The ascent of mouse: advances in modelling human depression and anxiety

Emotion circuits in the brain

LeDoux, J. E. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.155 · Cited by 8,444 · see citing works

Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene

Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., McClay, J., Mill, J., Martin, J., Braithwaite, A., et al. (2003) · Science · doi:10.1126/science.1083968 · Cited by 8,120 · see citing works

The Epidemiology of Major Depressive Disorder: Results From the National Comorbidity Survey Replication (NCS-R)

Kessler, R. C., Berglund, P., Demler, O., Jin, R., Koretz, D., Merikangas, K. R., Rush, A. J., Walters, E. E., & Wang, P. S. (2003) · JAMA · doi:10.1001/jama.289.23.3095 · Cited by 7,988 · see citing works

Alternative projections of mortality and disability by cause 1990–2020: Global Burden of Disease Study

Murray, C. J. L., & López, A. D. (1997) · The Lancet · doi:10.1016/s0140-6736(96)07492-2 · Cited by 7,007 · see citing works

The Endophenotype Concept in Psychiatry: Etymology and Strategic Intentions

Gottesman, I. I., & Gould, T. D. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.4.636 · Cited by 5,615 · see citing works

Depression: a new animal model sensitive to antidepressant treatments

PORSOLT, R. D., LE PICHON, M., & JALFRE, M. (1977) · Nature · doi:10.1038/266730a0 · Cited by 4,451 · see citing works

The price of innovation: new estimates of drug development costs

DiMasi, J. A., Hansen, R. W., & Grabowski, H. G. (2003) · Journal of Health Economics · doi:10.1016/s0167-6296(02)00126-1 · Cited by 4,265 · see citing works

Deep Brain Stimulation for Treatment-Resistant Depression

Mayberg, H. S., Lozano, A. M., Voon, V., McNeely, H. E., Seminowicz, D., Hamani, C., Schwalb, J. M., & Kennedy, S. H. (2005) · Neuron · doi:10.1016/j.neuron.2005.02.014 · Cited by 4,059 · see citing works

Genetic Epidemiology of Major Depression: Review and Meta-Analysis

Sullivan, P. F., Neale, M. C., & Kendler, K. S. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.10.1552 · Cited by 3,431 · see citing works

Neurobiology of Depression

Nestler, E. J., Barrot, M., DiLeone, R. J., Eisch, A. J., Gold, S. J., & Monteggia, L. M. (2002) · Neuron · doi:10.1016/s0896-6273(02)00653-0 · Cited by 3,217 · see citing works

The role of childhood trauma in the neurobiology of mood and anxiety disorders: preclinical and clinical studies

Heim, C., & Nemeroff, C. B. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01157-x · Cited by 2,791 · see citing works

Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations

Meaney, M. J. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.1161 · Cited by 2,708 · see citing works

Conditioned Reflexes: An Investigation of the Physiological Activity of the Cerebral Cortex.

Pavlov, P. I. (1930) · Archives of Neurology And Psychiatry · doi:10.1001/archneurpsyc.1930.02220110256018 · Cited by 2,681 · see citing works

THE EFFECTS OF STRESSFUL LIFE EVENTS ON DEPRESSION

Kessler, R. C. (1997) · Annual Review of Psychology · doi:10.1146/annurev.psych.48.1.191 · Cited by 2,111 · see citing works

Failure to escape traumatic shock.

Seligman, M. E., & Maier, S. F. (1967) · Journal of Experimental Psychology · doi:10.1037/h0024514 · Cited by 1,981 · cited 1× · see citing works

Neurobiology of Pavlovian fear conditioning.

Maren, S. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.897 · Cited by 1,866 · see citing works

Conditioned Reflexes: an Investigation of the Physiological Activity of the Cerebral Cortex

Denny-Brown, D. E. (1928) · Nature · doi:10.1038/121662a0 · Cited by 1,854 · see citing works

Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation

Willner, P. (1997) · Psychopharmacology · doi:10.1007/s002130050456 · Cited by 1,832 · see citing works

The endogenous cannabinoid system controls extinction of aversive memories

Marsicano, G., Wotjak, C. T., Azad, S. C., Bisogno, T., Rammes, G., Cascio, M. G., Hermann, H., Tang, J., Hofmann, C., Zieglgänsberger, W., et al. (2002) · Nature · doi:10.1038/nature00839 · Cited by 1,728 · see citing works

The tail suspension test as a model for assessing antidepressant activity: Review of pharmacological and genetic studies in mice

Cryan, J. F., Mombereau, C., & Vassout, A. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.03.009 · Cited by 1,674 · see citing works

Genetics of Mouse Behavior: Interactions with Laboratory Environment

Crabbe, J. C., Wahlsten, D., & Dudek, B. C. (1999) · Science · doi:10.1126/science.284.5420.1670 · Cited by 1,666 · see citing works

Assessing antidepressant activity in rodents: recent developments and future needs

Cryan, J. F., Markou, A., & Lucki, I. (2002) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(02)02017-5 · Cited by 1,551 · see citing works

Prefrontal executive and cognitive functions in rodents: neural and neurochemical substrates

Dalley, J. W., Cardinal, R. N., & Robbins, T. W. (2004) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.09.006 · Cited by 1,329 · see citing works

The developmental role of serotonin: news from mouse molecular genetics

Gaspar, P., Cases, O., & Maroteaux, L. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1256 · Cited by 1,297 · see citing works

The Economic Burden of Depression in the United States: How Did It Change Between 1990 and 2000?

Greenberg, P. E., Kessler, R. C., Birnbaum, H. G., Leong, S. A., Lowe, S. W., Berglund, P. A., & Corey-Lisle, P. K. (2003) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v64n1211 · Cited by 1,280 · see citing works

Fear and anxiety: Animal models and human cognitive psychophysiology

Lang, P. J., Davis, M., & Öhman, A. (2000) · Journal of Affective Disorders · doi:10.1016/s0165-0327(00)00343-8 · Cited by 1,162 · see citing works

Discovering Endophenotypes for Major Depression

Hasler, G., Drevets, W. C., Manji, H. K., & Charney, D. S. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300506 · Cited by 1,123 · see citing works

Assessing substrates underlying the behavioral effects of antidepressants using the modified rat forced swimming test

Cryan, J. F., Valentino, R. J., & Lucki, I. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.03.008 · Cited by 1,115 · see citing works

The neuroanatomical and neurochemical basis of conditioned fear

Fendt, M., & Fanselow, M. S. (1999) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(99)00016-0 · Cited by 1,092 · see citing works

Cognitive Enhancers as Adjuncts to Psychotherapy: Use of D-Cycloserine in Phobic Individuals to Facilitate Extinctionof Fear

Ressler, K. J., Rothbaum, B. O., Tannenbaum, L., Anderson, P., Graap, K., Zimand, E., Hodges, L., & Davis, M. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.11.1136 · Cited by 1,063 · see citing works

Neuropsychopharmacology: The Fifth Generation of Progress

Sagduyu, K. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.7.1251-a · Cited by 1,023 · see citing works

Forced swimming test in mice: A review of antidepressant activity

Petit-Demouliere, B., Chenu, F., & Bourin, M. (2005) · Psychopharmacology · doi:10.1007/s00213-004-2048-7 · Cited by 1,003 · see citing works

Untitled work

(2000) · Cited by 919 · see citing works

Measuring normal and pathological anxiety-like behaviour in mice: a review

Belzung, C., & Griebel, G. (2001) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00291-1 · Cited by 912 · see citing works

Serotonin1A receptor acts during development to establish normal anxiety-like behaviour in the adult

Gross, C. T., Zhuang, X., Stark, K. L., Ramboz, S., Oosting, R. S., Kirby, L. G., Santarelli, L., Beck, S. G., & Hen, R. (2002) · Nature · doi:10.1038/416396a · Cited by 906 · see citing works

Mice deficient for corticotropin-releasing hormone receptor-2 display anxiety-like behaviour and are hypersensitive to stress

Bale, T. L., Contarino, A., Smith, G. W., Chan, R. K. W., Gold, L. H., Sawchenko, P. E., Koob, G. F., Vale, W. W., & Lee, K. (2000) · Nature Genetics · doi:10.1038/74263 · Cited by 850 · see citing works

A simple and reliable conflict procedure for testing anti-anxiety agents

Vogel, J. R., Beer, B., & Clody, D. E. (1971) · Psychopharmacology · doi:10.1007/bf00403989 · Cited by 844 · see citing works

Cognitive bias and affective state

Harding, E. J., Paul, E. S., & Mendl, M. (2004) · Nature · doi:10.1038/427312a · Cited by 835 · see citing works

Measuring emotional processes in animals: the utility of a cognitive approach

Paul, E. S., Harding, E. J., & Mendl, M. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.01.002 · Cited by 809 · see citing works

The effects of meprobamate, barbiturates, d-amphetamine and promazine on experimentally induced conflict in the rat

Geller, I., & Seifter, J. (1960) · Psychopharmacology · doi:10.1007/bf00429273 · Cited by 787 · see citing works

A CRITICAL APPRAISAL

Dave, K. A., & White, S. W. (2002) · World Highways/Routes du Monde · Cited by 767 · see citing works

Understanding Human Nature.

