Remyelination in the CNS: from biology to therapy

Rejuvenation of aged progenitor cells by exposure to a young systemic environment

Conboy, I. M., Conboy, M. J., Wagers, A. J., Girma, E. R., Weissman, I. L., & Rando, T. A. (2005) · Nature · doi:10.1038/nature03260 · Cited by 2,287 · see citing works

Multiple sclerosis

Compston, A., & Coles, A. (2002) · The Lancet · doi:10.1016/s0140-6736(02)08220-x · Cited by 1,743 · see citing works

Multiple Sclerosis: An Immune or Neurodegenerative Disorder?

Trapp, B. D., & Nave, K.-A. (2008) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.30.051606.094313 · Cited by 1,724 · see citing works

Cellular mechanotransduction: putting all the pieces together again

Ingber, D. E. (2006) · The FASEB Journal · doi:10.1096/fj.05-5424rev · Cited by 1,627 · see citing works

Rate of Pregnancy-Related Relapse in Multiple Sclerosis

Confavreux, C., Hutchinson, M., Hours, M. M., Cortinovis-Tourniaire, P., & Moreau, T. (1998) · New England Journal of Medicine · doi:10.1056/nejm199807303390501 · Cited by 1,559 · see citing works

Competing waves of oligodendrocytes in the forebrain and postnatal elimination of an embryonic lineage

Kessaris, N., Fogarty, M., Iannarelli, P., Grist, M., Wegner, M., & Richardson, W. D. (2006) · Nature Neuroscience · doi:10.1038/nn1620 · Cited by 1,195 · see citing works

Cost of disorders of the brain in Europe

Andlin‐Sobocki, P., Jönsson, B., Wïttchen, H., & Olesen, J. (2005) · European Journal of Neurology · doi:10.1111/j.1468-1331.2005.01202.x · Cited by 1,139 · see citing works

Injection of adult neurospheres induces recovery in a chronic model of multiple sclerosis

Pluchino, S., Quattrini, A., Brambilla, E., Gritti, A., Salani, G., Dina, G., Galli, R., Carro, U. D., Amadio, S., Bergami, A., et al. (2003) · Nature · doi:10.1038/nature01552 · Cited by 1,071 · see citing works

Glutamatergic synapses on oligodendrocyte precursor cells in the hippocampus

Bergles, D. E., Roberts, J. D. B., Somogyi, P., & Jahr, C. E. (2000) · Nature · doi:10.1038/35012083 · Cited by 1,062 · see citing works

Disruption of Cnp1 uncouples oligodendroglial functions in axonal support and myelination

Lappe-Siefke, C., Goebbels, S., Gravel, M., Nicksch, E., Lee, J., Braun, P. E., Griffiths, I. R., & Nave, K.-A. (2003) · Nature Genetics · doi:10.1038/ng1095 · Cited by 1,036 · see citing works

TNFα promotes proliferation of oligodendrocyte progenitors and remyelination

Arnett, H. A., Mason, J., Marino, M., Suzuki, K., Matsushima, G. K., & Ting, J. P.-Y. (2001) · Nature Neuroscience · doi:10.1038/nn738 · Cited by 1,012 · see citing works

Premyelinating Oligodendrocytes in Chronic Lesions of Multiple Sclerosis

Chang, A., Tourtellotte, W. W., Rudick, R., & Trapp, B. D. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa010994 · Cited by 991 · see citing works

The Neurotoxicant, Cuprizone, as a Model to Study Demyelination and Remyelination in the Central Nervous System

Matsushima, G. K., & Morell, P. (2001) · Brain Pathology · doi:10.1111/j.1750-3639.2001.tb00385.x · Cited by 984 · see citing works

Embryonic Stem Cell-Derived Glial Precursors: A Source of Myelinating Transplants

Brüstle, O., Jones, K. N., Learish, R. D., Karram, K., Choudhary, K., Wiestler, O. D., Duncan, I. D., & McKay, R. D. G. (1999) · Science · doi:10.1126/science.285.5428.754 · Cited by 976 · see citing works

Origin of oligodendrocytes in the subventricular zone of the adult brain

Menn, B., Garcia-Verdugo, J. M., Yaschine, C., Gonzalez-Perez, O., Rowitch, D., & Alvarez-Buylla, A. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.1299-06.2006 · Cited by 972 · see citing works

Axonal Neuregulin-1 Regulates Myelin Sheath Thickness

Michailov, G. V., Sereda, M. W., Brinkmann, B. G., Fischer, T. M., Haug, B., Birchmeier, C., Role, L. W., Lai, C., Schwab, M. H., & Nave, K. (2004) · Science · doi:10.1126/science.1095862 · Cited by 940 · see citing works

Late Oligodendrocyte Progenitors Coincide with the Developmental Window of Vulnerability for Human Perinatal White Matter Injury

Back, S. A., Luo, N. L., Borenstein, N. S., Levine, J. M., Volpe, J. J., & Kinney, H. C. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-04-01302.2001 · Cited by 936 · see citing works

NG2-expressing glial progenitor cells: an abundant and widespread population of cycling cells in the adult rat CNS

Dawson, M. (2003) · Molecular and Cellular Neuroscience · doi:10.1016/s1044-7431(03)00210-0 · Cited by 927 · see citing works

Multiple Sclerosis and Chronic Autoimmune Encephalomyelitis

Kornek, B., Storch, M. K., Weissert, R., Wallstroem, E., Stefferl, A., Olsson, T. P., Linington, C., Schmidbauer, M., & Lassmann, H. (2000) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64537-3 · Cited by 914 · see citing works

Axonal Swellings and Degeneration in Mice Lacking the Major Proteolipid of Myelin

Griffiths, I., Klugmann, M., Anderson, T., Yool, D., Thomson, C., Schwab, M. H., Schneider, A., Zimmermann, F., McCulloch, M., Nadon, N., et al. (1998) · Science · doi:10.1126/science.280.5369.1610 · Cited by 889 · see citing works

Mitochondrial dysfunction as a cause of axonal degeneration in multiple sclerosis patients

Dutta, R., McDonough, J., Yin, X., Peterson, J. W., Chang, A., Torres, T., Gudz, T. I., Macklin, W. B., Lewis, D., Fox, R., et al. (2006) · Annals of Neurology · doi:10.1002/ana.20736 · Cited by 881 · see citing works

Oligodendrocyte Precursor Cells Reprogrammed to Become Multipotential CNS Stem Cells

Kondo, T., & RAFF, M. C. (2000) · Science · doi:10.1126/science.289.5485.1754 · Cited by 880 · see citing works

Differentiation block of oligodendroglial progenitor cells as a cause for remyelination failure in chronic multiple sclerosis

Kuhlmann, T., Miron, V., Cuo, Q., Wegner, C., Antel, J., & Bruck, W. (2008) · Brain · doi:10.1093/brain/awn096 · Cited by 864 · see citing works

Why does remyelination fail in multiple sclerosis?

Franklin, R. J. M. (2002) · Nature reviews. Neuroscience · doi:10.1038/nrn917 · Cited by 837 · see citing works

Remyelination is extensive in a subset of multiple sclerosis patients

Patrikios, P., Stadelmann, C., Kutzelnigg, A., Rauschka, H., Schmidbauer, M., Laursen, H., Sorensen, P. S., Bruck, W., Lucchinetti, C., & Lassmann, H. (2006) · Brain · doi:10.1093/brain/awl217 · Cited by 807 · see citing works

Proliferation and Differentiation of Progenitor Cells Throughout the Intact Adult Rat Spinal Cord

Horner, P. J., Power, A. E., Kempermann, G., Kuhn, H. G., Palmer, T. D., Winkler, J., Thal, L. J., & Gage, F. H. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-06-02218.2000 · Cited by 777 · see citing works

NMDA receptors are expressed in oligodendrocytes and activated in ischaemia

Káradóttir, R. T., Cavelier, P., Bergersen, L. H., & Attwell, D. (2005) · Nature · doi:10.1038/nature04302 · Cited by 773 · see citing works

The Neurobiology of Multiple Sclerosis: Genes, Inflammation, and Neurodegeneration

Hauser, S. L., & Oksenberg, J. R. (2006) · Neuron · doi:10.1016/j.neuron.2006.09.011 · Cited by 773 · see citing works

Myelin Impairs CNS Remyelination by Inhibiting Oligodendrocyte Precursor Cell Differentiation

Kotter, M. R., Li, W.-W., Zhao, C., & Franklin, R. J. M. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.2615-05.2006 · Cited by 768 · see citing works

Neurosphere-derived multipotent precursors promote neuroprotection by an immunomodulatory mechanism

Pluchino, S., Zanotti, L., Rossi, B., Brambilla, E., Ottoboni, L., Salani, G., Martinello, M., Cattalini, A., Bergami, A., Furlan, R., et al. (2005) · Nature · doi:10.1038/nature03889 · Cited by 762 · see citing works

NG2-Positive Oligodendrocyte Progenitor Cells in Adult Human Brain and Multiple Sclerosis Lesions

Chang, A., Nishiyama, A., Peterson, J. W., Prineas, J. W., & Trapp, B. D. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-17-06404.2000 · Cited by 711 · see citing works

Notch Receptor Activation Inhibits Oligodendrocyte Differentiation

Wang, S., Sdrulla, A. D., diSibio, G., Bush, G., Nofziger, D., Hicks, C. D., Weinmaster, G., & Barres, B. A. (1998) · Neuron · doi:10.1016/s0896-6273(00)80515-2 · Cited by 706 · see citing works

Stem cells, ageing and the quest for immortality

Rando, T. A. (2006) · Nature · doi:10.1038/nature04958 · Cited by 695 · see citing works

