Anxiolytic Effects in Mice of a Dual Blocker of Fatty Acid Amide Hydrolase and Transient Receptor Potential Vanilloid Type-1 Channels
Open accessAbstract
The endocannabinoid-inactivating enzyme, fatty acid amide hydrolase (FAAH), and the transient receptor potential vanilloid type-1 (TRPV1) channel are new targets for the development of anxiolytic drugs. We studied the effect on anxiety-like behavior in the elevated plus maze of a dual FAAH/TRPV1 blocker, N-arachidonoyl-serotonin (AA-5-HT). In male C57BL/6J mice, acute intraperitoneal administration of AA-5-HT (0.1-2.5 mg/kg) increased both the time spent and the number of entries in the open arm, while being inactive at the highest dose tested (5 mg/kg). AA-5-HT was more potent than selective blockers of FAAH or TRPV1 (URB597 and SB366791, respectively). In male Swiss mice, AA-5-HT had to be administered chronically to observe an anxiolytic effect at an intermediate dose (2.5 mg/kg), the highest dose (5 mg/kg) being anxiogenic, and 1 mg/kg being ineffective. In both strains, the anxiolytic effects of AA-5-HT were paralleled by elevation of brain endocannabinoid levels and were reversed by per se inactive doses of the cannabinoid receptors of type-1 (CB(1)) receptor antagonist AM251, or the TRPV1 agonist, olvanil. Immunohistochemical localization of CB(1) and TRPV1 receptors was observed in mouse prefrontal cortex, nucleus accumbens, amygdala, and hippocampus. Simultaneous 'indirect' activation of CB(1) receptors following FAAH inhibition, and antagonism at TRPV1 receptors might represent a new therapeutic strategy against anxiety.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Bromazepam and buspirone have diminished anxiolytic effects in CB1-knockout mice.
“the anxiolytic agent, diazepam, increases AEA in the amygdala, and bromazepam and buspirone have diminished anxiolytic effects in CB1knockout mice (Micale et al, 2009;Uriguen et al, 2004).”
From Acute stress increases circulating anandamide and other N-acylethanolamines in healthy humans (2012) · cites this paper as Micale et al, 2009
Diazepam increases AEA in the amygdala.
“the anxiolytic agent, diazepam, increases AEA in the amygdala, and bromazepam and buspirone have diminished anxiolytic effects in CB1knockout mice (Micale et al, 2009;Uriguen et al, 2004).”
From Acute stress increases circulating anandamide and other N-acylethanolamines in healthy humans (2012) · cites this paper as Micale et al, 2009
Cites
Isolation and Structure of a Brain Constituent That Binds to the Cannabinoid Receptor
Devane, W. A., Hanuš, L., Breuer, A., Pertwee, R. G., Stevenson, L. A., Griffin, G., Gibson, D., Mandelbaum, A., Etinger, A., & Mechoulam, R. (1992) · Science · doi:10.1126/science.1470919 · Cited by 5,633 · see citing works
Mechoulam, R., Ben-Shabat, S., Hanus, L., Ligumsky, M., Kaminski, N. E., Schatz, A. R., Gopher, A., Almog, S., Martin, B. R., Compton, D. R., et al. (1995) · Biochemical Pharmacology · doi:10.1016/0006-2952(95)00109-d · Cited by 2,913 · see citing works
2-Arachidonoylgylcerol: A Possible Endogenous Cannabinoid Receptor Ligand in Brain
Sugiura, T., Kondo, S., Sukagawa, A., Nakane, S., Shinoda, A., Itoh, K., Yamashita, A., & Waku, K. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.2437 · Cited by 2,196 · see citing works
Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide
Zygmunt, P. M., Petersson, J., Andersson, D. A., Chuang, H.-H., Sørgård, M., Di Marzo, V., Julius, D., & Högestätt, E. D. (1999) · Nature · doi:10.1038/22761 · Cited by 2,142 · see citing works
The endogenous cannabinoid system controls extinction of aversive memories
Marsicano, G., Wotjak, C. T., Azad, S. C., Bisogno, T., Rammes, G., Cascio, M. G., Hermann, H., Tang, J., Hofmann, C., Zieglgänsberger, W., et al. (2002) · Nature · doi:10.1038/nature00839 · Cited by 1,728 · see citing works
Role of Endogenous Cannabinoids in Synaptic Signaling
Freund, T. F., Katona, I., & Piomelli, D. (2003) · Physiological Reviews · doi:10.1152/physrev.00004.2003 · Cited by 1,567 · see citing works
Crawley, J. N., Belknap, J. K., Collins, A. C., Crabbe, J. C., Frankel, W. N., Henderson, N. D., HITZEMANN, R. J., Maxson, S. C., Miner, L. L., Silva, A. J., et al. (1997) · Psychopharmacology · doi:10.1007/s002130050327 · Cited by 1,372 · see citing works
Modulation of anxiety through blockade of anandamide hydrolysis
