Cited by 122Antioxidant Activity and Oxidative StressNeurological Disease Mechanisms and TreatmentsGenetic Neurodegenerative Diseases

The DOI matches its Crossref record; 87 of the 87 references it cites were found in a registry or an index.

Vitamin E is essential for Purkinje neuron integrity

Open access

Ulatowski, L., Parker, R., Warrier, G., Sultana, R., Butterfield, D.A., Manor, D.·2014·Neuroscience

DOI 10.1016/j.neuroscience.2013.12.001PMC PMC3943241

Open this paper in CoChat — free account

Abstract

α-Tocopherol (vitamin E) is an essential dietary antioxidant with important neuroprotective functions. α-Tocopherol deficiency manifests primarily in neurological pathologies, notably cerebellar dysfunctions such as spinocerebellar ataxia. To study the roles of α-tocopherol in the cerebellum, we used the α-tocopherol transfer protein for the murine version (Ttpa(-/)(-)) mice which lack the α-tocopherol transfer protein (TTP) and are a faithful model of vitamin E deficiency and oxidative stress. When fed vitamin E-deficient diet, Ttpa(-/)(-) mice had un-detectable levels of α-tocopherol in plasma and several brain regions. Dietary supplementation with α-tocopherol normalized plasma levels of the vitamin, but only modestly increased its levels in the cerebellum and prefrontal cortex, indicating a critical function of brain TTP. Vitamin E deficiency caused an increase in cerebellar oxidative stress evidenced by increased protein nitrosylation, which was prevented by dietary supplementation with the vitamin. Concomitantly, vitamin E deficiency precipitated cellular atrophy and diminished dendritic branching of Purkinje neurons, the predominant output regulator of the cerebellar cortex. The anatomic decline induced by vitamin E deficiency was paralleled by behavioral deficits in motor coordination and cognitive functions that were normalized upon vitamin E supplementation. These observations underscore the essential role of vitamin E and TTP in maintaining CNS function, and support the notion that α-tocopherol supplementation may comprise an effective intervention in oxidative stress-related neurological disorders.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.neuroscience.2013.12.001