Astrocytes promote myelination in response to electrical impulses

Ishibashi, T., Dakin, K. A., Stevens, B., Lee, P. R., Kozlov, S. V., Stewart, C. L., & Fields, R. D. (2006) · Neuron · doi:10.1016/j.neuron.2006.02.006 · Cited by 689 · see citing works

The oligodendrocyte precursor cell in health and disease

Levine, J. M., Reynolds, R., & Fawcett, J. W. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01691-x · Cited by 673 · see citing works

The local differentiation of myelinated axons at nodes of Ranvier

Poliak, S., & Peles, E. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1253 · Cited by 673 · see citing works

Mechanisms of axon ensheathment and myelin growth

Sherman, D. L., & Brophy, P. J. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1743 · Cited by 668 · see citing works

Ionic mechanisms of anoxic injury in mammalian CNS white matter: role of Na+ channels and Na(+)-Ca2+ exchanger

Stys, P., Waxman, S., & Ransom, B. (1992) · The Journal of Neuroscience · doi:10.1523/jneurosci.12-02-00430.1992 · Cited by 662 · see citing works

Identification and isolation of multipotential neural progenitor cells from the subcortical white matter of the adult human brain

Nunes, M. C., Roy, N. S., Keyoung, H. M., Goodman, R. R., McKhann, G. M., Jiang, L., Kang, J., Nedergaard, M., & Goldman, S. A. (2003) · Nature Medicine · doi:10.1038/nm837 · Cited by 659 · see citing works

LINGO-1 negatively regulates myelination by oligodendrocytes

Mi, S., Miller, R. H., Lee, X., Scott, M. L., Shulag-Morskaya, S., Shao, Z., Chang, J., Thill, G., Levesque, M., Zhang, M., et al. (2005) · Nature Neuroscience · doi:10.1038/nn1460 · Cited by 628 · see citing works

The Age-Related Decrease in CNS Remyelination Efficiency Is Attributable to an Impairment of Both Oligodendrocyte Progenitor Recruitment and Differentiation

Sim, F. J., Zhao, C., Penderis, J., & Franklin, R. J. M. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-07-02451.2002 · Cited by 625 · see citing works

Hyaluronan accumulates in demyelinated lesions and inhibits oligodendrocyte progenitor maturation

Back, S. A., Tuohy, T. M. F., Chen, H., Wallingford, N., Craig, A., Struve, J., Luo, N. L., Banine, F., Liu, Y., Chang, A., et al. (2005) · Nature Medicine · doi:10.1038/nm1279 · Cited by 612 · see citing works

Human embryonic stem cells differentiate into oligodendrocytes in high purity and myelinate after spinal cord transplantation

Nistor, G. I., Totoiu, M. O., Haque, N. S. K., Carpenter, M. K., & Keirstead, H. S. (2004) · Glia · doi:10.1002/glia.20127 · Cited by 580 · see citing works

Progenitor cells of the adult mouse subventricular zone proliferate, migrate and differentiate into oligodendrocytes after demyelination

Nait‐Oumesmar, B., Decker, L., Lachapelle, F., Avellana‐Adalid, V., Bachelin, C., & Van Evercooren, A. B. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00873.x · Cited by 560 · see citing works

Endogenous progenitors remyelinate demyelinated axons in the adult CNS

Gensert, J. M., & Goldman, J. E. (1997) · Neuron · doi:10.1016/s0896-6273(00)80359-1 · Cited by 544 · see citing works

Interleukin-1β Promotes Repair of the CNS

Mason, J. L., Suzuki, K., Chaplin, D. D., & Matsushima, G. K. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-18-07046.2001 · Cited by 502 · see citing works

Chronic stage multiple sclerosis lesions contain a relatively quiescent population of oligodendrocyte precursor cells

Wolswijk, G. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-02-00601.1998 · Cited by 498 · see citing works

LINGO-1 antagonist promotes spinal cord remyelination and axonal integrity in MOG-induced experimental autoimmune encephalomyelitis

Mi, S., Hu, B., Hahm, K., Luo, Y., Hui, E. S. K., Yuan, Q., Wong, W. M., Wang, L., Su, H., Chu, T., et al. (2007) · Nature Medicine · doi:10.1038/nm1664 · Cited by 493 · see citing works

Postnatal NG2 proteoglycan–expressing progenitor cells are intrinsically multipotent and generate functional neurons

Belachew, S. M., Chittajallu, R., Aguirre, A. A., Yuan, X. Q., Kirby, M., Anderson, S. M., & Gallo, V. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200210110 · Cited by 489 · see citing works

Age-dependent epigenetic control of differentiation inhibitors is critical for remyelination efficiency

Shen, S., Sandoval, J., Swiss, V. A., Li, J., Dupree, J. L., Franklin, R. J. M., & Casaccia‐Bonnefil, P. (2008) · Nature Neuroscience · doi:10.1038/nn.2172 · Cited by 486 · see citing works

Identification of an adult-specific glial progenitor cell

Wolswijk, G., & Noble, M. A. (1989) · Development · doi:10.1242/dev.105.2.387 · Cited by 485 · see citing works

Multiple sclerosis: Re-expression of a developmental pathway that restricts oligodendrocyte maturation

John, G. R., Shankar, S. L., Shafit‐Zagardo, B., Massimi, A. B., Lee, S. C., Raine, C. S., & Brosnan, C. F. (2002) · Nature Medicine · doi:10.1038/nm781 · Cited by 478 · see citing works

Rapid Conduction and the Evolution of Giant Axons and Myelinated Fibers

Hartline, D. K., & Colman, D. R. (2007) · Current Biology · doi:10.1016/j.cub.2006.11.042 · Cited by 478 · cited 1× · see citing works

Vesicular release of glutamate from unmyelinated axons in white matter

Ziskin, J. L., Nishiyama, A., Rubio, M. E., Fukaya, M., & Bergles, D. E. (2007) · Nature Neuroscience · doi:10.1038/nn1854 · Cited by 476 · see citing works

Experimental autoimmune encephalomyelitis mobilizes neural progenitors from the subventricular zone to undergo oligodendrogenesis in adult mice

Picard-Riéra, N., Decker, L., Delarasse, C., Goude, K., Nait‐Oumesmar, B., Liblau, R., Pham-Dinh, D., & Evercooren, A. B. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.192314199 · Cited by 469 · see citing works

Vesicular glutamate release from axons in white matter

Kukley, M., Capetillo‐Zarate, E., & Dietrich, D. (2007) · Nature Neuroscience · doi:10.1038/nn1850 · Cited by 460 · see citing works

Fetal and adult human oligodendrocyte progenitor cell isolates myelinate the congenitally dysmyelinated brain

Windrem, M. S., Nunes, M. C., Rashbaum, W. K., Schwartz, T. H., Goodman, R. A., McKhann, G., Roy, N. S., & Goldman, S. A. (2004) · Nature Medicine · doi:10.1038/nm974 · Cited by 451 · see citing works

Molecular changes in neurons in multiple sclerosis: Altered axonal expression of Na v 1.2 and Na v 1.6 sodium channels and Na + /Ca 2 + exchanger

Craner, M. J., Newcombe, J., Black, J. A., Hartle, C., Cuzner, M. L., & Waxman, S. G. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402765101 · Cited by 446 · see citing works

Repair of demyelinated lesions by transplantation of purified 0-2A progenitor cells

Groves, A. K., Barnett, S. C., Franklin, R. J. M., Crang, A. J., Mayer, M., Blakemore, W. F., & Noble, M. (1993) · Nature · doi:10.1038/362453a0 · Cited by 445 · see citing works

Remyelination protects axons from demyelination-associated axon degeneration

Irvine, K. A., & Blakemore, W. F. (2008) · Brain · doi:10.1093/brain/awn080 · Cited by 420 · see citing works

Neuregulin-1/ErbB Signaling Serves Distinct Functions in Myelination of the Peripheral and Central Nervous System

Brinkmann, B. G., Agarwal, A., Sereda, M. W., Garratt, A. N., Müller, T. H., Wende, H., Stassart, R. M., Nawaz, S., Humml, C., Velanac, V., et al. (2008) · Neuron · doi:10.1016/j.neuron.2008.06.028 · Cited by 419 · see citing works

bHLH Transcription Factor Olig1 Is Required to Repair Demyelinated Lesions in the CNS

Arnett, H. A., Fancy, S. P. J., Alberta, J. A., Zhao, C., Plant, S. R., Kaing, S., Raine, C. S., Rowitch, D. H., Franklin, R. J. M., & Stiles, C. D. (2004) · Science · doi:10.1126/science.1103709 · Cited by 416 · see citing works

Axonal conduction and injury in multiple sclerosis: the role of sodium channels

Waxman, S. G. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn2023 · Cited by 398 · see citing works

In vivo time-lapse imaging shows dynamic oligodendrocyte progenitor behavior during zebrafish development

Kirby, B. B., Takada, N., Latimer, A. J., Shin, J., Carney, T. J., Kelsh, R. N., & Appel, B. (2006) · Nature Neuroscience · doi:10.1038/nn1803 · Cited by 394 · see citing works

The Chemokine Receptor CXCR2 Controls Positioning of Oligodendrocyte Precursors in Developing Spinal Cord by Arresting Their Migration

Tsai, H., Frost, E. E., To, V., Robinson, S., ffrench‐Constant, C., Geertman, R. T., Ransohoff, R. M., & Miller, R. H. (2002) · Cell · doi:10.1016/s0092-8674(02)00838-3 · Cited by 388 · see citing works

Proliferating bipotential glial progenitor cells in adult rat optic nerve

ffrench‐Constant, C., & RAFF, M. C. (1986) · Nature · doi:10.1038/319499a0 · Cited by 385 · see citing works

Macrophage depletion impairs oligodendrocyte remyelination following lysolecithin-induced demyelination

Kotter, M. R., Setzu, A., Sim, F. J., Van Rooijen, N., & Franklin, R. J. M. (2001) · Glia · doi:10.1002/glia.1085 · Cited by 385 · see citing works

Oligodendrocyte wars

Richardson, W. D., Kessaris, N., & Pringle, N. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn1826 · Cited by 385 · see citing works

Spiking and nonspiking classes of oligodendrocyte precursor glia in CNS white matter

Káradóttir, R. T., Hamilton, N. B., Bakiri, Y., & Attwell, D. (2008) · Nature Neuroscience · doi:10.1038/nn2060 · Cited by 370 · see citing works

F3/Contactin Acts as a Functional Ligand for Notch during Oligodendrocyte Maturation

Hu, Q., Ang, B.-T., Karsak, M., Hu, W.-P., Cui, X., Duka, T., Takeda, Y., Chia, W., Sankar, N., Ng, Y., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00810-9 · Cited by 367 · see citing works

A functional role for EGFR signaling in myelination and remyelination

Aguirre, A. A., Dupree, J. L., Mangin, J., & Gallo, V. (2007) · Nature Neuroscience · doi:10.1038/nn1938 · Cited by 352 · see citing works

The genetics of multiple sclerosis: SNPs to pathways to pathogenesis

Oksenberg, J. R., Baranzini, S. E., Sawcer, S., & Hauser, S. L. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2395 · Cited by 347 · see citing works

Generation of oligodendrocyte precursor cells from mouse dorsal spinal cord independent of Nkx6 regulation and Shh signaling.

