Dendritic spines disappear with chilling but proliferate excessively upon rewarming of mature hippocampus

An Energy Budget for Signaling in the Grey Matter of the Brain

Attwell, D., & Laughlin, S. B. (2001) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200110000-00001 · Cited by 3,543

Synaptic Activity and the Construction of Cortical Circuits

Katz, L. C., & Shatz, C. J. (1996) · Science · doi:10.1126/science.274.5290.1133 · Cited by 3,048

Ischemic Cell Death in Brain Neurons

Lipton, P. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.4.1431 · Cited by 3,043

Imaging Neuronal Subsets in Transgenic Mice Expressing Multiple Spectral Variants of GFP

Feng, G., Mellor, R. H., Bernstein, M., Keller-Peck, C., Nguyen, Q. T., Wallace, M., Nerbonne, J. M., Lichtman, J. W., & Sanes, J. R. (2000) · Neuron · doi:10.1016/s0896-6273(00)00084-2 · Cited by 3,042

Molecular biology of the cell

Gautier, J. (1993) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(93)90025-i · Cited by 2,200

Longitudinal Assessment of Neurocognitive Function after Coronary-Artery Bypass Surgery

Newman, M. F., Kirchner, J., Phillips‐Bute, B., Gaver, V., Grocott, H. P., Jones, R. H., Mark, D. B., Reves, J. G., & Blumenthal, J. A. (2001) · New England Journal of Medicine · doi:10.1056/nejm200102083440601 · Cited by 1,963

Axo-somatic and axo-dendritic synapses of the cerebral cortex: an electron microscope study.

Eg, G. (1959) · PubMed · Cited by 1,768

Dendritic Spines: Cellular Specializations Imparting Both Stability and Flexibility to Synaptic Function

Harris, K. M., & Kater, S. B. (1994) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.17.030194.002013 · Cited by 1,020

Evidence for a Role of Dendritic Filopodia in Synaptogenesis and Spine Formation

Ziv, N. E., & Smith, S. J. (1996) · Neuron · doi:10.1016/s0896-6273(00)80283-4 · Cited by 882

Synaptogenesis Via Dendritic Filopodia in Developing Hippocampal Area CA1

Fiala, J. C., Feinberg, M., Popov, V., & Harris, K. M. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-21-08900.1998 · Cited by 758

Proteins That Promote Filopodia Stability, but Not Number, Lead to More Axonal-Dendritic Contacts

Arstikaitis, P., Gauthier-Campbell, C., Huang, K., El-Husseini, A., & Murphy, T. H. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016998 · Cited by 27

Calcium‐triggered exit of F‐actin and IP3 3‐kinase A from dendritic spines is rapid and reversible

Schell, M. J., & Irvine, R. F. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05125.x · Cited by 25

Slice It Hot: Acute Adult Brain Slicing in Physiological Temperature

Ankri, L., Yarom, Y., & Uusisaari, M. Y. (2014) · Journal of Visualized Experiments · doi:10.3791/52068 · Cited by 25

Technical report: surgical preparation of human brain tissue for clinical and basic research

Straehle, J., Ravi, V. M., Heiland, D. H., Galanis, C., Lenz, M., Zhang, J., Neidert, N. N., Rahal, A. E., Vasilikos, I., Kellmeyer, P., et al. (2023) · Acta Neurochirurgica · doi:10.1007/s00701-023-05611-9 · Cited by 23

Synaptic Odyssey

Harris, K. M. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.0735-19.2019 · Cited by 20

Neuronal pannexin-1 channels are not molecular routes of water influx during spreading depolarization-induced dendritic beading

Sword, J., Croom, D., Wang, P. L., Thompson, R. J., & Kirov, S. A. (2016) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x16639328 · Cited by 20

Protein components of post‐synaptic density lattice, a backbone structure for type I excitatory synapses

Suzuki, T., Kametani, K., Weiheng, G., & Li, W. (2017) · Journal of Neurochemistry · doi:10.1111/jnc.14254 · Cited by 20

Rapid dendritic and axonal responses to neuronal insults

Mizielinska, S., Greenwood, S. M., Tummala, H., & Connolly, C. N. (2009) · Biochemical Society Transactions · doi:10.1042/bst0371389 · Cited by 18

