Single-nucleus transcriptome analysis reveals cell-type-specific molecular signatures across reward circuitry in the human brain

Tran, Matthew N., Maynard, Kristen R., Spangler, Abby, Huuki, Louise A., Montgomery, Kelsey D., Sadashivaiah, Vijay, Tippani, Madhavi, Barry, Brianna K., Hancock, Dana B., Hicks, Stephanie C., Kleinman, Joel E., Hyde, Thomas M., Collado-Torres, Leonardo, Jaffe, Andrew E., Martinowich, Keri·2021·Neuron
DOI 10.1016/j.neuron.2021.09.001

Cited by (217)

Items 101–200 of 217

  1. Haloperidol-Induced Immediate Early Genes in Striatopallidal Neurons Requires the Converging Action of cAMP/PKA/DARPP-32 and mTOR Pathways
    Oriane Onimus, E. Valjent, G. Fisone, G. Gangarossa · 2022 · bioRxiv
  2. Translational Insights From Cell Type Variation Across Amygdala Subnuclei in Rhesus Monkeys and Humans
    Shawn Kamboj, Erin L. Carlson, Bradley P. Ander, Kari L. Hanson, Karl D. Murray, Julie L. Fudge, Melissa D. Bauman, Cynthia Mills Schumann, Andrew S. Fox · 2024 · American Journal of Psychiatry
  3. Drugs and Addiction Science: NIDA Celebrates 50 Years of Research and Looks to the Future
    Nora D. Volkow · 2024 · American Journal of Psychiatry
  4. Sex-Specific Concordance of Striatal Transcriptional Signatures of Opioid Addiction in Human and Rodent Brains
    Micah A. Shelton, Nicole L. Horan, Xiangning Xue, Lisa Maturin, Darrell Eacret, Julie Michaud, Navsharan Singh, Benjamin R. Williams, Mackenzie C. Gamble, Joseph A. Seggio et al. · 2025 · Biological Psychiatry Global Open Science
  5. Chronic stress in mice: how gut bacteria influence gene activity in key brain neurons
    Wenxia Jiang, Yifan Li, Jie Yang, Xunmin Tan, Ruimin Tian, Guojing Ma, Jing Wu, Jianping Zhang, Yu Huang, Ping Liu et al. · 2025 · Translational Psychiatry
  6. Single-nucleus transcriptome analysis reveals transcriptional profiles of circadian clock and pain related genes in human and mouse trigeminal ganglion
    Yanhao Chu, Yaqi Wu, Shilin Jia, Ke Xu, Jinyue Liu, Lijia Mai, Wenguo Fan, Fang Ping Huang · 2023 · Frontiers in Neuroscience
  7. Sex and cell-specific gene expression in corticolimbic brain regions associated with psychiatric disorders revealed by bulk and single-nuclei RNA sequencing
    Eamon Fitzgerald, Danusa Mar Arcego, Mojun Shen, Nicholas O’Toole, Xianglan Wen, Corina Nagy, Sara Mostafavi, Kelly Craig, Patrícia Pelufo Silveira, Nirmala Arul Rayan et al. · 2023 · EBioMedicine
  8. Cell-type and sex-specific rhythmic gene expression in the nucleus accumbens
    Lauren M. DePoy, Kaitlyn A. Petersen, Wei Zong, Kyle D. Ketchesin, Ross C. Matthaei, RuoFei Yin, Megan S. Perez, Chelsea A. Vadnie, Darius D. Becker‐Krail, Madeline R. Scott et al. · 2024 · Molecular Psychiatry
  9. A multi-omics and cell type-specific characterization of the ventral striatum in human cocaine use disorder
    Eric Zillich, Annasara Artioli, A.C. Rossetti, Diana Avetyan, Hanna Belschner, Josef Frank, Frank Stein, Jennifer Schwarz, Naguib Mechawar, Gustavo Turecki et al. · 2025 · Cell Reports
  10. Deep learning-based cell type profiles reveal signatures of Alzheimer’s disease resilience and resistance
    Eloïse Berson, Amalia Perna, Syed Abbas Bukhari, Yeasul Kim, Lei Xue, David Seong, Samson J. Mataraso, Marc Ghanem, Alan Lee Chang, Kathleen S. Montine et al. · 2025 · Brain
  11. Epigenomic profiling of mouse nucleus accumbens at single-cell resolution
    Bhatia, Parth, Yang, Lite, Luo, Jay X.J., Xu, Mengyi, Renthal, William · 2023 · Molecular and Cellular Neuroscience
  12. Reelin marks cocaine-activated striatal neurons, promotes neuronal excitability, and regulates cocaine reward