ADLER, A., & Wolfe, W. B. (1928) · JAMA · doi:10.1001/jama.1928.02690420071048 · Cited by 743 · see citing works

Toward an objective characterization of an anhedonic phenotype: A signal-detection approach

Pizzagalli, D. A., Jahn, A. L., & O’Shea, J. P. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.11.026 · Cited by 738 · see citing works

Animal Model of Depression

McKinney, W. T. (1969) · Archives of General Psychiatry · doi:10.1001/archpsyc.1969.01740200112015 · Cited by 710 · see citing works

Tryptophan Hydroxylase-2 Controls Brain Serotonin Synthesis

Zhang, X., Beaulieu, J., Sotnikova, T. D., Gainetdinov, R. R., & Caron, M. G. (2004) · Science · doi:10.1126/science.1097540 · Cited by 683 · see citing works

Effects of Chronic Fluoxetine in Animal Models of Anxiety and Depression

Dulawa, S. C., Holick, K. A., Gundersen, B., & Hen, R. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300433 · Cited by 671 · see citing works

Research and treatment approaches to depression

Wong, M.-L., & Licinio, J. (2001) · Nature Reviews Neuroscience · doi:10.1038/35072566 · Cited by 656 · see citing works

Animal models of anxiety: an ethological perspective

Rodgers, R. J., Cao, B.-J., Dalvi, A., & Holmes, A. (1997) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x1997000300002 · Cited by 642 · see citing works

“Behavioural despair” in rats and mice: Strain differences and the effects of imipramine

Porsolt, R. D., Bertin, A., & Jalfre, M. (1978) · European Journal of Pharmacology · doi:10.1016/0014-2999(78)90414-4 · Cited by 640 · see citing works

In search of a depressed mouse: utility of models for studying depression-related behavior in genetically modified mice

Cryan, J. F., & Mombereau, C. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001457 · Cited by 616 · see citing works

The knockout mouse project

The Comprehensive Knockout Mouse Project Consortium (2004) · Nature Genetics · doi:10.1038/ng0904-921 · Cited by 608 · see citing works

Gene Targeting: A Practical Approach

Hirst, M. C. (1994) · Journal of Medical Genetics · doi:10.1136/jmg.31.10.821-a · Cited by 593 · see citing works

Abnormal adaptations to stress and impaired cardiovascular function in mice lacking corticotropin-releasing hormone receptor-2

Coste, S. C., Kesterson, R. A., Heldwein, K. A., Stevens, S. L., Heard, A. D., Hollis, J. H., Murray, S., Hill, J. K., Pantely, G. A., Hohimer, A. R., et al. (2000) · Nature Genetics · doi:10.1038/74255 · Cited by 588 · see citing works

Textbook of psychopharmacology

Edwards, G. (1975) · Nature · doi:10.1038/258648b0 · Cited by 583 · see citing works

The use of behavioral test batteries: Effects of training history

McIlwain, K. L., Merriweather, M. Y., Yuva-Paylor, L. A., & Paylor, R. (2001) · Physiology & Behavior · doi:10.1016/s0031-9384(01)00528-5 · Cited by 579 · see citing works

Gene targeting: a practical approach.

Joyner, A. L. (1993) · Cited by 575 · see citing works

Stress-Induced Anhedonia in Mice is Associated with Deficits in Forced Swimming and Exploration

Strekalova, T. V., Spanagel, R., Bartsch, D., Henn, F. A., & Gass, P. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300532 · Cited by 564 · see citing works

Decreased GABAA-receptor clustering results in enhanced anxiety and a bias for threat cues

Crestani, F., Lorez, M., Baer, K., Essrich, C., Benke, D., Laurent, J. P., Belzung, C., Fritschy, J.-M., Lüscher, B., & Mohler, H. (1999) · Nature Neuroscience · doi:10.1038/12207 · Cited by 550 · see citing works

Anxiety and Cognition: A Unified Theory

Eysenck, M. W. (2014) · Medical Entomology and Zoology · Cited by 531 · see citing works

Analysis of GABA A Receptor Function and Dissection of the Pharmacology of Benzodiazepines and General Anesthetics Through Mouse Genetics

Rudolph, U., & Möhler, H. (2004) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.44.101802.121429 · Cited by 518 · see citing works

Sensitivity to the effects of pharmacologically selective antidepressants in different strains of mice

Lucki, I., Dalvi, A., & Mayorga, A. J. (2001) · Psychopharmacology · doi:10.1007/s002130100694 · Cited by 506 · see citing works

Deletion of Crhr2 reveals an anxiolytic role for corticotropin-releasing hormone receptor-2

Kishimoto, T., Radulović, J., Radulović, M., Lin, C. R., Schrick, C., Hooshmand, F., Hermanson, O., Rosenfeld, M. G., & Spiess, J. (2000) · Nature Genetics · doi:10.1038/74271 · Cited by 502 · see citing works

Different data from different labs: Lessons from studies of gene–environment interaction

Wahłsten, D., Metten, P., Phillips, T. J., Boehm, S. L., Burkhart‐Kasch, S., Dorow, J. D., Doerksen, S., Downing, C., Fogarty, J., Rodd‐Henricks, K., et al. (2002) · Journal of Neurobiology · doi:10.1002/neu.10173 · Cited by 495 · see citing works

Evaluation of marble-burying behavior as a model of anxiety

Njung'e, K., & Handley, S. L. (1991) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(91)90590-x · Cited by 487 · see citing works

Pet-1 ETS gene plays a critical role in 5-HT neuron development and is required for normal anxiety-like and aggressive behavior.

Hendricks, T. J., Fyodorov, D., Wegman, L. J., Lelutiu, N. B., Pehek, E. A., Yamamoto, B., Silver, J., Weeber, E., Sweatt, J., & Deneris, E. S. (2003) · Neuron · doi:10.1016/s0896-6273(02)01167-4 · Cited by 486 · see citing works

Loss-of-Function Mutation in Tryptophan Hydroxylase-2 Identified in Unipolar Major Depression

Zhang, X., Gainetdinov, R. R., Beaulieu, J.-M., Sotnikova, T. D., Burch, L. H., Williams, R. B., Schwartz, D. A., Krishnan, K. R. R., & Caron, M. G. (2005) · Neuron · doi:10.1016/j.neuron.2004.12.014 · Cited by 473 · see citing works

Anxiolytic- and antidepressant-like effects of the non-peptide vasopressin V _1b receptor antagonist, SSR149415, suggest an innovative approach for the treatment of stress-related disorders

Griebel, G., Simiand, J., Serradeil-Le Gal, C., Wagnon, J., Pascal, M., Scatton, B., Maffrand, J.-P., & Soubrié, P. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.092012099 · Cited by 471 · see citing works

Longitudinal trajectories of depression and anxiety in a prospective community study: the Zurich Cohort Study.

Merikangas, K., Zhang, H.-P., Avenevoli, S., Acharyya, S., Neuenschwander, M., & Angst, J. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.9.993 · Cited by 466 · see citing works

Mice lacking the norepinephrine transporter are supersensitive to psychostimulants

Xu, F., Gainetdinov, R. R., Wetsel, W. C., Jones, S. R., Bohn, L., Miller, G. W., Wang, Y.-M., & Caron, M. G. (2000) · Nature Neuroscience · doi:10.1038/74839 · Cited by 464 · see citing works

Gene-Environment Interplay in Relation to Emotional and Behavioral Disturbance

Rutter, M. L., & Silberg, J. L. (2002) · Annual Review of Psychology · doi:10.1146/annurev.psych.53.100901.135223 · Cited by 459 · see citing works

Animal models for the study of anti-anxiety agents: A review

Treit, D. (1985) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(85)90046-6 · Cited by 449 · see citing works

The Neural Basis of Mood-Congruent Processing Biases in Depression

Elliott, R., Rubinsztein, J. S., Sahakian, B. J., & Dolan, R. J. (2002) · Archives of General Psychiatry · doi:10.1001/archpsyc.59.7.597 · Cited by 440 · see citing works

Animal models of ‘anxiety’: Where next?

Rodgers, R. J. (1997) · Behavioural Pharmacology · doi:10.1097/00008877-199711000-00003 · Cited by 437 · cited 1× · see citing works

Sleep deprivation in depression: what do we know, where do we go?

