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Cited by 144Pain Mechanisms and TreatmentsHerpesvirus Infections and TreatmentsPain Management and Treatment

The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.

Further characterization of a rat model of varicella zoster virus-associated pain: Relationship between mechanical hypersensitivity and anxiety-related behavior, and the influence of analgesic drugs

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Hasnie, F.S., Breuer, J., Parker, S., Wallace, V., Blackbeard, J., Lever, I., Kinchington, P.R., Dickenson, A.H., Pheby, T., Rice, A.S.C.·2007·Neuroscience
DOI 10.1016/j.neuroscience.2006.11.029PMC PMC2394505
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Abstract

Persistent herpes zoster-associated pain is a significant clinical problem and an area of largely unmet therapeutic need. Progress in elucidating the underlying pathophysiology of zoster-associated pain and related co-morbidity behavior, in addition to appropriately targeted drug development has been hindered by the lack of an appropriate animal model. This study further characterizes a recently developed rat model of zoster-associated hypersensitivity and investigates (a) response to different viral strains; (b) relationship between viral inoculum concentration ('dose') and mechanical hypersensitivity ('response'); (c) attenuation of virus-associated mechanical hypersensitivity by clinically useful analgesic drugs; and (d) measurement of pain co-morbidity (anxiety-like behavior) and pharmacological intervention in the open field paradigm (in parallel with models of traumatic peripheral nerve injury). Varicella zoster virus was propagated on fibroblast cells before s.c. injection into the glabrous footpad of the left hind limb of adult male Wistar rats. Control animals received injection of uninfected fibroblast cells. Hind-limb reflex withdrawal thresholds to mechanical, noxious thermal and cooling stimuli were recorded at specified intervals post-infection. Infection with all viral strains was associated with a dose-dependent mechanical hypersensitivity but not a thermal or cool hypersensitivity. Systemic treatment with i.p. morphine (2.5 mg/kg), amitriptyline (10 mg/kg), gabapentin (30 mg/kg), (S)-(+)-ibuprofen (20 mg/kg) and the cannabinoid WIN55,212-2 (2 mg/kg) but not the antiviral, acyclovir (50 mg/kg), was associated with a reversal of mechanical paw withdrawal thresholds. In the open field paradigm, virus-infected and nerve-injured animals demonstrated an anxiety-like pattern of ambulation (reduced entry into the central area of the open arena) which was positively correlated with mechanical hypersensitivity. This may reflect pain-related co-morbidity. Further, anxiety-like behavior was attenuated by acute i.p. administration of gabapentin (30 mg/kg) in nerve-injured, but not virus-infected animals. This model will prove useful in elucidating the pathophysiology of zoster-associated pain and provide a tool for pre-clinical screening of analgesic drugs.

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Crossref · 10.1016/j.neuroscience.2006.11.029

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  1. Kontinen, 2003, Predictive validity of neuropathic pain models in pharmacological studies with behavioural outcome in rat: a systematic review, Proceedings of the 10th World Congress on Pain, 24, 489

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Metadata

Authors
Hasnie, F. S., Breuer, J., Parker, S., Wallace, V., Blackbeard, J., Lever, I., Kinchington, P. R., Dickenson, A. H., Pheby, T., & Rice, A. S. C.
Affiliations
  • Chelsea and Westminster Hospital (GB)
  • Queen Mary University of London (GB)
  • University of Pittsburgh (US)
  • University College London (GB)
Corresponding author
Rice, A.S.C.
ORCID
Venue
Neuroscience
Publisher
Elsevier BV
Published
2007-02
Volume
144
Issue
4
Pages
1495-1508
ISSN
0306-4522 (ISSN-L)
DOI
10.1016/j.neuroscience.2006.11.029
PMC
PMC2394505
OpenAlex
W1987479668
Cited by
144
References
48
Citations by year
2026: 4 · 2025: 2 · 2024: 4 · 2023: 6 · 2022: 4 · 2021: 8 · 2020: 5 · 2019: 5 · 2018: 2 · 2017: 13 · 2016: 7 · 2015: 10 · 2014: 13 · 2013: 9 · 2012: 9
FWCI
5.97
Type
journal article
Language
en
Open access
Licence
Locations
  • Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • UCL Discovery (University College London) (submittedVersion)
Funders
  • Wellcome Trust
  • National Institutes of Health (5r01ey007397-14)
  • National Eye Institute (EY-07397, EY08098, R01EY009397, P30EY008098)
Topics
  • Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
  • Health Sciences › Medicine › Infectious Diseases › Herpesvirus Infections and Treatments
  • Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
Keywords
varicella-zoster virus, herpes zoster pain, postherpetic neuralgia, mechanical hypersensitivity, anxiety-like behavior, analgesics, gabapentin, morphine, amitriptyline, ibuprofen, WIN 55,212-2, cannabinoid analgesia, acyclovir, peripheral nerve injury, virus strain comparison, dose-response relationship, rat model
MeSH terms
Gabapentin, Amines, Analgesics, Animals, Anxiety Disorders, Cells, Cultured, Cyclohexanecarboxylic Acids, Disease Models, Animal, Fibroblasts, gamma-Aminobutyric Acid, Hyperalgesia, Male, Motor Activity, Nociceptors, Pain Measurement, Peripheral Nerves, Physical Stimulation, Anti-Anxiety Agents, Herpesvirus 3, Human, Rats, Wistar, Pain Threshold, Viral Load, Rats, Neuralgia, Postherpetic

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