The DOI matches its Crossref record; 149 of the 150 references it cites were found in a registry or an index.
Neurotransmitter roles in synaptic modulation, plasticity and learning in the dorsal striatum
Open accessAbstract
The dorsal striatum is a large forebrain region involved in action initiation, timing, control, learning and memory. Learning and remembering skilled movement sequences requires the dorsal striatum, and striatal subregions participate in both goal-directed (action-outcome) and habitual (stimulus-response) learning. Modulation of synaptic transmission plays a large part in controlling input to as well as the output from striatal medium spiny projection neurons (MSNs). Synapses in this brain region are subject to short-term modulation, including allosteric alterations in ion channel function and prominent presynaptic inhibition. Two forms of long-term synaptic plasticity have also been observed in striatum, long-term potentiation (LTP) and long-term depression (LTD). LTP at glutamatergic synapses onto MSNs involves activation of NMDA-type glutamate receptors and D1 dopamine or A2A adenosine receptors. Expression of LTP appears to involve postsynaptic mechanisms. LTD at glutamatergic synapses involves retrograde endocannabinoid signaling stimulated by activation of metabotropic glutamate receptors (mGluRs) and D2 dopamine receptors. While postsynaptic mechanisms participate in LTD induction, maintained expression involves presynaptic mechanisms. A similar form of LTD has also been observed at GABAergic synapses onto MSNs. Studies have just begun to examine the roles of synaptic plasticity in striatal-based learning. Findings to date indicate that molecules implicated in induction of plasticity participate in these forms of learning. Neurotransmitter receptors involved in LTP induction are necessary for proper skill and goal-directed instrumental learning. Interestingly, receptors involved in LTP and LTD at glutamatergic synapses onto MSNs of the "indirect pathway" appear to have important roles in habit learning. More work is needed to reveal if and when synaptic plasticity occurs during learning and if so what molecules and cellular processes, both short- and long-term, contribute to this plasticity.
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“It is believed that the interaction between glutamate and striatal activity serves as an important modulator of synaptic plasticity and neural excitability (Surmeier et al., 2007; Kreitzer et al., 2009; Lovinger et al., 2010; Gleich et al., 2015).”
From Circuit Mechanisms of Reward, Anhedonia, and Depression (2019) · cites this paper as Lovinger et al., 2010
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Citations
Cites
Short-Term Synaptic Plasticity
Zucker, R. S., & Regehr, W. G. (2002) · Annual Review of Physiology · doi:10.1146/annurev.physiol.64.092501.114547 · Cited by 5,068 · cited 1×
“The ratio of responses to paired afferent stimuli delivered at 50 ms intervals is sensitive to the probability of neurotransmitter release (Zucker, 1989), and an increase this paired-pulse ratio generally signals a decrease in release probability.”
D 1 and D 2 Dopamine Receptor-regulated Gene Expression of Striatonigral and Striatopallidal Neurons
Gerfen, C. R., Engber, T. M., Mahan, L. C., Susel, Z., Chase, T. N., Monsma, F. J., & Sibley, D. R. (1990) · Science · doi:10.1126/science.2147780 · Cited by 2,967 · cited 2×
“These striatonigral neurons strongly express D1Rs and generally do not express A2A or D2Rs (Augood and Emson, 1994; Gerfen et al., 1990; Gong et al., 2003).”
The role of the basal ganglia in habit formation
Yin, H. H., & Knowlton, B. J. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1919 · Cited by 2,402 · cited 5×
“The striatum is the major input nucleus of the basal ganglia, and as such it plays a crucial role in action control and action learning (Saint-Cyr et al., 1995; Graybiel,1998; Lalonde and Botez-Marquard, 1997; Yin and Knowlton, 2006).”
InfluentialA gene expression atlas of the central nervous system based on bacterial artificial chromosomes
Gong, S., Zheng, C., Doughty, M. L., Losos, K., Didkovsky, N., Schambra, U. B., Nowak, N. J., Joyner, A., Leblanc, G., Hatten, M. E., et al. (2003) · Nature · doi:10.1038/nature02033 · Cited by 2,108 · cited 2×
“These striatonigral neurons strongly express D1Rs and generally do not express A2A or D2Rs (Augood and Emson, 1994; Gerfen et al., 1990; Gong et al., 2003).”
