CNS Myelin Paranodes Require Nkx6-2 Homeoprotein Transcriptional Activity for Normal Structure
Open accessAbstract
Homeodomain proteins play critical roles during development in cell fate determination and proliferation, but few studies have defined gene regulatory networks for this class of transcription factors in differentiated cells. Using a lacZ-knock-in strategy to ablate Nkx6-2, we find that the Nkx6-2 promoter is active embryonically in neuroblasts and postnatally in oligodendrocytes. In addition to neurological deficits, we find widespread ultrastructural abnormalities in CNS white matter and aberrant expression of three genes encoding a paranodal microtubule destabilizing protein, stathmin 1, and the paranodal cell adhesion molecules neurofascin and contactin. The involvement of these downstream proteins in cytoskeletal function and cell adhesion reveals mechanisms whereby Nkx6-2 directly or indirectly regulates axon- glial interactions at myelin paranodes. Nkx6-2 does not appear to be the central regulator of axoglial junction assembly; nonetheless, our data constitute the first evidence of such a regulatory network and provide novel insights into the mechanism and effector molecules that are involved.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
This transition was accompanied by reduced activity of myelin-associated gene networks and diminished regulon activity of key transcriptional regulators, including MYRF and NKX6-2, which serve as central regulators of myelin gene expression programs.
“This transition was accompanied by reduced activity of myelin-associated gene networks and diminished regulon activity of key transcriptional regulators, including MYRF and NKX6-2, which serve as central regulators of myelin gene expression programs (53-55) (Fig. 5J).”
From Molecular and cellular processes disrupted in the early postnatal Down syndrome prefrontal cortex (2026) · cites this paper as [55]
Split into 2 atoms — 0 confirmed, 1 partially supported, 1 disputed, 0 misattributed, 0 unverifiable. Expand the claim to see per-atom verdicts.
Checked by a reasoning model — may be wrong.
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Axonal transection in the lesions of multiple sclerosis
Trapp, B. D., Peterson, J., Ransohoff, R. M., Rudick, R., Mörk, S., & Bö, L. (1998) · New England Journal of Medicine · doi:10.1056/nejm199801293380502 · Cited by 4,029 · see citing works
(1991) · Medical Entomology and Zoology · Cited by 1,512 · see citing works
Lu, Q. R., Sun, T., Zhu, Z.-M., Ma, N., García, M., Stiles, C., & Rowitch, D. (2002) · Cell · doi:10.1016/s0092-8674(02)00678-5 · Cited by 1,064 · see citing works
Spectrin and ankyrin-based pathways: metazoan inventions for integrating cells into tissues.
Bennett, V., & Baines, A. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.3.1353 · Cited by 993 · see citing works
Assessment of hearing in 80 inbred strains of mice by ABR threshold analyses
Zheng, Q. Y., Johnson, K. R., & Erway, L. C. (1999) · Hearing Research · doi:10.1016/s0378-5955(99)00003-9 · Cited by 832 · see citing works
CNS Myelin and Sertoli Cell Tight Junction Strands Are Absent in Osp/Claudin-11 Null Mice
Gow, A., Southwood, C. M., Li, J. S., Pariali, M., Riordan, G. P., Brodie, S. E., Danias, J., Bronstein, J. M., Kachar, B., & Lazzarini, R. A. (1999) · Cell · doi:10.1016/s0092-8674(00)81553-6 · Cited by 702 · see citing works
Self-citationCoetzee, T., Fujita, N., Dupree, J. L., Shi, R., Blight, A. R., Suzuki, K., Suzuki, K., & Popko, B. (1996) · Cell · doi:10.1016/s0092-8674(00)80093-8 · Cited by 624 · see citing works
Bhat, M., Rios, J. C., Lu, Y. C., Garcia-Fresco, G. P., Ching, W., Martin, M. S. S., Li, J., Einheber, S., Chesler, M., Rosenbluth, J., et al. (2001) · Neuron · doi:10.1016/s0896-6273(01)00294-x · Cited by 585 · see citing works
Recombinase-Mediated Gene Activation and Site-Specific Integration in Mammalian Cells
O’Gorman, S., Fox, D. T., & Wahl, G. M. (1991) · Science · doi:10.1126/science.1900642 · Cited by 574 · see citing works
Boyle, M. E., Berglund, E., Murai, K., Weber, L., Peles, E., & Ranscht, B. (2001) · Neuron · doi:10.1016/s0896-6273(01)00296-3 · Cited by 539 · see citing works
Sander, M., Sussel, L., Conners, J. R., Scheel, D., Kalamaras, J., Cruz, F. S. D., Schwitzgebel, V., Hayes-Jordan, A. A., & German, M. S. (2000) · Development · doi:10.1242/dev.127.24.5533 · Cited by 521 · see citing works
