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Cited by 23Neurotransmitter Receptor Influence on BehaviorPsychopathy, Forensic Psychiatry, Sexual OffendingNeuroendocrine regulation and behavior

Dysfunctional mesocortical dopamine circuit at pre-adolescence is associated to aggressive behavior in MAO-A hypomorphic mice exposed to early life stress

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Frau, Roberto, Fanni, Silvia, Serra, Valeria, Simola, Nicola, Godar, Sean C., Traccis, Francesco, Devoto, Paola, Bortolato, Marco +1 more·2019·Neuropharmacology
DOI 10.1016/j.neuropharm.2019.01.032PMC PMC12755307
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Abstract

Aggressive behavior (AB) is a multifaceted disorder based on the interaction between genetic and environmental factors whose underlying mechanisms remain elusive. The best-characterized gene by environment (GxE) interaction for AB is the relationship between child neglect/abuse and low-activity alleles of the monoamine-oxidase A (MAOA) gene. MAOA oxidizes monoamines like serotonin and dopamine, whose aberrant signaling at discrete developmental ages plays a pivotal role in the ontogeny of AB. Here, we investigated the impact of this GxE on dopamine function at pre-adolescence by exposing hypomorphic MAOA (MAO Neo) mice to early life stress (ES) and by performing behavioral and ex vivo electrophysiological analyses in the ventral tegmental area (VTA) and the prefrontal cortex (PFC). MAOA Neo ES mouse dopamine neurons exhibited an enhanced post-synaptic responsiveness to excitatory inputs, aberrant plasticity in the PFC, and an AB. Systemic administration of the selective antagonist at dopamine D1 receptors SCH23390 fully restored PFC function and rescued AB. Collectively, these findings reveal that dysfunctional mesocortical dopamine signaling at pre-adolescence ties to AB in the MAOA Neo ES mouse, and identify dopamine D1 receptor as a molecular target to be exploited for an age-tailored therapy. This article is part of the Special Issue entitled 'The neuropharmacology of social behavior: from bench to bedside'.

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  • In gene-by-environment studies, saline injections in combination with maternal separation increased aggression in MAOA hypomorphic, but not wild-type, mice when performed over the first week of life.

    “In gene-by-environment studies, saline injections in combination with maternal separation increased aggression in monoamine oxidase A (MAOA) hypomorphic, but not wild-type, mice when performed over the first week of life (Frau et al. 2019; Godar et al. 2019).”

    From Decoding the bidirectional links between alcohol misuse and aggression: toward a unified translational framework (2026) · cites this paper as Frau et al. 2019

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Authors
Frau, R., Fanni, S., Serra, V., Simola, N., Godar, S. C., Traccis, F., Devoto, P., Bortolato, M., & Melis, M.
Affiliations
  • University of Cagliari (IT)
  • University of Utah (US)
Corresponding author
Melis, Miriam
ORCID
Venue
Neuropharmacology
Publisher
Elsevier BV
Published
2019-11
Volume
159
Pages
107517
ISSN
0028-3908 (ISSN-L)
DOI
10.1016/j.neuropharm.2019.01.032
PMC
PMC12755307
OpenAlex
W2914981935
Cited by
23
References
8
Citations by year
2025: 4 · 2024: 3 · 2023: 5 · 2022: 2 · 2021: 2 · 2020: 4 · 2019: 3
FWCI
1.31
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Neuropharmacology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (publishedVersion)
  • UNICA IRIS Institutional Research Information System (University of Cagliari) (submittedVersion)
Funders
  • University of Cagliari (RICCAR 2017)
  • Region of Sardinia (L.R. 7 8/2007, RASSR32909, F72F16002850002)
  • National Institutes of Health (MH104603)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Keywords
aggression, monoamine oxidase A, early life stress, gene-environment interaction, ventral tegmental area, prefrontal cortex, dopamine D1 receptor, synaptic plasticity, late childhood, child neglect and abuse
MeSH terms
Age Factors, Aggression, Animals, Animals, Newborn, Benzazepines, Dopamine, Male, Mice, Transgenic, Monoamine Oxidase, Nerve Net, Random Allocation, Stress, Psychological, Prefrontal Cortex, Receptors, Dopamine D1, Ventral Tegmental Area, Excitatory Postsynaptic Potentials, Mice, Mice, 129 Strain, Dopaminergic Neurons

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