Cai, J., Qi, Y., Hu, X.-M., Tan, M., Liu, Z., Zhang, J.-S., Li, Q., Sander, M., & Qiu, M.-S. (2005) · Neuron · doi:10.1016/j.neuron.2004.12.028 · Cited by 345 · see citing works

Oligodendrocytes promote neuronal survival and axonal length by distinct intracellular mechanisms: a novel role for oligodendrocyte-derived glial cell line-derived neurotrophic factor

Wilkins, A., Majed, H., Layfield, R., Compston, A., & Chandran, S. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-12-04967.2003 · Cited by 337 · see citing works

Activation of the subventricular zone in multiple sclerosis: Evidence for early glial progenitors

Nait-Oumesmar, B., Picard-Riéra, N., Kerninon, C., Decker, L., Seilhean, D., Höglinger, G., Hirsch, E., Reynolds, R., & Evercooren, A. B.-V. (2007) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0606835104 · Cited by 336 · see citing works

Transplanted Olfactory Ensheathing Cells Remyelinate and Enhance Axonal Conduction in the Demyelinated Dorsal Columns of the Rat Spinal Cord

Imaizumi, T., Lankford, K. L., Waxman, S. G., Greer, C. A., & Kocsis, J. D. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-16-06176.1998 · Cited by 336 · see citing works

Platelet-derived growth factor regulates oligodendrocyte progenitor numbers in adult CNS and their response following CNS demyelination

Woodruff, R. H., Fruttiger, M., Richardson, W. D., & Franklin, R. J. M. (2004) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2003.10.014 · Cited by 335 · see citing works

Central remyelination restores secure conduction

Smith, K. J., Blakemore, W. F., & MCDONALD, W. I. (1979) · Nature · doi:10.1038/280395a0 · Cited by 332 · see citing works

Macrophage-depletion induced impairment of experimental CNS remyelination is associated with a reduced oligodendrocyte progenitor cell response and altered growth factor expression

Kotter, M. R., Zhao, C., van Rooijen, N., & Franklin, R. J. M. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2004.09.019 · Cited by 331 · see citing works

Remyelinated Lesions in Multiple Sclerosis

Barkhof, F., Brück, W., Groot, C. J. A. D., Bergers, E., Hulshof, S. C. J., Geurts, J. J. G., Polman, C. H., & van der Valk, P. (2003) · Archives of Neurology · doi:10.1001/archneur.60.8.1073 · Cited by 328 · see citing works

Oligodendroglial modulation of fast axonal transport in a mouse model of hereditary spastic paraplegia

Edgar, J. M., McLaughlin, M., Yool, D., Zhang, S.-C., Fowler, J. H., Montague, P., Barrie, J. A., McCulloch, M. C., Duncan, I. D., Garbern, J., et al. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200312012 · Cited by 328 · see citing works

NGF Controls Axonal Receptivity to Myelination by Schwann Cells or Oligodendrocytes

Chan, J. R., Watkins, T. A., Cosgaya, J. M., Zhang, C., Chen, L., Reichardt, L. F., Shooter, E. M., & Barres, B. A. (2004) · Neuron · doi:10.1016/j.neuron.2004.06.024 · Cited by 326 · see citing works

Histone modifications affect timing of oligodendrocyte progenitor differentiation in the developing rat brain

Shen, S., Li, J., & Casaccia‐Bonnefil, P. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200412101 · Cited by 320 · see citing works

Neonatal Chimerization with Human Glial Progenitor Cells Can Both Remyelinate and Rescue the Otherwise Lethally Hypomyelinated Shiverer Mouse

Windrem, M. S., Schanz, S. J., Guo, M., Tian, G.-F., Washco, V., Stanwood, N. L., Rasband, M. N., Roy, N. S., Nedergaard, M., Havton, L. A., et al. (2008) · Cell stem cell · doi:10.1016/j.stem.2008.03.020 · Cited by 315 · see citing works

Remyelination can be extensive in multiple sclerosis despite a long disease course

Patani, R., Balaratnam, M. S., Vora, A., & Reynolds, R. (2007) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2007.00805.x · Cited by 315 · see citing works

Extensive cortical remyelination in patients with chronic multiple sclerosis

Albert, M., Antel, J., Brück, W., & Stadelmann, C. (2007) · Brain Pathology · doi:10.1111/j.1750-3639.2006.00043.x · Cited by 314 · see citing works

Negative regulation of central nervous system myelination by polysialylated-neural cell adhesion molecule

Charles, P., Hernandez, M. P., Stankoff, B., Aigrot, M. S., Colin, C., Rougon, G., Zalc, B., & Lubetzki, C. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.100076197 · Cited by 306 · see citing works

Increased expression of Nkx2.2 and Olig2 identifies reactive oligodendrocyte progenitor cells responding to demyelination in the adult CNS

Fancy, S. P. J., Zhao, C., & Franklin, R. J. M. (2004) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2004.06.015 · Cited by 302 · see citing works

Astrocytes—Friends or foes in multiple sclerosis?

Williams, A., Piaton, G., & Lubetzki, C. (2007) · Glia · doi:10.1002/glia.20546 · Cited by 301 · see citing works

Patients lacking the major CNS myelin protein, proteolipid protein 1, develop length-dependent axonal degeneration in the absence of demyelination and inflammation

Garbern, J. Y., Yool, D. A., Moore, G. J., Wilds, I. B., Faulk, M. W., Klugmann, M., Nave, K., Sistermans, E. A., van der Knaap, M. S., Bird, T. D., et al. (2002) · Brain · doi:10.1093/brain/awf043 · Cited by 298 · see citing works

Oligodendrocyte progenitors are present in the normal adult human CNS and in the lesions of multiple sclerosis

Scolding, N. J. (1998) · Brain · doi:10.1093/brain/121.12.2221 · Cited by 293 · see citing works

Histone Deacetylase Activity Is Necessary for Oligodendrocyte Lineage Progression

Marin‐Husstege, M., Muggironi, M., Liu, A., & Casaccia-Bonnefil, P. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-23-10333.2002 · Cited by 293 · see citing works

Re-expression of PSA-NCAM by demyelinated axons: an inhibitor of remyelination in multiple sclerosis?

Charles, P. (2002) · Brain · doi:10.1093/brain/awf216 · Cited by 289 · see citing works

Multiple Sclerosis: Remyelination in Acute Lesions

Raine, C. S., & WU, E. (1993) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199305000-00003 · Cited by 285 · see citing works

Activation and Proliferation of Endogenous Oligodendrocyte Precursor Cells during Ethidium Bromide-Induced Demyelination

Levine, J. M., & Reynolds, R. (1999) · Experimental Neurology · doi:10.1006/exnr.1999.7224 · Cited by 282 · see citing works

Remyelination in Experimental Models of Toxin-Induced Demyelination

Blakemore, W. F., & Franklin, R. J. M. (2008) · Current Topics in Microbiology and Immunology · doi:10.1007/978-3-540-73677-6_8 · Cited by 275 · see citing works

Identification of Post-mitotic Oligodendrocytes Incapable of Remyelination within the Demyelinated Adult Spinal Cord

Keirstead, H. S., & Blakemore, W. (1997) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199711000-00003 · Cited by 272 · see citing works

Transplanted multipotential neural precursor cells migrate into the inflamed white matter in response to experimental autoimmune encephalomyelitis

Ben‐Hur, T., Einstein, O., Mizrachi‐Kol, R., Menachem-Zidon, O. B., Reinhartz, E., Karussis, D. M., & Abramsky, O. (2002) · Glia · doi:10.1002/glia.10159 · Cited by 272 · see citing works

Cortical Demyelination Is Prominent in the Murine Cuprizone Model and Is Strain-Dependent

Skripuletz, T., Lindner, M., Kotsiari, A., Garde, N., Fokuhl, J., Linsmeier, F., Trebst, C., & Stangel, M. (2008) · The American Journal of Pathology · doi:10.2353/ajpath.2008.070850 · Cited by 271 · see citing works

Oligodendrocyte precursor cells in the demyelinated multiple sclerosis spinal cord

Wolswijk, G. (2002) · Brain · doi:10.1093/brain/awf031 · Cited by 268 · see citing works

Multiple sclerosis. Oligodendrocyte proliferation and differentiation in fresh lesions.

