Enhancing myelin renewal reverses cognitive dysfunction in a murine model of Alzheimer’s disease

Neuroinflammation in Alzheimer's disease

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Oligodendroglia metabolically support axons and contribute to neurodegeneration

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Oligodendrocyte-specific knockout of FPN1 affects CNS myelination defects and depression-like behavior in mice

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Oligodendrocytes and myelination: pioneering new frontiers in cognitive neuroscience

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White matter damage in Alzheimer’s disease: contribution of oligodendrocytes

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Developing a human iPSC-derived three-dimensional myelin spheroid platform for modeling myelin diseases

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Clemastine-induced enhancement of hippocampal myelination alleviates memory impairment in mice with chronic pain

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Dynamics of myelin deficits in the 5xFAD mouse model for Alzheimer's disease and the protective role of BDNF

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Recognizing Alzheimer's disease from perspective of oligodendrocytes: Phenomena or pathogenesis?

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Astrocyte-secreted C3 signaling impairs neuronal development and cognition in autoimmune diseases

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Emerging Role of Oligodendrocytes Malfunction in the Progression of Alzheimer's Disease

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Cure of Alzheimer’s Dementia Requires Addressing All of the Affected Brain Cell Types

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Dysregulated Cholinergic Signaling Inhibits Oligodendrocyte Maturation Following Demyelination

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Sleep Deprivation Impairs Learning-Induced Increase in Hippocampal Sharp Wave Ripples and Associated Spike Dynamics during Recovery Sleep

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Oligodendrogenesis in Evolution, Development and Adulthood

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Mesenchymal stem cell-derived exosomes–a promising therapeutic approach to improve neurocognitive disorders in chronic obstructive pulmonary disease

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Drug repurposing: Clemastine fumarate and neurodegeneration

Zhu, J., Ma, R., & Li, G. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113904 · Cited by 16

The several ways to authentically cure Alzheimer’s dementia

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Utilizing hiPSC-derived oligodendrocytes to study myelin pathophysiology in neuropsychiatric and neurodegenerative disorders.

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Single‐cell transcriptomics analysis of cellular heterogeneity and immune mechanisms in neurodegenerative diseases

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Integrated Genomic, Transcriptomic and Proteomic Analysis for Identifying Markers of Alzheimer’s Disease

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New, Fully Implantable Device for Selective Clearance of CSF-Target Molecules: Proof of Concept in a Murine Model of Alzheimer’s Disease

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Roles of osteocalcin in the central nervous system

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Human longevity and Alzheimer’s disease variants act via microglia and oligodendrocyte gene networks

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Isoliensinine ameliorates cognitive dysfunction in AlCl3/D-gal-induced Alzheimer’s disease-like mice by inhibiting the calcium signaling pathway

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Targeting S100A9 attenuates social dysfunction by modulating neuroinflammation and myelination in a mouse model of autism

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Serum/glucocorticoid regulated kinase 1 (SGK1) in neurological disorders: pain or gain

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White Matter “Matters” in Alzheimer’s Disease

Xu, M., Xu, Z., & Wang, Y. (2021) · Neuroscience Bulletin · doi:10.1007/s12264-021-00803-8 · Cited by 14

LMP2 deficiency causes abnormal metabolism, oxidative stress, neuroinflammation, myelin loss and neurobehavioral dysfunctions

Chen, X., Mao, Y., Guo, Y., Xiao, D., Lin, Z., Huang, Y., Liu, Y. C., Zhang, X., & Wang, Y. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04071-0 · Cited by 14

Choline transporters are required for oligodendrocyte differentiation and myelin sheath formation in mouse postnatal brain

Liu, M., Yu, B., Xia, Y., Cheng, Q., Chen, Y., Gao, X., Wu, S.-L., Wang, F., Li, T., Xiao, L., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115852 · Cited by 12

Brain–Bone Axis in Physiological and Pathological Conditions

Massaccesi, L., Romanelli, M. M. C., & Galliera, E. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26199822 · Cited by 13

The role and potential therapeutic targets of astrocytes in central nervous system demyelinating diseases

Tan, R., Hong, R., Sui, C., Yang, D., Tian, H., Zhu, T., & Yang, Y. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1233762 · Cited by 13

Lateralized brunt of sleep deprivation on white matter injury in a rat model of Alzheimer’s disease

Mao, X., Han, D., Guo, W., Zhang, W., Wang, H., Zhang, G., Zhang, N., Jin, L.-Y., Nie, B., Li, H., et al. (2023) · GeroScience · doi:10.1007/s11357-023-01000-3 · Cited by 12