Kathuria, S., Gaetani, S., Fegley, D., Valiño, F., Duranti, A., Tontini, A., Mor, M., Tarzia, G., Rana, G. L., Calignano, A., et al. (2003) · Nature Medicine · doi:10.1038/nm803 · Cited by 1,293 · see citing works
A Comprehensive Profile of Brain Enzymes that Hydrolyze the Endocannabinoid 2-Arachidonoylglycerol
Blankman, J. L., Simon, G. M., & Cravatt, B. F. (2007) · Chemistry & Biology · doi:10.1016/j.chembiol.2007.11.006 · Cited by 1,177 · see citing works
Huang, S. M., Bisogno, T., Trevisani, M., Al‐Hayani, A., PETROCELLIS, L. D., Fezza, F., Tognetto, M., Petros, T. J., Krey, J. F., Chu, C. J., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.122196999 · Cited by 962 · see citing works
Cristino, L., PETROCELLIS, L. D., Pryce, G., Baker, D., Guglielmotti, V., & Marzo, V. D. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.02.074 · Cited by 489 · see citing works
Self-citationGriebel, G., Belzung, C., Perrault, G., & Sanger, D. J. (2000) · Psychopharmacology · doi:10.1007/s002130050038 · Cited by 420 · see citing works
Patel, S., & Hillard, C. J. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.101287 · Cited by 390 · see citing works
Biochemistry and pharmacology of endovanilloids
Starowicz, K., Nigam, S., & Marzo, V. D. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2007.01.005 · Cited by 381 · see citing works
Marsch, R., Foeller, E., Rammes, G., Bunck, M., Kössl, M., Holsboer, F., Zieglgänsberger, W., Landgraf, R., Lutz, B., & Wotjak, C. T. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.3303-06.2007 · Cited by 359 · see citing works
De Petrocellis, L., Bisogno, T., Davis, J. B., Pertwee, R. G., & Di Marzo, V. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)02082-2 · Cited by 347 · see citing works
Anandamide inhibits metabolism and physiological actions of 2-arachidonoylglycerol in the striatum
Maccarrone, M., Rossi, S., Bari, M., Chiara, V. D., Fezza, F., Musella, A., Gasperi, V., Prosperetti, C., Bernardi, G., Finazzi‐Agrò, A., et al. (2008) · Nature Neuroscience · doi:10.1038/nn2042 · Cited by 293 · see citing works
Maione, S., Bisogno, T., de Novellis, V., Palazzo, E., Cristino, L., Valenti, M., Petrosino, S., Guglielmotti, V., Rossi, F., & Marzo, V. D. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.093286 · Cited by 293 · see citing works
Self-citationRole in Anxiety Behavior of the Endocannabinoid System in the Prefrontal Cortex
Rubino, T., Realini, N., Castiglioni, C., Guidali, C., Viganò, D., Marras, E., Petrosino, S., Perletti, G., Maccarrone, M., Marzo, V. D., et al. (2007) · Cerebral Cortex · doi:10.1093/cercor/bhm161 · Cited by 283 · see citing works
Self-citationMoreira, F. A., Kaiser, N., Monory, K., & Lutz, B. (2007) · Neuropharmacology · doi:10.1016/j.neuropharm.2007.07.005 · Cited by 282 · see citing works
Marzo, V. D., PETROCELLIS, L. D., Fezza, F., Ligresti, A., & Bisogno, T. (2002) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1054/plef.2001.0349 · Cited by 238 · see citing works
van der Stelt, M., Mazzola, C., Esposito, G., Matias, I., Petrosino, S., Filippis, D. D., Micale, V., Steardo, L., Drago, F., Iuvone, T., et al. (2006) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-006-6037-3 · Cited by 223 · see citing works
Self-citationEndocannabinoid mechanisms of pain modulation
Hohmann, A. G., & Suplita, R. L. (2006) · The AAPS Journal · doi:10.1208/aapsj080479 · Cited by 213 · see citing works
Fatty Acids and Immune Responses—A New Perspective in Searching for Clues to Mechanism
Hwang, D. H. (2000) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.20.1.431 · Cited by 204 · see citing works
Gaal, L. V., Pi‐Sunyer, X., Després, J., McCarthy, C., & Scheen, A. J. (2008) · Diabetes Care · doi:10.2337/dc08-s258 · Cited by 198 · see citing works
Maione, S., PETROCELLIS, L. D., de Novellis, V., Moriello, A. S., Petrosino, S., Palazzo, E., Rossi, F., Woodward, D. F., & Marzo, V. D. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707145 · Cited by 195 · see citing works
Self-citationMorgese, M. G., Cassano, T., Cuomo, V., & Giuffrida, A. (2007) · Experimental Neurology · doi:10.1016/j.expneurol.2007.07.021 · Cited by 195 · see citing works
Evaluation of fatty acid amide hydrolase inhibition in murine models of emotionality
Naidu, P. S., Varvel, S. A., Ahn, K., Cravatt, B. F., Martin, B. R., & Lichtman, A. H. (2007) · Psychopharmacology · doi:10.1007/s00213-006-0689-4 · Cited by 184 · see citing works
