Chromatin Acetylation, Memory, and LTP Are Impaired in CBP+/− Mice

Alarcón, Juan M; Malleret, Gaël; Touzani, Khalid; Vronskaya, Svetlana; Ishii, Shunsuke; Kandel, Eric R; Barco, Angel

doi:10.1016/j.neuron.2004.05.021

Cited by 892Memory and Neural MechanismsGenetics and Neurodevelopmental DisordersGenomics and Chromatin Dynamics

Chromatin Acetylation, Memory, and LTP Are Impaired in CBP+/− Mice

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Alarcón, Juan M, Malleret, Gaël, Touzani, Khalid, Vronskaya, Svetlana, Ishii, Shunsuke, Kandel, Eric R, Barco, Angel·2004·Neuron

DOI 10.1016/j.neuron.2004.05.021

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Abstract

We studied a mouse model of the haploinsufficiency form of Rubinstein-Taybi syndrome (RTS), an inheritable disorder caused by mutations in the gene encoding the CREB binding protein (CBP) and characterized by mental retardation and skeletal abnormalities. In these mice, chromatin acetylation, some forms of long-term memory, and the late phase of hippocampal long-term potentiation (L-LTP) were impaired. We ameliorated the L-LTP deficit in two ways: (1) by enhancing the expression of CREB-dependent genes, and (2) by inhibiting histone deacetyltransferase activity (HDAC), the molecular counterpart of the histone acetylation function of CBP. Inhibition of HDAC also reversed the memory defect observed in fear conditioning. These findings suggest that some of the cognitive and physiological deficits observed on RTS are not simply due to the reduction of CBP during development but may also result from the continued requirement throughout life for both the CREB co-activation and the histone acetylation function of CBP.

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Other monogenic syndromes like Kleefstra, KBG, WitKoS, Angelman, Coffin-Sirris, Rubinstein-Taybi, Phelan-McDermid, Smith-Magenis Syndrome and Kabuki syndrome also have a clear prefrontal component in their behavioral and cognitive phenotype.
“Other monogenic syndromes like Kleefstra, KBG, WitKoS, Angelman, Coffin-Sirris, Rubinstein-Taybi, Phelan-McDermid, Smith–Magenis Syndrome and Kabuki syndrome also have a clear prefrontal component in their behavioral and cognitive phenotype [272–280].”
From Development of prefrontal cortex (2022) · cites this paper as [272]
The section on CBP+/− mice as a model for Rubinstein–Taybi syndrome (p. 8) describes short attention spans and difficulty planning and executing motor acts, supporting the behavioral aspect of the claim for that syndrome. It does not establish a prefrontal component; the same passage says future studies are needed to identify the brain regions involved. This citation is assessed for Rubinstein–Taybi syndrome, not the other syndromes covered by the citation range. (LLM, conf=0.84)
Experimental — accuracy not yet measured
LTP impairment seen in a mouse model of RTS was first simulated.
“LTP impairment seen in a mouse model of RTS95 was first simulated.”
From The right time to learn: Mechanisms and optimization of spaced learning (2016) · cites this paper as [95]
Cbp+/− mice show impaired LTP and long-term memory.
“Cbp+/− mice show impaired LTP and long-term memory95.”
From The right time to learn: Mechanisms and optimization of spaced learning (2016) · cites this paper as [95]

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Authors: Alarcón, J. M., Malleret, G., Touzani, K., Vronskaya, S., Ishii, S., Kandel, E. R., & Barco, A.
Affiliations: Columbia University (US)
RIKEN (JP)
Howard Hughes Medical Institute (US)
Corresponding author: Kandel, Eric R
ORCID: Alarcón, Juan M
Malleret, Gaël
Ishii, Shunsuke
Kandel, Eric R
Venue: Neuron
Publisher: Elsevier BV
Published: 2004-06
Volume: 42
Issue: 6
Pages: 947-959
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/j.neuron.2004.05.021
OpenAlex: W2046459630
Cited by: 892
References: 50
Citations by year: 2026: 17 · 2025: 14 · 2024: 30 · 2023: 20 · 2022: 23 · 2021: 35 · 2020: 30 · 2019: 23 · 2018: 30 · 2017: 36 · 2016: 59 · 2015: 45 · 2014: 74 · 2013: 66 · 2012: 61
FWCI: 17.63
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 3333 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Neuron (publishedVersion)
PubMed (publishedVersion)
DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
SUNY Digital Repository Support (State University of New York System) (submittedVersion, cc-by-nc-nd)
Funders: National Institute on Aging (P50AG008702, P50AG08702)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Keywords: Rubinstein-Taybi syndrome, CREB-binding protein, chromatin acetylation, histone acetylation, histone deacetylase inhibition, long-term potentiation, long-term memory, fear conditioning, intellectual disability, hippocampus
MeSH terms: Acetylation, Analysis of Variance, Animals, Cell Line, Chromatin, Conditioning, Psychological, Disease Models, Animal, Dynorphins, Electrophysiology, Embryo, Mammalian, Fear, Female, Heterozygote, Hippocampus, Humans, Immunohistochemistry, Kidney, Male, Memory, Mice, Inbred C57BL, Mice, Transgenic, Motor Activity, Neural Inhibition, Neurons, Nuclear Proteins, Phosphodiesterase Inhibitors, Psychomotor Performance, Reaction Time, Rubinstein-Taybi Syndrome, Time Factors, Transfection, Blotting, Western, Trans-Activators, Gene Expression, Synaptophysin, Proto-Oncogene Proteins c-fos, In Situ Hybridization, Long-Term Potentiation, Maze Learning, Brain-Derived Neurotrophic Factor, Excitatory Postsynaptic Potentials, Rolipram, Recognition, Psychology, CREB-Binding Protein, Mice, In Vitro Techniques

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Chromatin Acetylation, Memory, and LTP Are Impaired in CBP+/− Mice

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