Demyelination and impaired oligodendrogenesis in the corpus callosum following lead exposure

Liu, L. L., Emir, U. E., Gu, H., Sang, L. T., Sawiak, S. J., Cannon, J. R., Du, Y., & Zheng, W. (2024) · Toxicological Sciences · doi:10.1093/toxsci/kfae100 · Cited by 12

Unraveling the Roles of UBE3A in Neurodevelopment and Neurodegeneration

Yang, X., & Huang, Y. A. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26052304 · Cited by 12

Multimodal imaging of microstructural cerebral alterations and loss of synaptic density in Alzheimer’s disease

Moallemian, S., Salmon, É., Bahri, M. A., Beliy, N., Delhaye, E., Balteau, E., Degueldre, C., Phillips, C. L. M., & Bastin, C. (2023) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2023.08.001 · Cited by 16

Inhibition of GPR17/ID2 Axis Improve Remyelination and Cognitive Recovery after SAH by Mediating OPC Differentiation in Rat Model

Wang, Y., Jiang, A., Yan, J., Wen, D., Gu, N., Li, Z., Sun, X., Wu, Y., & Guo, Z. (2023) · Translational Stroke Research · doi:10.1007/s12975-023-01201-0 · Cited by 13

The Multifaceted Role of Extracellular Vesicles in Alzheimer's Disease

Conceição, A. R., Marinatto, J., Pinheiro, L. S., Rody, T., & Felice, F. G. D. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.70209 · Cited by 15

Immune–stem cell crosstalk in the central nervous system: how oligodendrocyte progenitor cells interact with immune cells

Cabeza‐Fernández, S., White, J. A., McMurran, C. E., Gomez-Sanchez, J. A., & de la Fuente, A. G. (2022) · Immunology and Cell Biology · doi:10.1111/imcb.12610 · Cited by 12

Progress on the hippocampal circuits and functions based on sharp wave ripples

Xie, B., Zhen, Z., Guo, O., Li, H., Guo, M., & Zhen, J. (2023) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2023.110695 · Cited by 13

Minimum effective dose of clemastine in a mouse model of preterm white matter injury

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Reflective imaging of myelin integrity in the human and mouse central nervous systems

Craig, G. A., Ryan, L., Thapar, J., McNamara, N. B., Hoffmann, A., Page, D., Rose, J. L., Cox, S. R., & Miron, V. E. (2024) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2024.1408182 · Cited by 12

Demyelination of the amygdala mediates psychological stress-induced emotional disorders partially contributed by activation of P2X7R/NLRP3 cascade

Li, Y., Zhang, Y., Lin, D., Fu, X., & Jing, C. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.12.023 · Cited by 12

The potential link between the development of Alzheimer’s disease and osteoporosis

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Clemastine attenuates subarachnoid haemorrhage pathology in a mouse model via Nrf2/SQSTM1‐mediated autophagy

Zou, Y., Tao, Z., Li, P., Yang, J., Xu, Q., Xu, X., Miao, Z., & Zhao, X. (2025) · British Journal of Pharmacology · doi:10.1111/bph.17465 · Cited by 11

Ventromedial Thalamus-Projecting DCN Neurons Modulate Associative Sensorimotor Responses in Mice

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Electroacupuncture promotes remyelination and alleviates cognitive deficit via promoting OPC differentiation in a rat model of subarachnoid hemorrhage

Wang, Y., Yang, X., Cao, Y., Li, X., Xu, R. C., Yan, J., Guo, Z., Sun, S., Sun, X., & Wu, Y. (2022) · Metabolic Brain Disease · doi:10.1007/s11011-022-01102-5 · Cited by 12

Evidence That DDR1 Promotes Oligodendrocyte Differentiation during Development and Myelin Repair after Injury

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Slc22a17 governs postnatal neurogenesis by maintaining the iron homeostasis in hippocampus

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Enhancing axonal myelination: Clemastine attenuates cognitive impairment in a rat model of diffuse traumatic brain injury

Huang, Z., Feng, Y., Zhang, Y., Ma, X., Zong, X., Jordan, J. D., & Zhang, Q. (2024) · Translational research · doi:10.1016/j.trsl.2024.01.008 · Cited by 13

Xinshubao tablet rescues cognitive dysfunction in a mouse model of vascular dementia: Involvement of neurogenesis and neuroinflammation