Ahluwalia, J., Urbán, L., Bevan, S., & Nagy, I. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02703.x · Cited by 181 · see citing works
Endogenous Unsaturated C18 N-Acylethanolamines Are Vanilloid Receptor (TRPV1) Agonists
Movahed, P., Jönsson, B., Birnir, B., Wingstrand, J. A., Dyhring, T., Ermund, A., Sterner, O., Zygmunt, P. M., & Högestätt, E. D. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m507429200 · Cited by 172 · see citing works
Arachidonoylserotonin and Other Novel Inhibitors of Fatty Acid Amide Hydrolase
Bisogno, T., Melck, D. J., PETROCELLIS, L. D., Bobrov, М. Y., Gretskaya, N. M., Безуглов, В. В., Sitachitta, N., Gerwick, W. H., & Marzo, V. D. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.8874 · Cited by 171 · see citing works
Starowicz, K., Maione, S., Cristino, L., Palazzo, E., Marabese, I., Rossi, F., de Novellis, V., & Marzo, V. D. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3258-07.2007 · Cited by 168 · see citing works
Self-citationReceptor-independent actions of cannabinoids on cell membranes: Focus on endocannabinoids
Öz, M. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.09.009 · Cited by 164 · see citing works
Marinelli, S., Marzo, V. D., Florenzano, F., Fezza, F., Viscomi, M. T., van der Stelt, M., Bernardi, G., Molinari, M., Maccarrone, M., & Mercuri, N. B. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301118 · Cited by 155 · see citing works
Marzo, V. D., Starowicz, K., & Cristino, L. (2008) · Current Pharmaceutical Design · doi:10.2174/138161208783330790 · Cited by 153 · see citing works
Self-citationEndocannabinoid System and Synaptic Plasticity: Implications for Emotional Responses
Viveros, M., Marco, E. M., Llorente, R., & López‐Gallardo, M. (2007) · Neural Plasticity · doi:10.1155/2007/52908 · Cited by 144 · see citing works
Dual effect of cannabinoid CB 1 receptor stimulation on a vanilloid VR1 receptor-mediated response
Hermann, H., PETROCELLIS, L. D., Bisogno, T., Moriello, A. S., Lutz, B., & Marzo, V. D. (2003) · Cellular and Molecular Life Sciences · doi:10.1007/s000180300052 · Cited by 144 · see citing works
Lepicard, E. M., Joubert, C., Hagneau, I., Pérez-Díaz, F., & Chapouthier, G. (2000) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(00)00419-6 · Cited by 143 · see citing works
Tzavara, E. T., Li, D. L., Moutsimilli, L., Bisogno, T., Marzo, V. D., Phebus, L. A., Nomikos, G. G., & Bruno Giros, A. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.08.019 · Cited by 141 · see citing works
Marinelli, S., Pascucci, T., Bernardi, G., Puglisi‐Allegra, S., & Mercuri, N. B. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300615 · Cited by 137 · see citing works
Lafenêtre, P., Chaouloff, F., & Marsicano, G. (2007) · Pharmacological Research · doi:10.1016/j.phrs.2007.09.006 · Cited by 135 · see citing works
Development of the first potent and specific inhibitors of endocannabinoid biosynthesis
Bisogno, T., Cascio, M. G., Saha, B., Mahadevan, A., Urbani, P., Minassi, A., Appendino, G., Saturnino, C., Martin, B. R., & Razdan, R. K. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2005.12.009 · Cited by 124 · see citing works
Impaired cannabinoid receptor type 1 signaling interferes with stress-coping behavior in mice
Steiner, M. A., Wanisch, K., Monory, K., Marsicano, G., Borroni, E., Bächli, H., Holsboer, F., Lutz, B., & Wotjak, C. T. (2007) · The Pharmacogenomics Journal · doi:10.1038/sj.tpj.6500466 · Cited by 123 · see citing works
The Endocannabinoid System and Extinction Learning
Lutz, B. (2007) · Molecular Neurobiology · doi:10.1007/s12035-007-8004-x · Cited by 121 · see citing works
Marzo, V. D., Bisogno, T., & PETROCELLIS, L. D. (2007) · Chemistry & Biology · doi:10.1016/j.chembiol.2007.05.014 · Cited by 116 · see citing works
FAAH and anandamide: is 2-AG really the odd one out?
Marzo, V. D., & Maccarrone, M. (2008) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2008.03.001 · Cited by 107 · see citing works
Marzo, V. D., Capasso, R., Matias, I., Aviello, G., Petrosino, S., Borrelli, F., Romano, B., Orlando, P., Capasso, F., & Izzo, A. A. (2008) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707682 · Cited by 102 · see citing works
Self-citationAre the anxiogenic effects of yohimbine mediated by its action at benzodiazepine receptors?