Polarized Domains of Myelinated Axons
Salzer, J. L. (2003) · Neuron · doi:10.1016/s0896-6273(03)00628-7 · Cited by 399 · see citing works
Control of oligodendrocyte differentiation by theNkx2.2homeodomain transcription factor
Qi, Y. B., Cai, J., Wu, Y., Wu, R., Lee, J. D., Fu, H. Q., Rao, M. S., Sussel, L., Rubenstein, J. L. R., & Qiu, M. S. (2001) · Development · doi:10.1242/dev.128.14.2723 · Cited by 356 · see citing works
Tait, S., Gunn-Moore, F., Collinson, J., Huang, J., Lubetzki, C., Pedraza, L., Sherman, D., Colman, D., & Brophy, P. (2000) · Journal of Cell Biology · doi:10.1083/jcb.150.3.657 · Cited by 339 · see citing works
Dependence of nodal sodium channel clustering on paranodal axoglial contact in the developing CNS
Rasband, M. N., Peles, E., Trimmer, J. S., Levinson, S. R., Lux, S. E., & Shrager, P. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-17-07516.1999 · Cited by 325 · see citing works
Charles, P., Tait, S., Faivre‐Sarrailh, C., Barbin, G., Gunn‐Moore, F. J., Denisenko, N., Guennoc, A., Girault, J., Brophy, P., & Lubetzki, C. (2002) · Current Biology · doi:10.1016/s0960-9822(01)00680-7 · Cited by 297 · see citing works
Vallstedt, A., Muhr, J., Pattyn, A., Pierani, A., Mendelsohn, M., Sander, M., Jessell, T., & Ericson, J. (2001) · Neuron · doi:10.1016/s0896-6273(01)00412-3 · Cited by 288 · see citing works
Rios, J. C., Melendez-Vasquez, C., Einheber, S., Lustig, M., Grumet, M., Hemperly, J., Peles, E., & Salzer, J. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-22-08354.2000 · Cited by 287 · see citing works
Physiology and Pathobiology of Axons
Waxman, S. G., & Byers, M. R. (1979) · Anesthesiology · doi:10.1097/00000542-197902000-00041 · Cited by 265 · see citing works
Textura del sistema nervioso del hombre y de los vertebrados
Agüeras, S. R. Y. C. (1992) · Dialnet (Universidad de la Rioja) · Cited by 264 · see citing works
The L1 Family of Neural Cell Adhesion Molecules: Old Proteins Performing New Tricks
Hortsch, M. (1996) · Neuron · doi:10.1016/s0896-6273(00)80192-0 · Cited by 259 · see citing works
A computer simulation of conduction in demyelinated nerve fibres
Koles, Z. J., & Rasminsky, M. (1972) · The Journal of Physiology · doi:10.1113/jphysiol.1972.sp010036 · Cited by 248 · see citing works
Gow, A., Davies, C., Southwood, C. M., Frolenkov, G. I., Chrustowski, M., Ng, L., Yamauchi, D., Marcus, D. C., & Kachar, B. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1640-04.2004 · Cited by 227 · see citing works
Self-citationGow, A., Southwood, C. M., & Lazzarini, R. A. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.140.4.925 · Cited by 218 · see citing works
Self-citationSpindle assembly and the art of regulating microtubule dynamics by MAPs and Stathmin/Op18
Andersen, S. (2000) · Trends in Cell Biology · doi:10.1016/s0962-8924(00)01786-4 · Cited by 211 · see citing works
Stolt, C., Lommes, P., Friedrich, R., & Wegner, M. (2004) · Development · doi:10.1242/dev.01114 · Cited by 204 · see citing works
Morphology of Myelin and Myelination
Raine, C. S. (1984) · Springer eBooks · doi:10.1007/978-1-4757-1830-0_1 · Cited by 194 · see citing works
Organizing Principles of the Axoglial Apparatus
Pedraza, L., Huang, J. K., & Colman, D. (2001) · Neuron · doi:10.1016/s0896-6273(01)00306-3 · Cited by 179 · see citing works
Gow, A., Friedrich, V. L., & Lazzarini, R. A. (1992) · The Journal of Cell Biology · doi:10.1083/jcb.119.3.605 · Cited by 147 · see citing works
Self-citationDenisenko‐Nehrbass, N., Oguievetskaia, K., Goutebroze, L., Galvez, T., Yamakawa, H., Ohara, O., Carnaud, M., & Girault, J. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02441.x · Cited by 142 · see citing works
Tuvia, S., Garver, T. D., & Bennett, V. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.24.12957 · Cited by 129 · see citing works
Structural Requirements for Association of Neurofascin with Ankyrin
Zhang, X., Davis, J. Q., Carpenter, S., & Bennett, V. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.46.30785 · Cited by 124 · see citing works
Pattyn, A., Vallstedt, A., Dias, J. M., Sander, M., & Ericson, J. (2003) · Development · doi:10.1242/dev.00641 · Cited by 112 · see citing works
Development of nodes of Ranvier.