Wirz-Justice, A., & Van den Hoofdakker, R. H. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00125-0 · Cited by 429 · see citing works

Animal models of depression: An overview

Willner, P. (1990) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(90)90076-e · Cited by 428 · see citing works

Differences in anxiety-related behaviours and in sensitivity to diazepam in inbred and outbred strains of mice

Griebel, G., Belzung, C., Perrault, G., & Sanger, D. J. (2000) · Psychopharmacology · doi:10.1007/s002130050038 · Cited by 420 · see citing works

Mouse ENU Mutagenesis

Justice, M. J. (1999) · Human Molecular Genetics · doi:10.1093/hmg/8.10.1955 · Cited by 418 · see citing works

Generalised anxiety disorder

Tyrer, P., & Baldwin, D. (2006) · The Lancet · doi:10.1016/s0140-6736(06)69865-6 · Cited by 404 · see citing works

Neuropeptide systems as novel therapeutic targets for depression and anxiety disorders

Holmes, A., Heilig, M. A., Rupniak, N. M. J., Steckler, T., & Griebel, G. (2003) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2003.09.011 · Cited by 401 · see citing works

Twin studies of psychiatric illness: an update.

Kendler, K. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.11.1005 · Cited by 376 · see citing works

Neurobiological bases for the relation between sleep and depression

Adrien, J. (2002) · Sleep Medicine Reviews · doi:10.1053/smrv.2001.0200 · Cited by 350 · see citing works

Genetic and Pharmacological Evidence of a Role for GABAB Receptors in the Modulation of Anxiety- and Antidepressant-Like Behavior

Mombereau, C., Kaupmann, K., Froestl, W., Sansig, G., van der Putten, H., & Cryan, J. F. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300413 · Cited by 348 · see citing works

Do animal models of anxiety predict anxiolytic-like effects of antidepressants?

Borsini, F., Podhorna, J., & Marazziti, D. (2002) · Psychopharmacology · doi:10.1007/s00213-002-1155-6 · Cited by 347 · see citing works

Genetic Dissection of Complex Traits with Chromosome Substitution Strains of Mice

Singer, J. B., Hill, A. E., Burrage, L. C., Olszens, K. R., Song, J., Justice, M. J., O’Brien, W. E., Conti, D. V., Witte, J. S., Lander, E. S., et al. (2004) · Science · doi:10.1126/science.1093139 · Cited by 347 · see citing works

Abnormal behavioral phenotypes of serotonin transporter knockout mice: parallels with human anxiety and depression

Holmes, A., Murphy, D. L., & Crawley, J. N. (2003) · Biological Psychiatry · doi:10.1016/j.biopsych.2003.09.003 · Cited by 342 · see citing works

Local gene knockdown in the brain using viral-mediated RNA interference

Hommel, J. D., Sears, R. M., Georgescu, D., Simmons, D. L., & DiLeone, R. J. (2003) · Nature Medicine · doi:10.1038/nm964 · Cited by 334 · see citing works

Epigenetic sources of behavioral differences in mice

Francis, D. D., Szegda, K. L., Campbell, G., Martin, W. D., & Insel, T. R. (2003) · Nature Neuroscience · doi:10.1038/nn1038 · Cited by 333 · see citing works

Early life genetic, epigenetic and environmental factors shaping emotionality in rodents

Holmes, A., Guisquet, A. M. L., Vogel, E., Millstein, R. A., Leman, S., & Belzung, C. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.04.012 · Cited by 296 · see citing works

The Mouse Defense Test Battery: pharmacological and behavioral assays for anxiety and panic

Blanchard, D. C., Griebel, G., & Blanchard, R. J. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)01276-7 · Cited by 295 · see citing works

Evaluation of Antidepressant-related Behavioral Responses in Mice Lacking the Serotonin Transporter

Holmes, A. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(02)00374-3 · Cited by 288 · see citing works

Genetic dissection of a behavioral quantitative trait locus shows that Rgs2 modulates anxiety in mice

Yalcin, B., Willis‐Owen, S. A. G., Fullerton, J. M., Meesaq, A., Deacon, R. M. J., Rawlins, J. N. P., Copley, R. R., Morris, A. P., Jonathan Flint, C., & Mott, R. (2004) · Nature Genetics · doi:10.1038/ng1450 · Cited by 279 · see citing works

Aggression, anxiety and vocalizations in animals: GABAA and 5-HT anxiolytics

Miczek, K. A., Weerts, E. M., Vivian, J. A., & Barros, H. M. T. (1995) · Psychopharmacology · doi:10.1007/bf02245590 · Cited by 277 · see citing works

Behavioural analysis of four mouse strains in an anxiety test battery

van Gaalen, M. M., & Steckler, T. (2000) · Behavioural Brain Research · doi:10.1016/s0166-4328(00)00240-0 · Cited by 267 · see citing works

Antidepressant and anxiolytic‐like effects in mice lacking the group III metabotropic glutamate receptor mGluR7

Cryan, J. F., Kelly, P. H., Neijt, H. C., Sansig, G., Flor, P. J., & van der Putten, H. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02667.x · Cited by 266 · see citing works

Behavioral, neurochemical, and electrophysiological characterization of a genetic mouse model of depression

Yacoubi, M. E., Bouali, S., Popa, D., Naudon, L., Leroux‐Nicollet, I., Hamon, M., Costentin, J., Adrien, J., & Vaugeois, J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1034823100 · Cited by 263 · see citing works

Identification of Glyoxalase-I as a Protein Marker in a Mouse Model of Extremes in Trait Anxiety

Krömer, S. A., Kessler, M. S., Milfay, D., Birg, I., Bunck, M., Czibere, L., Panhuysen, M., Pütz, B., Deussing, J. M., Holsboer, F., et al. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0115-05.2005 · Cited by 263 · see citing works

Norepinephrine-deficient mice lack responses to antidepressant drugs, including selective serotonin reuptake inhibitors

Cryan, J. F., O’Leary, O. F., Jin, S., Friedland, J. C., Ouyang, M., Hirsch, B. R., Page, M. E., Dalvi, A., THOMAS, S. A., & Lucki, I. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401080101 · Cited by 252 · see citing works

Modern biomedical research: an internally self-consistent universe with little contact with medical reality?

Horrobin, D. F. (2003) · Nature Reviews Drug Discovery · doi:10.1038/nrd1012 · Cited by 248 · see citing works

d-cycloserine facilitates extinction of learned fear: Effects on reacquisition and generalized extinction

Ledgerwood, L., Richardson, R., & Cranney, J. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.01.023 · Cited by 243 · see citing works

Effects of the selective nonpeptide corticotropin-releasing factor receptor 1 antagonist antalarmin in the chronic mild stress model of depression in mice

Ducottet, C., Griebel, G., & Belzung, C. (2003) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(03)00051-4 · Cited by 236 · see citing works

From monoamines to genomic targets: a paradigm shift for drug discovery in depression

Wong, M., & Licinio, J. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1303 · Cited by 225 · see citing works

Conditioned taste aversion as a learning and memory paradigm

Welzl, H., D’Adamo, P., & Lipp, H.-P. (2001) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00302-3 · Cited by 220 · see citing works

The reality of comorbidity: Depression and drug abuse

Volkow, N. D. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.07.007 · Cited by 213 · see citing works

Neurochemical and behavioral consequences of widespread gene knockdown in the adult mouse brain by using nonviral RNA interference

Thakker, D. R., Natt, F., Hüsken, D., Maier, R., Müller, M., van der Putten, H., Hoyer, D., & Cryan, J. F. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0406214101 · Cited by 211 · see citing works

Analysis of quantitative trait loci that influence animal behavior

Jonathan Flint, C. (2002) · Journal of Neurobiology · doi:10.1002/neu.10161 · Cited by 210 · see citing works

Stress-induced hyperthermia and anxiety: pharmacological validation

Olivier, B., Zethof, T. J. J., Pattij, T., van Bogaert, M. J. V., van Oorschot, R., Leahy, C. L., Oosting, R. S., Bouwknecht, J. A., Veening, J. G., van der Gugten, J., et al. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)01326-8 · Cited by 209 · see citing works

Depression and Cardiovascular Disease

Rumsfeld, J. S., & Ho, P. M. (2005) · Circulation · doi:10.1161/01.cir.0000154573.62822.89 · Cited by 208 · see citing works

Psychogenic, neurogenic, and systemic stressor effects on plasma corticosterone and behavior: Mouse strain-dependent outcomes.

