D1 and D2 dopamine-receptor modulation of striatal glutamatergic signaling in striatal medium spiny neurons
Abstract
Dopamine shapes a wide variety of psychomotor functions. This is mainly accomplished by modulating cortical and thalamic glutamatergic signals impinging upon principal medium spiny neurons (MSNs) of the striatum. Several lines of evidence suggest that dopamine D1 receptor signaling enhances dendritic excitability and glutamatergic signaling in striatonigral MSNs, whereas D2 receptor signaling exerts the opposite effect in striatopallidal MSNs. The functional antagonism between these two major striatal dopamine receptors extends to the regulation of synaptic plasticity. Recent studies, using transgenic mice in which cells express D1 and D2 receptors, have uncovered unappreciated differences between MSNs that shape glutamatergic signaling and the influence of DA on synaptic plasticity. These studies have also shown that long-term alterations in dopamine signaling produce profound and cell-type-specific reshaping of corticostriatal connectivity and function.
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The interaction between glutamate and striatal activity serves as an important modulator of synaptic plasticity and neural excitability.
“It is believed that the interaction between glutamate and striatal activity serves as an important modulator of synaptic plasticity and neural excitability (Surmeier et al., 2007; Kreitzer et al., 2009; Lovinger et al., 2010; Gleich et al., 2015).”
From Circuit Mechanisms of Reward, Anhedonia, and Depression (2019) · cites this paper as Surmeier et al., 2007
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- Authors
- Surmeier, D. J., Ding, J., Day, M., Wang, Z., & Shen, W.
- Affiliations
- Northwestern University (US)
- Corresponding author
- Surmeier, D. James
- Venue
- Trends in Neurosciences
- Publisher
- Elsevier BV
- Published
- 2007-05
- Volume
- 30
- Issue
- 5
- Pages
- 228-235
- ISSN
- 0166-2236 (ISSN-L)
- OpenAlex
- W2167021628
- Cited by
- 1,203
- References
- 142
- Citations by year
- 2026: 37 · 2025: 51 · 2024: 52 · 2023: 44 · 2022: 58 · 2021: 59 · 2020: 53 · 2019: 64 · 2018: 68 · 2017: 64 · 2016: 76 · 2015: 70 · 2014: 79 · 2013: 61 · 2012: 74
- FWCI
- 5.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Neurosciences (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke (NS 34696)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Keywords
- dopamine D1 receptor, dopamine D2 receptor, striatum, medium spiny neurons, glutamatergic signaling, striatonigral neurons, striatopallidal neurons, dendritic excitability, synaptic plasticity, corticostriatal connectivity, dopamine signaling
- MeSH terms
- Animals, Corpus Striatum, Dopamine, Glutamine, Humans, Neural Pathways, Synaptic Transmission, Neuronal Plasticity, Neurons, Signal Transduction, Receptors, Dopamine D1, Receptors, Dopamine D2
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