Norepinephrine and Dopamine Regulate Signals and Noise in the Prefrontal Cortex: (Brainstorms)
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Article AbstractThe prefrontal cortex (PFC) is composed of a seriesof neuronal networks that establish the circuitry toprocess information in the brain. Depending on which areasof PFC are involved, malfunctioning of different circuitscan generate a wide range of psychiatric symptoms fromproblems of cognition and impulsivity to disorders of moodand anxiety. Such malfunctioning PFC circuits can even bevisualized and topographically localized with modern neuroimagingtechniques.
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Both dopamine and norepinephrine have distinct roles to facilitate information processing in the prefrontal cortex.
“both neuromodulators have distinct roles to facilitate information processing in the prefrontal cortex [33, 34].”
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Mechanism of Action of Stimulants in Attention-Deficit/Hyperactivity Disorder
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The Prefrontal Cortex Is Out of Tune in Attention-Deficit/Hyperactivity Disorder
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- Authors
- Stahl, S. M.
- Affiliations
- University of California San Diego (US)
- Corresponding author
- Stahl, Stephen M.
- ORCID
- Stahl, Stephen M.
- Venue
- The Journal of Clinical Psychiatry
- Publisher
- Physicians Postgraduate Press, Inc
- Published
- 2009-05-15
- Volume
- 70
- Issue
- 5
- Pages
- 617-618
- ISSN
- 0160-6689 (ISSN-L)
- OpenAlex
- W2411243654
- Cited by
- 11
- References
- 3
- Citations by year
- 2024: 2 · 2022: 1 · 2019: 2 · 2015: 1 · 2014: 2
- FWCI
- 0.41
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Clinical Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- norepinephrine, dopamine, prefrontal cortex, neural noise, signal-to-noise ratio, neural circuits, mental illness, cognitive impairment, impulsivity, mood disorders, anxiety disorders
- MeSH terms
- Cyclic AMP, Dopamine, Humans, Noise, Norepinephrine, Signal Transduction, Up-Regulation, Prefrontal Cortex, Receptors, Dopamine D1, Pyramidal Cells
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