Anisman, H., Hayley, S. P., Kelly, O. P., Borowski, T. B., & Merali, Z. (2001) · Behavioral Neuroscience · doi:10.1037/0735-7044.115.2.443 · Cited by 206 · see citing works

Toward Behavioral Genomics

McGuffin, P., Riley, B. P., & Plomin, R. J. (2001) · Science · doi:10.1126/science.1057264 · Cited by 204 · see citing works

Galanin GAL-R1 Receptor Null Mutant Mice Display Increased Anxiety-Like Behavior Specific to the Elevated Plus-Maze

Holmes, A., Kinney, J. W., Wrenn, C. C., Li, Q., Yang, R. J., Ma, L., Vishwanath, J., Saavedra, M. C., Innerfield, C. E., Jacoby, A. S., et al. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300164 · Cited by 202 · see citing works

Escape performance following exposure to inescapable shock: Deficits in motor response maintenance.

Anisman, H., deCatanzaro, D., & Remington, G. J. (1978) · Journal of Experimental Psychology Animal Behavior Processes · doi:10.1037/0097-7403.4.3.197 · Cited by 200 · see citing works

Neural Circuitry of Anxiety: Evidence from Structural and Functional Neuroimaging Studies

Cannistraro, P. A., Rauch, S. L., Rauch, A. S. L., & MD (2025) · Psychopharmacology Bulletin · doi:10.64719/pb.4161 · Cited by 199 · see citing works

Withdrawal from chronic amphetamine induces Depressive-Like behavioral effects in rodents

Cryan, J. F., Hoyer, D., & Markou, A. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01730-4 · Cited by 199 · see citing works

Targeted gene mutation approaches to the study of anxiety-like behavior in mice

Holmes, A. (2001) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(01)00012-4 · Cited by 198 · see citing works

Multiple neurochemical and behavioral consequences of stressors: Implications for depression

Anisman, H., & Zacharko, R. M. (1990) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(90)90039-5 · Cited by 196 · see citing works

The α2A-Adrenergic Receptor Plays a Protective Role in Mouse Behavioral Models of Depression and Anxiety

Schramm‐Sapyta, N. L., McDonald, M. P., & Limbird, L. E. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-13-04875.2001 · Cited by 194 · see citing works

Effects of transgenic overproduction of CRH on anxiety‐like behaviour

van Gaalen, M. M., Stenzel‐Poore, M. P., Holsboer, F., & Steckler, T. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.02040.x · Cited by 189 · see citing works

Animal models of anxiety based on classical conditioning: The conditioned emotional response (CER) and the fear-potentiated startle effect

Davis, M. E. (1990) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(90)90084-f · Cited by 187 · see citing works

QTL analysis identifies multiple behavioral dimensions in ethological tests of anxiety in laboratory mice

Turri, M. G., Datta, S. R., DeFries, J. C., Henderson, N. D., & Jonathan Flint, C. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00206-8 · Cited by 169 · see citing works

Anxiety, motor activation, and maternal–infant interactions in 5HT1B knockout mice.

Brunner, D., Buhot, M.-C., Hen, R., & Hofer, M. A. (1999) · Behavioral Neuroscience · doi:10.1037/0735-7044.113.3.587 · Cited by 168 · see citing works

Increased Fear Response to Contextual Cues in Mice Lacking the 5-HT1A Receptor

Klemenhagen, K. C., Gordon, J. A., David, D. J. P., Hen, R., & Gross, C. T. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300774 · Cited by 167 · see citing works

Genetic animal models of anxiety

Finn, D. A., Rutledge-Gorman, M. T., & Crabbe, J. C. (2003) · Neurogenetics · doi:10.1007/s10048-003-0143-2 · Cited by 166 · see citing works

Anxiety, motor activation, and maternal-infant interactions in 5HT-sub(1B ) knockout mice.

Brunner, D., Buhot, M.-C., Hen, R., & Hofer, M. A. (1999) · Behavioral Neuroscience · doi:10.1037//0735-7044.113.3.587 · Cited by 164 · see citing works

Stress-induced vocalisation in adult animals. A valid model of anxiety?

Sánchez, C. (2003) · European Journal of Pharmacology · doi:10.1016/s0014-2999(03)01277-9 · Cited by 163 · see citing works

siRNA-mediated knockdown of the serotonin transporter in the adult mouse brain

Thakker, D. R., Natt, F., Hüsken, D., van der Putten, H., Maier, R., Hoyer, D., & Cryan, J. F. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001687 · Cited by 159 · see citing works

Do infant rats cry?

Blumberg, M. S., & Sokoloff, G. (2001) · Psychological Review · doi:10.1037/0033-295x.108.1.83 · Cited by 157 · see citing works

Validation of a simple, ethologically relevant paradigm for assessing anxiety in mice

Merali, Z., Levac, C., & Anisman, H. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01827-9 · Cited by 157 · see citing works

A ‘crash’ course on psychostimulant withdrawal as a model of depression

Barr, A. M., Markou, A., & Phillips, A. G. (2002) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(02)02086-2 · Cited by 156 · see citing works

Fear potentiation and fear inhibition in a human fear-potentiated startle paradigm

Jovanovic, T., Keyes, M., Fiallos, A., Myers, K. M., Davis, M., & Duncan, E. J. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.02.025 · Cited by 150 · see citing works

In search of a better mouse test.

Wahlsten, D., Rustay, N., Metten, P., & Crabbe, J. (2003) · Trends in Neurosciences · doi:10.1016/s0166-2236(03)00033-x · Cited by 149 · see citing works

Par-4 Links Dopamine Signaling and Depression

Park, S. K., Nguyen, M. D., Fischer, A., Luke, M. P.-S., Affar, E. B., Dieffenbach, P. B., Tseng, H.-C., Shi, Y., & Tsai, L. (2005) · Cell · doi:10.1016/j.cell.2005.05.031 · Cited by 144 · see citing works

Phenotypic analysis of dopamine receptor knockout mice; recent insights into the functional specificity of dopamine receptor subtypes

Holmes, A., Lachowicz, J. E., & Sibley, D. R. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.07.034 · Cited by 133 · see citing works

The complete introductory lectures on psychoanalysis

Freud, S., & Strachey, J. (1971) · Medical Entomology and Zoology · Cited by 132 · see citing works

Altered anxiety and depression-related behaviour in mice lacking GABAB(2) receptor subunits

Mombereau, C., Kaupmann, K., Gassmann, M., Bettler, B., van der Putten, H., & Cryan, J. F. (2005) · Neuroreport · doi:10.1097/00001756-200502280-00021 · Cited by 132 · see citing works

Dissection of behavior and psychiatric disorders using the mouse as a model

Tarantino, L. M. (2000) · Human Molecular Genetics · doi:10.1093/hmg/9.6.953 · Cited by 130 · see citing works

Depression, antidepressants and suicidality: a critical appraisal

Licinio, J., & Wong, M. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1634 · Cited by 129 · see citing works

Altered Anxiety-Related Responses in Mutant Mice Lacking the β4 Subunit of the Nicotinic Receptor

Salas, R., Pieri, F., Fung, B., Dani, J. A., & De Biasi, M. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-15-06255.2003 · Cited by 128 · see citing works

Dissociating anorexia and anhedonia elicited by interleukin-1β: antidepressant and gender effects on responding for "free chow" and "earned" sucrose intake

Merali, Z., Brennan, K., Brau, P., & Anisman, H. (2003) · Psychopharmacology · doi:10.1007/s00213-002-1273-1 · Cited by 127 · see citing works

Evaluation of an Anxiety-Related Phenotype in Galanin Overexpressing Transgenic Mice

Holmes, A., Yang, R. J., & Crawley, J. N. (2002) · Journal of Molecular Neuroscience · doi:10.1385/jmn:18:1-2:151 · Cited by 126 · see citing works

Research on Major Depression

Insel, T. R., & Charney, D. S. (2003) · JAMA · doi:10.1001/jama.289.23.3167 · Cited by 117 · see citing works

The Genes and Brains of Mice and Men

Tecott, L. H. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.4.646 · Cited by 116 · see citing works

A rodent model of sleep disturbances in posttraumatic stress disorder: The role of context after fear conditioning

Pawlyk, A. C., Jha, S. K., Brennan, F. X., Morrison, A. R., & Ross, R. J. M. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.11.008 · Cited by 115 · see citing works

New estimates of drug development costs

Frank, R. G. (2003) · Journal of Health Economics · doi:10.1016/s0167-6296(03)00002-x · Cited by 115 · see citing works

Prolonged fear responses in mice lacking dopamine D1 receptor

El-Ghundi, M., O’Dowd, B. F., & George, S. R. (2001) · Brain Research · doi:10.1016/s0006-8993(00)03234-0 · Cited by 112 · see citing works

