The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Effects of the histone deacetylase inhibitor sodium butyrate in models of depression and anxiety
Open accessAbstract
Histone modification, which affects the rate of transcription without altering DNA sequence, occurs in response to various psychiatric drugs and in several models of psychiatric disease. As increases in histone acetylation have been seen after treatment with antidepressants, we investigated whether directly increasing histone acetylation using a histone deacetylase inhibitor would have antidepressant effects. We administered sodium butyrate (NaB, 100 mg/kg, i.p.) to mice acutely (3 injections over 24 h) or chronically (twice daily for 21 days) and subjected them to a number of behavioral tests of antidepressant response. This dose of NaB had no effect on overall locomotor activity after either acute or chronic treatment. Acutely treated mice showed an increase in immobility in the forced-swim test (FST) and an increase in latency to consume in the novel environment of the novelty-induced hypophagia (NIH) paradigm, an anxiogenic effect. The effect of NaB on anxiety did not generalize to another test, the elevated zero maze, where it had no effect. Chronic treatment with NaB had no effect on latency to consume in the NIH or immobility in the FST. However, this dose did alter histone acetylation in the hippocampus. While H4 acetylation increased in the hippocampus 30 min following acute NaB, chronic treatment caused a decrease in AcH4. There were no changes in AcH3 following either treatment. While changes in chromatin structure may be involved in the mechanism of action of antidepressant drugs, these data suggest that increasing histone acetylation pharmacologically is not sufficient to produce antidepressant effects.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“using this method of administration results in a stress-like effect and increased anxiety-like behavior”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Gundersen and Blendy, 2009
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
A Neurotrophic Model for Stress-Related Mood Disorders
Duman, R. S., & Monteggia, L. M. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.02.013 · Cited by 3,375
Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action
Tsankova, N. M., Berton, O., Renthal, W., Kumar, A., Neve, R. L., & Nestler, E. J. (2006) · Nature Neuroscience · doi:10.1038/nn1659 · Cited by 1,780
Hippocampal Volume Reduction in Major Depression
Bremner, J. D., Narayan, M., Anderson, E. R., Staib, L. H., Miller, H. L., & Charney, D. S. (2000) · American Journal of Psychiatry · doi:10.1176/ajp.157.1.115 · Cited by 1,670
Assessing antidepressant activity in rodents: recent developments and future needs
Cryan, J. F., Markou, A., & Lucki, I. (2002) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(02)02017-5 · Cited by 1,551 · cited 1×
“Thus, they may not be appropriate to test the efficacy of any antidepressant acting by a novel pathway, e.g. direct changes in gene expression (Cryan et al., 2002).”
BackgroundSheline, Y. I., Sanghavi, M., Mintun, M. A., & Gado, M. H. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-12-05034.1999 · Cited by 1,382 · cited 1×
“The observation of decreased hippocampal volume in depressed humans (Bremner et al., 2000; Sheline et al., 1999), combined with studies showing molecular and cellular changes in the hippocampi of rodents after chronic stress, and their reversal by antidepressants, have focused depression research…”
BackgroundRegulation of histone acetylation during memory formation in the hippocampus
Levenson, J. M., O'Riordan, K. J., Brown, K. D., Trinh, M. A., Molfese, D. L., & Sweatt, J. D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402229200 · Cited by 1,131
Chromatin Acetylation, Memory, and LTP Are Impaired in CBP+/− Mice
Alarcón, J. M., Malleret, G., Touzani, K., Vronskaya, S., Ishii, S., Kandel, E. R., & Barco, A. (2004) · Neuron · doi:10.1016/j.neuron.2004.05.021 · Cited by 892
Hockly, E., Richon, V. M., Woodman, B., Smith, D. L., Zhou, X., Rosa, E., Sathasivam, K., Ghazi‐Noori, S., Mahal, A., Lowden, P. A. S., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0437870100 · Cited by 847