Girault, J., & Peles, E. (2002) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(02)00370-7 · Cited by 110 · see citing works
Liedtke, W., Leman, E. E., Fyffe, R. E. W., Raine, C. S., & Schubart, U. K. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64866-3 · Cited by 110 · see citing works
Stecca, B. A., Southwood, C. M., Gragerov, A., Kelley, K. A., Friedrich, V. L., & Gow, A. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-11-04002.2000 · Cited by 104 · see citing works
Self-citationMolecular organization of axo-glial junctions.
Bhat, M. (2003) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2003.09.004 · Cited by 92 · see citing works
Komuro, I., Schalling, M., Jahn, L., Bodmer, R., Jenkins, N. A., Copeland, N. G., & Izumo, S. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb05783.x · Cited by 84 · see citing works
Farhadi, H. F., Lepage, P., Forghani, R., Friedman, H. C., Orfali, W., Jasmin, L., Miller, W., Hudson, T. J., & Peterson, A. C. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-32-10214.2003 · Cited by 83 · see citing works
Galactosphingolipids and axono-glial interaction in myelin of the central nervous system
Bosio, A., Büssow, H., Adam, J., & Stoffel, W. (1998) · Cell and Tissue Research · doi:10.1007/s004410051051 · Cited by 81 · see citing works
Myelin abnormalities in mice deficient in galactocerebroside and sulfatide
Dupree, J. L., Coetzee, T., Suzuki, K., & Popko, B. (1998) · Journal of Neurocytology · doi:10.1023/a:1006908013972 · Cited by 79 · see citing works
Awatramani, R., Scherer, S. S., Grinspan, J. B., Collarini, E. J., Skoff, R. P., O’Hagan, D., Garbern, J. Y., & Kamholz, J. A. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-17-06657.1997 · Cited by 74 · see citing works
Self-citationDrosophilaStathmin: A Microtubule-destabilizing Factor Involved in Nervous System Formation
Ozon, S., Guichet, A., Gavet, O., Roth, S., & Sobel, A. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.01-07-0362 · Cited by 74 · see citing works
Superoxide mediates the cell-death-enhancing action of presenilin-1 mutations
Guo, Q., Fu, W., Holtsberg, F. W., Steiner, S. M., & Mattson, M. P. (1999) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19990601)56:5 · Cited by 69 · see citing works
Sim, F. J., Hinks, G. L., & Franklin, R. J. M. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00252-9 · Cited by 64 · see citing works
Liu, A., Muggironi, M., Marin‐Husstege, M., & Casaccia‐Bonnefil, P. (2003) · Glia · doi:10.1002/glia.10290 · Cited by 58 · see citing works
The myelin deficit in quaking mice
Friedrich, V. L. (1974) · Brain Research · doi:10.1016/0006-8993(74)90902-0 · Cited by 54 · see citing works
Internodal specializations of myelinated axons in the central nervous system
Arroyo, E., Xu, T., Poliak, S., Watson, M. R., Peles, E., & Scherer, S. (2001) · Cell and Tissue Research · doi:10.1007/s004410100403 · Cited by 53 · see citing works
Self-citationAbnormal axoglial junctions in the myelin-deficient rat mutant
D, J. R. M. (1987) · Journal of Neurocytology · doi:10.1007/bf01668504 · Cited by 48 · see citing works
The transcriptional regulator Yin Yang 1 activates the myelin PLP gene
Berndt, J. A., Kim, J. G., Toŝić, M., Kim, C., & Hudson, L. D. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00307.x · Cited by 46 · see citing works
Power, S. C., Lancman, J. J., & Smith, S. M. (1999) · Developmental Dynamics · doi:10.1002/(sici)1097-0177(199912)216:4/5 · Cited by 44 · see citing works
Knobler, R. L., Stempak, J. G., & Laurencin, M. (1974) · Journal of Ultrastructure Research · doi:10.1016/s0022-5320(74)90076-8 · Cited by 37 · see citing works
β3-tubulin is directly repressed by the Engrailed protein in Drosophila
Serrano, N., Brock, H. W., & Maschat, F. (1997) · Development · doi:10.1242/dev.124.13.2527 · Cited by 31 · see citing works
Mice Lacking the Nkx6.2 (Gtx) Homeodomain Transcription Factor Develop and Reproduce Normally
Cai, J., Qi, Y. B., Wu, R., Modderman, G., Fu, H. Q., Liu, R., & Qiu, M. S. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.13.4399-4403.2001 · Cited by 30 · see citing works
Restoration of Brain Stem Auditory-Evoked Potentials by Gene Transfer in Shiverer Mice