Animal models of depression: navigating through the clinical fog

Matthews, K., Christmas, D. M., Swan, J., & Sorrell, E. (2005) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.03.005 · Cited by 112 · see citing works

Fear conditioning in virtual reality contexts: a new tool for the study of anxiety

Baas, J. M., Nugent, M., Lissek, S., Pine, D. S., & Grillon, C. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.02.024 · Cited by 111 · see citing works

Identification of Multiple Genetic Loci Linked to the Propensity for “Behavioral Despair” in MicePreprint

Yoshikawa, T., Watanabe, A., Ishitsuka, Y., Nakaya, A., & Nakatani, N. (2002) · Genome Research · doi:10.1101/gr.222602 · Cited by 108 · see citing works

Olfactory bulbectomy in mice induces alterations in exploratory behavior

Zueger, M., Urani, A., Chourbaji, S., Zacher, C., Roche, M., Harkin, A., & Gass, P. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.10.040 · Cited by 108 · see citing works

Influence of Shock Training and Explicit Fear-Conditioned Cues on Sleep Architecture in Mice: Strain Comparison

Sanford, L. D., Tang, X., Ross, R. J., & Morrison, A. R. (2003) · Behavior Genetics · doi:10.1023/a:1021051516829 · Cited by 106 · see citing works

Separation of anxiety and depressive disorders: blind alley in psychopharmacology and classification of disease

Shorter, E., & Tyrer, P. (2003) · BMJ · doi:10.1136/bmj.327.7407.158 · Cited by 105 · see citing works

A review of the relevance and validity of olfactory bulbectomy as a model of depression

Harkin, A., Kelly, J. P., & Leonard, B. E. (2003) · Clinical Neuroscience Research · doi:10.1016/s1566-2772(03)00087-2 · Cited by 103 · see citing works

Prior test experience compromises the anxiolytic efficacy of chlordiazepoxide in the mouse light/dark exploration test

Holmes, A., Iles, J. P., Mayell, S. J., & Rodgers, R. J. (2001) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00184-x · Cited by 102 · see citing works

Animal Models of Anxiety Disorders

Graeff, F. G., & Zangrossi, H. (2002) · Biological Psychiatry · doi:10.1002/0470854871.chxix1 · Cited by 101 · see citing works

Summary of a National Institute of Mental Health workshop: developing animal models of anxiety disorders

Shekhar, A., McCann, U., Meaney, M. J., Blanchard, D. C., Davis, M., Frey, K. A., Liberzon, I., Overall, K. L., Shear, M., Tecott, L. H., et al. (2001) · Psychopharmacology · doi:10.1007/s002130100859 · Cited by 101 · see citing works

Reduction in preference for saccharin by repeated unpredictable stress in mice and its prevention by imipramine

Harkin, A., Houlihan, D. D., & Kelly, J. P. (2002) · Journal of Psychopharmacology · doi:10.1177/026988110201600201 · Cited by 98 · see citing works

Reduced stress‐induced hyperthermia in mGluR5 knockout mice

Brodkin, J. D., BRADBURY, M. J., Busse, C. S., Warren, N., Bristow, L. J., & Varney, M. A. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.02294.x · Cited by 90 · see citing works

AX+, BX- Discrimination Learning in the Fear-Potentiated Startle Paradigm: Possible Relevance to Inhibitory Fear Learning in ExtinctionPreprint

Myers, K. M., & Davis, M. E. (2004) · Learning & Memory · doi:10.1101/lm.74704 · Cited by 87 · see citing works

A comparison of anxiolytic and nonanxiolytic agents in the shock-probe/burying test for anxiolytics

Treit, D. (1990) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(90)90151-7 · Cited by 86 · see citing works

Can anthropomorphic analyses of separation cries in other animals inform us about the emotional nature of social loss in humans? Comment on Blumberg and Sokoloff (2001).

Panksepp, J. (2003) · Psychological Review · doi:10.1037/0033-295x.110.2.376 · Cited by 85 · see citing works

Developmental disruption of serotonin transporter function impairs cerebral responses to whisker stimulation in mice

Esaki, T., Cook, M., Shimoji, K., Murphy, D. L., Sokoloff, L., & Holmes, A. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501509102 · Cited by 85 · see citing works

REM sleep: a sensitive index of fear conditioning in rats

Jha, S. K., Brennan, F. X., Pawlyk, A. C., Ross, R. J. M., & Morrison, A. R. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.03920.x · Cited by 83 · see citing works

Harnessing the mouse to unravel the genetics of human disease

Phillips, T. J., Belknap, J. K., Hitzemann, R., Buck, K. J., Cunningham, C. L., & Crabbe, J. C. (2002) · Genes Brain & Behavior · doi:10.1046/j.1601-1848.2001.00011.x · Cited by 82 · see citing works

Generalised Anxiety Disorder

Sramek, J. J., Zarotsky, V., & Cutler, N. R. (2002) · Drugs · doi:10.2165/00003495-200262110-00005 · Cited by 80 · see citing works

Depression, anxiety, and the cardiovascular system: the cardiologist's perspective.

Sheps, D. S., & Sheffield, D. (2001) · PubMed · Cited by 80 · see citing works

A Comparative Review of Rodent Prefrontal Cortex and Working Memory

Jones, M. W. (2002) · Current Molecular Medicine · doi:10.2174/1566524023361989 · Cited by 78 · see citing works

Emotional reactivity in mice may not be inherited but influenced by parents

Calatayud, F., Coubard, S., & Belzung, C. (2003) · Physiology & Behavior · doi:10.1016/j.physbeh.2003.10.001 · Cited by 75 · see citing works

9.3 Implications for Research

Solmaz, O. (2025) · Multilingual Matters eBooks · doi:10.21832/9781800418745-058 · Cited by 73 · see citing works

Gender Differences in Learned Helplessness Behavior Are Influenced by Genetic Background

Caldarone, B. J., George, T. P., Zachariou, V., & Picciotto, M. R. (2000) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(00)00271-9 · Cited by 72 · see citing works

Overview of the past contributions of animal models and their changing place in psychiatry

McKinney, W. T. (2001) · Seminars in Clinical Neuropsychiatry · doi:10.1053/scnp.2001.20292 · Cited by 69 · see citing works

Homology in behavioural pharmacology: an approach to animal models of human cognition

Robbins, T. W. (1998) · Behavioural Pharmacology · doi:10.1097/00008877-199811000-00005 · Cited by 64 · see citing works

Anxiogenic Effect of Cholecystokinin in the Dorsal Periaqueductal Gray

Netto, C. F., & Guimarães, F. S. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300334 · Cited by 64 · see citing works

Combining pindolol and paroxetine in an animal model of chronic antidepressant action—can early onset of action be detected?

Cryan, J. F., McGrath, C., Leonard, B. E., & Norman, T. R. (1998) · European Journal of Pharmacology · doi:10.1016/s0014-2999(98)00402-6 · Cited by 63 · see citing works

Strain-specific effects of antidepressants on escape deficits induced by inescapable shock

Shanks, N. M., & Anisman, H. (1989) · Psychopharmacology · doi:10.1007/bf00634465 · Cited by 60 · see citing works

Genetic deletion and pharmacological blockade of CB1 receptors modulates anxiety in the shock‐probe burying test

Degroot, A., & Nomikos, G. G. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03556.x · Cited by 58 · see citing works

The complete introductory lectures on psychoanalysis

WOLFF, H. H. (1967) · Journal of Psychosomatic Research · doi:10.1016/0022-3999(67)90092-x · Cited by 49 · see citing works

The serotonin transporter gene‐linked polymorphism and negative emotionality: placing single gene effects in the context of genetic background and environment

Holmes, A., & Hariri, A. R. (2003) · Genes Brain & Behavior · doi:10.1046/j.1601-1848.2003.00052.x · Cited by 47 · see citing works

Corticotropin-Releasing Factor Receptor 1 and Central Heart Rate Regulation in Mice during Expression of Conditioned Fear

Stiedl, O., Meyer, M., Jahn, O., Ögren, S. O., & Spiess, J. (2005) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.104.075820 · Cited by 42 · see citing works

Cocaine and SKF-82958 potentiate brain stimulation reward in Swiss-Webster mice

Gilliss, B., Malanga, C. J., Pieper, J. O., et al. (2002) · Psychopharmacology · doi:10.1007/s00213-002-1153-8 · Cited by 40 · see citing works

Opportunities to Discover Genes Regulating Depression and Antidepressant Response from Rodent Behavioral Genetics

Crowley, J. J., & Lucki, I. (2005) · Current Pharmaceutical Design · doi:10.2174/1381612053382278 · Cited by 40 · see citing works

Anxiety-like state associates with taste to produce conditioned taste aversion

Guitton, M. J., & Dudai, Y. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.08.024 · Cited by 38 · see citing works

Olfactory bulbectomy increases prepro-enkephalin mRNA levels in the ventral striatum in rats

Holmes, P. V. (1999) · Neuropeptides · doi:10.1054/npep.1999.0031 · Cited by 28 · see citing works

Effects of midazolam on the expression of conditioned taste aversion in rats

Yasoshima, Y., & Yamamoto, T. (2005) · Brain Research · doi:10.1016/j.brainres.2005.02.070 · Cited by 26 · see citing works

An Ethological Perspective

Stevenson‐Hinde, J. (1994) · Psychological Inquiry · doi:10.1207/s15327965pli0501_13 · Cited by 25 · see citing works

The Mousetrap: Managing the Placebo Effect in Antidepressant Trials

Lakoff, A. (2002) · Molecular Interventions · doi:10.1124/mi.2.2.72 · Cited by 21 · see citing works

Transgenic and Knockout Models of Psychiatric Disorders

Fisch, G. S. (2006) · Contemporary clinical neuroscience · doi:10.1007/978-1-59745-058-4_1 · Cited by 16 · see citing works

Therapeutic area influences drug development costs

Frantz, S. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1436 · Cited by 16 · see citing works

The Internal Conflict Model: A Theoretical Framework for Integration.

