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Cited by 44Ion channel regulation and functionNeuroscience and Neuropharmacology ResearchReceptor Mechanisms and Signaling

Regulation of neural ion channels by muscarinic receptors

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Brown, David A.·2018·Neuropharmacology
DOI 10.1016/j.neuropharm.2017.11.024
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Abstract

The excitable behaviour of neurons is determined by the activity of their endogenous membrane ion channels. Since muscarinic receptors are not themselves ion channels, the acute effects of muscarinic receptor stimulation on neuronal function are governed by the effects of the receptors on these endogenous neuronal ion channels. This review considers some principles and factors determining the interaction between subtypes and classes of muscarinic receptors with neuronal ion channels, and summarizes the effects of muscarinic receptor stimulation on a number of different channels, the mechanisms of receptor - channel transduction and their direct consequences for neuronal activity. Ion channels considered include potassium channels (voltage-gated, inward rectifier and calcium activated), voltage-gated calcium channels, cation channels and chloride channels. This article is part of the Special Issue entitled 'Neuropharmacology on Muscarinic Receptors'.

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  • Many ion channels and transporters in the plasma membrane depend on PI(4,5)P2 for correct functioning.

    “Like endocytosis, many ion channels and transporters in the plasma membrane also depend on the presence of PI(4,5)P2 for correct functioning [112–114].”

    From Phosphatidylinositol(4,5)bisphosphate: diverse functions at the plasma membrane (2020) · cites this paper as [114]

    Section 2.1.1.4 states that Kir channels require PIP2 for activity, and the Final thoughts section identifies several other PIP2-sensitive channel types. These passages support the ion-channel part of the claim, but our copy does not establish the asserted dependence of plasma-membrane transporters on PIP2. (LLM, conf=0.87)

    Experimental — accuracy not yet measured

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Authors
Brown, D. A.
Affiliations
University College London (GB)
Corresponding author
Brown, David A.
ORCID
Brown, David A.
Venue
Neuropharmacology
Publisher
Elsevier BV
Published
2018-07
Volume
136
Issue
Pt C
Pages
383-400
ISSN
0028-3908 (ISSN-L)
DOI
10.1016/j.neuropharm.2017.11.024
OpenAlex
W2769904229
Cited by
44
References
2
Citations by year
2026: 4 · 2025: 5 · 2024: 7 · 2023: 8 · 2022: 5 · 2021: 2 · 2020: 6 · 2019: 3 · 2018: 4
FWCI
0.34
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Neuropharmacology (publishedVersion)
  • PubMed (publishedVersion)
  • UCL Discovery (University College London) (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Keywords
muscarinic receptors, neuronal ion channels, muscarinic receptor subtypes, voltage-gated potassium channels, inwardly rectifying potassium channels, calcium-activated potassium channels, voltage-gated calcium channels, cation channels, chloride channels, neuronal excitability
MeSH terms
Animals, Humans, Ion Channels, Neurons, Receptors, Muscarinic

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