Pellow, S., Chopin, P., & File, S. E. (1985) · Neuroscience Letters · doi:10.1016/0304-3940(85)90303-9 · Cited by 95 · see citing works
Effects of the vanilloid agonist olvanil and antagonist capsazepine on rat behaviors
Kasckow, J., Mulchahey, J. J., & Geracioti, T. D. (2003) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2003.10.007 · Cited by 89 · see citing works
Interaction between cannabinoid compounds and diazepam on anxiety-like behaviour of mice
Naderi, N., Haghparast, A., Saber-Tehrani, A. S., Rezaii, N., Alizadeh, A.-M., Khani, A., & Motamedi, F. (2007) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2007.11.001 · Cited by 85 · see citing works
de Lago, E., Petrosino, S., Valenti, M., Morera, E., Ortega‐Gutiérrez, S., Fernández‐Ruíz, J., & Marzo, V. D. (2005) · Biochemical Pharmacology · doi:10.1016/j.bcp.2005.05.011 · Cited by 85 · see citing works
Self-citationLee, J., Marzo, V. D., & Brotchie, J. M. (2006) · Neuropharmacology · doi:10.1016/j.neuropharm.2006.04.016 · Cited by 72 · see citing works
NewN-Arachidonoylserotonin Analogues with Potential “Dual” Mechanism of Action against Pain
Ortar, G., Cascio, M. G., PETROCELLIS, L. D., Morera, E., Rossi, F., Moriello, A. S., Nalli, M., de Novellis, V., Woodward, D. F., Maione, S., et al. (2007) · Journal of Medicinal Chemistry · doi:10.1021/jm070678q · Cited by 67 · see citing works
Bisogno, T., & Marzo, V. D. (2007) · Pharmacological Research · doi:10.1016/j.phrs.2007.09.002 · Cited by 56 · see citing works
Consoli, D., Leggio, G. M., Mazzola, C., Micale, V., & Drago, F. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.06.048 · Cited by 53 · see citing works
Self-citationLeggio, G. M., Micale, V., & Drago, F. (2007) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2007.07.003 · Cited by 37 · see citing works
Self-citationKim, S. R., Chung, Y. C., Chung, E. S., Park, K. W., Won, S.-Y., Bok, E., Park, E. S., & Jin, B. K. (2007) · Molecular Neurobiology · doi:10.1007/s12035-007-0030-1 · Cited by 34 · see citing works
USEFULNESS OF ANIMAL MODELS WITH NEWER ANXIOLYTICS
File, S. E. (1992) · Clinical Neuropharmacology · doi:10.1097/00002826-199201001-00273 · Cited by 25 · see citing works
Fowler, C. J., Tiger, G., López-Rodríguez, M. L., Viso, A., Ortega‐Gutiérrez, S., & Ramos, J. A. (2003) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/1475636031000080216 · Cited by 21 · see citing works
Flagged first, then by citations
1 of the 60 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
New approaches and challenges to targeting the endocannabinoid system
Marzo, V. D. (2018) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2018.115 · Cited by 480 · see citing works
Ligresti, A., PETROCELLIS, L. D., & Marzo, V. D. (2016) · Physiological Reviews · doi:10.1152/physrev.00002.2016 · Cited by 482 · see citing works
Postsynaptic TRPV1 triggers cell type–specific long-term depression in the nucleus accumbens
Grueter, B. A., Brasnjo, G., & Malenka, R. C. (2010) · Nature Neuroscience · doi:10.1038/nn.2685 · Cited by 353 · see citing works
Why do cannabinoid receptors have more than one endogenous ligand?
Di Marzo, V., & De Petrocellis, L. (2012) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2011.0382 · Cited by 290 · see citing works
Best Practice & Research Clinical Endocrinology & Metabolism
Grieb, M. (2009) · Cited by 276 · see citing works
Moreira, F. A., Grieb, M., & Lutz, B. (2009) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2008.09.003 · Cited by 272 · see citing works
Acute stress increases circulating anandamide and other N-acylethanolamines in healthy humans
Dlugos, A., Childs, E., Stuhr, K. L., Hillard, C. J., & de Wit, H. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.100 · Cited by 248 · see citing works
The endocannabinoid system in anxiety, fear memory and habituation
Ruehle, S., Rey, A. A., Remmers, F., & Lutz, B. (2011) · Journal of Psychopharmacology · doi:10.1177/0269881111408958 · Cited by 236 · see citing works
The endocannabinoid system as a target for novel anxiolytic drugs
Patel, S., Hill, M. N., Cheer, J. F., Wotjak, C. T., & Holmes, A. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.12.033 · Cited by 233 · see citing works
Endocannabinoid system and mood disorders: Priming a target for new therapies
Micale, V., Marzo, V. D., Šulcová, A., Wotjak, C. T., & Drago, F. (2012) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2012.12.002 · Cited by 222 · see citing works
Self-citationPETROCELLIS, L. D., & Marzo, V. D. (2009) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-009-9177-z · Cited by 216 · see citing works
Effects of endocannabinoid system modulation on cognitive and emotional behavior
Zanettini, C. (2011) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2011.00057 · Cited by 214 · see citing works
Endocannabinoid influence in drug reinforcement, dependence and addiction-related behaviors
Serrano, A., & Parsons, L. H. (2011) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2011.06.005 · Cited by 180 · see citing works
Sciolino, N. R., Zhou, W., & Hohmann, A. G. (2011) · Pharmacological Research · doi:10.1016/j.phrs.2011.04.010 · Cited by 179 · see citing works
Moreira, F. A., & Wotjak, C. T. (2009) · Current topics in behavioral neurosciences · doi:10.1007/7854_2009_16 · Cited by 177 · see citing works
Hill, M. N., Hillard, C. J., Bambico, F. R., Patel, S., Gorzalka, B. B., & Gobbi, G. (2009) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2009.06.006 · Cited by 172 · see citing works