Chromatin Remodeling Is a Key Mechanism Underlying Cocaine-Induced Plasticity in Striatum
Kumar, A., Choi, K.-H., Renthal, W., Tsankova, N. M., Theobald, D. E. H., Truong, H.-T., Russo, S. J., LaPlant, Q., Sasaki, T. S., Whistler, K. N., et al. (2005) · Neuron · doi:10.1016/j.neuron.2005.09.023 · Cited by 764
Ferrante, R. J., Kubilus, J. K., Lee, J.-H., Ryu, H., Beesen, A. A., Zucker, B., Smith, K., Kowall, N. W., Ratan, R. R., Luthi‐Carter, R., et al. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-28-09418.2003 · Cited by 705
Research works printed but not linked: 1
- Soubrie, 1975, Effects of antianxiety drugs on the food intake in trained and untrained rats and mice (author's transl.), Psychopharmacologia, 45, 203
Cited by
Sorted by citations
Items 101–112 of 112
Regional and cell-type specific distribution of HDAC2 in the adult mouse brain
YaoLing, Z.-G., Huang, Z., ZhuYing, H., & Qin, S.-L. S. (2013)
The Neurobiology and Treatment of Bipolar Disorder
Burdick, K. E., Ospina, L. H., Haggarty, S. J., & Perlis, R. H. (2017) · Oxford University Press eBooks · doi:10.1093/med/9780190681425.003.0020
Coelho, A. A. (2024) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.17.2024.tde-25072024-105142
Crosstalk between gut-brain axis and brain components along with associated neurological disorders
Bindal, P., Kaushal, S., Singh, C., & Singh, A. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-21680-0.00005-5
Pharmacoepigenetics of mood disorders
Bellia, F., Ballerini, P., & D’Addario, C. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-18722-3.00019-0
Cavallo, F., Troglio, F., Fagà, G., Fancelli, D., Shyti, R., Trattaro, S., Zanella, M., D’Agostino, G., Hughes, J. M., Cera, M. R., et al. (2020) · Figshare · doi:10.6084/m9.figshare.13257785
Cavallo, F., Troglio, F., Fagà, G., Fancelli, D., Shyti, R., Trattaro, S., Zanella, M., D’Agostino, G., Hughes, J. M., Cera, M. R., et al. (2020) · Figshare · doi:10.6084/m9.figshare.13257791
Cavallo, F., Troglio, F., Fagà, G., Fancelli, D., Shyti, R., Trattaro, S., Zanella, M., D’Agostino, G., Hughes, J. M., Cera, M. R., et al. (2020) · Figshare · doi:10.6084/m9.figshare.13257788
Role of the gut-brain axis in early stress-induced emotional vulnerability
Rincel, M. (2017) · theses.fr (ABES) · doi:10.70675/5e8a972cz9ad1z42aezb89cze6474124ef90
Vagus Nerve Modulation of the Gut–Brain Axis: Implications for Mental Health and Cognitive Function
Álvarez-Mejía, D., Mascialino, G., & León-Rojas, J. E. (2026) · The Neuroscientist · doi:10.1177/10738584261464980
Metadata
- Authors
- Gundersen, B. B., & Blendy, J. A.
- Affiliations
- University of Pennsylvania (US)
- Corresponding author
- Blendy, Julie A.
- Venue
- Neuropharmacology
- Publisher
- Elsevier BV
- Published
- 2009-07
- Volume
- 57
- Issue
- 1
- Pages
- 67-74
- ISSN
- 0028-3908 (ISSN-L)
- PMC
- PMC2702471
- OpenAlex
- W1996116694
- Cited by
- 112
- References
- 32
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 5 · 2023: 4 · 2022: 5 · 2021: 4 · 2020: 12 · 2019: 7 · 2018: 4 · 2017: 7 · 2016: 9 · 2015: 6 · 2014: 5 · 2013: 12 · 2012: 9
- FWCI
- 6.01
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neuropharmacology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (U01MH072832)
- National Institute on Drug Abuse (R01DA011649)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Histone Deacetylase Inhibitors Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- sodium butyrate, histone deacetylase inhibitors, histone acetylation, depression, anxiety, antidepressant effects, forced swim test, novelty-induced hypophagia, elevated zero maze, hippocampus, histone H4 acetylation, histone H3 acetylation, chromatin structure, locomotor activity
- MeSH terms
- Acetylation, Analysis of Variance, Animals, Antidepressive Agents, Tricyclic, Anxiety, Butyrates, Chlordiazepoxide, Depression, Desipramine, Disease Models, Animal, Drug Administration Schedule, Enzyme Inhibitors, Exploratory Behavior, Hippocampus, Histone Deacetylases, Histones, Mice, Inbred C57BL, Motor Activity, Swimming, Time Factors, Anti-Anxiety Agents, Maze Learning, Mice, Histone Deacetylase Inhibitors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