Cites

87 of 87 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

A Controlled Trial of Selegiline, Alpha-Tocopherol, or Both as Treatment for Alzheimer's Disease
Sano, M., Ernesto, C., Thomas, R. G., Klauber, M. R., Schafer, K., Grundman, M., Woodbury, P., Growdon, J., Cotman, C. W., Pfeiffer, E., et al. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704243361704 · Cited by 2,380
A Note on a Simple Apparatus for Detecting Neurological Deficit in Rats and Mice**College of Pharmacy, University of Nebraska, Lincoln 8.
Dunham, N. W., & Miya, T. S. (1957) · Journal of the American Pharmaceutical Association (Scientific ed ) · doi:10.1002/jps.3030460322 · Cited by 1,713
Vitamin E, antioxidant and nothing more
Traber, M. G., & Atkinson, J. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.03.024 · Cited by 1,547
Postnatal development of the cerebellar cortex in the rat. II. Phases in the maturation of Purkinje cells and of the molecular layer
Altman, J. (1972) · Journal of Comparative Neurology · doi:10.1002/cne.901450402 · Cited by 996
The excitatory synaptic action of climbing fibres on the Purkinje cells of the cerebellum
Eccles, J. C., Llinas, R. H., & Sasaki, K. (1966) · The Journal of Physiology · doi:10.1113/jphysiol.1966.sp007824 · Cited by 991
Vitamin E: Antioxidant Activity, Biokinetics, And Bioavailability
Burton, G. W., & Traber, M. G. (1990) · Annual Review of Nutrition · doi:10.1146/annurev.nu.10.070190.002041 · Cited by 795
Affinity for α‐tocopherol transfer protein as a determinant of the biological activities of vitamin E analogs
Hosomi, A., Arita, M., Sato, Y., Kiyose, C., 植田, 忠., Igarashi, O., Arai, H., & Inoue, K. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)00499-7 · Cited by 633
The quantitative measurement of motor inco-ordination in naive mice using an accelerating rotarod
Jones, B. J., & Roberts, D. J. (1968) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1968.tb09743.x · Cited by 583
Ataxia with isolated vitamin E deficiency is caused by mutations in the α–tocopherol transfer protein
Ouahchi, K., Arita, M., Kayden, H. J., Hentati, F., Hamida, M. B., Sokol, R. J., Arai, H., Inoue, K., Mandel, J., & Koenig, M. (1995) · Nature Genetics · doi:10.1038/ng0295-141 · Cited by 574
Foods, Fortificants, and Supplements: Where Do Americans Get Their Nutrients?
Fulgoni, V. L. I., Keast, D. R., Bailey, R. L., & Dwyer, J. T. (2011) · Journal of Nutrition · doi:10.3945/jn.111.142257 · Cited by 473
Cytochrome P450 ω-Hydroxylase Pathway of Tocopherol Catabolism
Sontag, T. J., & Parker, R. S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201466200 · Cited by 458
Self-citation
Friedreich's ataxia: Pathology, pathogenesis, and molecular genetics
Koeppen, A. H. (2011) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2011.01.010 · Cited by 447
THE CLINICAL FEATURES AND CLASSIFICATION OF THE LATE ONSET AUTOSOMAL DOMINANT CEREBELLAR ATAXIAS
Harding, A. E. (1982) · Brain · doi:10.1093/brain/105.1.1 · Cited by 410
Methods of Behavior Analysis in Neuroscience
(2000) · CRC Press eBooks · doi:10.1201/9781420041811 · Cited by 345
Ataxia with Isolated Vitamin E Deficiency: Heterogeneity of Mutations and Phenotypic Variability in a Large Number of Families
Cavalier, L., Ouahchi, K., Kayden, H. J., Donato, S. D., Reutenauer, L., Mandel, J., & Koenig, M. (1998) · The American Journal of Human Genetics · doi:10.1086/301699 · Cited by 305
Early Vitamin E supplementation in young but not aged mice reduces Aβ levels and amyloid deposition in a transgenic model of Alzheimer's disease
Sung, S., Yao, Y., Uryu, K., Yang, H., Lee, V. M. ‐., Trojanowski, J. Q., & Praticò, D. (2003) · The FASEB Journal · doi:10.1096/fj.03-0961fje · Cited by 304
Parallel fibre stimulation and the responses induced thereby in the Purkinje cells of the cerebellum
Eccles, J. C., Llin�s, R., & Sasaki, K. S. (1966) · Experimental Brain Research · doi:10.1007/bf00235207 · Cited by 303
Evidence of Toxicity, Oxidative Stress, and Neuronal Insult in Autism
Kern, J. K., & Jones, A. M. (2006) · Journal of Toxicology and Environmental Health, Part B · doi:10.1080/10937400600882079 · Cited by 265