Fujiyoshi, T., Hood, L., & Yoo, T. J. (1994) · Annals of Otology Rhinology & Laryngology · doi:10.1177/000348949410300606 · Cited by 26 · see citing works
The NeuronalMicrotubule-Associated Protein 1BIs under Homeoprotein Transcriptional Control
Montesinos, M. L., Foucher, I., Conradt, M., Mainguy, G., Robel, L., Prochiantz, A., & Volovitch, M. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-10-03350.2001 · Cited by 25 · see citing works
Southwood, C. M., & Gow, A. (2001) · CRC Press eBooks · doi:10.1201/9781420038538-35 · Cited by 5 · see citing works
Self-citationFunctions of OSP/Claudin- 11-Containing Parallel Tight Junctions
Southwood, C. M., & Gow, A. (2001) · CRC Press eBooks · doi:10.1201/9781420038538.ch33 · Cited by 2 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Myelin gene regulatory factor is a critical transcriptional regulator required for CNS myelination
Emery, B., Agalliu, D., Cahoy, J. D., Watkins, T. A., Dugas, J. C., Mulinyawe, S. B., Ibrahim, A., Ligon, K. L., Rowitch, D. H., & Barres, B. A. (2009) · Cell · doi:10.1016/j.cell.2009.04.031 · Cited by 559 · see citing works
Characterization of Nkx6-2-Derived Neocortical Interneuron Lineages
Sousa, V. H., Miyoshi, G., Hjerling-Leffler, J., Karayannis, T., & Fishell, G. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhp038 · Cited by 328 · see citing works
Emery, B., & Lu, Q. R. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a020461 · Cited by 293 · see citing works
Molecular Control of Oligodendrocyte Development
Elbaz, B., & Popko, B. (2019) · Trends in Neurosciences · doi:10.1016/j.tins.2019.01.002 · Cited by 286 · see citing works
Mechanisms regulating the development of oligodendrocytes and central nervous system myelin.
Mitew, S., Hay, C., Peckham, H., Xiao, J., Koenning, M., & Emery, B. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2013.11.029 · Cited by 259 · see citing works
Pillai, A., Thaxton, C., Pribisko, A. L., Cheng, J.-G., Dupree, J. L., & Bhat, M. (2009) · Journal of Neuroscience Research · doi:10.1002/jnr.22015 · Cited by 214 · see citing works
Contactin-1 IgG4 antibodies cause paranode dismantling and conduction defects.
Manso, C., Querol, L., Mekaouche, M., Illa, I., & Devaux, J. (2016) · Brain : a journal of neurology · doi:10.1093/brain/aww062 · Cited by 155 · see citing works
Microtubule Deacetylases, SirT2 and HDAC6, in the Nervous System
Southwood, C. M., Peppi, M., Dryden, S. C., Tainsky, M. A., & Gow, A. (2006) · Neurochemical Research · doi:10.1007/s11064-006-9127-6 · Cited by 143 · see citing works
Self-citationTranscriptional control of oligodendrogenesis
Nicolay, D. J., Doucette, J. R., & Nazarali, A. (2007) · Glia · doi:10.1002/glia.20540 · Cited by 137 · see citing works
Lonigro, A., & Devaux, J. J. (2008) · Brain · doi:10.1093/brain/awn281 · Cited by 126 · see citing works
A Matter of Identity: Transcriptional Control in Oligodendrocytes
Wegner, M. (2008) · Journal of Molecular Neuroscience · doi:10.1007/s12031-007-9008-8 · Cited by 131 · see citing works
Specification of CNS glia from neural stem cells in the embryonic neuroepithelium
Kessaris, N., Pringle, N., & Richardson, W. (2008) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2006.2013 · Cited by 125 · see citing works
White matter integrity in mice requires continuous myelin synthesis at the inner tongue
Meschkat, M., Steyer, A. M., Weil, M.-T., Kusch, K., Jahn, O., Piepkorn, L., Agüi-Gonzalez, P., Phan, N. T. N., Ruhwedel, T., Sadowski, B., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-28720-y · Cited by 112 · see citing works
Anti–neurofascin-155 IgG4 antibodies prevent paranodal complex formation in vivo
Manso, C., Querol, L., Lleixà, C., Poncelet, M., Mekaouche, M., Vallat, J., Illa, I., & Devaux, J. J. (2019) · Journal of Clinical Investigation · doi:10.1172/jci124694 · Cited by 110 · see citing works
Tight junctions potentiate the insulative properties of small CNS myelinated axons
Devaux, J. J., & Gow, A. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200808034 · Cited by 108 · see citing works
Self-citationTwo-tier transcriptional control of oligodendrocyte differentiation
Li, H., He, Y., Richardson, W., & Casaccia, P. (2009) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2009.08.004 · Cited by 98 · see citing works