McPartland, J. M., Guy, G. W., & Marzo, V. D. (2014) · PLoS ONE · doi:10.1371/journal.pone.0089566 · Cited by 161 · see citing works
The endocannabinoid system and psychiatric disorders
Parolaro, D., Realini, N., Viganò, D., Guidali, C., & Rubino, T. (2010) · Experimental Neurology · doi:10.1016/j.expneurol.2010.03.018 · Cited by 150 · see citing works
Promising cannabinoid-based therapies for Parkinson’s disease: motor symptoms to neuroprotection
More, S. V., & Choi, D. (2015) · Molecular Neurodegeneration · doi:10.1186/s13024-015-0012-0 · Cited by 145 · see citing works
Endocannabinoid System Components as Potential Biomarkers in Psychiatry
Navarrete, F., García‐Gutiérrez, M. S., Barba, R. J., Rubio, G., Gasparyan, A., Austrich-Olivares, A., & Manzanares, J. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00315 · Cited by 134 · see citing works
Endocannabinoid signals in the control of emotion
Lutz, B. (2009) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2008.12.001 · Cited by 124 · see citing works
Casarotto, P. C., Terzian, A. L. B., Aguiar, D. C., Zangrossi, H., Guimarães, F. S., Wotjak, C. T., & Moreira, F. A. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.207 · Cited by 117 · see citing works
Moreira, F. A., de Aguiar, D. C., Terzian, A. L. B., Guimarães, F. S., & Wotjak, C. T. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.08.046 · Cited by 112 · see citing works
Interleukin-1β Causes Anxiety by Interacting with the Endocannabinoid System
Rossi, S., Sacchetti, L., Napolitano, F., Chiara, V. D., Motta, C., Studer, V., Musella, A., Barbieri, F. R., Bari, M., Bernardi, G., et al. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.1515-12.2012 · Cited by 113 · see citing works
Endocannabinoids: A unique opportunity to develop multitarget analgesics
Maione, S., Costa, B., & Marzo, V. D. (2013) · Pain · doi:10.1016/j.pain.2013.03.023 · Cited by 102 · see citing works
Involvement of endocannabinoids in antidepressant and anti-compulsive effect of fluoxetine in mice
Umathe, S. N., Manna, S. S. S., & Jain, N. S. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.04.031 · Cited by 96 · see citing works
The active alkaloids of Gelsemium elegans Benth. are potent anxiolytics
Liu, M., Huang, H., Yang, J., Su, Y., Lin, H., Lin, L., Liao, W.-J., & Yu, C. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2867-x · Cited by 93 · see citing works
Endocannabinoid-mediated synaptic plasticity and addiction-related behavior
Sidhpura, N., & Parsons, L. H. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.05.034 · Cited by 92 · see citing works
Marzo, V. D. (2020) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2020.22.3/vdimarzo · Cited by 91 · see citing works
TRPV1 in the Central Nervous System: Synaptic Plasticity, Function, and Pharmacological Implications
Edwards, J. G. (2014) · Springer eBooks · doi:10.1007/978-3-0348-0828-6_3 · Cited by 90 · see citing works
Štark, T., Kučerová, J., Iannotti, F. A., D’Addario, C., Marco, R. D., Pekařík, V., Dražanová, E., Piscitelli, F., Bari, M., Babinská, Z., et al. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.11.035 · Cited by 89 · see citing works
Self-citationFogaça, M. V., de Aguiar, D. C., Moreira, F. A., & Guimarães, F. S. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.03.007 · Cited by 89 · see citing works
TRPV1 channels control synaptic plasticity in the developing superior colliculus
Maione, S., Cristino, L., Al, M., Georgiou, A. L., Starowicz, K., Salt, T. E., & Marzo, V. D. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.171900 · Cited by 88 · see citing works
Self-citationRen, S., Wang, Z., Zhang, Y., & Chen, N. (2020) · Acta Pharmacologica Sinica · doi:10.1038/s41401-020-0385-7 · Cited by 88 · see citing works
Finn, D. P. (2009) · Immunobiology · doi:10.1016/j.imbio.2009.05.011 · Cited by 88 · see citing works
From endocannabinoid profiling to ‘endocannabinoid therapeutics’
Ligresti, A., Petrosino, S., & Marzo, V. D. (2009) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2009.04.615 · Cited by 85 · see citing works
Self-citationRossi, S., De Chiara, V., Musella, A., Sacchetti, L., Cantarella, C., Castelli, M., Cavasinni, F., Motta, C., Studer, V., Bernardi, G., et al. (2010) · Molecular Pharmacology · doi:10.1124/mol.110.064196 · Cited by 82 · see citing works
Cannabinoids and emotionality: a neuroanatomical perspective
McLaughlin, R. J., & Gobbi, G. (2011) · Neuroscience · doi:10.1016/j.neuroscience.2011.07.052 · Cited by 82 · see citing works
Navarria, A., Tamburella, A., Iannotti, F. A., Micale, V., Camillieri, G., Gozzo, L., Verde, R., Imperatore, R., Leggio, G. M., Drago, F., et al. (2014) · Pharmacological Research · doi:10.1016/j.phrs.2014.04.014 · Cited by 82 · see citing works
Self-citationRole of endocannabinoids and endovanilloids in Ca2+ signalling
PETROCELLIS, L. D., & Marzo, V. D. (2009) · Cell Calcium · doi:10.1016/j.ceca.2009.03.003 · Cited by 80 · see citing works
Capsaicin-Induced Changes in LTP in the Lateral Amygdala Are Mediated by TRPV1
Zschenderlein, C. A., Gebhardt, C., Halbach, O. V. B. U., Kulisch, C., & Albrecht, D. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016116 · Cited by 78 · see citing works
Manna, S. S. S., & Umathe, S. N. (2012) · Epilepsy Research · doi:10.1016/j.eplepsyres.2012.02.003 · Cited by 77 · see citing works
Cannabinoid interventions for PTSD: Where to next?