Delayed-onset ataxia in mice lacking α-tocopherol transfer protein: Model for neuronal degeneration caused by chronic oxidative stress
Yokota, T., Igarashi, K., Uchihara, T., Jishage, K.-I., Tomita, H., Inaba, A., Li, Y., Arita, M., Suzuki, H., Mizusawa, H., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.261456098 · Cited by 261
The pathogenesis of spinocerebellar ataxia
Koeppen, A. H. (2005) · The Cerebellum · doi:10.1080/14734220510007950 · Cited by 233
Increased atherosclerosis in hyperlipidemic mice deficient in α-tocopherol transfer protein and vitamin E
Terasawa, Y., Ladha, Z., Leonard, S. W., Morrow, J. D., Newland, D., Sanan, D. A., Packer, L., Traber, M. G., & Farese, R. V. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.240462697 · Cited by 232
Antioxidant Treatment of Patients With Friedreich Ataxia
Hart, P. E., Lodi, R., Rajagopalan, B., Bradley, J. L., Crilley, J. G., Turner, C., Blamire, A. M., Manners, D. N., Styles, P., Schapira, A. H. V., et al. (2005) · Archives of Neurology · doi:10.1001/archneur.62.4.621 · Cited by 224
Cell-Autonomous Death of Cerebellar Purkinje Neurons with Autophagy in Niemann-Pick Type C Disease
Ko, D. C., Milenković, L., Beier, S., Manuel, H., Buchanan, J., & Scott, M. P. (2005) · PLoS Genetics · doi:10.1371/journal.pgen.0010007 · Cited by 220
Leptin Reduces Pathology and Improves Memory in a Transgenic Mouse Model of Alzheimer's Disease
Greco, S. J., Bryan, K. J., Sarkar, S., Zhu, X., Smith, M. A., Ashford, J. W., Johnston, J. M., Tezapsidis, N., & Casadesús, G. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-1308 · Cited by 220
The mossy fibre-granule cell relay of the cerebellum and its inhibitory control by Golgi cells
Eccles, J. C., Llin�s, R., & Sasaki, K. S. (1966) · Experimental Brain Research · doi:10.1007/bf00235211 · Cited by 211
Friedreich Ataxia
Pandolfo, M. (2008) · Archives of Neurology · doi:10.1001/archneur.65.10.1296 · Cited by 206
Friedreich Ataxia Mouse Models with Progressive Cerebellar and Sensory Ataxia Reveal Autophagic Neurodegeneration in Dorsal Root Ganglia
Simon, D., Seznec, H., Gansmuller, A., Carelle, N., Weber, P., Metzger, D., Rustin, P., Koenig, M., & Puccio, H. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.4549-03.2004 · Cited by 205
The inhibitory interneurones within the cerebellar cortex
Eccles, J. C., Llin�s, R., & Sasaki, K. S. (1966) · Experimental Brain Research · doi:10.1007/bf00235206 · Cited by 192
Somatic and Dendritic Small-Conductance Calcium-Activated Potassium Channels Regulate the Output of Cerebellar Purkinje Neurons
Womack, M. D., & Khodakhah, K. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-07-02600.2003 · Cited by 189
Influence of major structural features of tocopherols and tocotrienols on their ω-oxidation by tocopherol-ω-hydroxylase
Sontag, T. J., & Parker, R. S. (2007) · Journal of Lipid Research · doi:10.1194/jlr.m600514-jlr200 · Cited by 182
Self-citation
α-Tocopherol Transfer Protein Is Important for the Normal Development of Placental Labyrinthine Trophoblasts in Mice
Jishage, K.-I., Arita, M., Igarashi, K., Iwata, T., Watanabe, M., Ogawa, M., Ueda, O., Kamada, N., Inoue, K., Arai, H., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c000676200 · Cited by 180
Spinocerebellar Degeneration Associated with a Selective Defect of Vitamin E Absorption
Harding, A. E., Matthews, S., Jones, S., Ellis, C. J. K., Booth, I. W., & Muller, D. P. R. (1985) · New England Journal of Medicine · doi:10.1056/nejm198507043130107 · Cited by 179
Vitamin E Deficiency and Neurologic Disease
Sokol, R. J. (1988) · Annual Review of Nutrition · doi:10.1146/annurev.nu.08.070188.002031 · Cited by 175
Vitamin E as an Antioxidant in vitro and in vivo
Burton, G. W., Cheeseman, K. H., Doba, T., Ingold, K. U., & Slater, T. F. (1983) · Novartis Foundation symposium · doi:10.1002/9780470720820.ch2 · Cited by 148
Studies of LDL oxidation following α-, γ-, or δ-tocotrienyl acetate supplementation of hypercholesterolemic humans
O’Byrne, D., Grundy, S. M., Packer, L., Devaraj, S., Baldenius, K., Hoppe, P. P., Kraemer, K., Jialal, I., & Traber, M. G. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00371-3 · Cited by 137