Combination of diOlistic labeling with retrograde tract tracing and immunohistochemistry

Neely, M. D., Stanwood, G. D., & Deutch, A. Y. (2009) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2009.08.016 · Cited by 18

Focal Cooling Devices for the Surgical Treatment of Epilepsy

Smyth, M. D., & Rothman, S. M. (2011) · Neurosurgery Clinics of North America · doi:10.1016/j.nec.2011.07.011 · Cited by 18

Cold‐induced exodus of postsynaptic proteins from dendritic spines

Cheng, H., Huang, Z., Lin, W., Chow, W., & Chang, Y. (2008) · Journal of Neuroscience Research · doi:10.1002/jnr.21852 · Cited by 18

Rescue of Synaptic Phenotypes and Spatial Memory in Young Fragile X Mice

Sun, M., Hongpaisan, J., & Alkon, D. L. (2016) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.115.231100 · Cited by 17

Acute slice preparation for electrophysiology increases spine numbers equivalently in the male and female juvenile hippocampus: a DiI labeling study

Triviño-Paredes, J., Nahirney, P. C., Pinar, C., Grandes, P., & Christie, B. R. (2019) · Journal of Neurophysiology · doi:10.1152/jn.00332.2019 · Cited by 17

Novel mechanism of hypoxic neuronal injury mediated by non‐excitatory amino acids and astroglial swelling

Álvarez‐Merz, I., Fomitcheva, I. V., Sword, J., Hernández-Guijo, J. M., Solís, J. M., & Kirov, S. A. (2022) · Glia · doi:10.1002/glia.24241 · Cited by 17

Automated and quantitative image analysis of ischemic dendritic blebbing using in vivo 2-photon microscopy data

Chen, S., Tran, S., Sigler, A., & Murphy, T. H. (2010) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2010.12.018 · Cited by 16

Cortical Composition Hierarchy Driven by Spine Proportion Economical Maximization or Wire Volume Minimization

Karbowski, J. (2015) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1004532 · Cited by 18

Moniliform deformation of retinal ganglion cells by formaldehyde‐based fixatives

Stradleigh, T. W., Greenberg, K. P., Partida, G. J., Pham, A., & Ishida, A. T. (2014) · The Journal of Comparative Neurology · doi:10.1002/cne.23689 · Cited by 15

Dynamic imaging of cerebellar Purkinje cells reveals a population of filopodia which cross-link dendrites during early postnatal development

Sdrulla, A. D., & Linden, D. J. (2006) · The Cerebellum · doi:10.1080/14734220600620908 · Cited by 16

The role of cAMP in synaptic homeostasis in response to environmental temperature challenges and hyperexcitability mutations

Ueda, A., & Wu, C. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00010 · Cited by 15

Consciousness in hibernation and synthetic torpor

Cerri, M. (2017) · Journal of Integrative Neuroscience · doi:10.3233/jin-170063 · Cited by 15

The cortical stab injury induces beading of fibers expressing ecto-nucleoside triphosphate diphosphohydrolase 3

Bjelobaba, I. M., Lavrnja, I. C., Parabucki, A., Stojkov, D., Stojiljković, M., Peković, S., & Nedeljković, N. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.06.063 · Cited by 14

Activity-Dependent Structural Plasticity of Dendritic Spines

Chapleau, C. A., & Pozzo‐Miller, L. D. (2008) · Elsevier eBooks · doi:10.1016/b978-012370509-9.00039-5 · Cited by 14

Neuronal Activity: From In Vitro Preparation to Behaving Animals

Windels, F. (2006) · Molecular Neurobiology · doi:10.1385/mn:34:1:1 · Cited by 13

Identification of a prosurvival neuroprotective mitochondrial peptide in a mammalian hibernator

Szereszewski, K. E., & Storey, K. B. (2019) · Cell Biochemistry and Function · doi:10.1002/cbf.3422 · Cited by 13

Metabolic Changes in Brain Slices over Time: a Multiplatform Metabolomics Approach

González-Riaño, C., Tapia‐González, S., Perea, G., González-Arias, C., DeFelipe, J., & Barbas, C. (2021) · Molecular Neurobiology · doi:10.1007/s12035-020-02264-y · Cited by 13

NF-κB activity in distinct neural subtypes of the rat hippocampus: Influence of time and GABA antagonism in acute slice preparationsPreprint

Sheridan, G. K., Pickering, M., Twomey, C., Moynagh, P. N., O'Connor, J. J., & Murphy, K. J. (2007) · Learning & Memory · doi:10.1101/lm.590007 · Cited by 13

Baptisms of fire or death knells for acute-slice physiology in the age of ‘omics’ and light?