Ney, L. J., Matthews, A. J., Bruno, R., & Felmingham, K. L. (2019) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2019.03.017 · Cited by 76 · see citing works
Concordance and incongruence in preclinical anxiety models: Systematic review and meta-analyses
Mohammad, F., Ho, J., Woo, J. H., Lim, C. L., Poon, D., Lamba, B., & Claridge‐Chang, A. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.04.011 · Cited by 73 · see citing works
Cannabinoid modulation of noradrenergic circuits: Implications for psychiatric disorders
Carvalho, A. F., & Bockstaele, E. J. V. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.01.008 · Cited by 72 · see citing works
Endocannabinoids and Mental Disorders
Rubino, T., Zamberletti, E., & Parolaro, D. (2015) · Handbook of experimental pharmacology · doi:10.1007/978-3-319-20825-1_9 · Cited by 71 · see citing works
Payahoo, L., Khajebishak, Y., Barzegari, A., Alipour, S., Jafarabadi, M. A., Farrin, N., & Alireza, O. (2018) · Appetite · doi:10.1016/j.appet.2018.05.129 · Cited by 65 · see citing works
Endocannabinoids mediate anxiolytic-like effect of acetaminophen via CB1 receptors
Umathe, S. N., Manna, S. S. S., Utturwar, K. S., & Jain, N. S. (2009) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2009.06.020 · Cited by 66 · see citing works
Marco, E. M., & Giovanni Laviola, A. (2011) · Journal of Psychopharmacology · doi:10.1177/0269881111408459 · Cited by 65 · see citing works
Micale, V., Stepan, J., Jurik, A., Pamplona, F. A., Marsch, R., Drago, F., Eder, M., & Wotjak, C. T. (2017) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2017.02.002 · Cited by 62 · see citing works
Self-citationGray, R. A., Stott, C. G., Jones, N. A., Marzo, V. D., & Whalley, B. J. (2019) · Cannabis and Cannabinoid Research · doi:10.1089/can.2019.0028 · Cited by 62 · see citing works
Antiaversive Effects of Cannabinoids: Is the Periaqueductal Gray Involved?
Moreira, F. A., de Aguiar, D. C., Campos, A. C., Lisboa, S. F. D. S., Terzian, A. L. B., Resstel, L. B. M., & Guimarães, F. S. (2008) · Neural Plasticity · doi:10.1155/2009/625469 · Cited by 61 · see citing works
Brain transient receptor potential channels and stroke
Zhang, E., & Liao, P. H. (2014) · Journal of Neuroscience Research · doi:10.1002/jnr.23529 · Cited by 60 · see citing works
Endocannabinoid system alterations in Alzheimer’s disease: A systematic review of human studies
Berry, A. J., Zubko, O., Reeves, S., & Howard, R. J. (2020) · Brain Research · doi:10.1016/j.brainres.2020.147135 · Cited by 58 · see citing works
Interactions between the cannabinoid and dopaminergic systems: Evidence from animal studies
Khoury, M. E., Gorgievski, V., Moutsimilli, L., Bruno Giros, A., & Tzavara, E. T. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2011.12.005 · Cited by 58 · see citing works
Modulation of defensive behavior by transient receptor potential vanilloid type-1 (TRPV1) channels
Aguiar, D. C., Moreira, F. A., Terzian, A. L., Fogaça, M. V., Lisboa, S. F., Wotjak, C. T., & Guimaraes, F. S. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.03.026 · Cited by 57 · see citing works
TRPV1 acts as a synaptic protein and regulates vesicle recycling
Goswami, C., Rademacher, N., Smalla, K., Kalscheuer, V. M., Ropers, H., Gundelfinger, E. D., & Hucho, T. B. (2010) · Journal of Cell Science · doi:10.1242/jcs.065144 · Cited by 57 · see citing works
The Endocannabinoid System and Anxiety
Lisboa, S. F. D. S., Gomes, F. V., Terzian, A. L. B., de Aguiar, D. C., Moreira, F. A., Resstel, L. B. M., & Guimarães, F. S. (2016) · Vitamins and hormones · doi:10.1016/bs.vh.2016.09.006 · Cited by 56 · see citing works
Lisboa, S. F. D. S., & Guimarães, F. S. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.02.008 · Cited by 54 · see citing works
de Almeida, V., Peres, F. F., Levin, R. R., Suiama, M. A., Calzavara, M. B., Zuardi, A. W., Hallak, J. E. C., Crippa, J. A., & Abílio, V. C. (2014) · Schizophrenia Research · doi:10.1016/j.schres.2014.01.039 · Cited by 53 · see citing works
Fowler, C. J. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.02.005 · Cited by 52 · see citing works
Bennion, D. M., Jensen, T., Walther, C., Hamblin, J., Wallmann, A., Couch, J., Blickenstaff, J., Castle, M., Dean, L., Beckstead, S., et al. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.05.018 · Cited by 52 · see citing works
Hakimizadeh, E., Oryan, S., Moghaddam, A. H., Shamsizadeh, A., & Roohbakhsh, A. (2012) · Europe PMC (PubMed Central) · Cited by 53 · see citing works
Cell-Type- and Endocannabinoid-Specific Synapse Connectivity in the Adult Nucleus Accumbens Core
Deroche, M. A., Lassalle, O., Castell, L., Valjent, E., & Manzoni, O. J. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.1100-19.2019 · Cited by 48 · see citing works