Prineas, J. W., Kwon, E. E., Goldenberg, P. Z., Ilyas, A. A., Quarles, R. H., Benjamins, J. A., & Sprinkle, T. J. (1989) · PubMed · Cited by 265 · see citing works

Differential myelinogenic capacity of specific developmental stages of the oligodendrocyte lineage upon transplantation into hypomyelinating hosts

Warrington, A. E., Barbarese, E., & Pfeiffer, S. E. (1993) · Journal of Neuroscience Research · doi:10.1002/jnr.490340102 · Cited by 262 · see citing works

Differentiation of proliferated NG2-positive glial progenitor cells in a remyelinating lesion

Watanabe, M., Toyama, Y., & Nishiyama, A. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10338 · Cited by 261 · see citing works

Matrix Metalloproteinase-9 Facilitates Remyelination in Part by Processing the Inhibitory NG2 Proteoglycan

Larsen, P. H., Wells, J. E. A., Stallcup, W. B., Opdenakker, G., & Yong, V. W. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-35-11127.2003 · Cited by 260 · see citing works

Identification of a human olfactory ensheathing cell that can effect transplant-mediated remyelination of demyelinated CNS axons

Barnett, S. C. (2000) · Brain · doi:10.1093/brain/123.8.1581 · Cited by 260 · see citing works

Proteolipid Protein Is Required for Transport of Sirtuin 2 into CNS Myelin

Werner, H. B., Kuhlmann, K., Shen, S., Uecker, M., Schardt, A., Dimova, K. P., Orfaniotou, F., Dhaunchak, A. S., Brinkmann, B. G., Möbius, W., et al. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.1254-07.2007 · Cited by 259 · see citing works

RESEARCH ARTICLE: Myelin Abnormalities without Oligodendrocyte Loss in Periventricular Leukomalacia

Billiards, S., Haynes, R., Folkerth, R., Borenstein, N. S., Trachtenberg, F., Rowitch, D., Ligon, K., Volpe, J., & Kinney, H. C. (2008) · Brain Pathology · doi:10.1111/j.1750-3639.2007.00107.x · Cited by 257 · see citing works

Human monoclonal antibodies reactive to oligodendrocytes promote remyelination in a model of multiple sclerosis

Warrington, A. E., Asakura, K., Bieber, A. J., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.12.6820 · Cited by 257 · see citing works

Oligodendroglial progenitors labeled with the O4 antibody persist in the adult rat cerebral cortex in vivo

Reynolds, R., & Hardy, R. (1997) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19970301)47:5 · Cited by 257 · see citing works

Myelinogenesis and Axonal Recognition by Oligodendrocytes in Brain Are Uncoupled inOlig1-Null Mice

Xin, M., Yue, T., Ma, Z., Wu, F.-F., Gow, A., & Lu, Q. R. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3034-04.2005 · Cited by 254 · see citing works

Restoration of Normal Conduction Properties in Demyelinated Spinal Cord Axons in the Adult Rat by Transplantation of Exogenous Schwann Cells

Honmou, O., Felts, P. A., Waxman, S. G., & Kocsis, J. D. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-10-03199.1996 · Cited by 249 · see citing works

Neural precursors attenuate autoimmune encephalomyelitis by peripheral immunosuppression

Einstein, O., Fainstein, N., Vaknin, I., Mizrachi‐Kol, R., Reihartz, E., Grigoriadis, N., Lavon, I., Baniyash, M., Lassmann, H., & Ben‐Hur, T. (2006) · Annals of Neurology · doi:10.1002/ana.21033 · Cited by 248 · see citing works

Cooperation between PDGF and FGF converts slowly dividing O-2Aadult progenitor cells to rapidly dividing cells with characteristics of O-2Aperinatal progenitor cells.

Wolswijk, G., & Noble, M. A. (1992) · The Journal of Cell Biology · doi:10.1083/jcb.118.4.889 · Cited by 232 · see citing works

White Matter Plasticity and Enhanced Remyelination in the Maternal CNS

Gregg, C., Shikar, V., Larsen, P. H., Mak, G. K., Chojnacki, A. K., Yong, V. W., & Weiss, S. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4441-06.2007 · Cited by 231 · see citing works

Inflammation stimulates remyelination in areas of chronic demyelination

Foote, A. K. (2005) · Brain · doi:10.1093/brain/awh417 · Cited by 230 · see citing works

Semaphorin 3A and 3F: key players in myelin repair in multiple sclerosis?

Williams, A., Piaton, G., Aigrot, M., Belhadi, A., Théaudin, M., Petermann, F., Thomas, J., Zalc, B., & Lubetzki, C. (2007) · Brain · doi:10.1093/brain/awm202 · Cited by 227 · see citing works

Quantifying the early stages of remyelination following cuprizone-induced demyelination

Stidworthy, M. F., Genoud, S., Suter, U., Mantei, N., & Franklin, R. J. M. (2003) · Brain Pathology · doi:10.1111/j.1750-3639.2003.tb00032.x · Cited by 224 · see citing works

Interferon-γ inhibits central nervous system remyelination through a process modulated by endoplasmic reticulum stress

Lin, W., Kemper, A., Dupree, J. L., Harding, H. P., Ron, D., & Popko, B. (2006) · Brain · doi:10.1093/brain/awl044 · Cited by 222 · see citing works

A new focal EAE model of cortical demyelination: Multiple sclerosis-like lesions with rapid resolution of inflammation and extensive remyelination

Merkler, D. (2006) · Brain · doi:10.1093/brain/awl135 · Cited by 222 · see citing works

Distinctive Patterns of PDGF-A, FGF-2, IGF-I, and TGF-β1 Gene Expression during Remyelination of Experimentally-Induced Spinal Cord Demyelination

Hinks, G. L., & Franklin, R. J. M. (1999) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.1999.0771 · Cited by 220 · see citing works

Adult brain retains the potential to generate oligodendroglial progenitors with extensive myelination capacity

Zhang, S., Ge, B., & Duncan, I. D. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.7.4089 · Cited by 217 · see citing works

Insulin-like growth factor I treatment reduces demyelination and up-regulates gene expression of myelin-related proteins in experimental autoimmune encephalomyelitis.

Yao, D. L., Liu, X., Hudson, L. D., & Webster, H. D. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.13.6190 · Cited by 215 · see citing works

Gene Expression in Brain during Cuprizone-Induced Demyelination and Remyelination

Morell, P., Barrett, C. V., Mason, J. L., Toews, A. D., Hostettler, J. D., Knapp, G. W., & Matsushima, G. K. (1998) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.1998.0715 · Cited by 213 · see citing works

Oligodendrocytes and Progenitors Become Progressively Depleted within Chronically Demyelinated Lesions

Mason, J. L., Toews, A., Hostettler, J. D., Morell, P., Suzuki, K., Goldman, J. E., & Matsushima, G. K. (2004) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)63726-1 · Cited by 212 · see citing works

Notch1 control of oligodendrocyte differentiation in the spinal cord

Genoud, S., Lappe-Siefke, C., Goebbels, S., Radtke, F., Aguet, M., Scherer, S. S., Suter, U., Nave, K.-A., & Mantei, N. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200202002 · Cited by 211 · see citing works

Conduction in Segmentally Demyelinated Mammalian Central Axons

Felts, P. A., Baker, T. A., & Smith, K. J. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-19-07267.1997 · Cited by 211 · see citing works

Diffusion barriers evoked in the rat cortex by reactive astrogliosis

Roitbak, T., & Sykov�, E. (1999) · Glia · doi:10.1002/(sici)1098-1136(199910)28:1 · Cited by 208 · see citing works

Locomotor deficits induced by experimental spinal cord demyelination are abolished by spontaneous remyelination

Jeffery, N. D. (1997) · Brain · doi:10.1093/brain/120.1.27 · Cited by 196 · see citing works

Efficient central nervous system remyelination requires T cells

Bieber, A. J., Kerr, S., & Rodriguez, M. (2003) · Annals of Neurology · doi:10.1002/ana.10578 · Cited by 196 · see citing works

Endogenous Nkx2.2+/Olig2+ oligodendrocyte precursor cells fail to remyelinate the demyelinated adult rat spinal cord in the absence of astrocytes

Talbott, J. F., Loy, D. N., Liu, Y., Qiu, M. S., Bunge, M. B., Rao, M. S., & Whittemore, S. R. (2004) · Experimental Neurology · doi:10.1016/j.expneurol.2004.05.038 · Cited by 195 · see citing works

Type III neuregulin‐1 promotes oligodendrocyte myelination

Taveggia, C., Thaker, P., Petrylak, A., Caporaso, G. L., Toews, A. D., Falls, D. L., Einheber, S., & Salzer, J. L. (2007) · Glia · doi:10.1002/glia.20612 · Cited by 193 · see citing works

Transplantation of CNS Fragments into the Brain of Shiverer Mutant Mice: Extensive Myelination by Implanted Oligodendrocytes

Lachapelle, F., Gumpel, M., Baulac, M., Jacque, C., Duc, P., & Baumann, N. (2007) · Developmental Neuroscience · doi:10.1159/000112359 · Cited by 192 · see citing works

Genotype–phenotype correlation in inherited brain myelination defects due to proteolipid protein gene mutations

Cailloux, F., Gauthier‐Barichard, F., Mimault, C., et al. (2000) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5200537 · Cited by 191 · see citing works

Functional Genomic Analysis of Remyelination Reveals Importance of Inflammation in Oligodendrocyte Regeneration

Arnett, H. A., Wang, Y., Matsushima, G. K., Suzuki, K., & Ting, J. P.-Y. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-30-09824.2003 · Cited by 190 · see citing works

Abnormal sodium channel distribution in optic nerve axons in a model of inflammatory demyelination

Craner, M. J. (2003) · Brain · doi:10.1093/brain/awg153 · Cited by 187 · see citing works

Pattern of remyelination in the CNS

BLAKEMORE, W. F. (1974) · Nature · doi:10.1038/249577a0 · Cited by 182 · see citing works