    Kasey L. Brida, Emily T. Jorgensen, Robert A. Phillips, Catherine E. Newman, Jennifer J. Tuscher, Emily K. Morring, Morgan E. Zipperly, Lara Ianov, Kelsey D. Montgomery, Madhavi Tippani et al. · 2025 · Science Advances
  13. Dopamine and serotonin inversely modulate D2 medium spiny neurons to regulate cocaine reward
    Daniel F. Cardozo Pinto, Michaela Y. Guo, Matthew B. Pomrenze, Wade Morishita, Mona X. Li, Larry S. Zweifel, Neir Eshel, Robert C. Malenka · 2026 · Nature Communications
  14. Investigating trait variability of gene co-expression network architecture in brain by controlling for genomic risk of schizophrenia
    Eugenia Radulescu, Qiang Chen, Giulio Pergola, Nicholas J. Eagles, Joshua M. Stolz, Joo Heon Shin, Thomas M. Hyde, Joel E. Kleinman, Daniel R. Weinberger · 2023 · PLoS Genetics
  15. Genetic Implication of Prenatal GABAergic and Cholinergic Neuron Development in Susceptibility to Schizophrenia
    Darren Cameron, Ngoc‐Nga Vinh, Parinda Prapaiwongs, Elizabeth A Perry, James Walters, Meng Li, Michael C. O’Donovan, Nicholas J. Bray · 2024 · Schizophrenia Bulletin
  16. Absolute Number of Three Populations of Interneurons and All GABAergic Synapses in the Human Hippocampus
    Virág T. Takács, Péter Papp, Áron Orosz, Zsuzsanna Bardóczi, Tamás Zsoldos, Krisztián Zichó, Masahiko Watanabe, Zsófia Maglóczky, Péter Gombás, Tamás F. Freund et al. · 2025 · Journal of Neuroscience
  17. EphB1 controls long-range cortical axon guidance through a cell non-autonomous role in GABAergic cells
    Ahlem Assali, George Chenaux, Jennifer Y. Cho, Stefano Berto, Nathan A. Ehrlich, Christopher W. Cowan · 2024 · Development
  18. Microglial function interacts with the environment to affect sex-specific depression risk
    Eamon Fitzgerald, Irina Pokhvisneva, Sachin H Patel, Shi Yu Chan, Ai Peng Tan, Helen Chen, Patrícia Pelufo Silveira, Michael J. Meaney · 2024 · Brain Behavior and Immunity
  19. Psychedelic Drugs in Mental Disorders: Current Clinical Scope and Deep Learning‐Based Advanced Perspectives
    Sung‐Hyun Kim, Sumin Yang, Jeehye Jung, Jeonghyeon Choi, Mingon Kang, Jae‐Yeol Joo · 2025 · Advanced Science
  20. Single-cell transcriptional profiling in brain reward structures
    Jeremy J. Day, Keri Martinowich · 2022 · Neuropsychopharmacology
  21. The gene expression landscape of the human locus coeruleus revealed by single-nucleus and spatially-resolved transcriptomics
    Lukas M. Weber, Heena R. Divecha, Matthew Nguyen Tran, Sang Ho Kwon, Abby Spangler, Kelsey D. Montgomery, Madhavi Tippani, Rahul A. Bharadwaj, Joel E. Kleinman, Stephanie C. Page et al. · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  22. Single nucleus RNA-sequencing reveals transcriptional synchrony across different relationships
    Liza E. Brusman, Julie M. Sadino, Allison C. Fultz, Michael A. Kelberman, Robin D. Dowell, Mary Ann Allen, Zoe R. Donaldson · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  23. Generation of hiPSC-Derived Brain Microvascular Endothelial Cells Using Directed Differentiation and Transcriptional Reprogramming
    Aomeng Cui, Ronak Patel, Patrick Bosco, Uğur Akcan, Emily Richters, Paula Barrilero Delgado, Dritan Agalliu, Andrew A. Sproul · 2025 · Arteriosclerosis Thrombosis and Vascular Biology
  24. Central amygdala single-nucleus atlas reveals chromatin and gene transcription dynamics in human alcohol use disorder
    Che-Yu Lee, Ahyeon Hwang, Delaney McRiley, Jaywon Lee, Geneviève Thibodeau, Catharine H. Duman, Xiangyu Zhang, Mario Škarica, Jensine M. Coudriet, Siwei Xu et al. · 2026 · Nature Communications
  25. The cellular choreography of brain aging: a neuroimmune network perspective
    Ludmila Müller, Svetlana Di Benedetto, Viktor Müller · 2026 · Frontiers in Aging Neuroscience
  26. Morphological heterogeneity of neurons in the human central amygdaloid nucleus
