Presynaptic Calcium Current Modulation by a Metabotropic Glutamate Receptor
Abstract
Metabotropic glutamate receptors (mGluRs) regulate transmitter release at mammalian central synapses. However, because of the difficulty of recording from mammalian presynaptic terminals, the mechanism underlying mGluR-mediated presynaptic inhibition is not known. Here, simultaneous recordings from a giant presynaptic terminal, the calyx of Held, and its postsynaptic target in the medial nucleus of the trapezoid body were obtained in rat brainstem slices. Agonists of mGluRs suppressed a high voltage-activated P/Q-type calcium conductance in the presynaptic terminal, thereby inhibiting transmitter release at this glutamatergic synapse. Because several forms of presynaptic modulation and plasticity are mediated by mGluRs, this identification of a target ion channel is a first step toward elucidation of their molecular mechanism.
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Activation of mGluR2s most likely affects presynaptic calcium channel function, as found in the calyx of Held.
“Most likely, activation of mGluR2s affects presynaptic calcium channel function as was found in the calyx of Held, by direct electrophysiological recordings from presynaptic terminals (Takahashi et al. 1996).”
From Short- and Long-Term Consequences of Nicotine Exposure during Adolescence for Prefrontal Cortex Neuronal Network Function (2012) · cites this paper as Takahashi et al. 1996
mGluR agonists suppress high voltage-activated P/Q-type calcium channels in the presynaptic terminal, inhibiting transmitter release.
“Agonists of mGluRs suppressed high voltage-activated P/Q-type calcium channels in the presynaptic terminal, thereby inhibiting transmitter release (Takahashi et al. 1996).”
From Short- and Long-Term Consequences of Nicotine Exposure during Adolescence for Prefrontal Cortex Neuronal Network Function (2012) · cites this paper as Takahashi et al. 1996
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- Authors
- Takahashi, T., Forsythe, I. D., Tsujimoto, T., Barnes-Davies, M., & Onodera, K.
- Affiliations
- The University of Tokyo (JP)
- University of Leicester (GB)
- I. D. Forsythe and M. Barnes-Davies, Ion Channel Group, Department of Cell Physiology and Pharmacology, University of Leicester, Post Office Box 138, Leicester LE1 9HN, UK.
- Corresponding author
- Takahashi, Tomoyuki
- Venue
- Science
- Published
- 1996-10-25
- Volume
- 274
- Issue
- 5287
- Pages
- 594-597
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2014492558
- Cited by
- 392
- References
- 45
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 4 · 2020: 7 · 2019: 7 · 2018: 9 · 2017: 9 · 2016: 7 · 2015: 7 · 2014: 4 · 2013: 9 · 2012: 16
- FWCI
- 12.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Leicester Research Archive (University of Leicester) (submittedVersion)
- Funders
- Wellcome Trust
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Keywords
- metabotropic glutamate receptors, presynaptic inhibition, calyx of Held, P/Q-type calcium channels, presynaptic calcium currents, glutamatergic synapses, neurotransmitter release, medial nucleus of the trapezoid body, ion channel modulation
- MeSH terms
- Aminobutyrates, Animals, Brain Stem, Cadmium, Calcium, Calcium Channel Blockers, Synaptic Transmission, Potassium, Synapses, Calcium Channels, Potassium Channels, Rats, Wistar, Presynaptic Terminals, Receptors, Metabotropic Glutamate, Neurotransmitter Agents, Patch-Clamp Techniques, Excitatory Amino Acid Agonists, Rats, In Vitro Techniques
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