Generation of oligodendroglial progenitors in acute inflammatory demyelinating lesions of the rat brain stem is associated with demyelination rather than inflammation

di Bello, I. C., Dawson, M. R. L., Levine, J. M., & Reynolds, R. (1999) · Journal of Neurocytology · doi:10.1023/a:1007069815302 · Cited by 178 · see citing works

Absence of fibroblast growth factor 2 promotes oligodendroglial repopulation of demyelinated white matter

Armstrong, R. C., Le, T. Q., Frost, E. E., Borke, R. C., & Vana, A. C. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-19-08574.2002 · Cited by 178 · see citing works

NG2 proteoglycan‐expressing cells of the adult rat brain: Possible involvement in the formation of glial scar astrocytes following stab wound

Alonso, G. (2004) · Glia · doi:10.1002/glia.20121 · Cited by 178 · see citing works

Insulin-like growth factor (IGF) signaling through type 1 IGF receptor plays an important role in remyelination

Mason, J. L., Xuan, S., Dragatsis, I., Efstratiadis, A., & Goldman, J. E. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-20-07710.2003 · Cited by 177 · see citing works

Oxidative and Nitrative Injury in Periventricular Leukomalacia: A Review

Haynes, R. L., Baud, O., Li, J., Kinney, H. C., Volpe, J. J., & Folkerth, R. D. (2005) · Brain Pathology · doi:10.1111/j.1750-3639.2005.tb00525.x · Cited by 177 · see citing works

Remyelination of the superior cerebellar peduncle in the mouse following demyelination induced by feeding cuprizone

Blakemore, W. F. (1973) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(73)90119-6 · Cited by 177 · see citing works

The response of NG2-expressing oligodendrocyte progenitors to demyelination in MOG-EAE and MS

Reynolds, R., Dawson, M., Papadopoulos, D., Polito, A., di Bello, I. C., Pham-Dinh, D., & Levine, J. (2002) · Journal of Neurocytology · doi:10.1023/a:1025747832215 · Cited by 175 · see citing works

INVASION OF SCHWANN CELLS INTO THE SPINAL CORD OF THE RAT FOLLOWING LOCAL INJECTIONS OF LYSOLECITHIN

Blakemore, W. F. (1976) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.1976.tb00559.x · Cited by 174 · see citing works

The use of cultured autologous Schwann cells to remyelinate areas of persistent demyelination in the central nervous system

Blakemore, W. F., & Crang, A. J. (1985) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(85)90088-7 · Cited by 172 · see citing works

Episodic demyelination and subsequent remyelination within the murine central nervous system: changes in axonal calibre

Mason, J. L., Langaman, C., Morell, P., Suzuki, K., & Matsushima, G. K. (2001) · Neuropathology and Applied Neurobiology · doi:10.1046/j.0305-1846.2001.00301.x · Cited by 172 · see citing works

Inflammation stimulates myelination by transplanted oligodendrocyte precursor cells

Setzu, A., Lathia, J. D., Zhao, C., Wells, K., Rao, M. S., ffrench‐Constant, C., & Franklin, R. J. M. (2006) · Glia · doi:10.1002/glia.20371 · Cited by 171 · see citing works

Transplantation of Cryopreserved Adult Human Schwann Cells Enhances Axonal Conduction in Demyelinated Spinal Cord

Kohama, I., Lankford, K. L., Preiningerova, J. L., White, F. A., Vollmer, T. L., & Kocsis, J. D. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-03-00944.2001 · Cited by 167 · see citing works

Thyroid hormone administration enhances remyelination in chronic demyelinating inflammatory disease

Fernández, M., Giuliani, A., Pirondi, S., D’Intino, G., Giardino, L., Aloe, L., Levi‐Montalcini, R., & Calzà, L. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407262101 · Cited by 167 · see citing works

Effects of commissural de- and remyelination on motor skill behaviour in the cuprizone mouse model of multiple sclerosis

LIEBETANZ, D., & MERKLER, D. (2006) · Experimental Neurology · doi:10.1016/j.expneurol.2006.05.032 · Cited by 166 · see citing works

Transplantation of rat schwann cells grown in tissue culture into the mouse spinal cord

Duncan, I. D., Aguayo, A. J., Bunge, R. P., & Wood, P. M. (1981) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(81)90082-4 · Cited by 163 · see citing works

Efficient recolonisation of progenitor-depleted areas of the CNS by adult oligodendrocyte progenitor cells

Chari, D. M., & Blakemore, W. F. (2002) · Glia · doi:10.1002/glia.10038 · Cited by 161 · see citing works

Notch1 and Jagged1 are expressed after CNS demyelination, but are not a major rate-determining factor during remyelination

Stidworthy, M. F. (2004) · Brain · doi:10.1093/brain/awh217 · Cited by 158 · see citing works

PDGF and FGF2 pathways regulate distinct oligodendrocyte lineage responses in experimental demyelination with spontaneous remyelination

Murtie, J. C., Zhou, Y.-X., Le, T. Q., Vana, A. C., & Armstrong, R. C. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2004.12.006 · Cited by 157 · see citing works

Delayed Changes in Growth Factor Gene Expression during Slow Remyelination in the CNS of Aged Rats

Hinks, G. L., & Franklin, R. J. M. (2000) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.2000.0897 · Cited by 156 · see citing works

Osteopontin is upregulated during in vivo demyelination and remyelination and enhances myelin formation in vitro

Selvaraju, R., Bernasconi, L., Losberger, C., Graber, P., Kadi, L., Avellana-Adalid, V., Picard-Riera, N., Van Evercooren, A. B., Cirillo, R., Kosco-Vilbois, M., et al. (2004) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2003.12.014 · Cited by 156 · see citing works

Minocycline-mediated inhibition of microglia activation impairs oligodendrocyte progenitor cell responses and remyelination in a non-immune model of demyelination

Li, W., Setzu, A., Zhao, C., & Franklin, R. J. M. (2004) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2004.08.011 · Cited by 155 · see citing works

The neuregulin, glial growth factor 2, diminishes autoimmune demyelination and enhances remyelination in a chronic relapsing model for multiple sclerosis

Cannella, B., Hoban, C. J., Gao, Y.-L., Garcia‐Arenas, R., Lawson, D., Marchionni, M. A., Gwynne, D. I., & Raine, C. S. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.17.10100 · Cited by 154 · see citing works

Synaptic transmission onto hippocampal glial cells with hGFAP promoter activity

Jabs, R., Pivneva, T. A., Hüttmann, K., Wyczynski, A., Nolte, C., Kettenmann, H., & Steinhäuser, C. (2005) · Journal of Cell Science · doi:10.1242/jcs.02515 · Cited by 153 · see citing works

In vivo evaluation of remyelination in rat brain by magnetization transfer imaging

Deloire-Grassin, M., Brochet, B., Quesson, B., Delalande, C., Dousset, V., Canioni, P., & Petry, K. G. (2000) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(00)00331-2 · Cited by 150 · see citing works

Thyroid hormones promote differentiation of oligodendrocyte progenitor cells and improve remyelination after cuprizone-induced demyelination

Franco, P. G., Silvestroff, L., Soto, E. F., & Pasquini, J. M. (2008) · Experimental Neurology · doi:10.1016/j.expneurol.2008.04.039 · Cited by 147 · see citing works

Complementary patterns of gene expression by human oligodendrocyte progenitors and their environment predict determinants of progenitor maintenance and differentiation

Sim, F. J., Lang, J. K., Waldau, B., Roy, N. S., Schwartz, T. E., Pilcher, W. H., Chandross, K. J., Natesan, S., Merrill, J. E., & Goldman, S. A. (2006) · Annals of Neurology · doi:10.1002/ana.20812 · Cited by 147 · see citing works

Oligodendrocytes, their Progenitors and other Neuroglial Cells in the Aging Primate Cerebral Cortex

Peters, A. (2004) · Cerebral Cortex · doi:10.1093/cercor/bhh060 · Cited by 147 · see citing works

Induction of persistently demyelinated lesions in the rat following the repeated adoptive transfer of encephalitogenic T cells and demyelinating antibody

Linington, C., Engelhardt, B., Kapócs, G., et al. (1992) · Journal of Neuroimmunology · doi:10.1016/0165-5728(92)90136-9 · Cited by 147 · see citing works

Long-Term Culture of Purified Postnatal Oligodendrocyte Precursor Cells

Tang, D. G., Tokumoto, Y. M., & RAFF, M. C. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.148.5.971 · Cited by 144 · see citing works

In vitro analysis of the origin and maintenance of O-2Aadult progenitor cells.

Wren, D. R., Wolswijk, G., & Noble, M. A. (1992) · The Journal of Cell Biology · doi:10.1083/jcb.116.1.167 · Cited by 144 · see citing works

Expression of NR1 and NR2A/B subunits of the NMDA receptor in cortical astrocytes

Conti, F., Debiasi, S., Minelli, A., & Melone, M. (1996) · Glia · doi:10.1002/(sici)1098-1136(199607)17:3 · Cited by 143 · see citing works

Differences in the early inflammatory responses to toxin-induced demyelination are associated with the age-related decline in CNS remyelination

Zhao, C., Li, W.-W., & Franklin, R. J. M. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.06.008 · Cited by 142 · cited 1× · see citing works

Acceleration in the Rate of CNS Remyelination in Lysolecithin-Induced Demyelination

Pavelko, K., van Engelen, B. V., & Rodriguez, M. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-07-02498.1998 · Cited by 140 · see citing works

Myelination of the canine central nervous system by glial cell transplantation: A model for repair of human myelin disease

Archer, D. R., Cuddon, P. A., Lipsitz, D., & Duncan, I. D. (1997) · Nature Medicine · doi:10.1038/nm0197-54 · Cited by 138 · see citing works

Myelination Following Transplantation of EGF-Responsive Neural Stem Cells into a Myelin-Deficient Environment

Hammang, J. P., Archer, D. R., & Duncan, I. D. (1997) · Experimental Neurology · doi:10.1006/exnr.1997.6592 · Cited by 138 · see citing works

Transplanted type-1 astrocytes facilitate repair of demyelinating lesions by host oligodendrocytes in adult rat spinal cord

Franklin, R. J. M., Crang, A. J., & Blakemore, W. F. (1991) · Journal of Neurocytology · doi:10.1007/bf01355538 · Cited by 136 · see citing works

A genetic screen identifies genes essential for development of myelinated axons in zebrafish.