    Carlos E. Vásquez, Kétlyn T. Knak Guerra, Josué Renner, Alberto A. Rasia‐Filho · 2024 · Journal of Neuroscience Research
  27. Single-cell transcriptomic reveals a cell atlas and diversity of chicken amygdala responded to social hierarchy
    Siyu Chen, Limin Xing, Zhijiang Xie, Mengqiao Zhao, Hui Yu, Jiankang Gan, Haiquan Zhao, Zheng Ma, Hua Li · 2024 · iScience
  28. Altered transcriptomes, cell type proportions, and dendritic spine morphology in hippocampus of suicide decedents
    Sujan Chandra Das, Anton Schulmann, William Brandon Callor, Leslie Jerominski, Mitradas M. Panicker, Erik D. Christensen, William E. Bunney, Megan E. Williams, Hilary H Coon, Marquis P. Vawter · 2024 · Journal of Affective Disorders
  29. lute: estimating the cell composition of heterogeneous tissue with varying cell sizes using gene expression
    Sean K. Maden, Louise A. Huuki-Myers, Sang Ho Kwon, Leonardo Collado‐Torres, Kristen R. Maynard, Stephanie C. Hicks · 2025 · BMC Genomics
  30. NPAS4 supports drug-cue associations and relapse-like behavior through regulation of the cell type-specific activation balance in the nucleus accumbens
    Brandon W. Hughes, Evgeny Tsvetkov, Benjamin M. Siemsen, Kirsten K. Snyder, Rose Marie Akiki, Daniel James Wood, Rachel D. Penrod, Michael D. Scofield, Stefano Berto, Makoto Taniguchi et al. · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  31. The gene expression landscape of the human locus coeruleus revealed by single-nucleus and spatially-resolved transcriptomics
    Lukas M. Weber, Heena R. Divecha, Matthew Nguyen Tran, Sang Ho Kwon, Abby Spangler, Kelsey D. Montgomery, Madhavi Tippani, Rahul A. Bharadwaj, Joel E. Kleinman, Stephanie C. Page et al. · 2023 · eLife
  32. Natural variation in oxytocin receptor signaling causes widespread changes in brain transcription: a link to the natural killer gene complex
    Arjen J. Boender, Zachary V. Johnson, Kayla K. Green, George W. Gruenhagen, Brianna E. Hegarty, Kengo Horie, Kiyoshi Inoue, Ewoud R.E. Schmidt, Jeffrey Todd Streelman, Hasse Walum et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  33. An Efficient and Principled Model to Jointly Learn the Agnostic and Multifactorial Effect in Large-Scale Biological Data
    Zuolin Cheng, Songtao Wei, Yinxue Wang, Yizhi Wang, Qing Richard Lu, Yue Wang, Guoqiang Yu · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  34. Purinergic exposure induces epigenomic and transcriptomic-mediated preconditioning resembling epilepsy-associated microglial states
    Ricardo Martins-Ferreira, Josep Calafell-Segura, João Chaves, Laura Ciudad, António Martins da Silva, Paulo Costa, Bárbara Leal, Esteban Ballestar · 2024 · iScience
  35. Single-Nucleus Transcriptomics of the Nucleus Accumbens Reveals Cell-Type-Specific Dysregulation in Adolescent Macaques with Depressive-Like Behaviors
    Teng Teng, Qingyuan Wu, Bangmin Yin, Jushuang Zhang, Xuemei Li, Lige Zhang, Xinyu Zhou, Peng Xie · 2025 · Neuroscience Bulletin
  36. Spatiomolecular mapping reveals anatomical organization of heterogeneous cell types in the human nucleus accumbens
    Prashanthi Ravichandran, Svitlana V. Bach, Robert A. Phillips, Madeline R. Valentine, Nicholas J. Eagles, Yufeng Du, Ishbel Del Rosario, Haya A. AlGrain, Sarah E. Maguire, Ryan A. Miller et al. · 2026 · Neuron
  37. Cross-species single-cell atlas of the striatum defines cell-type and subregion disease vulnerabilities
    Raleigh M. Linville, Benjamin T. James, Kyriaki Galani, Li‐Lun Ho, Jung Hoon Shin, Esaria Oliver, Stuart B. Fass, James C. Cameron, Brent E. Fitzwalter, Roland Bock et al. · 2026 · Cell
  38. Circuit-Wide Gene Network Analysis Reveals Sex-Specific Roles for Phosphodiesterase 1b in Cocaine Addiction
