Cited by 334Sulfur Compounds in BiologyRedox biology and oxidative stressCatalysis and Hydrodesulfurization Studies

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Chemical foundations of hydrogen sulfide biology

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Li, Qian, Lancaster, Jack R.·2013·Nitric Oxide

DOI 10.1016/j.niox.2013.07.001PMC PMC3843984

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Abstract

Following nitric oxide (nitrogen monoxide) and carbon monoxide, hydrogen sulfide (or its newer systematic name sulfane, H2S) became the third small molecule that can be both toxic and beneficial depending on the concentration. In spite of its impressive therapeutic potential, the underlying mechanisms for its beneficial effects remain unclear. Any novel mechanism has to obey fundamental chemical principles. H2S chemistry was studied long before its biological relevance was discovered, however, with a few exceptions, these past works have received relatively little attention in the path of exploring the mechanistic conundrum of H2S biological functions. This review calls attention to the basic physical and chemical properties of H2S, focuses on the chemistry between H2S and its three potential biological targets: oxidants, metals and thiol derivatives, discusses the applications of these basics into H2S biology and methodology, and introduces the standard terminology to this youthful field.

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Authors: Li, Q., & Lancaster, J. R.
Affiliations: University of Alabama at Birmingham (US)
Corresponding author: Li, Qian
Venue: Nitric Oxide
Publisher: Elsevier BV
Published: 2013-11
Volume: 35
Pages: 21-34
ISSN: 1089-8603 (ISSN-L)
DOI: 10.1016/j.niox.2013.07.001
PMC: PMC3843984
OpenAlex: W2070744732
Cited by: 334
References: 317
Citations by year: 2026: 11 · 2025: 20 · 2024: 26 · 2023: 30 · 2022: 21 · 2021: 49 · 2020: 23 · 2019: 27 · 2018: 17 · 2017: 30 · 2016: 30 · 2015: 26 · 2014: 22 · 2013: 2
FWCI: 2.48
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by-nc-nd/4.0/ (vor)
Locations: Nitric Oxide (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Department of Anesthesiology, University of Alabama at Birmingham
NIH grant CA-131653
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Sulfur Compounds in Biology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Physical Sciences › Chemical Engineering › Catalysis › Catalysis and Hydrodesulfurization Studies
Keywords: hydrogen sulfide, sulfanes, gasotransmitters, redox chemistry, metal sulfides, thiol derivatives, oxidizing agents
MeSH terms: Animals, Biochemistry, Heme, Humans, Hydrogen Sulfide, Metals, Oxides, Sulfhydryl Compounds, Mice

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