Pogoda, H.-M., Sternheim, N., Lyons, D., Diamond, B., Hawkins, T. A., Woods, I., Bhatt, D. H., Franzini-armstrong, C., Dominguez, C., Arana, N., et al. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.06.021 · Cited by 135 · see citing works

No evidence for chronic demyelination in spared axons after spinal cord injury in a mouse

Lasiene, J., Shupe, L., Perlmutter, S., & Horner, P. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4756-07.2008 · Cited by 133 · see citing works

Integrin‐growth factor interactions as regulators of oligodendroglial development and function

Baron, W., Colognato, H., & ffrench-Constant, C. (2005) · Glia · doi:10.1002/glia.20132 · Cited by 129 · see citing works

Impaired remyelination and depletion of oligodendrocyte progenitors does not occur following repeated episodes of focal demyelination in the rat central nervous system

Penderis, J., Shields, S. A., & Franklin, R. J. M. (2003) · Brain · doi:10.1093/brain/awg126 · Cited by 129 · see citing works

The injury response of oligodendrocyte precursor cells is induced by platelets, macrophages and inflammation-associated cytokines

Rhodes, K. E., Raivich, G., & Fawcett, J. W. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.01.055 · Cited by 128 · see citing works

Systemic progesterone administration results in a partial reversal of the age‐associated decline in CNS remyelination following toxin‐induced demyelination in male rats

Ibanez, C., Shields, S. A., El‐Etr, M., Baulieu, E. E., Schumacher, M., & Franklin, R. J. M. (2003) · Neuropathology and Applied Neurobiology · doi:10.1046/j.0305-1846.2003.00515.x · Cited by 128 · see citing works

Innate immunity triggers oligodendrocyte progenitor reactivity and confines damages to brain injuries

Glezer, I., Lapointe, A., & Rivest, S. (2006) · The FASEB Journal · doi:10.1096/fj.05-5234fje · Cited by 126 · see citing works

Endogenous cell repair of chronic demyelination

Armstrong, R. C., Le, T. Q., Flint, N. C., Vana, A. C., & Zhou, Y.-X. (2006) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/01.jnen.0000205142.08716.7e · Cited by 125 · see citing works

Untitled work

(1980) · PubMed · Cited by 125 · see citing works

Combinatorial Profiles of Oligodendrocyte-Selective Classes of Transcriptional Regulators Differentially Modulate Myelin Basic Protein Gene Expression

Gokhan, S., Marin-Husstege, M., Yung, S.-Y., Fontanez, D. E., Casaccia-Bonnefil, P., & Mehler, M. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1850-05.2005 · Cited by 123 · see citing works

Sodium Channels and Multiple Sclerosis: Roles in Symptom Production, Damage and Therapy

Smith, K. J. (2007) · Brain Pathology · doi:10.1111/j.1750-3639.2007.00066.x · Cited by 123 · see citing works

Co-expression of PDGF α receptor and NG2 by oligodendrocyte precursors in human CNS and multiple sclerosis lesions

Wilson, H., Scolding, N. J., & Raine, C. S. (2006) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2006.04.014 · Cited by 122 · see citing works

Identification of the adult resting progenitor cell by autoradiographic tracking of oligodendrocyte precursors in experimental CNS demyelination

Carroll, W. M. (1998) · Brain · doi:10.1093/brain/121.2.293 · Cited by 122 · see citing works

Transcription factor co‐expression patterns indicate heterogeneity of oligodendroglial subpopulations in adult spinal cord

Kitada, M., & Rowitch, D. (2006) · Glia · doi:10.1002/glia.20354 · Cited by 121 · see citing works

Histological and Ultrastructural Analysis of White Matter Damage after Naturally‐occurring Spinal Cord Injury

Smith, P. M., & Jeffery, N. D. (2006) · Brain Pathology · doi:10.1111/j.1750-3639.2006.00001.x · Cited by 120 · see citing works

Expression of dominant-negative and chimeric subunits reveals an essential role for beta1 integrin during myelination.

Relvas, J., Setzu, A., Baron, W., Buttery, P., LaFlamme, S., Franklin, R., & ffrench-Constant, C. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00292-5 · Cited by 118 · see citing works

β1-Integrin Signaling Mediates Premyelinating Oligodendrocyte Survival But Is Not Required for CNS Myelination and Remyelination

Benninger, Y., Colognato, H., Thurnherr, T., Franklin, R., Leone, D. P., Atanasoski, S., Nave, K., ffrench-Constant, C., Suter, U., & Relvas, J. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0444-06.2006 · Cited by 118 · see citing works

Age increases axon loss associated with primary demyelination in cuprizone-induced demyelination in C57BL/6 mice

Irvine, K.-A., & Blakemore, W. F. (2006) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2006.03.002 · Cited by 117 · see citing works

Contact with Central Nervous System Myelin Inhibits Oligodendrocyte Progenitor Maturation

Robinson, S., & Miller, R. H. (1999) · Developmental Biology · doi:10.1006/dbio.1999.9466 · Cited by 115 · see citing works

Early recruitment of oligodendrocyte precursors in CNS demyelination

Carroll, W. M., & Jennings, A. R. (1994) · Brain · doi:10.1093/brain/117.3.563 · Cited by 112 · see citing works

Imaging correlates of decreased axonal Na + /K + ATPase in chronic multiple sclerosis lesions

Young, E. A., Fowler, C. D., Kidd, G. J., Chang, A., Rudick, R. A., Fisher, E., & Trapp, B. D. (2008) · Annals of Neurology · doi:10.1002/ana.21381 · Cited by 111 · see citing works

Understanding CNS remyelination: Clues from developmental and regeneration biology

Franklin, R. J. M., & Hinks, G. L. (1999) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19991015)58:2 · Cited by 110 · see citing works

Remyelination by Oligodendrocytes Stimulated by Antiserum to Spinal Cord

Rodriguez, M., Lennon, V. A., Benveniste, E. N., et al. (1987) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-198701000-00008 · Cited by 105 · see citing works

Failure to achieve remyelination of demyelinated rat axons following transplantation of glial cells obtained from the adult human brain

Targett, M. P., Sussmant, J., Scoldingt, N., O'Leary, M. T., Compston, D. A. S., & Blakemore, W. F. (1996) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.1996.tb00895.x · Cited by 104 · see citing works

Monoclonal autoantibodies promote central nervous system repair in an animal model of multiple sclerosis

Miller, D. J., Sanborn, K. S., Katzmann, J., & Rodriguez, M. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-10-06230.1994 · Cited by 102 · see citing works

Platelet-Derived Growth Factor Promotes Repair of Chronically Demyelinated White Matter

Vana, A. C., Flint, N. C., Harwood, N. E., Le, T. Q., Fruttiger, M., & Armstrong, R. C. (2007) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3181587d46 · Cited by 101 · see citing works

Astrocytes produce CNTF during the remyelination phase of viral-induced spinal cord demyelination to stimulate FGF-2 production

Albrecht, P. J., Murtie, J. C., Ness, J. K., Redwine, J. M., Enterline, J. R., Armstrong, R. C., & Levison, S. W. (2003) · Neurobiology of Disease · doi:10.1016/s0969-9961(03)00019-6 · Cited by 99 · see citing works

Voxel-based analysis of the evolution of magnetization transfer ratio to quantify remyelination and demyelination with histopathological validation in a multiple sclerosis lesion

Chen, J. T., Kuhlmann, T., Jansen, G. H., Collins, D. L., Atkins, H. L., Freedman, M. S., O'Connor, P. W., & Arnold, D. L. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.03.073 · Cited by 98 · see citing works

The Pathobiology of Vascular Dementia

Iadecola, C. (2013) · Neuron · doi:10.1016/j.neuron.2013.10.008 · Cited by 1,857 · see citing works

Progressive multiple sclerosis: pathology and pathogenesis

Lassmann, H., van Horssen, J., & Mahad, D. (2012) · Nature Reviews Neurology · doi:10.1038/nrneurol.2012.168 · Cited by 1,033 · see citing works

Oligodendrocytes: biology and pathology

Bradl, M., & Lassmann, H. (2010) · Acta Neuropathologica · doi:10.1007/s00401-009-0601-5 · Cited by 933 · see citing works

CNS-resident glial progenitor/stem cells produce Schwann cells as well as oligodendrocytes during repair of CNS demyelination

Zawadzka, M., Rivers, L. E., Fancy, S. P. J., Zhao, C., Tripathi, R., Jamen, F., Young, K., Goncharevich, A., Pohl, H., Rizzi, M., et al. (2010) · Cell stem cell · doi:10.1016/j.stem.2010.04.002 · Cited by 650 · see citing works

Regenerating CNS myelin — from mechanisms to experimental medicines

Franklin, R. J. M., & ffrench-Constant, C. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.136 · Cited by 647 · see citing works

Origin of New Glial Cells in Intact and Injured Adult Spinal Cord

Barnabé-Heider, F., Göritz, C., Sabelström, H., Takebayashi, H., Pfrieger, F. W., Meletis, K., & Frisén, J. (2010) · Cell Stem Cell · doi:10.1016/j.stem.2010.07.014 · Cited by 628 · see citing works