    Collin D. Teague, Tamara Markovic, Xianxiao Zhou, Freddyson J. Martínez-Rivera, Angelica M. Minier-Toribio, Alexander K. Zinsmaier, Nathalia V. Pulido, Kyra H. Schmidt, Kelsey E. Lucerne, Arthur Godino et al. · 2024 · Journal of Neuroscience
  39. Genetic Implication of Specific Glutamatergic Neurons of the Prefrontal Cortex in the Pathophysiology of Schizophrenia
    Claire E. Tume, Sophie L Chick, Peter Holmans, Elliott Rees, Michael C. O’Donovan, Darren Cameron, Nicholas J. Bray · 2024 · Biological Psychiatry Global Open Science
  40. Genes with disrupted connectivity in the architecture of schizophrenia gene co-expression networks highlight atypical neuronal-glial interactions
    Eugenia Radulescu, Petra E. Vértes, Shizhong Han, Tom M. Hyde, Joel E. Kleinman, Edward Thomas Bullmore, Daniel R. Weinberger · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  41. Bulk and single-cell transcriptomic brain data identify overlapping processes and cell-types with human AUD and mammalian models of alcohol use
    Spencer B. Huggett, S. Selveraj, John E. McGeary, Ami Sala Ikeda, Emerald Yuan, Lauren B. Loeffel, Rohan H. C. Palmer · 2026 · Translational Psychiatry
  42. Breaking the Chains: Advances in Substance Addiction Research through Single-Cell Sequencing, Epigenetics, and Epitranscriptomic
    Ana Filošević, Ivana Stanković Matić, Lara Saftić Martinović, Sanja Dević Pavlić · 2024 · Future Pharmacology
  43. Deciphering brain cellular and behavioral mechanisms: Insights from single‐cell and spatial RNA sequencing
    Renrui Chen, Pengxing Nie, Jing Wang, Guang‐Zhong Wang · 2024 · Wiley Interdisciplinary Reviews - RNA
  44. The left amygdala is genetically sexually-dimorphic: multi-omics analysis of structural MRI volumes
    Yuanyuan Gui, Geyu Zhou, Shuya Cui, Hongyu Li, Hui Juan Lu, Hongyu Zhao · 2025 · Translational Psychiatry
  45. Characterizing oligodendrocyte-lineage cells and myelination in the basolateral amygdala: Insights from a novel methodology in postmortem human brain
    Kelly Perlman, Emanuel Curto, Sarah Barnett-Burns, Maria Antonietta Davoli, Volodymyr Yerko, Reem Merza, Andreas Ioannis Papadakis, Alan Spatz, Christopher Robert Pryce, Gustavo Turecki et al. · 2025 · Psychiatry Research
  46. Leveraging circuits to understand addiction
    Michael C. Salling · 2023 · Elsevier eBooks
  47. EPIC: inferring relevant cell types for complex traits by integrating genome-wide association studies and single-cell RNA sequencing
    Rujin Wang, Danyu Y. Lin, Yuchao Jiang · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  48. Cocaine addiction-like behaviors are associated with long-term changes in gene regulation, energy metabolism, and GABAergic inhibition within the amygdala
    Jessica Zhou, Giordano de Guglielmo, Aaron J. Ho, Marsida Kallupi, Narayan Prasad Pokhrel, Hairi Li, Apurva S. Chitre, Daniel B. Munro, Pejman Mohammadi, Lieselot L. G. Carrette et al. · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  49. Mechanistic convergence of depression and suicidality on astrocyte fatty acid metabolism
    Eamon Fitzgerald, Nicholas O’Toole, Irina Pokhvisneva, Gustavo Turecki, Corina Nagy, Michael Joseph Meaney · 2023 · medRxiv
  50. Genetic and environmental contributions to ancestry differences in gene expression in the human brain
    Kynon JM Benjamin, Qiang Chen, Nicholas J. Eagles, Louise A. Huuki-Myers, Leonardo Collado‐Torres, Joshua M. Stolz, Geo M. Pertea, Joo Heon Shin, Apuã C.M. Paquola, Thomas M. Hyde et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  51. Spatial transcriptomics and single-nucleus RNA sequencing reveal a transcriptomic atlas of adult human spinal cord