Sato, T. (2005) · The Humanistic Psychologist · doi:10.1207/s15473333thp3301_4 · Cited by 10 · see citing works

Hard heads and open minds: A reply to Panksepp (2003).

Blumberg, M. S., & Sokoloff, G. (2003) · Psychological Review · doi:10.1037/0033-295x.110.2.389 · Cited by 9 · see citing works

Animal models of anxiety; grounds for depression? Commentary on Rodgers, ???Animal models of anxiety: where next????

Stephens, D. N. (1997) · Behavioural Pharmacology · doi:10.1097/00008877-199711000-00004 · Cited by 4 · see citing works

Reduced anxiety-like behavior and central neurochemical change in germ-free mice: Behavior in germ-free mice

Neufeld, K. M., Kang, N., Bienenstock, J., & Foster, J. A. (2011) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2010.01620.x · Cited by 1,392 · see citing works

Genetic Sensitivity to the Environment: The Case of the Serotonin Transporter Gene and Its Implications for Studying Complex Diseases and Traits

Caspi, A., Hariri, A. R., Holmes, A., Uher, R., & Moffitt, T. E. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2010.09101452 · Cited by 1,346 · see citing works

Gene–environment interactions in psychiatry: joining forces with neuroscience

Caspi, A., & Moffitt, T. E. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1925 · Cited by 1,300 · see citing works

Using the rat forced swim test to assess antidepressant-like activity in rodents

Slattery, D. A., & Cryan, J. F. (2012) · Nature Protocols · doi:10.1038/nprot.2012.044 · Cited by 903 · see citing works

Resolving the neural circuits of anxiety

Calhoon, G. G., & Tye, K. M. (2015) · Nature Neuroscience · doi:10.1038/nn.4101 · Cited by 766 · see citing works

Stress, serotonin, and hippocampal neurogenesis in relation to depression and antidepressant effects

Mahar, I., Bambico, F. R., Mechawar, N., & Nobrega, J. N. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.11.009 · Cited by 694 · see citing works

Aberrant light directly impairs mood and learning through melanopsin-expressing neurons

LeGates, T. A., Altimus, C. M., Wang, H., Lee, H.-K., Yang, S., Zhao, H., Kirkwood, A., Weber, E. T., & Hattar, S. (2012) · Nature · doi:10.1038/nature11673 · Cited by 577 · see citing works

Anxiety disorders

Craske, M. G., Stein, M. B., Eley, T. C., Milad, M. R., Holmes, A., Rapee, R. M., & Wittchen, H.-U. (2017) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2017.24 · Cited by 652 · see citing works

Behavioral phenotypes of Disc1 missense mutations in mice

Clapcote, S. J., Lipina, T. V., Millar, J. K., Mackie, S., Christie, S., Ogawa, F., Lerch, J. P., Trimble, K., Uchiyama, M., Sakuraba, Y., et al. (2007) · Neuron · doi:10.1016/j.neuron.2007.04.015 · Cited by 526 · see citing works

The neurobiology of depression and antidepressant action

Willner, P., Scheel-Krüger, J., & Belzung, C. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.12.007 · Cited by 519 · see citing works

Antidepressants recruit new neurons to improve stress response regulation

Surget, A., Tanti, A., Leonardo, E. D., Laugeray, A., Rainer, Q., Touma, C., Palme, R., Griebel, G., Ibarguen-Vargas, Y., Hen, R., et al. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.48 · Cited by 471 · see citing works

Stress-induced prefrontal reorganization and executive dysfunction in rodents

Holmes, A., & Wellman, C. L. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.11.005 · Cited by 469 · see citing works

Brief Uncontrollable Stress Causes Dendritic Retraction in Infralimbic Cortex and Resistance to Fear Extinction in Mice

Izquierdo, A., Wellman, C. L., & Holmes, A. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.0474-06.2006 · Cited by 459 · see citing works

Effects of unpredictable chronic mild stress on anxiety and depression-like behavior in mice

Mineur, Y. S., Belzung, C., & Crusio, W. E. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.07.029 · Cited by 459 · see citing works

Melancholic microbes: a link between gut microbiota and depression

Dinan, T. G., & Cryan, J. F. (2013) · Neurogastroenterology & Motility · doi:10.1111/nmo.12198 · Cited by 424 · see citing works

Maternal separation as a model of brain-gut axis dysfunction

O’Mahony, S. M., Hyland, N. P., Dinan, T. G., & Cryan, J. F. (2011) · Psychopharmacology · doi:10.1007/s00213-010-2010-9 · Cited by 415 · see citing works

High-speed imaging reveals neurophysiological links to behavior in an animal model of depression

Airan, R. D., Meltzer, L. A., Roy, M., Gong, Y., Chen, H., & Deisseroth, K. (2007) · Science · doi:10.1126/science.1144400 · Cited by 396 · see citing works

Impaired stress-coping and fear extinction and abnormal corticolimbic morphology in serotonin transporter knock-out mice

Wellman, C. L., Izquierdo, A., Garrett, J. E., Martin, K. P., Carroll, J., Millstein, R., Lesch, K.-P., Murphy, D. L., & Holmes, A. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.4595-06.2007 · Cited by 366 · see citing works

Modeling madness in mice: one piece at a time

Arguello, P. A., & Gogos, J. A. (2006) · Neuron · doi:10.1016/j.neuron.2006.09.023 · Cited by 309 · see citing works

Convergent translational evidence of a role for anandamide in amygdala-mediated fear extinction, threat processing and stress-reactivity

Gunduz-Cinar, O., MacPherson, K. P., Cinar, R., Gamble-George, J., Sugden, K., Williams, B., Godlewski, G., Ramikie, T. S., Gorka, A. X., Alapafuja, S. O., et al. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.72 · Cited by 307 · see citing works

Hidden wounds? inflammatory links between childhood trauma and psychopathology

Danese, A., & Baldwin, J. R. (2017) · Annual Review of Psychology · doi:10.1146/annurev-psych-010416-044208 · Cited by 286 · see citing works

Stress, anxiety, and dendritic spines: What are the connections?

Leuner, B., & Shors, T. J. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2012.04.021 · Cited by 284 · see citing works

What's wrong with my mouse model?

Kalueff, A. V., Wheaton, M., & Murphy, D. L. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.01.023 · Cited by 285 · see citing works

The neurogenesis hypothesis of affective and anxiety disorders: Are we mistaking the scaffolding for the building?

Petrik, D., Lagace, D. C., & Eisch, A. J. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.09.003 · Cited by 241 · see citing works

The 5-HT7 receptor and disorders of the nervous system: an overview

Hedlund, P. B. (2009) · Psychopharmacology · doi:10.1007/s00213-009-1626-0 · Cited by 239 · see citing works

Novel pharmacological targets in drug development for the treatment of anxiety and anxiety-related disorders

Sartori, S. B., & Singewald, N. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.107402 · Cited by 236 · see citing works

Strain Differences in Stress Responsivity Are Associated with Divergent Amygdala Gene Expression and Glutamate-Mediated Neuronal Excitability

Mozhui, K., Karlsson, R.-M., Kash, T. L., Ihne, J., Norcross, M., Patel, S., Farrell, M. R., Hill, E. E., Graybeal, C., Martin, K. P., et al. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.5017-09.2010 · Cited by 226 · see citing works

Measuring behavior in mice with chronic stress depression paradigm

Strekalova, T., & Steinbusch, H. W. M. (2010) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2009.12.014 · Cited by 207 · see citing works

Early-life adversity and brain development: Is the microbiome a missing piece of the puzzle?