Xiao, H., Zhang, F.-R., Li, S., Guo, F., Jin-li, H., Wang, S.-C., Yu, J., Li, X., & Yang, H. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116219 · Cited by 10

Lead Acetate Exposure and Cerebral Amyloid Accumulation: Mechanistic Evaluations in APP/PS1 Mice

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The Link Between Paraquat and Demyelination: A Review of Current Evidence

Silva, R. V. D. S., Sobral, A. F., Dinis‐Oliveira, R. J., & Barbosa, D. J. (2024) · Antioxidants · doi:10.3390/antiox13111354 · Cited by 11

Lingo1 in the hippocampus contributes to cognitive dysfunction after anesthesia and surgery in aged mice

Liu, C., Zhang, C., Chen, L., Liu, X., Wu, J., Sun, Y., Liu, J., & Chen, C. (2024) · International Journal of Biological Sciences · doi:10.7150/ijbs.98376 · Cited by 10

Unveiling the impact of ferroptosis on diabetes‐associated cognitive decline through comprehensive single‐cell RNA sequencing and experimental studies

Zhang, Y., Hu, X., Chen, S., Hua, F., & Zeng, Z. (2025) · FEBS Journal · doi:10.1111/febs.70101 · Cited by 10

Oligomeric amyloid beta prevents myelination in a clusterin-dependent mannerPreprint

Beiter, R. M., Ennerfelt, H. E., Rivet-Noor, C. R., Merchak, A. R., Bai, R., Johanson, D. M., Slogar, E. R., Sol‐Church, K., Phillips, J. L., Bathe, T., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.03.06.981373 · Cited by 11

Is age-related myelinodegenerative change an initial risk factor of neurodegenerative diseases?

Wu, S., & Chen, J. (2025) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-24-00848 · Cited by 9

Deficient deposition of new myelin impairs adult optic nerve function in a murine model of diabetes

Wu, H., Chen, X., Yu, B., Zhang, J., Gu, X., Liu, W., Mei, F., Ye, J., & Xiao, L. (2023) · Glia · doi:10.1002/glia.24341 · Cited by 9

Brain region-specific myelinogenesis is not directly linked to amyloid-β in APP/PS1 transgenic mice

Wu, S.-L., Yu, B., Cheng, Y.-J., Ren, S.-Y., Wang, F., Xiao, L., Chen, J., & Mei, F. (2023) · Experimental Neurology · doi:10.1016/j.expneurol.2023.114344 · Cited by 9

Alleviating early demyelination in ischaemia/reperfusion by inhibiting sphingosine‐1‐phosphate receptor 2 could protect visual function from impairment

Xue, J., Lin, J., Liu, Z., Zhang, Q., Tang, J., Han, J., Wu, S., Liu, C., Zhao, L., Li, Y., et al. (2023) · Brain Pathology · doi:10.1111/bpa.13161 · Cited by 8

Clemastine fumarate attenuates tauopathy and meliorates cognition in hTau mice via autophagy enhancement

Zhu, J., Jiang, X., Chang, Y., Wu, Y., Sun, S., Wang, C., Zheng, S., Wang, M., Yao, Y., Li, G., et al. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110649 · Cited by 9

Myelin organoids for the study of Alzheimer's disease

Cerneckis, J., & Shi, Y. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1283742 · Cited by 9

Paired vagus nerve stimulation drives precise remyelination and motor recovery after myelin loss

Huang, R., Carter, E., Hughes, E. G., & Welle, C. G. (2024) · Neuromodec journal. · doi:10.31641/nmj-fdgu6868 · Cited by 9

Promoting remyelination in central nervous system diseases: Potentials and prospects of natural products and herbal medicine

Zhu, H., Hu, E., Guo, X. H., Yuan, Z., Jiang, H., Zhang, W., Tang, T., Wang, Y., & Li, T. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107533 · Cited by 9

The Role of Oligodendrocyte Lineage Cells in the Pathogenesis of Alzheimer’s Disease

Liu, X., Lv, Z., Huang, Q., Lei, Y., Liu, H., & Xu, P. (2025) · Neurochemical Research · doi:10.1007/s11064-024-04325-3 · Cited by 9

Nalfurafine promotes myelination in vitro and facilitates recovery from cuprizone + rapamycin‐induced demyelination in mice

van de Wetering, R., Bibi, R., Biggerstaff, A., Hong, S., Pengelly, B., Prisinzano, T. E., Flamme, A. C. L., & Kivell, B. M. (2024) · Glia · doi:10.1002/glia.24583 · Cited by 8