Oxidative Stress Is Responsible for Deficient Survival and Dendritogenesis in Purkinje Neurons from Ataxia-Telangiectasia Mutated Mutant Mice
Chen, P., Peng, C., Luff, J., Spring, K. J., Watters, D. J., Bottle, S. E., Furuya, S., & Lavin, M. F. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-36-11453.2003 · Cited by 134
Intracellularly recorded responses of the cerebellar Purkinje cells
Eccles, J. C., Llin�s, R., & Sasaki, K. (1966) · Experimental Brain Research · doi:10.1007/bf00236869 · Cited by 132
Postsynaptic and Presynaptic Inhibitory Actions in the Spinal Cord
Eccles, J. C. (1963) · Progress in brain research · doi:10.1016/s0079-6123(08)60586-5 · Cited by 129
Roles of 3-nitrotyrosine- and 4-hydroxynonenal-modified brain proteins in the progression and pathogenesis of Alzheimer's disease
Butterfield, D. A., Reed, T. T., & Rukhsana Sultana, A. (2010) · Free Radical Research · doi:10.3109/10715762.2010.520014 · Cited by 125
Self-citation
Vitamin E and neurological function
Muller, D. P. R. (2010) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200900460 · Cited by 122
Distribution of serum concentrations of α-tocopherol and γ-tocopherol in the US population
Ford, E. S., Schleicher, R. L., Mokdad, A. H., Ajani, U. A., & Liu, S. (2006) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/84.2.375 · Cited by 119
Nutrients from dairy foods are difficult to replace in diets of Americans: food pattern modeling and an analyses of the National Health and Nutrition Examination Survey 2003-2006
Fulgoni, V. L. I., Keast, D. R., Auestad, N., & Quann, E. E. (2011) · Nutrition Research · doi:10.1016/j.nutres.2011.09.017 · Cited by 109
Depletion of Vitamin E Increases Amyloid β Accumulation by Decreasing Its Clearances from Brain and Blood in a Mouse Model of Alzheimer Disease
Nishida, Y., Ito, S., Ohtsuki, S., Yamamoto, N., Takahashi, T., Iwata, N., Jishage, K.-I., Yamada, H., Sasaguri, H., Yokota, S., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.054056 · Cited by 106
Npc1 Acting in Neurons and Glia Is Essential for the Formation and Maintenance of CNS Myelin
Yu, T., & Lieberman, A. P. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003462 · Cited by 103
Equine Degenerative Myeloencephalopathy: A Vitamin E Deficiency That May Be Familial
BVSc, I. G. M., Brown, C. M., Stowe, H. D., Trapp, A. L., Derksen, F. J., & Clément, S. F. (1987) · Journal of Veterinary Internal Medicine · doi:10.1111/j.1939-1676.1987.tb01985.x · Cited by 101
VITAMIN E DEFICIENCY IN THE MONKEY
Dinning, J. S., & Day, P. L. (1957) · The Journal of Experimental Medicine · doi:10.1084/jem.105.5.395 · Cited by 99
Distribution of serum concentrations of α-tocopherol and γ-tocopherol in the US population 1–3
Ford, E. S., Schleicher, R. L., Mokdad, A. H., Ajani, U. A., & Liu, S. (2006) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/84.1.375 · Cited by 94
Myopathy in vitamin E deficient rats: muscle fibre necrosis associated with disturbances of mitochondrial function.
Thomas, P. K., Cooper, J. A. D., King, R. H. M., Workman, J. M., Schapira, A. H. V., Goss-Sampson, M. A., & Muller, D. P. R. (1993) · PubMed · Cited by 93
Serun -Tecopherol Status in the United States Population: Findings from The Third National Health and Nutrition Examination Survey
Ford, E. S., & Sowell, A. L. (1999) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a010001 · Cited by 93
Plasma and CSF markers of oxidative stress are increased in Parkinson's disease and influenced by antiparkinsonian medication
Buhmann, C., Arlt, S., Kontush, A., Möller-Bertram, T., Sperber, S., Oechsner, M., Stuerenburg, H. J., & Beisiegel†, U. (2003) · Neurobiology of Disease · doi:10.1016/j.nbd.2003.10.003 · Cited by 91
EXPERIMENTAL VITAMIN E DEFICIENCY IN RATS
Southam, E., Thomas, P. K., King, R. H. M., Goss-Sampson, M. A., & Muller, D. P. R. (1991) · Brain · doi:10.1093/brain/114.2.915 · Cited by 90
Early oxidative stress in amniotic fluid of pregnancies with Down syndrome
Perrone, S., Longini, M., Bellieni, C. V., Centini, G., Kenanidis, A., Marco, L. D., Petraglia, F., & Buonocore, G. (2006) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2006.10.019 · Cited by 88
Deletion of vitamin E enhances phenotype of Alzheimer disease model mouse