Khurana, S., & Li, W.-K. (2013) · Reviews in the Neurosciences · doi:10.1515/revneuro-2013-0028 · Cited by 11

Functional and Structural Properties of Dentate Granule Cells with Hilar Basal Dendrites in Mouse Entorhino-Hippocampal Slice Cultures

Becker, D., Willems, L. M., Vnencak, M., Zahn, N., Schuldt, G., Jedlička, P., Maggio, N., Deller, T., & Vlachos, A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048500 · Cited by 12

Morphology and Fractal-Based Classifications of Neurons and Microglia in Two and Three Dimensions

Karperien, A., & Jelinek, H. F. (2024) · Advances in neurobiology · doi:10.1007/978-3-031-47606-8_7 · Cited by 8

Trauma in Neonatal Acute Brain Slices Alters Calcium and Network Dynamics and Causes Calpain-Mediated Cell Death

Suryavanshi, P. S., Baule, S. M., & Glykys, J. C. (2024) · eNeuro · doi:10.1523/eneuro.0007-24.2024 · Cited by 8

Spreading depolarization causes reversible neuronal mitochondria fragmentation and swelling in healthy, normally perfused neocortex

Sword, J., Fomitcheva, I. V., & Kirov, S. A. (2024) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x241257887 · Cited by 9

Propagation of sharp wave‐ripple activity in the mouse hippocampal CA3 subfield in vitro

Schieferstein, N., del Toro, A., Evangelista, R., Imbrosci, B., Swaminathan, A., Schmitz, D., Maier, N., & Kempter, R. (2024) · The Journal of Physiology · doi:10.1113/jp285671 · Cited by 9

Dendritic Spines and Pre-Synaptic Boutons Are Stable Despite Local Deep Hypothermic Challenge and Re-Warming In Vivo

Xie, Y., Chen, S., & Murphy, T. H. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036305 · Cited by 8

Hippocampal Sharp Wave/Ripple Complexes—Physiology and Mechanisms

Maier, N., & Kempter, R. (2017) · Studies in neuroscience, psychology and behavioral economics · doi:10.1007/978-3-319-45066-7_14 · Cited by 8

Chronic unpredictable stress abrogates the endotoxin tolerance induced by repeated peripheral LPS challenge via the TLR4 signaling pathway

Yan, J., Bai, J., Gao, C., Liang, Y., Zhao, B., & Bian, Y. (2017) · Neuroscience Letters · doi:10.1016/j.neulet.2017.02.070 · Cited by 9

Time-dependent phenotypical changes of microglia drive alterations in hippocampal synaptic transmission in acute slices

Ferrucci, L., Basilico, B., Reverte, I., Pagani, F., Scaringi, G., Cordella, F., Cortese, B., Propris, G. D., Galeone, A., Mazzarella, L., et al. (2024) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2024.1456974 · Cited by 7

Designing Tools for Assumption-Proof Brain Mapping

Marblestone, A. H., & Boyden, E. S. (2014) · Neuron · doi:10.1016/j.neuron.2014.09.004 · Cited by 7

Moderate Or Deep Local Hypothermia Does Not Prevent the Onset of Ischemia-Induced Dendritic Damage

Tran, S., Chen, S., Liu, R. R., Xie, Y., & Murphy, T. H. (2011) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2011.178 · Cited by 7

Morphology and Fractal-Based Classifications of Neurons and Microglia

Karperien, A., & Jelinek, H. F. (2016) · Springer series in computational neuroscience · doi:10.1007/978-1-4939-3995-4_6 · Cited by 7

Removal of area CA3 from hippocampal slices induces postsynaptic plasticity at Schaffer collateral synapses that normalizes CA1 pyramidal cell discharge