Sock, E., & Wegner, M. (2021) · Developmental Neurobiology · doi:10.1002/dneu.22849 · Cited by 85 · see citing works
Cai, J., Zhu, Q., Zheng, K., Li, H., Qi, Y., Cao, Q.-L., & Qiu, M.-S. (2009) · Glia · doi:10.1002/glia.20937 · Cited by 96 · see citing works
Vallejo, R., Kelley, C. A., Gupta, A., Smith, W. J., Vallejo, A., & Cedeño, D. L. (2020) · Molecular Pain · doi:10.1177/1744806920918057 · Cited by 94 · see citing works
Organization and maintenance of molecular domains in myelinated axons
Buttermore, E. D., Thaxton, C., & Bhat, M. A. (2013) · Journal of Neuroscience Research · doi:10.1002/jnr.23197 · Cited by 92 · see citing works
Transcriptional and post-transcriptional control of CNS myelination
Emery, B. (2010) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2010.05.005 · Cited by 92 · see citing works
Hypomyelination and Oligodendroglial Alterations in a Mouse Model of Autism Spectrum Disorder
Graciarena, M., Seiffe, A., Nait‐Oumesmar, B., & Depino, A. M. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00517 · Cited by 89 · see citing works
The Microtubule Regulator Stathmin Is an Endogenous Protein Agonist for TLR3
Bsibsi, M., Bajramovic, J., Vogt, M., van Duijvenvoorden, E., Baghat, A., Persoon‐Deen, C., Tielen, F., Verbeek, R., Huitinga, I., Ryffel, B., et al. (2010) · Journal of Immunology · doi:10.4049/jimmunol.0902419 · Cited by 91 · see citing works
Garcia-Fresco, G. P., Sousa, A. D., Pillai, A., Moy, S., Crawley, J., Tessarollo, L., Dupree, J., & Bhat, M. (2006) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0601082103 · Cited by 89 · see citing works
Kohnke, S., Buller, S. A., Nuzzaci, D., Ridley, K., Lam, B., Pivoňková, H., Bentsen, M. A., Alonge, K. M., Zhao, C., Tadross, J. A., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109362 · Cited by 74 · see citing works
Pentón-Rol, G., Marín-Prida, J., & McCarty, M. F. (2021) · Current Neuropharmacology · doi:10.2174/1570159x19666210408123807 · Cited by 73 · see citing works
Bordner, K. A., George, E. D., Carlyle, B. C., Duque, A., Kitchen, R. R., Lam, T. T., Colangelo, C. M., Stone, K. L., Abbott, T. B., Mane, S., et al. (2011) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2011.00018 · Cited by 65 · see citing works
Sundberg, M., Skottman, H., Suuronen, R., & Narkilahti, S. (2010) · Stem Cell Research · doi:10.1016/j.scr.2010.04.005 · Cited by 64 · see citing works
Dynamic signaling for neural stem cell fate determination
Wen, S., Li, H., & Liu, J. (2009) · Cell Adhesion & Migration · doi:10.4161/cam.3.1.7602 · Cited by 64 · see citing works
Devaux, J. J. (2012) · American Journal Of Pathology · doi:10.1016/j.ajpath.2012.06.034 · Cited by 59 · see citing works
SomethiNG 2 talk about-Transcriptional regulation in embryonic and adult oligodendrocyte precursors.
Küspert, M., & Wegner, M. (2016) · Brain Research · doi:10.1016/j.brainres.2015.07.024 · Cited by 48 · see citing works
Pang, Y., Zheng, B., Kimberly, S. L., Cai, Z., Rhodes, P. G., & Lin, R. C. S. (2012) · Brain and Behavior · doi:10.1002/brb3.33 · Cited by 55 · see citing works
Pedraza, L., Huang, J. K., & Colman, D. (2009) · Journal of Neuroscience Research · doi:10.1002/jnr.22004 · Cited by 52 · see citing works
Mutations in NKX6-2 Cause Progressive Spastic Ataxia and Hypomyelination
Chelban, V., Patel, N., Vandrovcová, J., Zanetti, M. N., Lynch, D. S., Ryten, M., Botía, J. A., Bello, O. D., Tribollet, E., Efthymiou, S., et al. (2017) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2017.05.009 · Cited by 52 · see citing works
Human Embryonic Stem Cell-Derived Oligodendrocytes: Protocols and Perspectives
Alsanie, W. F., Niclis, J. C., & Petratos, S. (2013) · Stem Cells and Development · doi:10.1089/scd.2012.0520 · Cited by 51 · see citing works
Pentón-Rol, G., Marín-Prida, J., & Falcón-Cama, V. (2018) · Behavioral Sciences · doi:10.3390/bs8010015 · Cited by 50 · see citing works
Tcf7l2 is Tightly Controlled During Myelin Formation
Fu, H., Kesari, S., & Cai, J. (2011) · Cellular and molecular neurobiology · doi:10.1007/s10571-011-9778-y · Cited by 41 · see citing works
Selective expression of <i>LDLR</i> and <i>VLDLR</i> in myelinating oligodendrocytes
Zhao, S., Hu, X., Park, J., Zhu, Y., Zhu, Q., Li, H., Luo, C., Han, R., Cooper, N., & Qiu, M. (2007) · Developmental Dynamics · doi:10.1002/dvdy.21283 · Cited by 39 · see citing works
