Elizabeth Fisher, Frances K. Wiseman · 2023 · Figshare
- Additional file 1 of Inhibition of microglia overactivation restores neuronal survival in a mouse model of CDKL5 deficiency disorderGiuseppe Galvani, Nicola Mottolese, Laura Gennaccaro, Manuela Loi, Giorgio Medici, Marianna Tassinari, Fuchs, Claudia, Elisabetta Ciani, Stefania Trazzi · 2021 · Figshare
- Additional file 2 of Inhibition of microglia overactivation restores neuronal survival in a mouse model of CDKL5 deficiency disorderGiuseppe Galvani, Nicola Mottolese, Laura Gennaccaro, Manuela Loi, Giorgio Medici, Marianna Tassinari, Fuchs, Claudia, Elisabetta Ciani, Stefania Trazzi · 2021 · Figshare
- Additional file 2 of Prolonged anesthesia induces neuroinflammation and complement-mediated microglial synaptic elimination involved in neurocognitive dysfunction and anxiety-like behaviorsXu, Feng, Han, Linlin, Wang, Yafeng, Daling Deng, Ding, Yuanyuan, Zhao, Shuai, Zhang, Qingtong, Ma, Lulin, Xiangdong Chen · 2023 · Figshare
- Additional file 1 of Prolonged anesthesia induces neuroinflammation and complement-mediated microglial synaptic elimination involved in neurocognitive dysfunction and anxiety-like behaviorsXu, Feng, Linlin Han, Wang, Yafeng, Daling Deng, Ding, Yuanyuan, Zhao, Shuai, Zhang, Qingtong, Ma, Lulin, Xiangdong Chen · 2023 · Figshare
- Down SyndromeMaria D. Torres, Isabel Rivera, Jorge A. Busciglio · 2026 · Springer eBooks
- Identifying priority pollutants NO2, O3, PM2.5 and PM10 for preventive strategies against birth defects in China: A regional analysisFalin He, Tiancheng Xie, Xinwen Huang, Chuan Wang, Zhenglu Wang, Tian Tang · 2026 · Journal of Hazardous Materials
- Anti-inflammatory and pro-proliferative effects of fasudil in human trisomy 21 neural progenitor cellsLaura L. Baxter, Sarah E. Lee, Kevin A. Fuentes, Iman A Mosley, Jonathan D. Raymond, Fayçal Guedj, Di Zhou, Donna K. Slonim, Elliot J. Glotfelty, David Tweedie et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- Étude du neurodéveloppement et de l'infertilité masculine chez différents modèles murins de Trisomie 21Rodolphe Dard · 2024
- Rescuing prefrontal cortical excitation-inhibition imbalance with early-life microglial ablation ameliorates ASD-like behaviors in male BTBR miceXinggao Zhang, Meifeng Gong, Zhenyang Chen, Jing Luo, Zijun Zhao, Zhirui Wu, Jinghui Zhao, Yuanyuan Ma, Lina Nie, Xiaotang Fan · 2026 · Brain Behavior and Immunity
- Fasudil induces anti-inflammatory transcriptomic changes and increased proliferation in human trisomy 21 neural progenitor cellsLaura L. Baxter, Sarah E. Lee, Kevin A. Fuentes, Iman A Mosley, Jonathan D. Raymond, Fayçal Guedj, Di Zhou, Donna K. Slonim, Elliot J. Glotfelty, David Tweedie et al. · 2026 · Biology Open
- Targeting the protein tyrosine phosphatase 1B signaling axis in Alzheimer's disease: Emerging therapeutic potential of ivermectin.Ritu Singh, Tripti Paliwal, Radhika Joshi, Vartika Paliwal, Priyanka Dubey, S. Bhardwaj, Smita Jain, S. Paliwal, Swapnil Sharma · 2026 · Biochemical and Biophysical Research Communications - BBRC
- Glial Dysfunction and Memory Impairments in a Model of Pediatric Obstructive Sleep ApneaMichael R. Williamson, Jorge Botas, Mahyar J. Hedayatpour, Thea Zlatkov, Akdes Serin Harmancı, Christopher M. Yates, Kenneth J. Nobleza, Roshan Ailani, Adam C. Adler, Farrah Kheradmand et al. · 2026 · Glia