Nishida, Y., Yokota, T., Takahashi, T., Uchihara, T., Jishage, K.-I., & Mizusawa, H. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.09.083 · Cited by 87
Longitudinal studies of the neurobiology of vitamin E and other antioxidant systems, and neurological function in the vitamin E deficient rat
Goss-Sampson, M. A., MacEvilly, C. J., & Muller, D. P. R. (1988) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(88)90051-2 · Cited by 76
Vitamin E and Neurologic Deficits
Sokol, R. J. (1990) · Advances in Pediatrics · doi:10.1016/s0065-3101(24)00241-x · Cited by 72
Prevention and Treatment of Alzheimer Disease and Aging: Antioxidants
Liu, Q., Xie, F., Rolston, R. K., Moreira, P. I., Nunomura, A., Zhu, X., Smith, M. A., & Perry, G. L. (2007) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/138955707779802552 · Cited by 68
Association of Variants in Two Vitamin E Transport Genes with Circulating Vitamin E Concentrations and Prostate Cancer Risk
Wright, M. E., Peters, U., Gunter, M. J., Moore, S. C., Lawson, K. A., Yeager, M., Weinstein, S. J., Snyder, K., Virtamo, J. R. K., & Albanes, D. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-2343 · Cited by 67
Retinitis Pigmentosa and Ataxia Caused by a Mutation in the Gene for the α-Tocopherol–Transfer Protein
Yokota, T., Shiojiri, T., Gotoda, T., & Arai, H. (1996) · New England Journal of Medicine · doi:10.1056/nejm199612053352315 · Cited by 67
α‐Tocopherol Transfer Protein Deficiency in Mice Causes Multi‐Organ Deregulation of Gene Networks and Behavioral Deficits with Age
Gohil, K., Godzdanker, R., O'Roark, E. M., Schock, B. C., Kaini, R. R., Packer, L., Cross, C. E., & Traber, M. G. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1331.012 · Cited by 60
Expression of the α-tocopherol transfer protein gene is regulated by oxidative stress and common single-nucleotide polymorphisms
Ulatowski, L. M., Dreussi, C., Noy, N., Barnholtz‐Sloan, J. S., Klein, E. A., & Manor, D. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.10.528 · Cited by 59
Self-citation
DEPOSITS OF FLUORESCENT ACID-FAST PRODUCTS IN THE NERVOUS SYSTEM AND SKELETAL MUSCLES OF ADULT RATS WITH CHRONIC VITAMIN-E DEFICIENCY
Einarson, L. (1953) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.16.2.98 · Cited by 58
Vitamin E and the nervous system.
Harding, A. E. (1987) · PubMed · Cited by 57
Prolonged α-Tocopherol Deficiency Decreases Oxidative Stress and Unmasks α-Tocopherol-dependent Regulation of Mitochondrial Function in the Brain
Cuddihy, S. L., Ali, S. S., Musiek, E. S., Lucero, J. D., Kopp, S. J., Morrow, J. D., & Dugan, L. L. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m702572200 · Cited by 52
Dietary α‐tocopherol and neuromuscular health: Search for optimal dose and molecular mechanisms continues!
Gohil, K., Vasu, V. T., & Cross, C. E. (2010) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200900575 · Cited by 44
Antioxidants are necessary for myelination of dorsal root ganglion neurons, in vitro
Podratz, J. L., Rodriguez, E. H., & Windebank, A. J. (2003) · Glia · doi:10.1002/glia.10302 · Cited by 44
Cerebellar pathology in ataxia-telangiectasia: the significance of basket cells.
Gatti, R. A., & Vinters, H. V. (1985) · PubMed · Cited by 43
Mice lacking α-tocopherol transfer protein gene have severe α-tocopherol deficiency in multiple regions of the central nervous system
Gohil, K., Oommen, S., Quach, H. T., Vasu, V. T., Aung, H. H., Schock, B. C., Cross, C. E., & Vatassery, G. T. (2008) · Brain Research · doi:10.1016/j.brainres.2008.01.044 · Cited by 40
Cerebellar cortex ultrastructure in ataxia‐telangiectasia
Paula‐Barbosa, M. M., Ruela, C., Tavares, M. A., Pontes, C., Saraiva, A., & Cruz, C. (1983) · Annals of Neurology · doi:10.1002/ana.410130312 · Cited by 38
Familial isolated vitamin E deficiency. Extensive study of a large family with a 5‐year therapeutic follow‐up
Amiel, J., Mazière, J., Beucler, I., Koenig, M., Reutenauer, L., Loux, N., Bonnefont‐Rousselot, D., Féo, C., & Landrieu, P. (1994) · Journal of Inherited Metabolic Disease · doi:10.1007/bf00710425 · Cited by 37
Concomitant brainstem axonal dystrophy and necrotizing myopathy in vitamin E-deficient rats