Ning, K., Duffy, B. A., Franklin, M., Matloff, W. J., Zhao, L., Arzouni, N., Sun, F., & Toga, A. W. (2021) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2021.03.014 · Cited by 38 · see citing works
Zhang, Y. P., Shields, L. B. E., Zhang, Y., Pei, J., Xu, X., Hoskins, R., Cai, J., Qiu, M. S., Magnuson, D. S. K., Burke, D. A., et al. (2007) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2007.05.021 · Cited by 38 · see citing works
A model of tight junction function in central nervous system myelinated axons
Gow, A., & Devaux, J. J. (2008) · Neuron Glia Biology · doi:10.1017/s1740925x09990391 · Cited by 36 · see citing works
Self-citationKim, T., Valera, E., & Desplats, P. (2019) · Molecular Neurobiology · doi:10.1007/s12035-019-1577-3 · Cited by 30 · see citing works
Emerging cellular themes in leukodystrophies
Nowacki, J. C., Fields, A. M., & Fu, M. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.902261 · Cited by 29 · see citing works
Proteomic analysis of optic nerve lipid rafts reveals new paranodal proteins
Ogawa, Y., & Rasband, M. N. (2009) · Journal of Neuroscience Research · doi:10.1002/jnr.21984 · Cited by 29 · see citing works
Necl-4/SynCAM-4 Is Expressed in Myelinating Oligodendrocytes but Not Required for Axonal Myelination
Zhu, Y., Li, H., Li, K., Zhao, X., An, T., Hu, X., Park, J., Huang, H., Yin, B., Qiang, B., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0064264 · Cited by 28 · see citing works
NKX6.1 Represses Tumorigenesis, Metastasis, and Chemoresistance in Colorectal Cancer
Chung, H.-H., Lee, C., Hu, J., Chou, Y., Lin, Y., & Shih, Y. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21145106 · Cited by 27 · see citing works
Paving the Axonal Highway: From Stem Cells to Myelin Repair
Peru, R. L., Mandrycky, N., Nait-Oumesmar, B., & Lu, Q. R. (2008) · Stem Cell Reviews · doi:10.1007/s12015-008-9043-z · Cited by 28 · see citing works
Southwood, C. M., Fyk‐Kolodziej, B. E., Maheras, K. J., Garshott, D. M., Estill, M. S., Fribley, A. M., & Gow, A. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.1118-15.2016 · Cited by 26 · see citing works
Self-citationDynamic expression patterns of Nkx6.1 and Nkx6.2 in the developing mes‐diencephalic basal plate
Moreno‐Bravo, J. A., Perez‐Balaguer, A., Martı́nez, S., & Puelles, E. (2010) · Developmental Dynamics · doi:10.1002/dvdy.22327 · Cited by 24 · see citing works
Biallelic mutations in the homeodomain of NKX6-2 underlie a severe hypomyelinating leukodystrophy
Dorboz, I., Aiello, C., Simons, C., Stone, R. T., Niceta, M., Elmaleh, M., Abuawad, M., Doummar, D., Bruselles, A., Wolf, N. I., et al. (2017) · Brain · doi:10.1093/brain/awx207 · Cited by 24 · see citing works
Volman, V., & Ng, L. J. (2014) · Journal of Computational Neuroscience · doi:10.1007/s10827-014-0515-7 · Cited by 23 · see citing works
Toch, M., Harris, A., Schakman, O., Kondratskaya, E., Boulland, J., Dauguet, N., Debrulle, S., Baudouin, C., Hidalgo‐Figueroa, M., Mu, X., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-57945-4 · Cited by 22 · see citing works
Self-citationZhu, Q., Tan, Z., Zhao, S., Huang, H., Zhao, X., Hu, X., Zhang, Y., Shields, C. B., Uetani, N., & Qiu, M. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.08.062 · Cited by 20 · see citing works
Sharma, R., Jiang, H., Zhong, L., Tseng, J., & Gow, A. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04646.x · Cited by 20 · see citing works
Self-citationZheng, C., Hervé, B., Meijer, M., Rodríguez-Kirby, L. A. R., Cacais, A. O. G., Kukanja, P., Kabbe, M., Jimenez-Beristain, T., Olsson, T., Agirre, E., et al. (2023) · bioRxiv · doi:10.1038/s41593-025-02100-3 · Cited by 15 · see citing works
Chang, S., Kuo, C.-C., Wu, C., Hsiao, C., Hu, J., Hsu, C., Chou, Y., Shih, Y., & Lin, Y. (2018) · Genes Chromosomes and Cancer · doi:10.1002/gcc.22529 · Cited by 19 · see citing works
Transgene-Mediated Rescue of Spermatogenesis in Cldn11-Null Mice1
Wu, X., Peppi, M., Vengalil, M. J., Maheras, K. J., Southwood, C. M., Bradley, M., & Gow, A. (2012) · Biology of Reproduction · doi:10.1095/biolreprod.111.096230 · Cited by 17 · see citing works
Self-citationMaheras, K. J., & Gow, A. (2013) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2013.07.004 · Cited by 14 · see citing works
