The DOI matches its Crossref record; 244 of the 248 references it cites were found in a registry or an index.
Dendritic spine pathology in schizophrenia
Open accessAbstract
Schizophrenia is a neurodevelopmental disorder whose clinical features include impairments in perception, cognition and motivation. These impairments reflect alterations in neuronal circuitry within and across multiple brain regions that are due, at least in part, to deficits in dendritic spines, the site of most excitatory synaptic connections. Dendritic spine alterations have been identified in multiple brain regions in schizophrenia, but are best characterized in layer 3 of the neocortex, where pyramidal cell spine density is lower. These spine deficits appear to arise during development, and thus are likely the result of disturbances in the molecular mechanisms that underlie spine formation, pruning, and/or maintenance. Each of these mechanisms may provide insight into novel therapeutic targets for preventing or repairing the alterations in neural circuitry that mediate the debilitating symptoms of schizophrenia.
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“In accordance with these theories, SZ patients display significant reductions in dendritic spine density in PFC 157”
From Mechanisms of synaptic transmission dysregulation in the prefrontal cortex: pathophysiological implications (2022) · cites this paper as [157]
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Schizophrenia risk from complex variation of complement component 4
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Metadata
- Authors
- Glausier, J. R., & Lewis, D. A.
- Affiliations
- University of Pittsburgh (US)
- Corresponding author
- Lewis, D.A.
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 2013-10
- Volume
- 251
- Pages
- 90-107
- ISSN
- 0306-4522 (ISSN-L)
- PMC
- PMC3413758
- OpenAlex
- W1997950587
- Cited by
- 581
- References
- 248
- Citations by year
- 2026: 29 · 2025: 37 · 2024: 43 · 2023: 52 · 2022: 50 · 2021: 48 · 2020: 55 · 2019: 42 · 2018: 43 · 2017: 43 · 2016: 42 · 2015: 48 · 2014: 32 · 2013: 12
- FWCI
- 4.13
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (P50MH084053, MH084053, R01MH043784, MH043784)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- schizophrenia, dendritic spines, synaptic dysfunction, pyramidal neurons, synaptic pruning, neural circuits, brain development, therapeutic target
- MeSH terms
- Humans, Schizophrenia, Pyramidal Cells, Neocortex, Dendritic Spines
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