Pillai, S., Traber, M. G., Kayden, H. J., Cox, N. R., Toivio‐Kinnucan, M., Wright, J. C., Braund, K. G., Whitley, R. D., Gilger, B. C., & Steiss, J. E. (1994) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(94)90205-4 · Cited by 35
Analysis of Postmortem Ventricular Cerebrospinal Fluid from Patients with and without Dementia Indicates Association of Vitamin E with Neuritic Plaques and Specific Measures of Cognitive Performance
Hensley, K., Barnes, L. L., Christov, A., Tangney, C., Honer, W. G., Schneider, J. A., Bennett, D. A., & Morris, M. C. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-101995 · Cited by 32
Degeneration of fasciculus gracilis in cystic fibrosis
Geller, A. C., Gilles, F. H., & Shwachman, H. (1977) · Neurology · doi:10.1212/wnl.27.2.185 · Cited by 32
Slot‐Blot Analysis of 3‐Nitrotyrosine‐Modified Brain Proteins
Rukhsana Sultana, A., & Butterfield, D. A. (2008) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(07)00820-8 · Cited by 27
Self-citation
The role of α-tocopherol in motor hypofunction with aging in α-tocopherol transfer protein knockout mice as assessed by oxidative stress biomarkers
Yoshida, Y., Itoh, N., Hayakawa, M., Habuchi, Y., Saito, Y., Tsukamoto, Y., Cynshi, O., Jishage, K.-I., Arai, H., & Niki, E. (2009) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2008.10.006 · Cited by 27
Apolipoprotein E exerts selective and differential control over vitamin E concentrations in different areas of mammalian brain
Vatassery, G. T., Lam, C. H., Smith, W. E., & Quach, H. T. (2006) · Journal of Neuroscience Research · doi:10.1002/jnr.21037 · Cited by 27
A longitudinal study of somatosensory, brainstem auditory and peripheral sensory-motor conduction during vitamin E deficiency in the rat
Goss-Sampson, M. A., Kriss, A., & Muller, D. P. R. (1990) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(90)90016-g · Cited by 26
Cortical Gene Expression in the Vitamin E-Deficient Rat: Possible Mechanisms for the Electrophysiological Abnormalities of Visual and Neural Function
Hyland, S. N., Muller, D. P. R., Hayton, S., Stoecklin, E., & Barella, L. (2006) · Annals of Nutrition and Metabolism · doi:10.1159/000094635 · Cited by 25
Axonal Dystrophy in the Gracile Nucleus in Children and Young Adults
Sung, J. H., Mastri, A. R., & Park, S. H. (1981) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-198101000-00005 · Cited by 23
A vitamin E-deficient diet affects nerve regeneration in rats
Enrione, E. B., Weeks, O. I., Kranz, S., & Shen, J. (1999) · Nutrition · doi:10.1016/s0899-9007(98)00167-1 · Cited by 20
Genetic vitamin E deficiency does not affect MPTP susceptibility in the mouse brain
Ren, Y., Nishida, Y., Yoshimi, K., Yasuda, T., Jishage, K., Uchihara, T., Yokota, T., Mizuno, Y., & Mochizuki, H. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03994.x · Cited by 19
Miscellaneous Neurologic or Neuromuscular Disorders in Horses
Aleman, M. R. (2011) · Veterinary Clinics of North America Equine Practice · doi:10.1016/j.cveq.2011.08.001 · Cited by 18
Apolipoprotein e deficiency leads to altered brain uptake of alpha tocopherol injected into lateral cerebral ventricles
Vatassery, G. T., Quach, H. T., Smith, W. E., SantaCruz, K. S., & Roy, S. (2007) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2007.04.006 · Cited by 16
Genetic vitamin E deficiency does not affect MPTP susceptibility in the mouse brain
任, 勇. (2007) · Medical Entomology and Zoology · Cited by 7
[A sporadic case of essential vitamin E deficiency manifested by sensory-dominant polyneuropathy and retinitis pigmentosa].
Matsuya, M., Matsumoto, H., Chiba, S., Kashiwagi, M., & Kasahara, M. (1994) · PubMed · Cited by 4
Low rates yield big returns
Optican, L. M. (1998) · Nature Neuroscience · doi:10.1038/204 · Cited by 3
Postmortem study of ataxia with retinitis pigmentosa by mutation of the α-tocopherol transfer protein gene
Yokota, T., Okeda, R., Mizusawa, H., Uchihara, T., Kumagai, J., Shiojiri, T., Pang, J. J., Arita, M., Hayashi, M., & Kiyosawa, M. (2000) · Institutional Repositories DataBase (IRDB) · doi:10.1136/jnnp.68.4.521
Untitled work
(1953) · Europe PMC (PubMed Central)