The role of TREM2 in myelin sheath dynamics: A comprehensive perspective from physiology to pathology

Que, X., Zhang, T., Liu, X. Y., Yin, Y., Xia, X., Gong, P., Song, W., Qin, Q., Xu, Q., & Tang, Y. (2025) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2025.102732 · Cited by 8

Huangqi Guizhi Wuwu decoction alleviate Oxaliplatin-Induced Peripheral Neuropathy by adjusting the myelin regeneration

Yang, X., Zhu, H., Li, Z., Wang, Q., Gao, Y., Li, Z., Tao, L., Li, L., Sun, D., Zhang, L., et al. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.157039 · Cited by 8

Hypomyelination in autism-associated neuroligin-3 mutant mice impairs parvalbumin interneuron excitability, gamma oscillations, and sensory discrimination

He, Y., Li, J., Zheng, W., Liu, J., Dong, Z.-J., Lü, Y., Tang, S., Zou, Y., Gao, T., Yang, Y., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-61455-0 · Cited by 8

PM2.5 exposure exacerbates Alzheimer's disease pathology through lysosomal dysfunction in APP/PS1 mice

Wei, M., Li, W., Bao, G., Yang, Z., Li, S., & Le, W. (2025) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2025.118918 · Cited by 12

Seed-induced Aβ deposits in the corpus callosum disrupt white matter integrity in a mouse model of Alzheimer’s disease

Aires, V., Ziegler‐Waldkirch, S., Friesen, M., Reichardt, W., Erny, D., Loreth, D., Harborne, A. C., Kretz, O., von Elverfeldt, D., & Meyer‐Luehmann, M. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.862918 · Cited by 8

Hydrogen peroxide in breast milk is crucial for gut microbiota formation and myelin development in neonatal mice

Kambe, J., Usuda, K., Inoüe, R., Hirayama, K., Ito, M., Suenaga, K., Masukado, S., Liu, H., Miyata, S., Li, C., et al. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2359729 · Cited by 8

Amyloid‐β Dysregulates Oligodendroglial Lineage Cell Dynamics and Myelination via PKC in the Zebrafish Spinal Cord

Balantzategi, U., Gaminde‐Blasco, A., Kearns, C. A., Bayón‐Cordero, L., Sánchez‐Gómez, M. V., Zugaza, J. L., Appel, B., & Alberdi, E. M. (2025) · Glia · doi:10.1002/glia.70015 · Cited by 9

Linking Plasma Amyloid Beta and Neurofilament Light Chain to Intracortical Myelin Content in Cognitively Normal Older Adults

Fernandez-Alvarez, M., Atienza, M., Zallo, F., Matute, C., Capetillo‐Zarate, E., & Cantero, J. L. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.896848 · Cited by 8

Alzheimer’s Disease-Related Phospho-Tau181 Signals Are Localized to Demyelinated Axons of Parvalbumin-Positive GABAergic Interneurons in an App Knock-In Mouse Model of Amyloid-β Pathology

Hirota, Y., Sakakibara, Y., Takei, K., Nishijima, R., Sekiya, M., & Iijima, K. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-230121 · Cited by 10

ApoE and immunity in Alzheimer’s disease and related tauopathies: Low-density lipoprotein receptor to the rescue

Mendiola, A. S., Tognatta, R., Yan, Z., & Akassoglou, K. (2021) · Neuron · doi:10.1016/j.neuron.2021.07.013 · Cited by 8

Early axonal degeneration linked to clinical decline in Alzheimer’s disease progression revealed with diffusion MRI

Gong, Z., Laporte, J. P., Guo, A. Y., Bilgel, M., Bae, J., Fox, N. Y., de Rouen, A., Zhang, N., Taranath, A., de Cabo, R., et al. (2026) · Journal of Clinical Investigation · doi:10.1172/jci196638 · Cited by 7

Demyelination in the medial prefrontal cortex by withdrawal from chronic nicotine causes impaired cognitive memory

Huang, B. Y., Chen, Z., Huang, F., Gao, F., Chen, J., Liu, P., Lu, Z., Chen, W., & Wu, J. (2023) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2023.110901 · Cited by 7

The Biological Intersection Between Chemotherapy-Related Cognitive Impairment and Alzheimer Disease

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G protein–coupled estrogen receptor deficiency exacerbates demyelination through microglial ferroptosis

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