Striatal responses to negative monetary outcomes differ between temperamentally inhibited and non-inhibited adolescents
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The present study compared blood oxygen level dependent (BOLD) response in behaviorally inhibited and behaviorally non-inhibited adolescents to positive and negative feedback following their choice in a reward task. Previous data in these same subjects showed enhanced activation in striatal areas in behaviorally inhibited subjects to cues predicting gain or a loss. However, no analyses had examined responses following actual gains or losses. Relative to non-inhibited subjects, behaviorally inhibited subjects in the current study showed enhanced caudate response to negative but not positive feedback, indicating that striatal sensitivity to feedback may be specific to aversive information. In addition, compared to non-inhibited subjects, behaviorally inhibited subjects exhibited reduced differentiation between positive and negative feedback in ventromedial prefrontal cortex (vmPFC). This suggests a perturbed ability to encode reward value.
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Non-BI adolescents showed greater vmPFC activation to reward versus punishment outcomes, whereas for BI adolescents, vmPFC activity did not distinguish between these outcomes.
“Specifically, non-BI adolescents showed greater vmPFC activation to reward versus punishment outcomes, whereas for BI adolescents, vmPFC activity did not distinguish between these outcomes.”
From Gaining insight into adolescent vulnerability for social anxiety from developmental cognitive neuroscience (2014) · cites this paper as Helfinstein et al., 2011
Adolescents with versus without BI history showed heightened caudate activation to punishment but not reward outcomes.
“As expected, adolescents with versus without BI history showed heightened caudate activation to punishment but not reward outcomes (Helfinstein et al., 2011).”
From Gaining insight into adolescent vulnerability for social anxiety from developmental cognitive neuroscience (2014) · cites this paper as Helfinstein et al., 2011
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References 43 · Cited by 75
- Authors
- Helfinstein, S. M., Benson, B., Perez-Edgar, K., Bar-Haim, Y., Detloff, A., Pine, D. S., Fox, N. A., & Ernst, M.
- Affiliations
- University of Maryland, College Park (US)
- National Institutes of Health (US)
- Corresponding author
- Helfinstein, Sarah M.
- Venue
- Neuropsychologia
- Publisher
- Elsevier BV
- Published
- 2011-02
- Volume
- 49
- Issue
- 3
- Pages
- 479-485
- ISSN
- 0028-3932 (ISSN-L)
- PMC
- PMC3065071
- OpenAlex
- W1969988461
- Cited by
- 75
- References
- 43
- Citations by year
- 2026: 4 · 2025: 1 · 2023: 1 · 2022: 6 · 2021: 5 · 2020: 6 · 2019: 1 · 2018: 4 · 2017: 3 · 2016: 6 · 2015: 8 · 2014: 12 · 2013: 10 · 2012: 6
- FWCI
- 3.48
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neuropsychologia (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Mental Health (R01MH074454)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R37HD017899)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- behavioral inhibition, temperament, adolescents, striatum, caudate nucleus, negative feedback, monetary outcomes, reward processing, ventromedial prefrontal cortex, BOLD signal
- MeSH terms
- Adolescent, Corpus Striatum, Cues, Female, Humans, Image Processing, Computer-Assisted, Inhibition, Psychological, Magnetic Resonance Imaging, Male, Motivation, Oxygen, Psychomotor Performance, Reward, Temperament, Prefrontal Cortex
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