Inefficient clearance of myelin debris by microglia impairs remyelinating processes

Lampron, A., Larochelle, A., Laflamme, N., Préfontaine, P., Plante, M.-M., Sánchez, M. G., Yong, V. W., Stys, P. K., Tremblay, M.-È., & Rivest, S. (2015) · Journal of Experimental Medicine · doi:10.1084/jem.20141656 · Cited by 595 · see citing works

Fibrinogen in neurological diseases: mechanisms, imaging and therapeutics

Petersen, M. A., Ryu, J. K., & Akassoglou, K. (2018) · Nature reviews. Neuroscience · doi:10.1038/nrn.2018.13 · Cited by 527 · see citing works

Single-nucleus transcriptome analysis reveals dysregulation of angiogenic endothelial cells and neuroprotective glia in Alzheimer’s disease

Lau, S.-F., Cao, H., Fu, A. K. Y., & Ip, N. Y. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2008762117 · Cited by 476 · see citing works

Oligodendrocyte precursors migrate along vasculature in the developing nervous system

Tsai, H.-H., Niu, J., Munji, R., Davalos, D., Chang, J., Zhang, H., Tien, A.-C., Kuo, C. J., Chan, J. R., Daneman, R., et al. (2016) · Science · doi:10.1126/science.aad3839 · Cited by 483 · see citing works

Olig2 Targets Chromatin Remodelers to Enhancers to Initiate Oligodendrocyte Differentiation

Yu, Y., Chen, Y., Kim, B., Wang, H., Zhao, C., He, X., Liu, L., Liu, W., Wu, L. M. N., Mao, M., et al. (2013) · Cell · doi:10.1016/j.cell.2012.12.006 · Cited by 375 · see citing works

Axin2 as regulatory and therapeutic target in newborn brain injury and remyelination

Fancy, S. P. J., Harrington, E. P., Yuen, T. J., Silbereis, J. C., Zhao, C., Baranzini, S. E., Bruce, C. C., Otero, J. J., Huang, E. J., Nusse, R., et al. (2011) · Nature Neuroscience · doi:10.1038/nn.2855 · Cited by 349 · see citing works

Enhancing myelin renewal reverses cognitive dysfunction in a murine model of Alzheimer’s disease

Chen, J.-F., Liu, K., Hu, B., Li, R.-R., Xin, W., Chen, H., Wang, F., Chen, L., Li, R.-X., Ren, S.-Y., et al. (2021) · Neuron · doi:10.1016/j.neuron.2021.05.012 · Cited by 346 · see citing works

NG2-glia as multipotent neural stem cells: fact or fantasy?

Richardson, W. D., Young, K. M., Tripathi, R. B., & McKenzie, I. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.013 · Cited by 300 · see citing works

Specific ablation of Nampt in adult neural stem cells recapitulates their functional defects during aging

Stein, L. R., & Imai, S. (2014) · The EMBO Journal · doi:10.1002/embj.201386917 · Cited by 265 · see citing works

BCAS1 expression defines a population of early myelinating oligodendrocytes in multiple sclerosis lesions

Fard, M. K., van der Meer, F., Sánchez, P., Cantuti-Castelvetri, L., Mandad, S., Jäkel, S., Fornasiero, E. F., Schmitt, S., Ehrlich, M., Starost, L., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aam7816 · Cited by 247 · see citing works

Neurite outgrowth inhibitor Nogo-A establishes spatial segregation and extent of oligodendrocyte myelination

Chong, S. Y. C., Rosenberg, S. S., Fancy, S. P. J., Zhao, C., Shen, Y.-A. A., Hahn, A. T., McGee, A. W., Xu, X., Zheng, B., Zhang, L. I., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1113540109 · Cited by 232 · see citing works

Act1 mediates IL-17-induced EAE pathogenesis selectively in NG2+ glial cells

Kang, Z., Wang, C., Zepp, J., Wu, L., Sun, K., Zhao, J., Chandrasekharan, U., DiCorleto, P. E., Trapp, B. D., Ransohoff, R. M., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3505 · Cited by 218 · see citing works

Accumulation of 8,9-unsaturated sterols drives oligodendrocyte formation and remyelination

Hubler, Z., Allimuthu, D., Bederman, I., Elitt, M. S., Madhavan, M., Allan, K. C., Shick, H. E., Garrison, E., T. Karl, M., Factor, D. C., et al. (2018) · Nature · doi:10.1038/s41586-018-0360-3 · Cited by 226 · see citing works

Dynamic changes in myelin aberrations and oligodendrocyte generation in chronic amyloidosis in mice and men

Behrendt, G., Baer, K., Buffo, A., Curtis, M. A., Faull, R. L., Rees, M. I., Götz, M., & Dimou, L. (2013) · Glia · doi:10.1002/glia.22432 · Cited by 219 · see citing works

Cortical remyelination: A new target for repair therapies in multiple sclerosis

Chang, A., Staugaitis, S. M., Dutta, R., Batt, C. E., Easley, K. E., Chomyk, A. M., Yong, V. W., Fox, R. J., Kidd, G. J., & Trapp, B. D. (2012) · Annals of Neurology · doi:10.1002/ana.23693 · Cited by 216 · see citing works

Astrocyte-derived endothelin-1 inhibits remyelination through notch activation

Hammond, T. R., Gadea, A., Dupree, J., Kerninon, C., Nait-Oumesmar, B., Aguirre, A., & Gallo, V. (2014) · Neuron · doi:10.1016/j.neuron.2013.11.015 · Cited by 206 · see citing works

Immune Surveillance of the CNS following Infection and Injury

Russo, M. V., & McGavern, D. B. (2015) · Trends in Immunology · doi:10.1016/j.it.2015.08.002 · Cited by 191 · see citing works

Cortical iron reflects severity of Alzheimer's disease

van Duijn, S., Bulk, M., van Duinen, S. G., Nabuurs, R. J. A., van Buchem, M. A., van der Weerd, L., & Natté, R. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-161143 · Cited by 172 · see citing works

Oligodendroglia and Myelin in Neurodegenerative Diseases: More Than Just Bystanders?

Ettle, B., Schlachetzki, J. C. M., & Winkler, J. (2016) · Molecular Neurobiology · doi:10.1007/s12035-015-9205-3 · Cited by 160 · see citing works

NMDA receptor signaling in oligodendrocyte progenitors is not required for oligodendrogenesis and myelination

De Biase, L. M., Kang, S. H., Baxi, E. G., Fukaya, M., Pucak, M. L., Mishina, M., Calabresi, P. A., & Bergles, D. E. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.2455-11.2011 · Cited by 161 · see citing works

Stearoyl-CoA desaturase-1 impairs the reparative properties of macrophages and microglia in the brain

Bogie, J. F. J., Grajchen, E., Wouters, E., Corrales, A. G., Dierckx, T., Vanherle, S., Mailleux, J., Gervois, P., Wolfs, E., Dehairs, J., et al. (2020) · Journal of Experimental Medicine · doi:10.1084/jem.20191660 · Cited by 151 · see citing works

Genetically Induced Adult Oligodendrocyte Cell Death Is Associated with Poor Myelin Clearance, Reduced Remyelination, and Axonal Damage

Pohl, H. B. F., Porcheri, C., Mueggler, T., Bachmann, L. C., Martino, G., Riethmacher, D., Franklin, R. J. M., Rudin, M., & Suter, U. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.5035-10.2011 · Cited by 145 · see citing works

Associations between white matter microstructure and amyloid burden in preclinical Alzheimer’s disease: a multimodal imaging investigation.

Racine, A. M., Adluru, N., Alexander, A. L., Christian, B. T., Okonkwo, O. C., Oh, J., Cleary, C. A., Birdsill, A., Hillmer, A. T., Murali, D., et al. (2014) · NeuroImage: Clinical · doi:10.1016/j.nicl.2014.02.001 · Cited by 136 · see citing works

Inhibition of CNS Remyelination by the Presence of Semaphorin 3A

Syed, Y. A., Hand, E., Möbius, W., Zhao, C., Hofer, M., Nave, K. A., & Kotter, M. R. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.4930-10.2011 · Cited by 134 · see citing works

Progesterone and Nestorone Facilitate Axon Remyelination: A Role for Progesterone Receptors

Hussain, R., El-Etr, M., Gaci, O., Rakotomamonjy, J., Macklin, W. B., Kumar, N., Sitruk-Ware, R., Schumacher, M., & Ghoumari, A. M. (2011) · Endocrinology · doi:10.1210/en.2011-1219 · Cited by 123 · see citing works

A genetic mouse model of adult-onset, pervasive central nervous system demyelination with robust remyelination

Traka, M., Arasi, K., Avila, R. L., Podojil, J. R., Christakos, A., Miller, S. D., Soliven, B., & Popko, B. (2010) · Brain · doi:10.1093/brain/awq247 · Cited by 118 · see citing works

Autophagy is essential for oligodendrocyte differentiation, survival, and proper myelination

Bankston, A. N., Forston, M. D., Howard, R. M., Andres, K. R., Smith, A. E., Ohri, S. S., Bates, M. L., Bunge, M. B., & Whittemore, S. R. (2019) · Glia · doi:10.1002/glia.23646 · Cited by 112 · see citing works

Digestion products of the PH20 hyaluronidase inhibit remyelination

Preston, M., Gong, X., Su, W., Matsumoto, S. G., Banine, F., Winkler, C., Foster, S., Xing, R., Struve, J., Dean, J., et al. (2013) · Annals of Neurology · doi:10.1002/ana.23788 · Cited by 107 · see citing works

Oligodendrocyte progenitor cells in Alzheimer's disease: from physiology to pathology

Zou, P., Wu, C., Liu, T. C.-Y., Duan, R., & Yang, L. (2023) · Translational Neurodegeneration · doi:10.1186/s40035-023-00385-7 · Cited by 97 · see citing works

