The DOI matches its Crossref record; 250 of the 251 references it cites were found in a registry or an index.
Regulation of neuron-astrocyte metabolic coupling across the sleep-wake cycle
Open accessAbstract
Over the last thirty years, a growing number of studies showed that astrocytes play a pivotal role in the energy support to synapses. More precisely, astrocytes adjust energy production to neuronal energy needs through different mechanisms grouped under the term "neurometabolic coupling" (NMC). In this review we describe these mechanisms of coupling and how they involve astrocytes. From a physiological point of view, these mechanisms of coupling are particularly important to ensure normal synaptic functioning when neurons undergo rapid and repetitive changes in the firing rate such as during the sleep/wake transitions. Investigations into brain energy metabolism during the sleep/wake cycle have been mainly focused on glucose (Gluc) consumption and on glycogen metabolism. However, the recent development of substrate-specific biosensors allowed measurements of the variation in extracellular levels of glutamate, Gluc and lactate (Lac) with a time resolution compatible with sleep stage duration. Together with gene expression data these experiments allowed to better define the variations of energy metabolite regulation across the sleep/wake cycle. The aim of this review is to bring into perspective the role of astrocytes and NMC in the regulation of the sleep/wake cycle. The data reviewed also suggest an important role of the astrocytic network. In addition, the role of astrocytes in NMC mechanisms is consistent with the "local and use dependent" sleep hypothesis.
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“A phenomenon known as ‘neurometabolic coupling’, adjusts the local energy supply and cerebral blood flow to variations in neuronal activity and enables appropriate metabolic substrate delivery to maintain functioning of neurons [32].”
From Vitamins and Minerals for Energy, Fatigue and Cognition: A Narrative Review of the Biochemical and Clinical Evidence (2020) · cites this paper as [32]
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Items 201–250 of 250
O’Brien, J., Kla, K. M., Hopkins, I. B., Malecki, E. A., & McKenna, M. C. (2006) · Neurochemical Research · doi:10.1007/s11064-006-9132-9 · Cited by 81
Laughton, J. D., Bittar, P. G., Charnay, Y., Pellerin, L., Kövari, E., Magistretti, P. J., & Bouras, C. (2007) · BMC Neuroscience · doi:10.1186/1471-2202-8-35 · Cited by 80
Self-citationGlycogen metabolism and the homeostatic regulation of sleep
Petit, J.-M., Burlet-Godinot, S., Magistretti, P. J., & Allaman, I. (2014) · Metabolic Brain Disease · doi:10.1007/s11011-014-9629-x · Cited by 79
Self-citationHeinrich, A., Andó, R., Turi, G. F., Rózsa, B. J., & Sperlágh, B. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2012.01932.x · Cited by 78
Changes in Brain Glycogen During Slow‐Wave Sleep in the Rat
Karnovsky, M. L., Reich, P., Anchors, J. M., & Burrows, B. L. (1983) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1983.tb00853.x · Cited by 78
Minelli, A., Barbaresi, P., Reimer, R. J., Edwards, R. H., & Conti, F. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00375-x · Cited by 75
Derouiche, A., Haseleu, J., & Korf, H. (2015) · Neurochemical Research · doi:10.1007/s11064-015-1563-8 · Cited by 75
Neurometabolic coupling between neural activity, glucose, and lactate in activated visual cortex
Li, B., & Freeman, R. D. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13143 · Cited by 70
Changes in brain glycogen after sleep deprivation vary with genotype
Franken, P., Gip, P., Hagiwara, G., Ruby, N. F., & Heller, H. C. (2003) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00668.2002 · Cited by 70
Norepinephrine depletion alters cerebral oxidative metabolism in the ‘active’ state
LaManna, J. C., Harik, S. I., Light, A. I., & Rosenthal, M. (1981) · Brain Research · doi:10.1016/0006-8993(81)90654-5 · Cited by 68
Brain extracellular glucose assessed by voltammetry throughout the rat sleep–wake cycle
Netchiporouk, L. I., Shram, N. F., Salvert, D., & Cespuglio, R. (2001) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2001.01503.x · Cited by 67
Physiology of Bergmann Gllal Cells
Müller, T. H., & Kettenmann, H. (1995) · International review of neurobiology · doi:10.1016/s0074-7742(08)60530-9 · Cited by 61