O’Mahony, S. M., Clarke, G., Dinan, T. G., & Cryan, J. F. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2015.09.068 · Cited by 203 · see citing works

Serotonin 5-HT7 receptor agents: structure-activity relationships and potential therapeutic applications in central nervous system disorders

Leopoldo, M., Lacivita, E., Berardi, F., Perrone, R., & Hedlund, P. B. (2011) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2010.08.013 · Cited by 198 · see citing works

Gut memories: Towards a cognitive neurobiology of irritable bowel syndrome

Kennedy, P. J., Clarke, G., Quigley, E. M. M., Groeger, J. A., Dinan, T. G., & Cryan, J. F. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.07.001 · Cited by 193 · see citing works

Pharmacological or genetic inactivation of the serotonin transporter improves reversal learning in mice

Brigman, J. L., Mathur, P., Harvey-White, J., Izquierdo, A., Saksida, L. M., Bussey, T. J., Fox, S., Deneris, E., Murphy, D. L., & Holmes, A. (2010) · Cerebral Cortex · doi:10.1093/cercor/bhp266 · Cited by 184 · see citing works

Ontogeny of fear-, anxiety- and depression-related behavior across adolescence in C57BL/6J mice

HEFNER, K., & HOLMES, A. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.10.001 · Cited by 183 · see citing works

Gene expression patterns in the hippocampus and amygdala of endogenous depression and chronic stress models

Andrus, B. M., Blizinsky, K., Vedell, P. T., Dennis, K., Shukla, P. K., Schaffer, D. J., Radulovic, J., Churchill, G. A., & Redei, E. E. (2012) · Molecular Psychiatry · doi:10.1038/mp.2010.119 · Cited by 178 · see citing works

Characterization of rodent models of HIV-gp120 and anti-retroviral-associated neuropathic pain

Wallace, V. C. J., Blackbeard, J., Segerdahl, A. R., Hasnie, F., Pheby, T., McMahon, S. B., & Rice, A. S. C. (2007) · Brain · doi:10.1093/brain/awm195 · Cited by 176 · see citing works

Evidence for the involvement of the kainate receptor subunit GluR6 (GRIK2) in mediating behavioral displays related to behavioral symptoms of mania

Shaltiel, G., Maeng, S., Malkesman, O., Pearson, B., Schloesser, R. J., Tragon, T., Rogawski, M., Gasior, M., Luckenbaugh, D., Chen, G., et al. (2008) · Molecular Psychiatry · doi:10.1038/mp.2008.20 · Cited by 173 · see citing works

Transgenerational transmission and modification of pathological traits induced by prenatal immune activation

Weber-Stadlbauer, U., Richetto, J., Labouesse, M. A., Bohacek, J., Mansuy, I. M., & Meyer, U. (2017) · Molecular Psychiatry · doi:10.1038/mp.2016.41 · Cited by 170 · see citing works

Gut Vagal Afferents Differentially Modulate Innate Anxiety and Learned Fear

Klarer, M., Arnold, M., Günther, L., Winter, C., Langhans, W., & Meyer, U. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.0252-14.2014 · Cited by 159 · see citing works

Update in the methodology of the chronic stress paradigm: internal control matters

Strekalova, T., Couch, Y., Kholod, N., Boyks, M., Malin, D., Leprince, P., & Steinbusch, H. M. (2011) · Behavioral and Brain Functions · doi:10.1186/1744-9081-7-9 · Cited by 163 · see citing works

Impaired Emotional-Like Behavior and Serotonergic Function During Protracted Abstinence from Chronic Morphine

Goeldner, C., Lutz, P.-E., Darcq, E., Halter, T., Clesse, D., Ouagazzal, A.-M., & Kieffer, B. L. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.08.021 · Cited by 163 · see citing works

Cholinergic interneurons in the nucleus accumbens regulate depression-like behavior

Warner-Schmidt, J. L., Schmidt, E. F., Marshall, J. J., Rubin, A. J., Arango-Lievano, M., Kaplitt, M. G., Ibañez-Tallon, I., Heintz, N., & Greengard, P. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1209293109 · Cited by 163 · see citing works

Differential effects of 5-HTTLPR genotypes on the behavioral and neural responses to tryptophan depletion in patients with major depression and controls

Neumeister, A., Hu, X.-Z., Luckenbaugh, D. A., Schwarz, M., Nugent, A. C., Bonne, O., Herscovitch, P., Goldman, D., Drevets, W. C., & Charney, D. S. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.9.978 · Cited by 161 · see citing works

Gutted! Unraveling the Role of the Microbiome in Major Depressive Disorder

Bastiaanssen, T. F. S., Cussotto, S., Claesson, M. J., Clarke, G., Dinan, T. G., & Cryan, J. F. (2020) · Harvard Review of Psychiatry · doi:10.1097/hrp.0000000000000243 · Cited by 159 · see citing works

Oxytocin mitigated the depressive-like behaviors of maternal separation stress through modulating mitochondrial function and neuroinflammation

Amini-Khoei, H., Mohammadi-Asl, A., Amiri, S., Hosseini, M.-J., Momeny, M., Hassanipour, M., Rastegar, M., Haj-Mirzaian, A., Mirzaian, A. H., Sanjarimoghaddam, H., et al. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.02.022 · Cited by 153 · see citing works

Optogenetic insights on the relationship between anxiety-related behaviors and social deficits

Allsop, S. A., Vander Weele, C. M., Wichmann, R., & Tye, K. M. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00241 · Cited by 150 · see citing works

AMPA receptor subunit 1 (GluR‐A) knockout mice model the glutamate hypothesis of depression

Chourbaji, S., Vogt, M. A., Fumagalli, F., Sohr, R., Frasca, A., Brandwein, C., Hörtnagl, H., Riva, M. A., Sprengel, R., & Gass, P. (2008) · The FASEB Journal · doi:10.1096/fj.08-106450 · Cited by 144 · see citing works

Further characterization of a rat model of varicella zoster virus-associated pain: Relationship between mechanical hypersensitivity and anxiety-related behavior, and the influence of analgesic drugs

Hasnie, F. S., Breuer, J., Parker, S., Wallace, V., Blackbeard, J., Lever, I., Kinchington, P. R., Dickenson, A. H., Pheby, T., & Rice, A. S. C. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2006.11.029 · Cited by 144 · see citing works

Cytisine, a partial agonist of high-affinity nicotinic acetylcholine receptors, has antidepressant-like properties in male C57BL/6J mice

Mineur, Y. S., Somenzi, O., & Picciotto, M. R. (2007) · Neuropharmacology · doi:10.1016/j.neuropharm.2007.01.006 · Cited by 137 · see citing works

mGluR7 facilitates extinction of aversive memories and controls amygdala plasticity

Fendt, M., Schmid, S., Thakker, D. R., Jacobson, L. H., Yamamoto, R., Mitsukawa, K., Maier, R., Natt, F., Hüsken, D., Kelly, P. H., et al. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002073 · Cited by 135 · see citing works

Fluoxetine ameliorates dysbiosis in a depression model induced by chronic unpredicted mild stress in mice

Sun, L., Zhang, H., Cao, Y., Wang, C., Zhao, C., Wang, H., Cui, G., Wang, M., Pan, Y., Shi, Y., et al. (2019) · International Journal of Medical Sciences · doi:10.7150/ijms.37322 · Cited by 127 · see citing works

Measuring behavior in the home cage: study design, applications, challenges, and perspectives

Grieco, F., Bernstein, B. J., Biemans, B., Bikovski, L., Burnett, C. J., Cushman, J. D., van Dam, E. A., Fry, S. A., Richmond-Hacham, B., Homberg, J. R., et al. (2021) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2021.735387 · Cited by 109 · see citing works

Developmental rodent models of fear and anxiety: from neurobiology to pharmacology

Ganella, D. E., & Kim, J. H. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12643 · Cited by 107 · see citing works

Anxiety- and depressive-like behaviors are associated with altered hippocampal energy and inflammatory status in a mouse model of Crohn's disease

Haj-Mirzaian, A., Amiri, S., Amini-Khoei, H., Hosseini, M.-J., Haj-Mirzaian, A., Momeny, M., Rahimi-Balaei, M., & Dehpour, A. R. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.10.023 · Cited by 100 · see citing works

Association of Oxidative Stress to the Genesis of Anxiety: Implications for Possible Therapeutic Interventions

Hassan, W., Barroso Silva, C., Mohammadzai, I. U., Teixeira da Rocha, J., & Landeira-Fernandez, J. (2014) · Current Neuropharmacology · doi:10.2174/1570159x11666131120232135 · Cited by 100 · see citing works