    Donghang Zhang, Yali Chen, Yiyong Wei, Hongjun Chen, Yujie Wu, Lin Wu, Jin Li, Qiyang Ren, Changhong Miao, Tao Zhu et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  52. Reelin marks cocaine-activated striatal ensembles, promotes neuronal excitability, and regulates cocaine reward
    Kasey L. Brida, Emily T. Jorgensen, Robert A. Phillips, Catherine E. Newman, Jennifer J. Tuscher, Emily K. Morring, Morgan E. Zipperly, Lara Ianov, Kelsey D. Montgomery, Madhavi Tippani et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  53. Platelet-derived LPA16:0 inhibits adult neurogenesis and stress resilience in anxiety disorder
    Thomas Larrieu, Charline Carron, Fabio Grieco, Crystal Weber, Kyllian Ginggen, Aurélie Delacrétaz, Héctor Gallart‐Ayala, Mumeko C. Tsuda, Heather A. Cameron, Chin B. Eap et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  54. Disruption of Cell-Type-Specific Molecular Programs of Medium Spiny Neurons in Autism
    Guohua Yuan, Varun Suresh, Emilie M. Wigdor, Yuhan Hao, Rachel Leonard, Marilyn R. Steyert, Michael Griffiths, Clements Evans, Narjes Rohani, Jakob Weiss et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  55. Multiscale Spatial Transcriptomic Atlas of Human Basal Ganglia Cell-Type and Cellular Community Organization
    Bereket T Berackey, Zhiqun Tan, Ginny Wu, Sujan Chandra Das, Li Ren, Benjamin Esser, Qiao Ye, Mahsa Nafisi, Samuel S. Park, Pedro Adolfo Sequeira Mendieta et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  56. Epigenetically constrained astrocyte states underlie prefrontal cortex vulnerability in Down syndrome–associated Alzheimer’s disease
    Chuhanwen Sun, Raina W. Thomas, Cherie A Stringer, Kyriaki Galani, Li‐Lun Ho, Na Sun, Ashley Renfro, Sierra T. Wright, Rosalind Mott Firenze, Li‐Huei Tsai et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  57. Three dimensional reconstruction of the human nucleus accumbens reveals topographic organization and molecular heterogeneity of D1-islands across the anterior posterior axis
    Robert A. Phillips, Jianing Yao, Svitlana V. Bach, Ishbel Del Rosario, Yufeng Du, Sarah E. Maguire, Ruth Zhang, Ryan A. Miller, Joel E. Kleinman, Thomas M. Hyde et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  58. Cell-type specific epigenetic and transcriptional mechanisms in substance use disorder
    Bin Wang, Jiale Wang, Nicholas J. Beacher, Da‐Ting Lin, Yan Zhang · 2025 · Frontiers in Cellular Neuroscience
  59. Corticotrophin-releasing hormone binding protein in the basolateral amygdala: divergent roles in cocaine and opioid addiction like behaviors
    Courtney P. Wood, Arnav Gurha, Caitlin Crook, Angelica R. Martinez, Selen Dirik, Cloe D Moreno, Anirudh Vaiyapuri, Avraham M. Libster, Francesca Telese, Giordano de Guglielmo · 2025 · Addiction Neuroscience
  60. Single‐Nucleus RNA Sequencing Reveals Mid‐Gestational Neurodevelopment Features in the Superior Temporal Plane from Fetuses with Nonsyndromic Cleft Lip and Palate
    Liu‐Lin Xiong, Xinwei Huang, Qiu‐Xia Xiao, Yinggang Zheng, Hao‐Yue Qin, Chang‐Le Fang, Li Chen, Ruo‐Lan Du, Qiulin Wang, Li‐Ren Huangfu et al. · 2025 · Advanced Science
  61. SpaNiche: spatial niche analysis to explore colocalization patterns and cellular interactions in spatial transcriptomics data
    Siyuan Huang, Qinghua Ran, Jie Tang, Xiaochen Wang, Junqing Xi, S X, Ruibin Xi · 2026 · Genome biology
  62. Cell-type-resolved transcriptomic landscape of human focal cortical dysplasia
    Chuantao Fang, Yi Liu, Xiaodan Zhang, Ziwu Wang, Rongliang Guo, Jingjing Guo, Xianming Liu, Yanfeng Tan, Haojie Lu, Rui Zhao et al. · 2026 · Proceedings of the National Academy of Sciences
  63. Dorsolateral Prefrontal Cortex Circuitry at the Intersection of Cognition and Disease