Dumas, T. C., Uttaro, M. R., Barriga, C., Brinkley, T., Halavi, M., Wright, S. N., Ferrante, M., Evans, R. C., Hawes, S., & Sanders, E. M. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2018.05.011 · Cited by 6

Hypothermia Affects Translocation of Numerous Cytoplasmic Proteins Following Global Cerebral Ischemia

Teilum, M., Krogh, M., Wieloch, T. W., & Mattiasson, G. (2007) · Journal of Proteome Research · doi:10.1021/pr070057l · Cited by 7

Artifactual dendritic beading in rat spinal cord induced by perfusion with cold saline and paraformaldehyde

Zhang, S., Holmberg, E. G., & Geddes, J. W. (2007) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2007.02.013 · Cited by 6

The Impact of Aquaporin‐4 Deletion on K + ‐Induced Astrocytic Swelling Depends on K + Concentration

Bakketun, C. B., Roth, L. C., Bjørnstad, D. M., Ottersen, O. P., Jensen, V., & Enger, R. (2025) · Glia · doi:10.1002/glia.70086 · Cited by 5

Neuroplasticity and brain health: insights from natural torpor

Shi, Z., Wang, X., Duan, W., Du, Y., Ling, S., Zhang, Z., Wang, G., Zhao, D., Ding, J., Zhang, K., et al. (2025) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.70069 · Cited by 5

Biolistic transfection and expression analysis of acute cortical slices

Hamad, M. I. K., Daoud, S., Petrova, P., Rabaya, O., Jbara, A., Melliti, N., Stichmann, S., Reiss, G., Herz, J., & Förster, E. (2020) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2020.108666 · Cited by 4

What are memories made of? A survey of neuroscientists on the structural basis of long-term memory

Zeleznikow-Johnston, A., Kendziorra, E., & McKenzie, A. T. (2025) · PLoS ONE · doi:10.1371/journal.pone.0326920 · Cited by 4

Alterations in the properties of neonatal thalamocortical synapses with time in in vitro slices

Luz, L. L., Currie, S. P., & Daw, M. I. (2017) · PLoS ONE · doi:10.1371/journal.pone.0171897 · Cited by 3

In vivo imaging of long-term changes in the Drosophila neuromuscular junction

Rasse, T. M. (2005) · doi:10.53846/goediss-309 · Cited by 3

Beyond the cold: New insights for neuroprotection and neurorecovery from functional genomics

Gupta, L., Amati, S., Ma, D. K., & Singhal, N. S. (2025) · Experimental Neurology · doi:10.1016/j.expneurol.2025.115558 · Cited by 3

Diversity in Synapse Structure and Composition

Hell, J. W., & Ehlers, M. (2008) · Springer eBooks · doi:10.1007/978-0-387-77232-5_1 · Cited by 2

Imaging Seizure Propagation In Vitro

Trevelyan, A. J., & Yuste, R. (2009) · Neuromethods · doi:10.1007/978-1-60327-263-6_9 · Cited by 2

Astroglial and Neuronal Integrity During Cortical Spreading Depolarization

Kirov, S. A. (2014) · Springer eBooks · doi:10.1007/978-1-4939-0974-2_7 · Cited by 2

Dendritic beading during early brain development impairs signal transmission and synaptic plasticity

Suryavanshi, P. S., Tadinada, S. M., Baule, S. M., Jhaveri-Cruz, N., Abel, T. G., & Glykys, J. C. (2025) · Acta Neuropathologica Communications · doi:10.1186/s40478-025-02123-8 · Cited by 1

Mammalian torpor and depressive disorders: a review of evidence for a connection

D’Agati, D. V., & D’Agati, D. C. (2026) · International Review of Psychiatry · doi:10.1080/09540261.2026.2753429 · Cited by 1

Adhesion Molecules at the Synapse

El-Husseini, A. (2008) · Springer eBooks · doi:10.1007/978-0-387-77232-5_7 · Cited by 1

Morphological and Neurochemical Characterization of Electrophysiologically Identified Cells

Kubota, Y. (2016) · Neuromethods · doi:10.1007/978-1-4939-3064-7_20 · Cited by 1

Soy-Enriched Bread, a Pilot Study to Determine Its Beneficial Effects in Menopause