Ascl1 lineage cells contribute to ischemia-induced neurogenesis and oligodendrogenesis

Zhang, R. L., Chopp, M., Roberts, C., Jia, L., Wei, M., Lu, M., Wang, X., Pourabdollah, S., & Zhang, Z. G. (2011) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2010.134 · Cited by 91 · see citing works

Differences in the immune-inflammatory profiles of unipolar and bipolar depression

Brunoni, A. R., Supasitthumrong, T., Teixeira, A. L., Vieira, E. L., Gattaz, W. F., Benseñor, I. M., Lotufo, P. A., Lafer, B., Berk, M., Carvalho, A. F., et al. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.10.037 · Cited by 94 · see citing works

A perspective on the role of class III semaphorin signaling in central nervous system trauma

Mecollari, V., Nieuwenhuis, B., & Verhaagen, J. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00328 · Cited by 79 · see citing works

Transcription factor induction of human oligodendrocyte progenitor fate and differentiation

Wang, J., Pol, S. U., Haberman, A. K., Wang, C., O’Bara, M. A., & Sim, F. J. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1408295111 · Cited by 79 · see citing works

Extrinsic immune cell-derived, but not intrinsic oligodendroglial factors contribute to oligodendroglial differentiation block in multiple sclerosis

Starost, L., Lindner, M., Herold, M., Xu, Y. K. T., Drexler, H. C. A., Heß, K., Ehrlich, M., Ottoboni, L., Ruffini, F., Stehling, M., et al. (2020) · Acta Neuropathologica · doi:10.1007/s00401-020-02217-8 · Cited by 79 · see citing works

Microglia promote remyelination independent of their role in clearing myelin debris

Baaklini, C. S., Ho, M. F. S., Lange, T., Hammond, B. P., Panda, S. P., Zirngibl, M., Zia, S., Himmelsbach, K., Rana, H., Phillips, B., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113574 · Cited by 73 · see citing works

Neural Stem Cells of the Subventricular Zone Contribute to Neuroprotection of the Corpus Callosum after Cuprizone-Induced Demyelination

Butti, E., Bacigaluppi, M., Chaabane, L., Ruffini, F., Brambilla, E., Berera, G., Montonati, C., Quattrini, A., & Martino, G. (2019) · The Journal of Neuroscience · doi:10.1523/jneurosci.0227-18.2019 · Cited by 67 · see citing works

The use of optical coherence tomography and visual evoked potentials in the 2024 McDonald diagnostic criteria for multiple sclerosis

Saidha, S., Green, A. J., Leocani, L., Vidal-Jordana, A., Kenney, R. C., Bsteh, G., Outteryck, O., Thompson, A., Montalban, X., Coetzee, T., et al. (2025) · The Lancet Neurology · doi:10.1016/s1474-4422(25)00275-3 · Cited by 66 · see citing works

LRP1 regulates peroxisome biogenesis and cholesterol homeostasis in oligodendrocytes and is required for proper CNS myelin development and repair

Lin, J.-P., Mironova, Y. A., Shrager, P., & Giger, R. J. (2017) · eLife · doi:10.7554/elife.30498 · Cited by 64 · see citing works

Myelin replacement triggered by single-cell demyelination in mouse cortex

Snaidero, N., Schifferer, M., Mezydlo, A., Zalc, B., Kerschensteiner, M., & Misgeld, T. (2020) · Nature Communications · doi:10.1038/s41467-020-18632-0 · Cited by 63 · see citing works

Senescent-like microglia limit remyelination through the senescence associated secretory phenotype

Gross, P. S., Durán-Laforet, V., Ho, L. T., Melchor, G. S., Zia, S., Manavi, Z., Barclay, W. E., Lee, S. H., Shults, N., Selva, S., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-57632-w · Cited by 62 · see citing works

Inhibition of phosphodiesterase‐4 promotes oligodendrocyte precursor cell differentiation and enhances CNS remyelination

Syed, Y. A., Baer, A., Hofer, M. P., González, G. A., Rundle, J., Myrta, S., Huang, J. K., Zhao, C., Rossner, M. J., Trotter, M. W. B., et al. (2013) · EMBO Molecular Medicine · doi:10.1002/emmm.201303123 · Cited by 58 · see citing works

Theranostic implications of nanotechnology in multiple sclerosis: a future perspective.

Singh, A. V., Khare, M., Gade, W. N., & Zamboni, P. (2012) · Autoimmune Diseases · doi:10.1155/2012/160830 · Cited by 58 · see citing works

C-Phycocyanin and Phycocyanobilin as Remyelination Therapies for Enhancing Recovery in Multiple Sclerosis and Ischemic Stroke: A Preclinical Perspective

Pentón-Rol, G., Marín-Prida, J., & Falcón-Cama, V. (2018) · Behavioral Sciences · doi:10.3390/bs8010015 · Cited by 50 · see citing works

Innate immune responses in central nervous system inflammation

Finsen, B., & Owens, T. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.05.030 · Cited by 50 · see citing works

The axo-myelinic synapse

Stys, P. K. (2011) · Trends in Neurosciences · doi:10.1016/j.tins.2011.06.004 · Cited by 51 · see citing works

The endocannabinoid 2-AG enhances spontaneous remyelination by targeting microglia

Mecha, M., Yanguas-Casás, N., Feliú, A., Mestre, L., Carrillo-Salinas, F., Azcoitia, I., Yong, V. W., & Guaza, C. (2019) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2018.12.013 · Cited by 47 · see citing works

Multiple sclerosis iPS-derived oligodendroglia conserve their properties to functionally interact with axons and glia in vivo

Mozafari, S., Starost, L., Manot-Saillet, B., Garcia-Diaz, B., Xu, Y. K. T., Roussel, D., Levy, M. J. F., Ottoboni, L., Kim, K.-P., Schöler, H. R., et al. (2020) · Science Advances · doi:10.1126/sciadv.abc6983 · Cited by 45 · see citing works

Brain lipid binding protein (FABP7) as modulator of astrocyte function

KIPP, M., CLARNER, T., GINGELE, S., POTT, F., AMOR, S., VAN DER VALK, P., & BEYER, C. (2011) · Physiological Research · doi:10.33549/physiolres.932168 · Cited by 42 · see citing works

Myt1L Promotes Differentiation of Oligodendrocyte Precursor Cells and is Necessary for Remyelination After Lysolecithin-Induced Demyelination.

Shi, Y., Shao, Q., Li, Z., Gonzalez, G. A., Lu, F., Wang, D., Pu, Y., Huang, A., Zhao, C., He, C., et al. (2018) · Neuroscience Bulletin · doi:10.1007/s12264-018-0207-9 · Cited by 34 · see citing works

An <i>in vitro</i> model for de‐ and remyelination using lysophosphatidyl choline in rodent whole brain spheroid cultures

Vereyken, E. J. F., Fluitsma, D. M., Bolijn, M. J., Dijkstra, C. D., & Teunissen, C. E. (2009) · Glia · doi:10.1002/glia.20852 · Cited by 33 · see citing works

Tamoxifen promotes differentiation of oligodendrocyte progenitors in vitro

Barratt, H. E., Budnick, H. C., Parra, R., Lolley, R. J., Perry, C. N., & Nesic, O. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.01.026 · Cited by 22 · see citing works

Acute TREM2 inhibition depletes MAFB-high microglia and hinders remyelination

Hou, J., Magliozzi, R., Chen, Y., Wu, J., Wulf, J., Strout, G., Fang, X., & Colonna, M. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2426786122 · Cited by 20 · see citing works

Failed remyelination of the nonhuman primate optic nerve leads to axon degeneration, retinal damages, and visual dysfunction

Sarrazin, N., Chavret-Reculon, E., Bachelin, C., Felfli, M., Arab, R., Gilardeau, S., Brazhnikova, E., Dubus, E., Yahia Cherif, L., Lorenceau, J., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2115973119 · Cited by 15 · see citing works

Investigation of sequential growth factor delivery during cuprizone challenge in mice aimed to enhance oligodendrogliogenesis and myelin repair

Sabo, J. K., Aumann, T. D., Kilpatrick, T. J., & Cate, H. S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0063415 · Cited by 13 · see citing works

Investigating demyelination, efficient remyelination and remyelination failure in organotypic cerebellar slice cultures: Workflow and practical tips

(2022) · Methods in Cell Biology · doi:10.1016/bs.mcb.2021.12.011 · Cited by 8 · see citing works

MicroRNAs in oligodendrocyte development and remyelination

Ngo, C., & Kothary, R. (2022) · Journal of Neurochemistry · doi:10.1111/jnc.15618 · Cited by 42 · see citing works

Myelin inhibits oligodendroglial maturation and regulates oligodendrocytic transcription factor expression

Plemel, J. R., Manesh, S. B., Sparling, J. S., & Tetzlaff, W. (2013) · Glia · doi:10.1002/glia.22535 · Cited by 107 · see citing works

IGF binding protein alterations on periplaque oligodendrocytes in multiple sclerosis: Implications for remyelination

Wilczak, N., Chesik, D., Hoekstra, D., & Keyser, J. D. (2008) · Neurochemistry International · doi:10.1016/j.neuint.2008.03.004 · Cited by 30 · see citing works

The orphan G protein‐coupled receptor GPR149 is a negative regulator of myelination and remyelination

Suo, N., He, B., Cui, S.-H., Yang, Y., Wang, M., Yuan, Q., & Xie, X. (2022) · Glia · doi:10.1002/glia.24233 · Cited by 15 · see citing works

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Hamaguchi, M., Muramatsu, R., Fujimura, H., Mochizuki, H., Kataoka, H., & Yamashita, T. (2019) · eLife · doi:10.7554/elife.41869 · Cited by 73 · see citing works