Self-citationExpanding the clinical and genetic spectra of NKX6‐2‐related disorder
Baldi, C., Bertoli‐Avella, A. M., Al-Sannaa, N. A., Alfadhel, M., Al‐Thihli, K., Alameer, S., Elmonairy, A. A., Al-Shamsi, A. M., Abdelrahman, H. A., Al‐Gazali, L., et al. (2018) · Clinical Genetics · doi:10.1111/cge.13221 · Cited by 14 · see citing works
Molecular and cellular processes disrupted in the early postnatal Down syndrome prefrontal cortex
Risgaard, R. D., Hanthanan Arachchilage, K., Knaack, S. A., Hosseini, M., Chen, R. J., Kumarage, P., Schmidt, D. K., Huang, X., Sheng, J., Wang, C. J., et al. (2026) · Science · doi:10.1126/science.aea1549 · Cited by 12 · see citing works
White matter integrity requires continuous myelin synthesis at the inner tonguePreprint
Meschkat, M., Steyer, A. M., Weil, M., Kusch, K., Jahn, O., Piepkorn, L., Agüi‐Gonzalez, P., Phan, N. T. N., Ruhwedel, T., Sadowski, B., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.09.02.279612 · Cited by 12 · see citing works
Antisense suppression of tau in cultured rat oligodendrocytes inhibits process formation
Gordon, D., Kidd, G. J., & Smith, R. (2008) · Journal of Neuroscience Research · doi:10.1002/jnr.21719 · Cited by 11 · see citing works
Pinch2 regulates myelination in the mouse central nervous system
de Faria, J. P., Vale-Silva, R. S., Fässler, R., Werner, H. B., & Relvas, J. B. (2022) · Development · doi:10.1242/dev.200597 · Cited by 9 · see citing works
Booth, J. S., Nicolay, D. J., Doucette, J. R., & Nazarali, A. J. (2007) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-007-9150-4 · Cited by 9 · see citing works
Expanding the clinical and neuroimaging features of NKX6-2-related hereditary spastic ataxia type 8
Bereshneh, A. H., Hosseipour, S., Rasoulinezhad, M., Pak, N., Garshasbi, M., & Tavasoli, A. R. (2020) · European Journal of Medical Genetics · doi:10.1016/j.ejmg.2020.103868 · Cited by 8 · see citing works
Ghosh, S., Bhatti, G. K., Sharma, P. K., Kandimalla, R. J. L., Mastana, S. S., & Bhatti, J. S. (2023) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-023-01434-5 · Cited by 7 · see citing works
Komleva, Y. K., Shpiliukova, K. A., Bondar, N., Salmina, A. B., Хилажева, Е. Д., Illarioshkin, S. N., & Пирадов, М. А. (2025) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2025.1562453 · Cited by 7 · see citing works
Butt, A. M., Niu, J., Yi, C., & Verkhratsky, A. (2026) · Physiological Reviews · doi:10.1152/physrev.00023.2025 · Cited by 7 · see citing works
Anne, A., Saxena, S., & Mohan, K. N. (2022) · Epigenomics · doi:10.2217/epi-2022-0184 · Cited by 7 · see citing works
Verkhratsky, A., & Butt, A. M. (2013) · Wiley eBooks · doi:10.1002/9781118402061.ch5 · Cited by 6 · see citing works
Choi, J. J., Svaren, J. P., & Wang, D. (2025) · Communications Biology · doi:10.1038/s42003-025-07570-6 · Cited by 8 · see citing works
Almatrafi, A., Umair, M., El-Dardear, A., Al‐Luqmani, M., Hashmi, J. A., Albalawi, A. M., Alfadhel, M., Ramzan, K., & Basit, S. (2020) · The Journal of Gene Medicine · doi:10.1002/jgm.3196 · Cited by 5 · see citing works
Kohnke, S., Lam, B., Buller, S. A., Zhao, C., Nuzzaci, D., Tadross, J. A., Holmqvist, S., Ridley, K., Hathaway, H. A., Macklin, W. B., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/751198 · Cited by 5 · see citing works
The epigenetic landscape of oligodendrocyte progenitors changes with timePreprint
Dansu, D. K., Sauma, S., Huang, D., Li, M., Moyon, S., & Casaccia, P. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.02.06.579145 · Cited by 5 · see citing works
Gow, A., Dupree, J. L., Feinstein, D. L., & Boullerne, A. I. (2025) · ASN NEURO · doi:10.1080/17590914.2024.2447336 · Cited by 4 · see citing works
Self-citationZinc-Finger Protein ZFP488 Regulates the Timing of Oligodendrocyte Myelination and Remyelination
Cui, S., Chen, T., Xin, D. E., Chen, F., Zhong, X., Dong, C., Chen, X., Chen, H., Zhou, W., Lin, Y., et al. (2024) · Journal of Neuroscience · doi:10.1523/jneurosci.0141-24.2024 · Cited by 3 · see citing works
Specification of oligodendrocytes
Wegner, M. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-814405-3.00034-5 · Cited by 1 · see citing works
