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Cited by 177Impact of Technology on AdolescentsGambling Behavior and TreatmentsSexuality, Behavior, and Technology

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Effects of craving behavioral intervention on neural substrates of cue-induced craving in Internet gaming disorder

Open access
Zhang, Jin-Tao, Yao, Yuan-Wei, Potenza, Marc N., Xia, Cui-Cui, Lan, Jing, Liu, Lu, Wang, Ling-Jiao, Liu, Ben, Ma, Shan-Shan, Fang, Xiao-Yi·2016·NeuroImage: Clinical
DOI 10.1016/j.nicl.2016.09.004PMC PMC5035334
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Abstract

Internet gaming disorder (IGD) is characterized by high levels of craving for online gaming and related cues. Since addiction-related cues can evoke increased activation in brain areas involved in motivational and reward processing and may engender gaming behaviors or trigger relapse, ameliorating cue-induced craving may be a promising target for interventions for IGD. This study compared neural activation between 40 IGD and 19 healthy control (HC) subjects during an Internet-gaming cue-reactivity task and found that IGD subjects showed stronger activation in multiple brain areas, including the dorsal striatum, brainstem, substantia nigra, and anterior cingulate cortex, but lower activation in the posterior insula. Furthermore, twenty-three IGD subjects (CBI + group) participated in a craving behavioral intervention (CBI) group therapy, whereas the remaining 17 IGD subjects (CBI - group) did not receive any intervention, and all IGD subjects were scanned during similar time intervals. The CBI + group showed decreased IGD severity and cue-induced craving, enhanced activation in the anterior insula and decreased insular connectivity with the lingual gyrus and precuneus after receiving CBI. These findings suggest that CBI is effective in reducing craving and severity in IGD, and it may exert its effects by altering insula activation and its connectivity with regions involved in visual processing and attention bias.

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Crossref · 10.1016/j.nicl.2016.09.004

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Fig. 1 Schematic illustration of 2 blocks of the fMRI Internet-gaming cue-reactivity task.
Fig. 1 Schematic illustration of 2 blocks of the fMRI Internet-gaming cue-reactivity task.CC BY-NC-ND · PubMed Central
Fig. 2 Whole-brain group comparison between IGDs and HCs in gaming-cue-induced brain activation. The 3D activation map is overlaid on an inflated surface using BrainNet Viewer, whereas the 2D activation maps are overlaid on a T1 image using DPABI.
Fig. 2 Whole-brain group comparison between IGDs and HCs in gaming-cue-induced brain activation. The 3D activation map is overlaid on an inflated surface using BrainNet Viewer, whereas the 2D activation maps are overlaid on a T1 image using DPABI.CC BY-NC-ND · PubMed Central
Fig. 3 Panel A: CIAS scores, durations of weekly gaming, and craving for gaming clips across groups and sessions. Panel B: Internet-gaming cue-induced activation in the right anterior insula across groups and sessions. Panel C: Functional connectivity (gaming versus control clips) between the right anterior insula and left lingual gyrus (right) and right precuneus/lingual gyrus (left) across groups and sessions. CIAS = Chen Internet addition scale; R = right; L = left.
Fig. 3 Panel A: CIAS scores, durations of weekly gaming, and craving for gaming clips across groups and sessions. Panel B: Internet-gaming cue-induced activation in the right anterior insula across groups and sessions. Panel C: Functional connectivity (gaming versus control clips) between the right anterior insula and left lingual gyrus (right) and right precuneus/lingual gyrus (left) across groups and sessions. CIAS = Chen Internet addition scale; R = right; L = left.CC BY-NC-ND · PubMed Central

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Metadata

Authors
Zhang, J.-T., Yao, Y.-W., Potenza, M. N., Xia, C.-C., Lan, J., Liu, L., Wang, L.-J., Liu, B., Ma, S.-S., & Fang, X.-Y.
Affiliations
  • Beijing Normal University (CN)
  • Yale University (US)
ORCID
Venue
NeuroImage: Clinical
Publisher
Elsevier BV
Published
2016-02
Volume
12
Pages
591-599
ISSN
2213-1582 (ISSN-L)
DOI
10.1016/j.nicl.2016.09.004
PMC
PMC5035334
OpenAlex
W2520888266
Cited by
177
References
63
Citations by year
2026: 16 · 2025: 13 · 2024: 9 · 2023: 23 · 2022: 12 · 2021: 13 · 2020: 63 · 2019: 12 · 2018: 7 · 2017: 8 · 2016: 1
FWCI
26.69
Type
journal article
Language
en
Open access
Licence
Locations
  • NeuroImage Clinical (publishedVersion, cc-by-nc-nd)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Institutes of Health (R01 DA035058, P50 DA09241)
  • Mohegan Sun Casino
  • National Center for Responsible Gaming
  • Pfizer
  • National Natural Science Foundation of China (31170990, 81100992)
  • MOE (15YJA190010)
  • Fundamental Research Funds for the Central Universities of China (2015KJJCA13)
  • National Center on Addictions and Substance Abuse
Topics
  • Social Sciences › Sociology and Political Science › Impact of Technology on Adolescents
  • Social Sciences › Psychology › Clinical Psychology › Gambling Behavior and Treatments
  • Social Sciences › Psychology › Clinical Psychology › Sexuality, Behavior, and Technology
Keywords
internet gaming disorder, cue-induced craving, cue reactivity, dorsal striatum, substantia nigra, anterior cingulate cortex, posterior insula, anterior insula, precuneus, lingual gyrus, group therapy, addiction, relapse
MeSH terms
Adult, Brain Stem, Cerebral Cortex, Cues, Female, Gyrus Cinguli, Humans, Magnetic Resonance Imaging, Male, Substantia Nigra, Behavior, Addictive, Neostriatum, Video Games, Internet, Young Adult, Craving

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