    Dibyadeep Datta, Amy F.T. Arnsten, Stacey J. Sukoff Rizzo, Afonso C. Silva, Mary Kate P. Joyce, Shreejoy J. Tripathy, Angela Roberts, David A. Lewis · 2026 · Biological Psychiatry
  64. Single-cell transcriptome of mouse hippocampus identifies neural precursor-like cells, and reveals IL15Rα knock out-mediated neuron remodeling
    Yanting Luo, Yadan Nie, Xuemei Huang, Haixia Wang, Zuoli Sun, Jian Yang, Yi He · 2025 · BMC Genomics
  65. Profiling transcriptomic responses of human stem cell-derived medium spiny neuron-like cells to exogenous phasic and tonic neurotransmitters
    Ryan W. Tam, Albert J. Keung · 2023 · Molecular and Cellular Neuroscience
  66. Human olfactory neuronal cells through nasal biopsy: molecular characterization and utility in brain science
    Kun Yang, Koko Ishizuka, Andrew P. Lane, Zui C. Narita, Arisa Hayashida, Yukiko Y. Lema, Emma Heffron, Haydn Loudd, Maeve Schumacher, Shin‐ichi Kano et al. · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  67. Dopamine and schizophrenia from bench to bedside: Discovery of a striatal co-expression risk gene set that predicts in vivo measures of striatal function
    Leonardo Sportelli, Daniel Paul Eisenberg, Roberta Passiatore, Enrico D’Ambrosio, Linda Antonella Antonucci, Qiang Chen, Jasmine Czarapata, Aaron L. Goldman, Michael A. Gregory, Kira Griffiths et al. · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  68. The gene expression landscape of the human locus coeruleus revealed by single-nucleus and spatially-resolved transcriptomics
    Lukas M. Weber, Heena R. Divecha, Matthew Nguyen Tran, Sang Ho Kwon, Abby Spangler, Kelsey D. Montgomery, Madhavi Tippani, Rahul A. Bharadwaj, Joel E. Kleinman, Stephanie C. Page et al. · 2023 · eLife
  69. Spatial transcriptomics and single-nucleus RNA sequencing reveal a transcriptomic atlas of adult human spinal cord
    Donghang Zhang, Yali Chen, Yiyong Wei, Hongjun Chen, Yujie Wu, Lin Wu, Jin Li, Qiyang Ren, Changhong Miao, Tao Zhu et al. · 2023 · eLife
  70. Community effort to unravel the complex human neuronal landscape exemplified for the striatum
    Joachim Ludwig Schultze, Shobhit Agrawal, Rebekka Scholz, Celia L. Hartmann, Leon Hetzel, Caterina Carraro, Joana P. Bernardes, Tobias Lautwein, Susanne Reinhardt, Marek Franitza et al. · 2024 · Research Square
  71. Differentially Altered Metabolic Pathways in the Amygdala of Subjects with Schizophrenia, Bipolar Disorder and Major Depressive Disorder
    Xiaolu Zhang, Jake Valeri, M. Eladawi, B. Gisabella, M. R. Garrett, Eric J. Vallender, Robert E. Mccullumsmith, H. Pantazopoulos, S. O'Donovan · 2024 · medRxiv
  72. Transcriptomics and proteomics of projection neurons in a circuit linking hippocampus with dorsolateral prefrontal cortex in the human brain
    Christopher Borcuk, Rahul A. Bharadwaj, Gianluca Christos Kikidis, Vamshi Mallepalli, Leonardo Sportelli, Alessandro Bertolino, Robert Norman Cole, Lauren R. Devine, Brady J. Maher, Srinidhi R. Sripathy et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  73. Bulk and Single-cell Transcriptomic Brain Data Identify Overlapping Processes and Cell-types with Human AUD and Mammalian Models of Alcohol Use
    Spencer B. Huggett, Sharmila Selveraj, John E. McGeary, Ami Sala Ikeda, Emerald Yuan, Lauren B. Loeffel, Rohan H. C. Palmer · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  74. Molecular Specification of Claustro-Amygdalar and Paleocortical Neurons and Connectivity
    Navjot Kaur, Rothem Kovner, Forrest O. Gulden, Mihovil Pletikos, David Andrijević, Tianjia Zhu, John C. Silbereis, Shaojie Ma, Nikkita Salla, Xabier de Martin et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  75. Characterizing Oligodendrocyte-Lineage Cells and Myelination in the Basolateral Amygdala: Insights from a Novel Methodology in Postmortem Human Brain
    Kelly Perlman, Emanuel Curto, Sarah Barnett-Burns, Maria Antonietta Davoli, Volodymyr Yerko, Reem Merza, Andreas Ioannis Papadakis, Alan Spatz, Christopher Robert Pryce, Gustavo Turecki et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  76. Single-nucleus transcriptomics reveals convergent effects of THC exposure and Reelin signaling on nucleus accumbens maturation in adolescence
    Yanning Zuo, Avraham M. Libster, Arnav Gurha, Numaan Formoli, Leanne Liaw, Daimeng Sun, Andrew V. Turner, Attilio Iemolo, Francesca Telese · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  77. Local control of dopamine release in nucleus accumbens gates opioid withdrawal aversion
    Matthew B. Pomrenze, Jason Tucciarone, Gavin C. Touponse, Nicholas Denomme, BaDoi N. Phan, Robyn St. Laurent, Julia A Galiza Soares, Daniel F. Cardozo Pinto, Michaela Y. Guo, Jinhee Baek et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  78. A conserved population of genetically defined striatal neurons gates opioid reward
    Olivia R. Drake, Caroline M. Fiore, Emily T. Jorgensen, Catherine E. Newman, Luke Potter, Austyn Trull, Aditya Pradeep, Lara Ianov, Jamie Peters, Jasper A. Heinsbroek et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  79. Altered transcriptomes, cell type proportions, and dendritic spine morphology in hippocampus of suicide deaths
    Sujan Chandra Das, Anton Schulmann, William Brandon Callor, Leslie Jerominski, Mitradas M. Panicker, Erik D. Christensen, William E. Bunney, Megan E. Williams, Hilary H Coon, Marquis P. Vawter · 2023 · medRxiv
  80. eLife assessment: The gene expression landscape of the human locus coeruleus revealed by single-nucleus and spatially-resolved transcriptomics
    Michael B. Eisen · 2023 · eLife
  81. Author Response: The gene expression landscape of the human locus coeruleus revealed by single-nucleus and spatially-resolved transcriptomics
    Lukas M. Weber, Heena R. Divecha, Matthew Nguyen Tran, Sang Ho Kwon, Abby Spangler, Kelsey D. Montgomery, Madhavi Tippani, Rahul A. Bharadwaj, Joel E. Kleinman, Stephanie C. Page et al. · 2023 · eLife
  82. Reviewer #2 (Public Review): The gene expression landscape of the human locus coeruleus revealed by single-nucleus and spatially-resolved transcriptomics
    2023 · eLife
  83. Reviewer #3 (Public Review): The gene expression landscape of the human locus coeruleus revealed by single-nucleus and spatially-resolved transcriptomics
    2023 · eLife
  84. Reviewer #1 (Public Review): The gene expression landscape of the human locus coeruleus revealed by single-nucleus and spatially-resolved transcriptomics
    2023 · eLife
  85. Microglial function moderates the relation between depression risk factors and depression outcomes across the life course in females
    Eamon Fitzgerald, Irina Pokhvisneva, Sachin H Patel, Shi Yu Chan, Ai Peng Tan, Helen Chen, Patrícia Pelufo Silveira, Michael Joseph Meaney · 2023 · medRxiv
  86. Purinergic Preconditioning Induces Epigenomic and Transcriptomic Changes Resembling Epilepsy-associated Microglial States
    Ricardo Martins-Ferreira, Josep Calafell-Segura, João Chaves, Laura Ciudad, António Martins da Silva, Paulo Costa, Bárbara Leal, Esteban Ballestar · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  87. Purinergic Preconditioning Induces Epigenomic and Transcriptomic-Mediated Training Resembling Epilepsy-Associated Microglial States
    Ricardo Martins-Ferreira, Josep Calafell-Segura, João Chaves, Laura Ciudad, António Martins da Silva, Paulo Costa, Bárbara Leal, Esteban Ballestar · 2023 · SSRN Electronic Journal