Vyazovskiy, V. V., Cirelli, C., Tononi, G., & Tobler, I. (2008) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2007.10.040 · Cited by 60
Shram, N. F., Netchiporouk, L. I., & Cespuglio, R. (2002) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2002.02081.x · Cited by 60
Allaman, I., Lengacher, S., Magistretti, P. J., & Pellerin, L. (2003) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00202.2002 · Cited by 60
Self-citationAstroglial Wiring is Adding Complexity to Neuroglial Networking
Giaume, C. (2010) · Frontiers in Neuroenergetics · doi:10.3389/fnene.2010.00129 · Cited by 58
Petit, J.-M., Gyger, J., Burlet-Godinot, S., Fiumelli, H., Martin, J., & Magistretti, P. J. (2013) · SLEEP · doi:10.5665/sleep.3034 · Cited by 56
Self-citationGlial calcium signaling in physiology and pathophysiology1
Verkhratsky, A. (2006) · Acta Pharmacologica Sinica · doi:10.1111/j.1745-7254.2006.00396.x · Cited by 56
Sleep deprivation decreases glycogen in the cerebellum but not in the cortex of young rats
Gip, P., Hagiwara, G., Ruby, N. F., & Heller, H. C. (2002) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00735.2001 · Cited by 55
Synaptically Evoked GABA Transporter Currents in Neocortical Glia
Kinney, G. A., & Spain, W. J. (2002) · Journal of Neurophysiology · doi:10.1152/jn.00037.2002 · Cited by 53
Sleep, Neuronal Plasticity and Brain Function
Meerlo, P., Benca, R. M., & Abel, T. G. (2015) · Current topics in behavioral neurosciences · doi:10.1007/978-3-662-46878-4 · Cited by 53
Lavado, E. M., Sánchez-Abarca, L. I., Tabernero, A., Bolaños, J. P., & Medina, J. M. (1997) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1997.69020721.x · Cited by 52
Changes in Extracellular Glutamate Levels in Rat Orbitofrontal Cortex During Sleep and Wakefulness
Lopez-Rodriguez, F., Medina‐Ceja, L., Wilson, C. L., Jhung, D., & Morales‐Villagrán, A. (2006) · Archives of Medical Research · doi:10.1016/j.arcmed.2006.07.004 · Cited by 52
Sleep/wake dependent changes in cortical glucose concentrations
Dash, M. B., Bellesi, M., Tononi, G., & Cirelli, C. (2012) · Journal of Neurochemistry · doi:10.1111/jnc.12063 · Cited by 49
John, J., Ramanathan, L., & Siegel, J. M. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90541.2008 · Cited by 49
Arbonés, M. L., Picatoste, F., & Garcı́a, A. (1990) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)11044-4 · Cited by 49
The psychostimulant modafinil enhances gap junctional communication in cortical astrocytes
Liu, X., Petit, J.-M., Ezan, P., Gyger, J., Magistretti, P. J., & Giaume, C. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.04.019 · Cited by 47
Self-citationEditorial [Hot Topic: Local Use-Dependent Sleep ( Guest Editors: J.M. Krueger & J.P. Wisor)]
Krueger, J. M., & Wisor, J. P. (2011) · Current Topics in Medicinal Chemistry · doi:10.2174/156802611797470295 · Cited by 46
Rattenborg, N. C., Lima, S. L., & Lesku, J. A. (2012) · The Neuroscientist · doi:10.1177/1073858412441086 · Cited by 41
Petit, J.-M., Tobler, I., Kopp, C., Morgenthaler, F. D., Borbély, A. A., & Magistretti, P. J. (2010) · SLEEP · doi:10.1093/sleep/33.7.901 · Cited by 40
Self-citationShram, N. F., Netchiporouk, L. I., Martelet, C., Jaffrezic-Renault, N. J., & Cespuglio, R. (1997) · Neuroreport · doi:10.1097/00001756-199703240-00009 · Cited by 37
Jay, T. M., Jouvet, M., & Rosiers, M. H. D. (1985) · Brain Research · doi:10.1016/0006-8993(85)91129-1 · Cited by 36
Rhythmic Enzyme Changes in Neurons and Glia during Sleep
Hydén, H., & Lange, P. W. (1965) · Science · doi:10.1126/science.149.3684.654 · Cited by 36
Sleep and Synaptic Homeostasis
Vyazovskiy, V. V., & Faraguna, U. (2014) · Current topics in behavioral neurosciences · doi:10.1007/7854_2014_301 · Cited by 35
Rex, A., Bert, B., Fink, H., & Voigt, J. (2009) · Physiology & Behavior · doi:10.1016/j.physbeh.2009.07.015 · Cited by 35
Sustained Sleep Fragmentation Induces Sleep Homeostasis in Mice
Baud, M. O., Magistretti, P. J., & Petit, J.-M. (2015) · SLEEP · doi:10.5665/sleep.4572 · Cited by 35
Self-citationSignaling from Nucleotide Receptors to Protein Kinase Cascades in Astrocytes
Neary, J. T., Kang, Y., & Shi, Y. (2004) · Neurochemical Research · doi:10.1007/s11064-004-6876-y · Cited by 35
Copelman, C. A., Cuzner, M. L., Groome, N. P., & Diemel, L. T. (2000) · Glia · doi:10.1002/(sici)1098-1136(200006)30:4 · Cited by 35