Potential Therapeutic Value of a Novel FAAH Inhibitor for the Treatment of Anxiety
Marco, E. M., Rapino, C., Caprioli, A., Borsini, F., Giovanni Laviola, A., & Maccarrone, M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0137034 · Cited by 48 · see citing works
Gentile, A., Fresegna, D., Musella, A., Sepman, H., Bullitta, S., Vito, F. D., Fantozzi, R., Usiello, A., Maccarrone, M., Mercuri, N. B., et al. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0682-8 · Cited by 48 · see citing works
Fluoxetine Facilitates Fear Extinction Through Amygdala Endocannabinoids
Gunduz‐Cinar, O., Flynn, S., Brockway, E. T., Kaugars, K. E., Báldi, R., Ramikie, T. S., Çınar, R., Kunos, G., Patel, S., & Holmes, A. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.318 · Cited by 47 · see citing works
Lieder, B., Holik, A., Somoza, M. M., Pignitter, M., Zaunschirm, M., Ley, J. P., Krammer, G. E., & Somoza, V. (2013) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201200846 · Cited by 47 · see citing works
Role of the Endocannabinoid System in Depression: from Preclinical to Clinical Evidence
Micale, V., Tabiová, K., Kučerová, J., & Drago, F. (2015) · Springer eBooks · doi:10.1007/978-1-4939-2294-9_5 · Cited by 47 · see citing works
Self-citationCampolongo, P., Ratano, P., Manduca, A., Scattoni, M. L., Palmery, M., Trezza, V., & Cuomo, V. (2012) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2012.00011 · Cited by 48 · see citing works
Polypharmacological Approaches for CNS Diseases: Focus on Endocannabinoid Degradation Inhibition
Papa, A., Pasquini, S., Contri, C., Gemma, S., Campiani, G., Butini, S., Varani, K., & Vincenzi, F. (2022) · Cells · doi:10.3390/cells11030471 · Cited by 45 · see citing works
Micale, V., Cristino, L., Tamburella, A., Petrosino, S., Leggio, G. M., Drago, F., & Marzo, V. D. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.06.015 · Cited by 44 · see citing works
Self-citationdos Anjos‐Garcia, T., Ullah, F., Falconi‐Sobrinho, L. L., & Coimbra, N. C. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.04.003 · Cited by 44 · see citing works
Saito, V. M., Wotjak, C. T., & Moreira, F. A. (2010) · PubMed · Cited by 43 · see citing works
Gobira, P. H., Lima, I. V. D. A., Batista, L. A., de Oliveira, A. C., Resstel, L. B. M., Wotjak, C. T., de Aguiar, D. C., & Moreira, F. A. (2017) · Journal of Psychopharmacology · doi:10.1177/0269881117691567 · Cited by 42 · see citing works
John, C. S., & Currie, P. J. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.05.025 · Cited by 41 · see citing works
Endocannabinoid analogues exacerbate marble-burying behavior in mice via TRPV1 receptor
Umathe, S. N., Manna, S. S. S., & Jain, N. S. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.12.030 · Cited by 41 · see citing works
Rea, K., Olango, W. M., Harhen, B., Kerr, D. M., Galligan, R., Fitzgerald, S. T., Moore, M., Roche, M., & Finn, D. P. (2012) · Pain · doi:10.1016/j.pain.2012.12.021 · Cited by 41 · see citing works
Endocannabinoids and striatal function
Moreira, F. A., Jupp, B., Belin, D., & Dalley, J. W. (2014) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000109 · Cited by 43 · see citing works
Xiao, Y., Chen, X., Zhang, P., Xu, Q., Zheng, H., & Xu, G. (2016) · Scientific Reports · doi:10.1038/srep29026 · Cited by 41 · see citing works
Multiple chemical sensitivity: It's time to catch up to the science
Molot, J., Sears, M., & Anisman, H. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105227 · Cited by 40 · see citing works
Chiara, V. D., Motta, C., Rossi, S., Studer, V., Barbieri, F. R., Lauro, D., Bernardi, G., & Centonze, D. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.06.069 · Cited by 40 · see citing works
Anandamide serves two masters in the brain
Marzo, V. D. (2010) · Nature Neuroscience · doi:10.1038/nn1210-1446 · Cited by 38 · see citing works
Batista, L. A., Gobira, P. H., Viana, T. G., de Aguiar, D. C., & Moreira, F. A. (2014) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000073 · Cited by 38 · see citing works
Murillo‐Rodríguez, E., Marzo, V. D., Machado, S. E. D. C., Rocha, N., Veras, A. B., Neto, G. D. A. M., Budde, H., Arias-Carrión, Ó., & Arankowsky‐Sandoval, G. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00152 · Cited by 38 · see citing works
Cannabis, Endocannabinoids and Brain Development: From Embryogenesis to Adolescence
Rodrigues, R. J., Marques, J. M., & Köfalvi, A. (2024) · Cells · doi:10.3390/cells13221875 · Cited by 37 · see citing works
The interactive role of cannabinoid and vanilloid systems in hippocampal synaptic plasticity in rats
Tahmasebi, L., Komaki, A., Karamian, R., Shahidi, ., Sarihi, A., Salehi, I., & Nikkhah, A. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.03.063 · Cited by 37 · see citing works
Brain TRPV1: a depressing TR(i)P down memory lane?