Involvement of Sigma-1 Receptors in the Antidepressant-like Effects of Dextromethorphan

Nguyen, L., Robson, M. J., Healy, J. R., Scandinaro, A. L., & Matsumoto, R. R. (2014) · PLoS ONE · doi:10.1371/journal.pone.0089985 · Cited by 99 · see citing works

Site-Specific Genetic Manipulation of Amygdala Corticotropin-Releasing Factor Reveals Its Imperative Role in Mediating Behavioral Response to Challenge

Regev, L., Tsoory, M., Gil, S., & Chen, A. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.05.036 · Cited by 93 · see citing works

Translational research in bipolar disorder: emerging insights from genetically based models

Chen, G., Henter, I. D., & Manji, H. K. (2010) · Molecular Psychiatry · doi:10.1038/mp.2010.3 · Cited by 95 · see citing works

Adolescent voluntary exercise attenuated hippocampal innate immunity responses and depressive-like behaviors following maternal separation stress in male rats

Sadeghi, M., Peeri, M., & Hosseini, M.-J. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.05.017 · Cited by 83 · see citing works

Transient inactivation of the infralimbic cortex induces antidepressant-like effects in the rat

Slattery, D. A., Neumann, I. D., & Cryan, J. F. (2011) · Journal of Psychopharmacology · doi:10.1177/0269881110368873 · Cited by 77 · see citing works

Mesopontine cholinergic inputs to midbrain dopamine neurons drive stress-induced depressive-like behaviors

Fernandez, S. P., Broussot, L., Marti, F., Contesse, T., Mouska, X., Soiza-Reilly, M., Marie, H., Faure, P., & Barik, J. (2018) · Nature Communications · doi:10.1038/s41467-018-06809-7 · Cited by 75 · see citing works

Increased novelty-induced motor activity and reduced depression-like behavior in neuropeptide Y (NPY)-Y4 receptor knockout mice

Tasan, R. O., Lin, S., Hetzenauer, A., Singewald, N., Herzog, H., & Sperk, G. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2008.11.048 · Cited by 71 · see citing works

Social isolation disrupts hippocampal neurogenesis in young non-human primates

Cinini, S. M., Barnabe, G. F., Galvão-Coelho, N., de Medeiros, M. A., Perez-Mendes, P., Sousa, M. B. C., Covolan, L., & Mello, L. E. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00045 · Cited by 71 · see citing works

Reverse translational strategies for developing animal models of bipolar disorder

Malkesman, O., Austin, D. R., Chen, G., & Manji, H. K. (2009) · Disease Models & Mechanisms · doi:10.1242/dmm.001628 · Cited by 70 · see citing works

Homer1/mGluR5 Activity Moderates Vulnerability to Chronic Social Stress

Wagner, K. V., Hartmann, J., Labermaier, C., Häusl, A. S., Zhao, G., Harbich, D., Schmid, B., Wang, X.-D., Santarelli, S., Kohl, C., et al. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2014.308 · Cited by 67 · see citing works

The effect of the palmitoylethanolamide analogue, palmitoylallylamide (L-29) on pain behaviour in rodent models of neuropathy

Wallace, V. C. J., Segerdahl, A. R., Lambert, D. M., Vandevoorde, S., Blackbeard, J., Pheby, T., Hasnie, F., & Rice, A. S. C. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707326 · Cited by 66 · see citing works

Short-term social isolation induces depressive-like behaviour and reinstates the retrieval of an aversive task: mood-congruent memory in male mice?

Takatsu-Coleman, A. L., Patti, C. L., Zanin, K. A., Zager, A., Carvalho, R. C., Borçoi, A. R., Ceccon, L. M. B., Berro, L. F., Tufik, S., Andersen, M. L., et al. (2013) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.120050 · Cited by 66 · see citing works

Cholecystokinin knock-down in the basolateral amygdala has anxiolytic and antidepressant-like effects in mice

Del Boca, C., Lutz, P. E., Le Merrer, J., Koebel, P., & Kieffer, B. L. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.05.022 · Cited by 59 · see citing works

Streptozotocin induced oxidative stress, innate immune system responses and behavioral abnormalities in male mice

Amiri, S., Haj-Mirzaian, A., Momeny, M., Amini-Khoei, H., Rahimi-Balaei, M., Poursaman, S., Rastegar, M., Nikoui, V., Mokhtari, T., Ghazi-Khansari, M., et al. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2016.11.003 · Cited by 58 · see citing works

Cyclooxygenase-2 inhibition reduces stress-induced affective pathology

Gamble-George, J. C., Baldi, R., Halladay, L., Kocharian, A., Hartley, N., Silva, C. G., Roberts, H., Haymer, A., Marnett, L. J., Holmes, A., et al. (2016) · eLife · doi:10.7554/elife.14137 · Cited by 55 · see citing works

α4β2 nicotinic acetylcholine receptor partial agonists with low intrinsic efficacy have antidepressant-like properties

Mineur, Y. S., Einstein, E. B., Seymour, P. A., Coe, J. W., O'Neill, B. T., Rollema, H., & Picciotto, M. R. (2011) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e328347546d · Cited by 49 · see citing works

Roles of p75NTR, Long-Term Depression, and Cholinergic Transmission in Anxiety and Acute Stress Coping

Martinowich, K., Schloesser, R. J., Lu, Y., Jimenez, D. V., Paredes, D., Greene, J. S., Greig, N. H., Manji, H. K., & Lu, B. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.08.014 · Cited by 48 · see citing works

Lithium attenuated the depressant and anxiogenic effect of juvenile social stress through mitigating the negative impact of interlukin-1β and nitric oxide on hypothalamic–pituitary–adrenal axis function

Haj-Mirzaian, A., Amiri, S., Kordjazy, N., Momeny, M., Razmi, A., Rahimi-Balaei, M., Amini-Khoei, H., Haj-Mirzaian, A., Marzban, H., Mehr, S. E., et al. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2015.12.024 · Cited by 46 · see citing works

Physiological and behavioural responsivity to stress and anxiogenic stimuli in COMT-deficient mice

Desbonnet, L., Tighe, O., Karayiorgou, M., Gogos, J. A., Waddington, J. L., & O’Tuathaigh, C. M. P. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.12.014 · Cited by 38 · see citing works

Serotonin Transporter and Plasma Membrane Monoamine Transporter Are Necessary for the Antidepressant-Like Effects of Ketamine in Mice

Bowman, M. A., Vitela, M., Clarke, K. M., Koek, W., & Daws, L. C. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207581 · Cited by 33 · see citing works

Why Should My Mouse Call Me? Acoustic Communication in Mouse Models of Social Disorders: Ultrasonic Vocalizations as an Index of Emotional and Motivational States

Granon, S., Faure, A., Chauveau, F., Cressant, A., & Ey, E. (2018) · Handbook of Behavioral Neuroscience · doi:10.1016/b978-0-12-809600-0.00040-8 · Cited by 33 · see citing works

SAHA improves depressive symptoms, cognitive impairment and oxidative stress: rise of a new antidepressant class

Ershadi, A. S. B., Amini-Khoei, H., Hosseini, M.-J., & Dehpour, A. R. (2021) · Neurochemical Research · doi:10.1007/s11064-021-03263-8 · Cited by 25 · see citing works

Anxiolytic drug discovery: What are the novel approaches and how can we improve them?

Stewart, A. M., & Kalueff, A. V. (2014) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2014.857309 · Cited by 22 · see citing works

Identification and interference of inpatients' anxiety

Huang, J. (2004)

Threat perception abnormalities in children: the role of anxiety disorders symptoms, chronic anxiety, and state anxiety

Muris, P., Rapee, R. M., Meesters, C. M. G., Schouten, E. G. W., & Geers, M. (2003) · Journal of Anxiety Disorders · doi:10.1016/s0887-6185(02)00199-8 · Cited by 97 · see citing works

Driving anxiety and fear in young older adults in New Zealand

Taylor, J. E., Alpass, F., Stephens, C., & Towers, A. (2011) · Age and Ageing · doi:10.1093/ageing/afq154 · Cited by 52 · see citing works

The Prevalence of Depression in Myasthenia Gravis

Stewart, S. B., Robertson, K. R., Johnson, K., et al. (2007) · Journal of Clinical Neuromuscular Disease · doi:10.1097/cnd.0b013e3180316324 · Cited by 13 · see citing works

Reassurance and the anxious cancer patient

Stark, D., Kiely, M., Smith, A. B., Morley, S., Selby, P. J., & House, A. O. (2004) · British Journal of Cancer · doi:10.1038/sj.bjc.6602077 · Cited by 67 · see citing works