Cited by 1,498Mitochondrial Function and PathologyNeuroscience and Neuropharmacology ResearchPharmacological Receptor Mechanisms and Effects

The importance of dendritic mitochondria in the morphogenesis and plasticity of spines and synapses

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Li, Zheng, Okamoto, Ken-Ichi, Hayashi, Yasunori, Sheng, Morgan·2004·Cell

Abstract

The proper intracellular distribution of mitochondria is assumed to be critical for normal physiology of neuronal cells, but direct evidence for this idea is lacking. Extension or movement of mitochondria into dendritic protrusions correlates with the development and morphological plasticity of spines. Molecular manipulations of dynamin-like GTPases Drp1 and OPA1 that reduce dendritic mitochondria content lead to loss of synapses and dendritic spines, whereas increasing dendritic mitochondrial content or mitochondrial activity enhances the number and plasticity of spines and synapses. Thus, the dendritic distribution of mitochondria is essential and limiting for the support of synapses. Reciprocally, synaptic activity modulates the motility and fusion/fission balance of mitochondria and controls mitochondrial distribution in dendrites.

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Crossref · 10.1016/j.cell.2004.11.003

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Authors
Li, Z., Okamoto, K.-I., Hayashi, Y., & Sheng, M.
Affiliations
  • Massachusetts Institute of Technology (US)
  • Howard Hughes Medical Institute (US)
Corresponding author
Sheng, Morgan
Venue
Cell
Publisher
Elsevier BV
Published
2004-12
Volume
119
Issue
6
Pages
873-887
ISSN
0092-8674 (ISSN-L)
OpenAlex
W2045085957
Cited by
1,498
References
40
Citations by year
2026: 42 · 2025: 53 · 2024: 75 · 2023: 86 · 2022: 61 · 2021: 89 · 2020: 101 · 2019: 56 · 2018: 85 · 2017: 65 · 2016: 82 · 2015: 66 · 2014: 66 · 2013: 70 · 2012: 78
FWCI
15.99
Type
journal article
Language
en
Open access
Locations
  • Cell (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Neurological Disorders and Stroke (F32NS046126)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pharmacological Receptor Mechanisms and Effects
Keywords
dendritic mitochondria, dendritic spines, synaptic development, synaptic plasticity, Drp1, OPA1, dynamin-related GTPase, mitochondrial fission, mitochondrial fusion, mitochondrial motility, synaptic activity, dendritic protrusions
MeSH terms
Animals, Cells, Cultured, Creatine, Electric Stimulation, Embryo, Mammalian, Hippocampus, Microtubule-Associated Proteins, Mitochondria, Morphogenesis, Synaptic Transmission, Neuronal Plasticity, Neurons, Synapses, Pyramidal Cells, GTP Phosphohydrolases, Dendritic Spines, Rats

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