Choi, J. J., Svaren, J. P., & Wang, D. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.06.19.599799 · Cited by 3 · see citing works
Major Components of Myelin in the Mammalian Central and Peripheral Nervous Systems
Kálmán, B., & Gow, A. (2007) · doi:10.1002/9780470692363.ch2 · Cited by 2 · see citing works
Self-citationSpecification of Macroglia by Transcription Factors: Oligodendrocytes
Wegner, M. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-397265-1.00081-2 · Cited by 1 · see citing works
Shurrab, S., Cordeiro, D., Mercimek‐Andrews, S., & Shuen, A. Y. (2023) · Brain Disorders · doi:10.1016/j.dscb.2023.100069 · Cited by 1 · see citing works
Hypomyelinating leukodystrophy and movement disorders
Ganguly, J., Sinha, J., Basu, P., Pal, A., Mondal, B., Tiwari, M., & Kumar, H. (2023) · Annals of Movement Disorders · doi:10.4103/aomd.aomd_1_23 · Cited by 1 · see citing works
A study of the generation of diversity in the central nervous system
Applequist, J. M. (2011) · Figshare
Nervus Trigeminus'un Basis Cranii İçinde Seyrinin İncelenmesi ve Histolojik Analizi
Songür, A., Acar, T., Özen, O. A., Baş, O., Şahin, Ö., Küçüker, H., & Üzün, İ. (2008) · DergiPark (Istanbul University)
Histone deacetylase inhibition-mediated cytotoxicity of oligodendrocytes.
Dincman, T. A. (2011) · doi:10.18297/etd/351
Transcription Factors in Myelinating Cells
Wegner, M. (2012) · Oxford University Press eBooks · doi:10.1093/med/9780199794591.003.0043
(2006) · Elsevier eBooks · doi:10.1016/b978-0-443-07271-0.50022-7
Pinch2 is a novel regulator of myelination in the Central Nervous SystemPreprint
de Faria, J. P., Vale-Silva, R. S., Fässler, R., Werner, H. B., & Relvas, J. B. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.03.04.483000
Is spastic ataxia 8 a protein misfolding disorder?
Ferreira-Peralta, P., França, B., Murtinheira, F., Rodrigues, M. S., & Herrera, F. (2023) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2023.166882
Kalinová, J., Appenroth, D., Bigot, Y., McDowell, R. J., Notash, S., Lucas, R. J., West, A. C., Wood, S. H., Dardente, H., & Hazlerigg, D. G. (2025) · Journal of Photochemistry and Photobiology · doi:10.1016/j.jpap.2025.100272
The role of Chd7 & Chd8 chromatin remodelers in oligodendrogenesis and (re)myelination
Marie, C. (2017) · theses.fr (ABES) · doi:10.70675/01ff9606zc0a7z47a8za3f4ze4f886e3bb00
Essential transcriptional regulators of cement proteins during barnacle settlement
Yao, S., Zhao, Y., Gao, X. D., Li, Z., Ma, Y., Ke, C., & 冯丹青 (2026) · Marine Life Science & Technology · doi:10.1007/s42995-026-00399-w
Hjorthaug, H. S., Heimli, M., Flåm, S. T., & Lie, B. A. (2026) · iScience · doi:10.1016/j.isci.2026.116916
- Authors
- Southwood, C., He, C., Garbern, J., Kamholz, J., Arroyo, E., & Gow, A.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- Wayne State University (US)
- University of Pennsylvania (US)
- Corresponding author
- Gow, Alexander
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2004-12-15
- Volume
- 24
- Issue
- 50
- Pages
- 11215-11225
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6730372
- OpenAlex
- W2075117058
- Cited by
- 94
- References
- 59
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 3 · 2023: 4 · 2022: 5 · 2021: 4 · 2020: 7 · 2019: 5 · 2018: 3 · 2017: 3 · 2016: 2 · 2015: 3 · 2014: 1 · 2013: 7 · 2012: 4
- FWCI
- 0.94
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Multiple Sclerosis Society (RG2891)
- Multiple Sclerosis Society
- National Institutes of Health
- National Institute on Deafness and Other Communication Disorders (DC006262, R01DC006262)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- NKX6-2, homeodomain transcription factor, oligodendrocytes, axon-glia interaction, STMN1, neurofascin, contactin, gene regulatory networks, CNS myelination
- MeSH terms
- Animals, Central Nervous System, Cranial Nerves, Intercellular Junctions, Microtubule Proteins, Motor Neurons, Myelin Sheath, Nerve Tissue Proteins, Oligodendroglia, Phosphoproteins, Psychomotor Performance, Recombinant Fusion Proteins, Transcription Factors, Transcription, Genetic, Evoked Potentials, Auditory, Brain Stem, Mice, Knockout, Homeodomain Proteins, Gene Expression Regulation, Developmental, Rotarod Performance Test, Stathmin, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