Self-citationMaher, F., & Simpson, I. A. (1994) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.1994.1044 · Cited by 34
Alteration of brain glycogen turnover in the conscious rat after 5h of prolonged wakefulness
Morgenthaler, F. D., Lanz, B., Petit, J.-M., Hanne Frenkel, A., Magistretti, P. J., & Rolf Gruetter, A. (2009) · Neurochemistry International · doi:10.1016/j.neuint.2009.02.023 · Cited by 29
Self-citationCerebral lactate dynamics across sleep/wake cycles
Rempe, M. J., & Wisor, J. P. (2015) · Frontiers in Computational Neuroscience · doi:10.3389/fncom.2014.00174 · Cited by 28
Hérard, A.-S., Dubois, A., Escartin, C., Tanaka, K., Delzescaux, T., Hantraye, P., & Bonvento, G. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04346.x · Cited by 25
Chauvet, N., Apert, C., Dumoulin, A., Epelbaum, J., & Alonso, G. (1997) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19970127)377:4 · Cited by 23
Mottin, S., Laporte, P., Jouvet, M., & Cespuglio, R. (1997) · Neuroscience · doi:10.1016/s0306-4522(96)00709-9 · Cited by 19
Glucose metabolites in the striatum of freely behaving rats following infusion of elevated potassium
Darbin, O., Carre, E., Naritoku, D. K., Risso, J. J., Lonjon, M., & Patrylo, P. R. (2006) · Brain Research · doi:10.1016/j.brainres.2006.06.095 · Cited by 17
Jakubcakova, V., Curzi, M. L., Flachskamm, C., Hambsch, B., Landgraf, R., & Kimura, M. (2013) · Journal of Psychopharmacology · doi:10.1177/0269881113495596 · Cited by 16
Hedera, P., Wu, D. H., Lewin, J. S., MILLER, D., Lerner, A. J., & Friedland, R. P. (1995) · Investigative Radiology · doi:10.1097/00004424-199511000-00001 · Cited by 12
Local cerebral glucose utilization in slow-wave sleep.
Kennedy, C., Gillin, J. C., Mendelson, W., Suda, S., Miyaoka, M., Ito, M., Nakamura, R., Fi, S., Pettigrew, K. D., Mishkin, M., et al. (1981) · PubMed · Cited by 12
Glutamate and GABA transporters in brain
eZhou, Y., & Danbolt, N. C. (2013) · Frontiers in Endocrinology · Cited by 1
Glucose transporter proteins in brain: Delivery of glucose to neurons and glia
Vannucci, S. J., Maher, F., & Simpson, I. A. (1997) · Glia · doi:10.1002/(sici)1098-1136(199709)21:1
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Magistretti, P. J., & Allaman, I. (2018) · Nature Reviews Neuroscience · doi:10.1038/nrn.2018.19 · Cited by 1,298
Self-citationTardy, A.-L., Pouteau, E., Marquez, D., Yilmaz, C., & Scholey, A. (2020) · Nutrients · doi:10.3390/nu12010228 · Cited by 541
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Brancaccio, M., Patton, A. P., Chesham, J. E., Maywood, E. S., & Hastings, M. H. (2017) · Neuron · doi:10.1016/j.neuron.2017.02.030 · Cited by 447
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Koob, G. F., & Colrain, I. M. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0446-0 · Cited by 302
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Papouin, T., Dunphy, J. M., Tolman, M., Foley, J., & Haydon, P. G. (2017) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2016.0154 · Cited by 243
Metadata
- Authors
- Petit, J.-M., & Magistretti, P. J.
- Affiliations
- Centre Hospitalier Universitaire Vaudois (CH)
- Corresponding author
- Petit, J.-M.
- ORCID
- Magistretti, P.J.
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 2016-05
- Volume
- 323
- Pages
- 135-156
- ISSN
- 0306-4522 (ISSN-L)
- OpenAlex
- W2200194422
- Cited by
- 92
- References
- 251
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 9 · 2023: 4 · 2022: 6 · 2021: 12 · 2020: 14 · 2019: 7 · 2018: 7 · 2017: 15 · 2016: 5
- FWCI
- 0.89
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Neuroscience (publishedVersion, cc-by)
- PubMed (publishedVersion)
- SERVAL (Université de Lausanne) (publishedVersion, other-oa)
- IRIS (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- King Abdullah University of Science and Technology Repository (King Abdullah University of Science and Technology) (submittedVersion)
- Funders
- National Science Foundation
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (3100AO, 108336)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- neurometabolic coupling, sleep-wake cycle, astrocytes, brain energy metabolism, glucose utilization, glycogen metabolism, glutamate, lactate
- MeSH terms
- Animals, Astrocytes, Humans, Neurons, Sleep, Wakefulness
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