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Interleukin-1β alters the sensitivity of cannabinoid CB1 receptors controlling glutamate transmission in the striatum

De Chiara, V., Motta, C., Rossi, S., Studer, V., Barbieri, F., Lauro, D., Bernardi, G., Centonze, D.·2013·Neuroscience
DOI 10.1016/j.neuroscience.2013.06.069
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Abstract

Proinflammatory cytokines such as tumor necrosis factor-α and interleukin-1β (IL1β) regulate both excitatory and inhibitory synaptic transmission in the central nervous system. The interaction between IL1β and endocannabinoid system (ECS) is also emerging, based on the evidence that IL1β effects on striatal spontaneous excitatory and inhibitory postsynaptic currents are regulated by transient receptor potential vanilloid 1 (TRPV1) channels, members of the ECS. Furthermore, IL1β has also been shown to control the sensitivity of cannabinoid CB1 receptors controlling GABA transmission (CB1Rs(GABA)) in the striatum. To better detail the synaptic action of IL1β, and to clarify its complex interaction with the ECS, here we investigated the possible interplay between IL1β and CB1Rs controlling glutamate transmission (CB1Rs(glu)), other critical elements of the ECS. Our results show that the sensitivity of CB1Rs(glu) is fully blocked in the presence of IL1β in corticostriatal brain slices, and that the protein kinase C/TRPV1 pathway is involved in this effect. IL1β failed to modulate the sensitivity of glutamate synapses to the stimulation of GABAB receptors. We also provided evidence that IL1β-CB1Rs(GABA) but not IL1β-CB1Rs(glu) interaction is under the control of the brain-derived neurotrophic factor (BDNF)/trkB signaling and of lipid raft composition, because BDNF gene partial deletion, pharmacological blockade of trkB and membrane cholesterol removal with methyl-β-cyclodextrin al…

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Research works printed but not linked: 31

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Metadata

Authors
De Chiara, V., Motta, C., Rossi, S., Studer, V., Barbieri, F., Lauro, D., Bernardi, G., & Centonze, D.
Venue
Neuroscience
Publisher
Elsevier BV
Published
2013-10
Volume
250
Pages
232-239
ISSN
0306-4522
DOI
10.1016/j.neuroscience.2013.06.069
Cited by
37
References
4
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Funders
  • Fondazione Italiana Sclerosi Multipla
  • Italian National Ministero dell’Università
  • Italian National Ministero della Salute

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