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Cited by 344Psychedelics and Drug StudiesForensic Toxicology and Drug AnalysisSchizophrenia research and treatment

The DOI matches its Crossref record; 133 of the 137 references it cites were found in a registry or an index.

Psychiatry & the psychedelic drugs. Past, present & future

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Rucker, James J.H., Iliff, Jonathan, Nutt, David J.·2018·Neuropharmacology
DOI 10.1016/j.neuropharm.2017.12.040
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Abstract

The classical psychedelic drugs, including psilocybin, lysergic acid diethylamide and mescaline, were used extensively in psychiatry before they were placed in Schedule I of the UN Convention on Drugs in 1967. Experimentation and clinical trials undertaken prior to legal sanction suggest that they are not helpful for those with established psychotic disorders and should be avoided in those liable to develop them. However, those with so-called 'psychoneurotic' disorders sometimes benefited considerably from their tendency to 'loosen' otherwise fixed, maladaptive patterns of cognition and behaviour, particularly when given in a supportive, therapeutic setting. Pre-prohibition studies in this area were sub-optimal, although a recent systematic review in unipolar mood disorder and a meta-analysis in alcoholism have both suggested efficacy. The incidence of serious adverse events appears to be low. Since 2006, there have been several pilot trials and randomised controlled trials using psychedelics (mostly psilocybin) in various non-psychotic psychiatric disorders. These have provided encouraging results that provide initial evidence of safety and efficacy, however the regulatory and legal hurdles to licensing psychedelics as medicines are formidable. This paper summarises clinical trials using psychedelics pre and post prohibition, discusses the methodological challenges of performing good quality trials in this area and considers a strategic approach to the legal and regulatory barriers to licensing psychedelics as a treatment in mainstream psychiatry. This article is part of the Special Issue entitled 'Psychedelics: New Doors, Altered Perceptions'.

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Research works printed but not linked: 2

  1. Prentiss, 1895, Anhalonium lewinii (mescal buttons), Ther. Gaz., 11, 577
  2. Savage, 1967, The effectiveness of psychedelic (LSD) therapy: a preliminary report, Br. J. Soc. Psychol., 2, 59

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Metadata

Authors
Rucker, J. J. H., Iliff, J., & Nutt, D. J.
Affiliations
  • King's College London (GB)
  • University College London (GB)
  • Imperial College London (GB)
Corresponding author
Rucker, James J.H.
ORCID
Venue
Neuropharmacology
Publisher
Elsevier BV
Published
2018-11
Volume
142
Pages
200-218
ISSN
0028-3908 (ISSN-L)
DOI
10.1016/j.neuropharm.2017.12.040
OpenAlex
W2781316183
Cited by
343
References
137
Citations by year
2026: 38 · 2025: 40 · 2024: 59 · 2023: 49 · 2022: 50 · 2021: 50 · 2020: 36 · 2019: 14 · 2018: 7
FWCI
2.38
Type
journal article
Language
en
Open access
Licence
Locations
  • Neuropharmacology (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Research Portal (King's College London) (submittedVersion, cc-by-nc-nd)
  • Spiral (Imperial College London) (submittedVersion, cc-by)
Funders
  • National Institute for Health Research (NIHR) Biomedical Research Centre at South London
  • Maudsley NHS Foundation Trust
  • King's College London
  • UK Medical Research Council (MR/J00460X/1)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Psychedelics and Drug Studies
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Forensic Toxicology and Drug Analysis
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Keywords
psychedelics, psilocybin, lysergic acid diethylamide, mescaline, psychedelic-assisted psychotherapy, unipolar mood disorders, alcoholism, adverse events, psychosis risk
MeSH terms
Animals, Mental Disorders, Clinical Trials as Topic, Hallucinogens, Humans, Psychiatry

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