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Effects of craving behavioral intervention on neural substrates of cue-induced craving in Internet gaming disorder
Open accessAbstract
Internet gaming disorder (IGD) is characterized by high levels of craving for online gaming and related cues. Since addiction-related cues can evoke increased activation in brain areas involved in motivational and reward processing and may engender gaming behaviors or trigger relapse, ameliorating cue-induced craving may be a promising target for interventions for IGD. This study compared neural activation between 40 IGD and 19 healthy control (HC) subjects during an Internet-gaming cue-reactivity task and found that IGD subjects showed stronger activation in multiple brain areas, including the dorsal striatum, brainstem, substantia nigra, and anterior cingulate cortex, but lower activation in the posterior insula. Furthermore, twenty-three IGD subjects (CBI + group) participated in a craving behavioral intervention (CBI) group therapy, whereas the remaining 17 IGD subjects (CBI - group) did not receive any intervention, and all IGD subjects were scanned during similar time intervals. The CBI + group showed decreased IGD severity and cue-induced craving, enhanced activation in the anterior insula and decreased insular connectivity with the lingual gyrus and precuneus after receiving CBI. These findings suggest that CBI is effective in reducing craving and severity in IGD, and it may exert its effects by altering insula activation and its connectivity with regions involved in visual processing and attention bias.
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“The targeted-effect size was chosen based on findings from studies employing CIC paradigms for drug craving52, food cravings25,37,53,54 and internet gaming craving27, which report medium-to-large effect sizes in cue reactivity52.”
From Acute social isolation evokes midbrain craving responses similar to hunger (2020) · cites this paper as [27]
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Metadata
- Authors
- Zhang, J.-T., Yao, Y.-W., Potenza, M. N., Xia, C.-C., Lan, J., Liu, L., Wang, L.-J., Liu, B., Ma, S.-S., & Fang, X.-Y.
- Affiliations
- Beijing Normal University (CN)
- Yale University (US)
- Venue
- NeuroImage: Clinical
- Publisher
- Elsevier BV
- Published
- 2016-02
- Volume
- 12
- Pages
- 591-599
- ISSN
- 2213-1582 (ISSN-L)
- PMC
- PMC5035334
- OpenAlex
- W2520888266
- Cited by
- 177
- References
- 63
- Citations by year
- 2026: 16 · 2025: 13 · 2024: 9 · 2023: 23 · 2022: 12 · 2021: 13 · 2020: 63 · 2019: 12 · 2018: 7 · 2017: 8 · 2016: 1
- FWCI
- 26.69
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- NeuroImage Clinical (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institutes of Health (R01 DA035058, P50 DA09241)
- Mohegan Sun Casino
- National Center for Responsible Gaming
- Pfizer
- National Natural Science Foundation of China (31170990, 81100992)
- MOE (15YJA190010)
- Fundamental Research Funds for the Central Universities of China (2015KJJCA13)
- National Center on Addictions and Substance Abuse
- Topics
- Social Sciences › Sociology and Political Science › Impact of Technology on Adolescents
- Social Sciences › Psychology › Clinical Psychology › Gambling Behavior and Treatments
- Social Sciences › Psychology › Clinical Psychology › Sexuality, Behavior, and Technology
- Keywords
- internet gaming disorder, cue-induced craving, cue reactivity, dorsal striatum, substantia nigra, anterior cingulate cortex, posterior insula, anterior insula, precuneus, lingual gyrus, group therapy, addiction, relapse
- MeSH terms
- Adult, Brain Stem, Cerebral Cortex, Cues, Female, Gyrus Cinguli, Humans, Magnetic Resonance Imaging, Male, Substantia Nigra, Behavior, Addictive, Neostriatum, Video Games, Internet, Young Adult, Craving
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