Risperidone reduction of amphetamine-induced self-injurious behavior in mice

Wagner, George C; Avena, Nicole; Kita, Taizo; Nakashima, Toshikatsu; Fisher, Hans; Halladay, Alycia K

doi:10.1016/j.neuropharm.2003.11.009

Cited by 22Neurotransmitter Receptor Influence on BehaviorSchizophrenia research and treatmentTryptophan and brain disorders

Risperidone reduction of amphetamine-induced self-injurious behavior in mice

Wagner, George C, Avena, Nicole, Kita, Taizo, Nakashima, Toshikatsu, Fisher, Hans, Halladay, Alycia K·2004·Neuropharmacology

DOI 10.1016/j.neuropharm.2003.11.009

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Abstract

The behavioral and neurochemical effects of high doses of amphetamine administered to BALB/c mice were examined in the presence and absence of co-administered haloperidol (a D2 antagonist), SCH 23390 (a D1 antagonist) and risperidone (a mixed 5-HT2/D2 antagonist). It was observed that mice displayed a dose-dependent increase in stereotypic behavior, oral dyskinesia, and self-injurious behavior (SIB) in response to amphetamine treatment. Furthermore, agents that blocked the SIB reversed the amphetamine-induced release of serotonin. This effect was unrelated to hyperthermia or non-specific sedation (as assessed by measurement of motor activity). These data are interpreted in the context of the underlying basis of murine SIB involving both dopaminergic and serotonergic activation and demonstrate the efficacy of risperidone in treating these behaviors.

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Inbred strains are genetically homogeneous and commercially available, maximizing their feasibility as translational tools in medications development.
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Authors: Wagner, G. C., Avena, N., Kita, T., Nakashima, T., Fisher, H., & Halladay, A. K.
Affiliations: Rutgers, The State University of New Jersey (US)
Nara Medical University (JP)
Corresponding author: Wagner, George C
ORCID: Wagner, George C
Avena, Nicole
Halladay, Alycia K
Venue: Neuropharmacology
Publisher: Elsevier BV
Published: 2004-04
Volume: 46
Issue: 5
Pages: 700-708
ISSN: 0028-3908 (ISSN-L)
DOI: 10.1016/j.neuropharm.2003.11.009
OpenAlex: W2069815211
Cited by: 22
References: 49
Citations by year: 2024: 1 · 2018: 1 · 2014: 2 · 2013: 3 · 2012: 2
FWCI: 0.70
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuropharmacology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r21ns043981-03)
National Institute of Neurological Disorders and Stroke (R21 NS 43981)
National Institute of Environmental Health Sciences (ES 11256, ES-05022., P01ES011256, P30ES005022)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords: risperidone, self-harm, amphetamine, stereotypy, oral dyskinesia, serotonin release, haloperidol, SCH 23390, dopamine D2 receptor antagonism, hyperthermia, sedation
MeSH terms: Amphetamine, Animals, Dose-Response Relationship, Drug, Male, Mice, Inbred BALB C, Motor Activity, Self-Injurious Behavior, Risperidone, Mice

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Risperidone reduction of amphetamine-induced self-injurious behavior in mice

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