Giustarini, D., Ricci, C., Ceccarelli, I., Pieretti, S., André, P., Migliorini, S., Massai, L., Minosi, P., Casini, I., & Aloisi, A. M. (2022) · Open Journal of Endocrine and Metabolic Diseases · doi:10.4236/ojemd.2022.122004 · Cited by 1

Morphological and Neurochemical Characterization of Electrophysiologically Identified Cells

Kubota, Y. (2021) · Neuromethods · doi:10.1007/978-1-0716-1522-5_24 · Cited by 1

The role of filopodia in the formation of spine synapses

Arstikaitis, P. (2011) · cIRcle (University of British Columbia) · doi:10.14288/1.0071638 · Cited by 1

Cellular mechanisms of synaptic plasticity in hippocampal area CA1

Guire, E. S. (2006) · doi:10.6083/m4mw2fdw

Fine morphological alterations during brain injury and recovery analyzed with intravital microscopy

Kislin, M. (2015) · Työväentutkimus Vuosikirja

Plasticity of the developing glutamate synapse in the hippocampus

Abrahamsson, T. (2007) · Gothenburg University Publications Electronic Archive (Gothenburg University)

Role of Actin-mediated Motility of Peripheral Astrocytic Processes in Synaptic Function

Molotkov, D. (2014) · Työväentutkimus Vuosikirja

Alterations of brain dendrite and synapse structure by the Streptococcus pneumoniae neurotoxin pneumolysin - Insights and pharmacological modulation Morphologische Veränderungen von Dendriten und Synapsen durch das Neurotoxin Pneumolysin - Einblicke und pharmakologischer Ansatz

Thesis, D., & Würzburg, J.-M.-U. (2012)

Dendrites: Recording from Fine Neuronal Structures Using Patch-Clamp and Imaging Techniques

Gasparini, S., & Palmer, L. M. (2016) · Neuromethods · doi:10.1007/978-1-4939-3411-9_5

Genetic Labeling of Synapses

Lois, C., & Kelsch, W. (2014) · Neuromethods · doi:10.1007/978-1-4939-1963-5_11

Imaging Spreading Depolarization in the Brainstem

Hsieh, Y. (2012) · QSpace (Queen's University Library)

Regulation of Antioxidant Defenses, DNA Damage Repair, the Immune Response, and Neuroprotection During Hibernation in the Thirteen-Lined Ground Squirrel

Szereszewski, K. E. (2019) · Carleton University's Institutional Repository (MacOdrum Library, Carleton University) · doi:10.22215/etd/2019-13837

Synaptic vesicle recycling in Vivo

Denker, A. (2012) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-535

Prenatal Alcohol Exposure Effects on NMDA Receptor Subunit Composition and Function in the Mouse Dentate Gyrus

Brady, M. L. (2012) · UNM’s Digital Repository (University of New Mexico)

Effects of natural deep hypothermia on cognitive abilities in mammals: hibernators and neonates

Hill, R. W. (2026) · Journal of Comparative Physiology B · doi:10.1007/s00360-026-01662-3

Dendrites are more spiny on mature hippocampal neurons when synapses are inactivated

Kirov, S. A., & Harris, K. M. (1999) · Nature Neuroscience · doi:10.1038/13178 · Cited by 194

Hypothermia-Associated Loss of Dendritic Spines

Roelandse, M., & Matus, A. I. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.2872-04.2004 · Cited by 56

[The effect of prolonged hypothermia on the structure and function of the neurons of surviving slices of guinea pig and suslik hippocampus].

Pavlik, L. L., Pakhotin, P. I., & Da, M. (1991) · PubMed · Cited by 4

Slices Have More Synapses than Perfusion-Fixed Hippocampus from both Young and Mature Rats

Kirov, S. A., Sorra, K. E., & Harris, K. M. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-08-02876.1999 · Cited by 279

Warmer preparation of hippocampal slices prevents synapse proliferation that might obscure LTP-related structural plasticity

Bourne, J. N., Kirov, S. A., Sorra, K. E., & Harris, K. M. (2006) · Neuropharmacology · doi:10.1016/j.neuropharm.2006.06.020 · Cited by 40