Embracing sulfide and CO to understand nitric oxide biology
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Embracing sulfide and CO to understand nitric oxide biologyResearch in the field of nitric oxide (NO) biology has come a long way from its humble beginnings revolving around the identification of the 'endothelium-dependent relaxing factor' (EDRF) to the ubiquitous cell messenger, modulator and regulator of cellular activity it is recognized today.Those of us who had the good fortune to witness the development of this field of research over the years will remember the moments where the cross-talk of NO with other biomolecules became a central feature of the NO signalling process.Some of you may even have had a similar ''deja-vu'' feeling as we experienced while listening to the other individual's lecture at one of those themed integrated physiology meetings.At the occasion of one such meeting in Glasgow in 2010 the two of us could not help wondering why NO and sulfide appeared so similar when viewed through the looking glass of ''hypoxic tolerance''.This Editorial serves to explain the Nitric Oxide Society Board Members' decision to expand the scope of our ''house journal'' to include the biology and chemistry of two other signalling molecules, a decision most of us feel is timely and justified as the field has evolved.
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NO, CO and H2S differ in potency and appear to mediate their biological action via different signaling pathways, but their action spectrum shows remarkable overlap.
“Although this recognition lacks universal agreement [6,7], and the three molecules differ in potency and appear to mediate their biological action via different signaling pathways, their action spectrum shows remarkable overlap.”
From On the chemical biology of the nitrite/sulfide interaction (2015) · cites this paper as [6]
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Hydrogen sulfide chemical biology: pathophysiological roles and detection
Kolluru, G. K., Shen, X., Bir, S. C., & Kevil, C. G. (2013) · Nitric Oxide · doi:10.1016/j.niox.2013.07.002 · Cited by 480 · see citing works
Chemical foundations of hydrogen sulfide biology
Li, Q., & Lancaster, J. R. (2013) · Nitric Oxide · doi:10.1016/j.niox.2013.07.001 · Cited by 334 · see citing works
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Cortese-Krott, M. M., Fernandez, B. O., Santos, J. L. T., Mergia, E., Grman, M., Nagy, P., Kelm, M., Butler, A., & Feelisch, M. (2014) · Redox Biology · doi:10.1016/j.redox.2013.12.031 · Cited by 153 · see citing works
On the chemical biology of the nitrite/sulfide interaction
Cortese-Krott, M. M., Fernandez, B. O., Kelm, M., Butler, A. R., & Feelisch, M. (2015) · Nitric Oxide · doi:10.1016/j.niox.2014.12.009 · Cited by 115 · see citing works
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- Authors
- Feelisch, M., & Olson, K. R.
- Affiliations
- Southampton General Hospital (GB)
- Indiana University South Bend (US)
- Corresponding author
- Feelisch, Martin
- Venue
- Nitric Oxide
- Publisher
- Elsevier BV
- Published
- 2013-11
- Volume
- 35
- Pages
- 2-4
- ISSN
- 1089-8603 (ISSN-L)
- OpenAlex
- W2059441563
- Cited by
- 20
- References
- 2
- Citations by year
- 2024: 2 · 2023: 2 · 2022: 2 · 2021: 3 · 2017: 2 · 2016: 4 · 2015: 2 · 2014: 3
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Nitric Oxide (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- ePrints Soton (University of Southampton) (acceptedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Sulfur Compounds in Biology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- sulfide, carbon monoxide, gasotransmitters, no-signaling, hypoxia tolerance, endothelium-derived relaxing factor, journal scope expansion
- MeSH terms
- Biochemistry, Carbon Monoxide, Humans, Nitric Oxide, Sulfides
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