Sorted by citations

Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease
Butterfield, D. A., & Halliwell, B. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-019-0132-6 · Cited by 1,954
Self-citation
Vitamin E: Emerging aspects and new directions
Galli, F., Azzi, A., Birringer, M., Cook‐Mills, J. M., Eggersdorfer, M. L., Frank, J., Cruciani, G., Lorkowski, S., & Özer, N. K. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.09.017 · Cited by 467
Vitamin E Inadequacy in Humans: Causes and Consequences
Traber, M. G. (2014) · Advances in Nutrition · doi:10.3945/an.114.006254 · Cited by 292
Many tocopherols, one vitamin E
Azzi, A. (2017) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2017.06.004 · Cited by 204
Vitamin A and Vitamin E: Will the Real Antioxidant Please Stand Up?
Blaner, W. S., Shmarakov, I. O., & Traber, M. G. (2021) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-082018-124228 · Cited by 211

See all 122

Authors: Ulatowski, L., Parker, R., Warrier, G., Sultana, R., Butterfield, D. A., & Manor, D.
Affiliations: Case Western Reserve University (US)
Cornell University (US)
University of Kentucky (US)
Corresponding author: Manor, D.
ORCID: Ulatowski, L.
Parker, R.
Warrier, G.
Butterfield, D.A.
Venue: Neuroscience
Publisher: Elsevier BV
Published: 2014-02
Volume: 260
Pages: 120-129
ISSN: 0306-4522 (ISSN-L)
DOI: 10.1016/j.neuroscience.2013.12.001
PMC: PMC3943241
OpenAlex: W1972998914
Cited by: 122
References: 87
Citations by year: 2026: 4 · 2025: 4 · 2024: 5 · 2023: 10 · 2022: 10 · 2021: 16 · 2020: 11 · 2019: 11 · 2018: 12 · 2017: 10 · 2016: 15 · 2015: 7 · 2014: 5
FWCI: 6.96
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (2r01dk067494-07)
National Institute of Diabetes and Digestive and Kidney Diseases (DK 067494, R01-DK067494)
Topics: Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Genetic Neurodegenerative Diseases
Keywords: vitamin E, alpha-tocopherol, alpha-tocopherol transfer protein, vitamin E deficiency, cerebellum, Purkinje cells, oxidative stress, protein nitrosylation, dendritic branching, neuronal atrophy, spinocerebellar ataxia, motor coordination, cognitive impairment, dietary supplementation, neuroprotection
MeSH terms: Animals, Carrier Proteins, Cerebellum, Motor Activity, Purkinje Cells, Tyrosine, Vitamin E Deficiency, Prefrontal Cortex, Mice, Knockout, Oxidative Stress, alpha-Tocopherol, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Vitamin E is essential for Purkinje neuron integrity

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks