The DOI matches its Crossref record; 87 of the 87 references it cites were found in a registry or an index.
Vitamin E is essential for Purkinje neuron integrity
Open accessAbstract
α-Tocopherol (vitamin E) is an essential dietary antioxidant with important neuroprotective functions. α-Tocopherol deficiency manifests primarily in neurological pathologies, notably cerebellar dysfunctions such as spinocerebellar ataxia. To study the roles of α-tocopherol in the cerebellum, we used the α-tocopherol transfer protein for the murine version (Ttpa(-/)(-)) mice which lack the α-tocopherol transfer protein (TTP) and are a faithful model of vitamin E deficiency and oxidative stress. When fed vitamin E-deficient diet, Ttpa(-/)(-) mice had un-detectable levels of α-tocopherol in plasma and several brain regions. Dietary supplementation with α-tocopherol normalized plasma levels of the vitamin, but only modestly increased its levels in the cerebellum and prefrontal cortex, indicating a critical function of brain TTP. Vitamin E deficiency caused an increase in cerebellar oxidative stress evidenced by increased protein nitrosylation, which was prevented by dietary supplementation with the vitamin. Concomitantly, vitamin E deficiency precipitated cellular atrophy and diminished dendritic branching of Purkinje neurons, the predominant output regulator of the cerebellar cortex. The anatomic decline induced by vitamin E deficiency was paralleled by behavioral deficits in motor coordination and cognitive functions that were normalized upon vitamin E supplementation. These observations underscore the essential role of vitamin E and TTP in maintaining CNS function, and support the notion that α-tocopherol supplementation may comprise an effective intervention in oxidative stress-related neurological disorders.
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“Although vitamin E administration has been observed to decrease oxidative damage levels in brain in vivo in some studies82”
From Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease (2019) · cites this paper as [82]
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Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease
Butterfield, D. A., & Halliwell, B. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-019-0132-6 · Cited by 1,954
Self-citationVitamin E: Emerging aspects and new directions
Galli, F., Azzi, A., Birringer, M., Cook‐Mills, J. M., Eggersdorfer, M. L., Frank, J., Cruciani, G., Lorkowski, S., & Özer, N. K. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.09.017 · Cited by 467
Vitamin E Inadequacy in Humans: Causes and Consequences
Traber, M. G. (2014) · Advances in Nutrition · doi:10.3945/an.114.006254 · Cited by 292
Many tocopherols, one vitamin E
Azzi, A. (2017) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2017.06.004 · Cited by 204
Vitamin A and Vitamin E: Will the Real Antioxidant Please Stand Up?
Blaner, W. S., Shmarakov, I. O., & Traber, M. G. (2021) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-082018-124228 · Cited by 211
Metadata
- Authors
- Ulatowski, L., Parker, R., Warrier, G., Sultana, R., Butterfield, D. A., & Manor, D.
- Affiliations
- Case Western Reserve University (US)
- Cornell University (US)
- University of Kentucky (US)
- Corresponding author
- Manor, D.
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 2014-02
- Volume
- 260
- Pages
- 120-129
- ISSN
- 0306-4522 (ISSN-L)
- PMC
- PMC3943241
- OpenAlex
- W1972998914
- Cited by
- 122
- References
- 87
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 5 · 2023: 10 · 2022: 10 · 2021: 16 · 2020: 11 · 2019: 11 · 2018: 12 · 2017: 10 · 2016: 15 · 2015: 7 · 2014: 5
- FWCI
- 6.96
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (2r01dk067494-07)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 067494, R01-DK067494)
- Topics
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Genetic Neurodegenerative Diseases
- Keywords
- vitamin E, alpha-tocopherol, alpha-tocopherol transfer protein, vitamin E deficiency, cerebellum, Purkinje cells, oxidative stress, protein nitrosylation, dendritic branching, neuronal atrophy, spinocerebellar ataxia, motor coordination, cognitive impairment, dietary supplementation, neuroprotection
- MeSH terms
- Animals, Carrier Proteins, Cerebellum, Motor Activity, Purkinje Cells, Tyrosine, Vitamin E Deficiency, Prefrontal Cortex, Mice, Knockout, Oxidative Stress, alpha-Tocopherol, Mice
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