Marzo, V. D., Gobbi, G., & SZALLASI, A. (2008) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2008.09.004 · Cited by 37 · see citing works
Iacob, E., Light, K. C., Tadler, S. C., Weeks, H. R., White, A. T., Hughen, R. W., VanHaitsma, T. A., Bushnell, L., & Light, A. R. (2013) · BMC Psychiatry · doi:10.1186/1471-244x-13-273 · Cited by 36 · see citing works
Dempsey, D. R., Jeffries, K. A., Anderson, R. L., Carpenter, A., Opsina, S. R., & Merkler, D. J. (2014) · FEBS Letters · doi:10.1016/j.febslet.2013.12.027 · Cited by 36 · see citing works
Getting high on the endocannabinoid system.
Alger, B. E. (2013) · Europe PMC (PubMed Central) · Cited by 35 · see citing works
Flannery, L. E., Kerr, D. M., Finn, D. P., & Roche, M. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.06.030 · Cited by 35 · see citing works
TRPV1 blockers as potential new treatments for psychiatric disorders
Iglesias, L. P., de Aguiar, D. C., & Moreira, F. A. (2020) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000603 · Cited by 35 · see citing works
Vincenzi, F., Ravani, A., Pasquini, S., Merighi, S., Gessi, S., Romagnoli, R., Baraldi, P. G., Borea, P. A., & Varani, K. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.09.015 · Cited by 34 · see citing works
Roles of the Cannabinoid System in the Basal Ganglia in Parkinson’s Disease
Wang, M., Liu, H., & Ma, Z. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.832854 · Cited by 35 · see citing works
Maione, S., Costa, B., Piscitelli, F., Morera, E., Chiaro, M. D., Comelli, F., Boccella, S., Guida, F., Verde, R., Ortar, G., et al. (2013) · Pharmacological Research · doi:10.1016/j.phrs.2013.07.003 · Cited by 33 · see citing works
dos Anjos‐Garcia, T., & Coimbra, N. C. (2019) · Psychopharmacology · doi:10.1007/s00213-019-5170-2 · Cited by 33 · see citing works
Ferber, S. G., Trezza, V., & Weller, A. (2019) · Developmental Psychobiology · doi:10.1002/dev.21944 · Cited by 33 · see citing works
Puente, N., Reguero, L., Elezgarai, I., Canduela, M. J., Mendizabal‐Zubiaga, J., Ramos, A., Fernández‐Espejo, E., & Grandes, P. (2014) · Brain Structure and Function · doi:10.1007/s00429-014-0711-2 · Cited by 33 · see citing works
Endocannabinoid Modulation of Dopaminergic Motor Circuits
Morera‐Herreras, T., Miguélez, C., Aristieta, A., Ruíz-Ortega, J. Á., & Ugedo, L. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2012.00110 · Cited by 33 · see citing works
- Authors
- Micale, V., Cristino, L., Tamburella, A., Petrosino, S., Leggio, G. M., Drago, F., & Di Marzo, V.
- Affiliations
- University of Catania (IT)
- Institute of Applied Science and Intelligent Systems (IT)
- Istituto di Chimica Biomolecolare (IT)
- Venue
- Neuropsychopharmacology
- Published
- 2008-06-25
- Volume
- 34
- Issue
- 3
- Pages
- 593-606
- ISSN
- 0893-133X (ISSN-L)
- 1740-634X
- OpenAlex
- W2024922848
- Cited by
- 207
- References
- 60
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 5 · 2023: 3 · 2022: 10 · 2021: 4 · 2020: 12 · 2019: 11 · 2018: 10 · 2017: 12 · 2016: 19 · 2015: 14 · 2014: 23 · 2013: 15 · 2012: 18
- FWCI
- 9.61
- Type
- journal article
- Language
- en
- Open access
- Licence
- other-oa
- www.springer.com/tdm (tdm)
- Locations
- Neuropsychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- INFM-OAR (INFN Catania) (submittedVersion, other-oa)
- Funders
- Università di Catania
- Topics
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- anxiolytic effects, fatty acid amide hydrolase, TRPV1, endocannabinoids, CB1 receptor, anxiety-like behavior, elevated plus maze, olvanil, URB597, SB366791, prefrontal cortex, amygdala, nucleus accumbens, hippocampus, cannabinoid receptor antagonism
- MeSH terms
- Fatty Acid Amide Hydrolases, Amidohydrolases, Anilides, Animals, Anxiety, Arachidonic Acids, Benzamides, Brain, Capsaicin, Carbamates, Cinnamates, Diazepam, Exploratory Behavior, Male, Mice, Inbred C57BL, Piperidines, Pyrazoles, Serotonin, Anti-Anxiety Agents, Receptor, Cannabinoid, CB1, TRPV Cation Channels, Mice, Cannabinoid Receptor Modulators
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
