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Cited by 20Neurogenesis and neuroplasticity mechanismsProtein Tyrosine PhosphatasesMultiple Sclerosis Research Studies

Developmental expression and function analysis of protein tyrosine phosphatase receptor type D in oligodendrocyte myelination

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Zhu, Q., Tan, Z., Zhao, S., Huang, H., Zhao, X., Hu, X., Zhang, Y., Shields, C.B. +2 more·2015·Neuroscience
DOI 10.1016/j.neuroscience.2015.08.062PMC PMC4600676
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Abstract

Receptor protein tyrosine phosphatases (RPTPs) are extensively expressed in the central nervous system (CNS), and have distinct spatial and temporal patterns in different cell types during development. Previous studies have demonstrated possible roles for RPTPs in axon outgrowth, guidance, and synaptogenesis. In the present study, our results revealed that protein tyrosine phosphatase, receptor type D (PTPRD) was initially expressed in mature neurons in embryonic CNS, and later in oligodendroglial cells at postnatal stages when oligodendrocytes undergo active axonal myelination process. In PTPRD mutants, oligodendrocyte differentiation was normal and a transient myelination delay occurred at early postnatal stages, indicating the contribution of PTPRD to the initiation of axonal myelination. Our results also showed that the remyelination process was not affected in the absence of PTPRD function after a cuprizone-induced demyelination in adult animals.

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  • OL2 upregulated several genes associated with myelination including Pprd, Mobp, and Adgrv1.

    “OL2 upregulated several genes associated with myelination including Pprd, Mobp, and Adgrv136 (Fig. 3E).”

    From The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway (2025) · cites this paper as [36]

    The Results section reports that PTPRD is expressed in mature myelinating oligodendrocytes and that PTPRD mutants have a transient early myelination defect. This supports an association between PTPRD (apparently the cited sentence’s “Pprd”) and myelination, but the paper does not report OL2 gene upregulation or establish the stated associations for Mobp and Adgrv1. (LLM, conf=0.85)

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Cited by

Sorted by citations

Authors
Zhu, Q., Tan, Z., Zhao, S., Huang, H., Zhao, X., Hu, X., Zhang, Y., Shields, C. B., Uetani, N., & Qiu, M.
Affiliations
  • University of Louisville (US)
  • Norton Healthcare (US)
  • McGill University (CA)
Corresponding author
Qiu, M.
ORCID
Venue
Neuroscience
Publisher
Elsevier BV
Published
2015-11
Volume
308
Pages
106-114
ISSN
0306-4522 (ISSN-L)
DOI
10.1016/j.neuroscience.2015.08.062
PMC
PMC4600676
OpenAlex
W1260057052
Cited by
20
References
4
Citations by year
2026: 2 · 2025: 4 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 2 · 2020: 1 · 2019: 3 · 2017: 1 · 2016: 1
FWCI
0.25
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • NIH (R01NS37717)
  • The National Basic Research Program of China (2013CB531300)
  • National Natural Science Foundation of China (31201697, 31372150, 31471955)
  • Kentucky Spinal Cord and Head Injury Trust
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
Keywords
PTPRD, oligodendrocyte myelination, oligodendrocyte differentiation, developmental gene expression, remyelination, cuprizone-induced demyelination
MeSH terms
Animals, Brain, Cell Differentiation, Cuprizone, Demyelinating Diseases, Disease Models, Animal, Immunohistochemistry, Mice, Transgenic, Motor Activity, Mutation, Oligodendroglia, Spinal Cord, Blotting, Western, In Situ Hybridization, Evoked Potentials, Motor, Transcranial Magnetic Stimulation, Receptor-Like Protein Tyrosine Phosphatases, Class 2

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