  88. How Can We Study the Mechanisms of Memory-Related Oscillations Using Multimodal in Vivo and in Vitro Approaches?
    H. C. Moore, Geneviève Konopka, Bradley Charles Lega · 2023 · Studies in neuroscience, psychology and behavioral economics
  89. Sex-specific Concordance of Striatal Transcriptional Signatures of Opioid Addiction in Human and Rodent Brains
    Ryan Wellington Logan, Micah A. Shelton, Nicole L. Horan, Xiangning Xue, Lisa Maturin, Darrell Eacret, Julie Michaud, Navsharan Singh, Benjamin Williams, Mackenzie C. Gamble et al. · 2024 · Research Square
  90. Cross-species dissection of the modular role of the ventral tegmental area in depressive disorders
    Laurel S. Morris, Jacqueline Beltran, James W. Murrough, Carole Morel · 2025 · Neuroscience
  91. 3A or not 3A: Cytidine deaminases in the etiology of the CAG-repeat expansion diseases
    Karen Usdin · 2025 · Proceedings of the National Academy of Sciences
  92. Peripheral blood cell-type and sex-specific signatures of alcohol misuse revealed by single-cell transcriptomics
    Amol Carl Shetty, Angela Verma, John M. Sivinski, Xueying Fan, Carolyn Doty, Brooke Hollander, Daniel Roche, Chamindi Seneviratne · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  93. Dissecting mammalian cortical circuit development at single-cell resolution using inducible barcoded rabies virus
    Zijian Zhang, Brooke R. D’Arcy, Lewei He, Diego Arroyo, Samantha Deasy, Elizabeth A. Matthews, Zihan Yan, Nirvika Rastogi, Walter Mancia Leon, Kiran Shehnaz Kaur et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  94. ER stress in D1-MSNs mediates cocaine-induced behavioral plasticity via the ATF4–SPTLC1 axis
    Yue Zhao, Shu Li, Linhong Jiang, Ying Zhao, Weihong Kuang, Qingfan Wei, Yuanyi Zhou, Shuang Han, Liang Wang, Hongchun Li et al. · 2025 · Frontiers in Pharmacology
  95. VGF in the Nucleus Accumbens Regulates Synaptic and Opioid-Evoked Plasticity
    Anisha P. Adke, Lydia B Cunitz, Rachel M. Dick, Tuba H. Ali, Carmen Julia Salvatierra Rocha, Ying Zhang, Lucy Vulchanova, Patrick E. Rothwell · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  96. Additional file 2 of Multi-slice spatial transcriptome domain analysis with SpaDo
    Bin Duan, Chen, Shaoqi, Xiaojie Cheng, Liu, Qi · 2024 · Figshare
  97. Additional file 1 of Multi-slice spatial transcriptome domain analysis with SpaDo
    Bin Duan, Chen, Shaoqi, Xiaojie Cheng, Liu, Qi · 2024 · Figshare
  98. Additional file 2 of Data-driven identification of total RNA expression genes for estimation of RNA abundance in heterogeneous cell types highlighted in brain tissue
    Louise A. Huuki-Myers, Kelsey D. Montgomery, Sang Ho Kwon, Stephanie C. Page, Stephanie C. Hicks, Maynard, Kristen R., Leonardo Collado‐Torres · 2024 · Figshare
  99. A systematic review and a meta-analysis of genetic studies linking dopaminergic alleles to aggression: Where are we now?
    Sara Palumbo, Giulia Grassi, Veronica Mariotti, Silvia Pellegrini · 2025 · Aggression and Violent Behavior
  100. Reinforced Hippocampus-Accumbens pathway marks a shift towards cognitive decline in aging
    Aurore Ribera, Brenda Fernandes-Dias, Larissa Yugay, Emma Deneuville, Manuel Dias‐Silva, Marion Violain, Thibault Bouet, Ingrid Bethus, Luísa Vaqueiro Lopes, Peter Vanhoutte et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)