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Cited by 47Epilepsy research and treatmentPharmacological Effects and Toxicity StudiesNeuroscience and Neuropharmacology Research

Hidden behavioral fingerprints in epilepsy

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Gschwind, Tilo, Zeine, Ayman, Raikov, Ivan, Markowitz, Jeffrey E., Gillis, Winthrop F., Felong, Sylwia, Isom, Lori L., Datta, Sandeep Robert +1 more·2023·Neuron
DOI 10.1016/j.neuron.2023.02.003PMC PMC10164063
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Abstract

Epilepsy is a major disorder affecting millions of people. Although modern electrophysiological and imaging approaches provide high-resolution access to the multi-scale brain circuit malfunctions in epilepsy, our understanding of how behavior changes with epilepsy has remained rudimentary. As a result, screening for new therapies for children and adults with devastating epilepsies still relies on the inherently subjective, semi-quantitative assessment of a handful of pre-selected behavioral signs of epilepsy in animal models. Here, we use machine learning-assisted 3D video analysis to reveal hidden behavioral phenotypes in mice with acquired and genetic epilepsies and track their alterations during post-insult epileptogenesis and in response to anti-epileptic drugs. These results show the persistent reconfiguration of behavioral fingerprints in epilepsy and indicate that they can be employed for rapid, automated anti-epileptic drug testing at scale.

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Cited by

Sorted by citations

Authors
Gschwind, T., Zeine, A., Raikov, I., Markowitz, J. E., Gillis, W. F., Felong, S., Isom, L. L., Datta, S. R., & Soltesz, I.
Affiliations
  • Stanford Medicine (US)
  • Harvard University (US)
  • University of Michigan (US)
Corresponding author
Gschwind, Tilo
ORCID
Venue
Neuron
Publisher
Elsevier BV
Published
2023-05
Volume
111
Issue
9
Pages
1440-1452.e5
ISSN
0896-6273 (ISSN-L)
DOI
10.1016/j.neuron.2023.02.003
PMC
PMC10164063
OpenAlex
W4321782624
Cited by
47
References
3
Citations by year
2026: 14 · 2025: 20 · 2024: 8 · 2023: 5
FWCI
9.57
Type
journal article
Language
en
Open access
Licence
Locations
  • Neuron (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Institute of Neurological Disorders and Stroke (NINDSR01NS114020, NINDSR37NS076752)
  • Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (174811, 186757)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmacological Effects and Toxicity Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
epilepsy, behavioral phenotypes, 3D video analysis, machine learning, epileptogenesis, acquired epilepsy, genetic epilepsy, mouse model
MeSH terms
Animals, Brain, Disease Models, Animal, Epilepsy, Mice

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