Packard, M. G., & McGaugh, J. L. (1996) · Neurobiology of Learning and Memory · doi:10.1006/nlme.1996.0007 · Cited by 1,566 · cited 2×
“…injection of a local anesthetic, which should inactivate the structure, just prior to a retention test did not impair the ability of the animal to perform a cross-maze task, but just altered the strategy used by the animal from a response-based to a place-based approach (Packard and McGaugh, 1996).”
The neostriatal mosaic: multiple levels of compartmental organization
Gerfen, C. R. (1992) · Trends in Neurosciences · doi:10.1016/0166-2236(92)90355-c · Cited by 1,471
Short-Term Synaptic Plasticity
Zucker, R. S. (1989) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.12.030189.000305 · Cited by 1,450
Integrative activity of the brain
Konorski, J. (1967) · Cited by 1,372
Yin, H. H., Knowlton, B. J., & Balleine, B. W. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03095.x · Cited by 1,226 · cited 1×
“Excitotoxic lesions of dorsolateral striatum disrupted habit learning in this study, as previously reported in rat (Hilario et al., 2007; Yin et al., 2004).”
Surmeier, D. J., Ding, J., Day, M., Wang, Z., & Shen, W. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.03.008 · Cited by 1,203 · cited 2×
“Dopamine can only act via GPCRs, and thus only modulates striatal neuronal function and synaptic transmission (Richfield et al., 1989; Surmeier et al., 2007).”
Cited by
Sorted by citations
Direct and indirect pathways of basal ganglia: a critical reappraisal
Calabresi, P., Picconi, B., Tozzi, A., Ghiglieri, V., & Filippo, M. D. (2014) · Nature Neuroscience · doi:10.1038/nn.3743 · Cited by 820
Metabotropic glutamate receptors: From the workbench to the bedside
Nicoletti, F., Bockaert, J., Collingridge, G. L., Conn, P. J., Ferraguti, F., Schoepp, D. D., Wroblewski, J. T., & Pin, J. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2010.10.022 · Cited by 680
“underlying habit memory and motor learning (reviewed by Gubellini et al., 2004; Bonsi et al., 2008; Lovinger, 2010).”
BackgroundTeleanu, R. I., Niculescu, A.-G., Roza, E., Vladâcenco, O. A., Grumezescu, A. M., & Teleanu, D. M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23115954 · Cited by 659
Alcohol and the Brain: Neuronal Molecular Targets, Synapses, and Circuits
Abrahao, K. P., Salinas, A. G., & Lovinger, D. M. (2017) · Neuron · doi:10.1016/j.neuron.2017.10.032 · Cited by 438
Addictions neuroclinical assessment: a neuroscience-based framework for addictive disorders
Kwako, L. E., Momenan, R., Litten, R. Z., Koob, G. F., & Goldman, D. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.10.024 · Cited by 395
“The phasic dopaminergic activation that drives incentive salience is hypothesized to also engage habit formation and compulsive-like responding for addictive agents via activation of cortical-striatal-pallidal-thalamic loops (90,91).”
Background
Metadata
- Authors
- Lovinger, D. M.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Lovinger, David M.
- ORCID
- Lovinger, David M.
- Venue
- Neuropharmacology
- Publisher
- Elsevier BV
- Published
- 2010-06
- Volume
- 58
- Issue
- 7
- Pages
- 951-961
- ISSN
- 0028-3908 (ISSN-L)
- PMC
- PMC2849868
- OpenAlex
- W2086614467
- Cited by
- 488
- References
- 150
- Citations by year
- 2026: 10 · 2025: 19 · 2024: 28 · 2023: 21 · 2022: 37 · 2021: 32 · 2020: 27 · 2019: 32 · 2018: 30 · 2017: 39 · 2016: 25 · 2015: 38 · 2014: 30 · 2013: 39 · 2012: 29
- FWCI
- 3.43
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neuropharmacology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute on Alcohol Abuse and Alcoholism (Z01AA000407)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- dorsal striatum, synaptic plasticity, long-term potentiation, long-term depression, medium spiny neurons, glutamatergic synapses, GABAergic synapses, NMDA receptor, dopamine D1 receptor, adenosine A2A receptor, dopamine D2 receptor, metabotropic glutamate receptors, retrograde endocannabinoid signaling, presynaptic inhibition, allosteric modulation, operant conditioning, habit learning, goal-directed learning, indirect pathway, neurotransmitter receptors
- MeSH terms
- Animals, Corpus Striatum, Learning, Neuronal Plasticity, Synapses, Neurotransmitter Agents
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